The G3BP stress-granule proteins reinforce the integrated stress response translation programme www.nature.com/articles/s41...

Can one map the genome-wide binding (1) and its protein partners (2) simultaneously from the same sample? Yes, one can. with CUT&ID ✂️🪪 Spearheaded — singlehandedly — by @annanordin.bsky.social No need of transgenesis, cloning and overexpression. Check it out, it's fast and its works.

🚨 New paper out! A human epiblast model reveals how dynamic TGF‑β signalling controls epithelial identity in early mammalian development Here is the full paper: rdcu.be/eSWEs 🧵 A twittorial: THREAD

So proud to share this beautiful work developed in collaboration with @lorealfrance.bsky.social Using 3D imaging at an outstanding level of resolution, we have uncovered the intricate cellular dynamics of human hair follicles - and the movies are stunning! More details here: tinyurl.com/4vrywf3z

An amazing preprint on molecular evolution (p63-Notch) of Epithelial Multilayering Cross-organ (14 in🐭), Cross-species (7🪰🐟x2🐸🐥🐭👤) single-cell transcriptomics p63+Jag2+ basal signal sendor▶️ p63-Hes1+ suprabasal receivers🐭 bioRxiv 2025 www.biorxiv.org/content/10.1...

Human epidermal Langerhans cells induce tolerance and hamper T cell function upon tick-borne pathogen transmission @natcomms.nature.com www.nature.com/articles/s41...

I am thrilled to share the latest manuscript from the Shain lab, describing the genetic changes that transform a keratinocyte into cutaneous squamous cell carcinoma (and everything in between). www.nature.com/articles/s41...

The latest in my favorite love triangle: Chromatin <-(💜)-> Condensates <-(💚)-> Mechanics

Selective RNA sequestration in biomolecular condensates directs cell fate transitions - @distefanolab.bsky.social @brumbaugh-lab.bsky.social go.nature.com/3X215du

Now online! Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity

Finally announcing our new study in @cp-immunity.bsky.social! We show that IL-17RA fulfills dual tumor suppressor function in late-stage colorectal cancer (CRC)! #immunosky #cancer #immunology @loewe-fci.bsky.social @cellpress.bsky.social @goetheuni.bsky.social Read here🧵👇: tinylink.net/OS41F

Messenger RNA is made in the nucleus before it is exported to the cytoplasm for translation. But how are only correctly made mRNAs chosen and remodeled in the nucleus for export? Our new paper investigates the nuclear events leading to human mRNA export. www.nature.com/articles/s41.... (1/4)

Last but not least, we are thrilled to have representatives from academia, industry, foundations and publishers to share with us their take during the roundtable discussion on Bridging Sectors for Translational Impact!

The 2nd @eurocancerdepmap.bsky.social meeting is starting with introduction from @francescoiorio.bsky.social ! Full day of exciting talks ahead. Stay with us for live updates @humantechnopole.bsky.social

Our latest paper has just been published in Cell! doi.org/10.1016/j.ce... We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.

Great collaboration on uncovering how ER organisation, curvature and mechanics are regulating collective cell migration. Experiments by Simran, Tamal and collaborators and a model by Pradeep.

Regulatory T cells in skin utilize the Cxcr4-Cxcl12 axis to promote hair follicle regeneration @cp-cellreports.bsky.social www.cell.com/cell-reports...

Multimodal learning enables chat-based exploration of single-cell data - @bocklab.bsky.social @cemm.oeaw.ac.at @meduniwien.ac.at go.nature.com/3WPGJnW

How does aging alter the translational landscape of stem cells and how do these changes impact their regenerative capacity? Here we developed an in vivo single-cell ribosome profiling strategy to monitor translational landscapes of the mouse epidermis 1/6 www.biorxiv.org/content/10.1...

Fibroinflammatory skin diseases are characterized by interferon independent fibroblast EGFR-STAT1 signaling that controls expression of fibrotic genes @natcomms.nature.com @yalepress.bsky.social www.nature.com/articles/s41...

My recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...

Latest from @ivaskalab.bsky.social @jrwconway.bsky.social in NCB. We find that SHP-2 inhibition stops TNBC invasion and limits metastasis by blocking integrin dephosphorylation! Read more at: www.nature.com/articles/s41...

Clinically-normal skin harbours widespread, sub-clinical fields of BRAF V600E-mutant melanocytes, which are oncogene-primed but apparently dormant. These fields concentrated around naevi & melanomas may represent a field cancerization. @thestarklab.bsky.social url: academic.oup.com/bjd/article/...

Programmable promoter editing for precise control of transgene expression - @mitcheme.bsky.social @mitdeptofbe.bsky.social go.nature.com/4h9wlR1

Pleased to share our review on “Synthetic Mechanotransduction” — now live at Nature Reviews Bioengineering. May the force be with you! www.nature.com/articles/s44...

We found that the ECM composition underlying the stem cells affects wound healing speed!

Proximity-specific ribosome profiling using light induced BirA. 😎 #Ribosome #RNASky

Check out our new RAEFISH spatial transcriptomics technology published in Cell! This work represents the first time that transcripts from more than 20,000 genes were directly imaged in situ with any technology, and the first time numerous gRNAs were directly probed in an image-based CRISPR screen.

What would happen if cells would express more molecular motors ? They would break all microtubules 😱 As shown by recent great work from @kjverhey1.bsky.social rupress.org/jcb/article-...

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

1/12 A very special moment for me! 🎉 My first paper as corresponding author—a @jcb.org Perspective on how contact-based decision-making in collective cell migration can itself encode blueprints for complex patterns and shapes. rupress.org/jcb/article/... #cellbio #devbio #science 🧵for details

...23 skin conditions including atopic dermatitis, alopecia areata, psoriasis, lupus, sarcoidosis, acne, cutaneaous melanoma, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), keloid scar, systemic sclerosis www.nature.com/articles/s41...

🧠 Why does glioblastoma always outsmart treatment? In our #Neuro-Oncology paper, we identified proneural-mesenchymal hybrid glioblastoma cells that are resistant to therapy and dependent on nuclear import. doi.org/10.1093/neuo... Short walkthrough below. Let’s dive in! 🧵 (1/9) #GBM, #BrainTumor

"It's official 🎉: Our remote magnetic control of #endosomes, driving invasive protrusions in living cells, has landed in #ScienceAdvances! #Magnetogenetics meets #Rabs! The journey was wild, but it works! 🔥 www.science.org/doi/full/10.... @imgprague.bsky.social #3Dmatrix #CellBiology @science.org

now online! check out our work describing roles for microtubules in tissue-resident macrophages during directed cell migration. thanks to @jcellsci.bsky.social for a stress-free publication process journals.biologists.com/jcs/article/...

Happy to share our latest publication on the role of Citrullination in the hair follicle stem cell lineage! Congratulations Kim Vikhe Patil and our fantastic collaborators from the Maria Kasper, Ryan Driskell and Priyanka Sharma labs! www.science.org/doi/10.1126/...

A new paper from the lab is out- www.sciencedirect.com/science/arti... A great collaboration between our lab in Muenster (Led by Dennis Hoffmann), Nir Gov (Weizmann/University of Cambridge), Ben Simons (University of Cambridge) and Tal Agranov (University of Cambridge).

Please RP. We are thrilled to announce that our lab’s first preprint is out! ”Whole-genome single-cell multimodal history tracing to reveal cell identity transition” We report HisTrac-seq, a multiomic single-cell molecular recording platform. www.biorxiv.org/content/10.1...

🍹Zhang et al. show that YAP binds to TDP-43 to promote TDP-43 multimerization and #PhaseSeparation. YAP and TDP-43 may co-localize in multiple cell types in oxidative stress and in brain samples from individuals with #AmyotrophicLateralSclerosis 👉https://rdcu.be/ezd0q bit.ly/4lYo1oO

Very happy to see our preprint on how the mechanosensitive ion channel Piezo1 controls intercellular junction maturation by balancing cortex and membrane tension now published in @jcellsci.bsky.social Congratulations to Ahsan & team! journals.biologists.com/jcs/article/...

Check out our new preprint Metabolic imprinting drives epithelial memory during mucosal #fungal infection. Thanks to all collaborators www.biorxiv.org/content/10.1...

our work on the molecular differences between transcription factor isoforms is out now in Molecular Cell! key point: 2/3rds of TF isos differ in properties like DNA binding & transcriptional activity many are "negative regulators" & misexpressed in cancer www.sciencedirect.com/science/arti...

💥 Very happy to share the latest publication of my friend Frederic Saltel 🤩 , where we helped them (a long time ago) going further into the biology of #invadosomes febs.onlinelibrary.wiley.com/doi/epdf/10....

“Beauty is skin deep” While searching for #melanoma cells (which are SOX10 positive), @katkajerabkova.bsky.social in the lab was taken back by the peculiar pattern of hair follicle under the #microscope.