How to link multivalent #RNAmotifs to their cognate #RBP regulator from #RNA-seq data only? Easy: RNAMaRs!💥 Relying on RBP binding principles and optimized #motif discovery RNAMaRs infers biologically interpretable motif-RBP associations. Check our new preprint here 👉 www.biorxiv.org/content/10.6...

Reprogramming mRNA localization by targeted RNA-protein interference https://www.biorxiv.org/content/10.64898/2026.02.27.708609v1

From Galbraith & Galbraith: “tradewinds” bring soluble proteins to the leading edge – with a nice assortment of microscopy approaches including iPALM www.nature.com/articles/s41...

Specific DNA sequence features encode the persistence of epigenetic memory of inflammation @science.org thefuchslab.bsky.social @rockefeller.edu @mskcancercenter.bsky.social www.science.org/doi/10.1126/...

Chronic gut inflammation leaves behind “molecular scars” that may raise the risk for developing cancer, according to a new study showing that epigenetic memory of colitis, along with a cancer-promoting mutation, can accelerate tumor growth in mice. @jbuenrostro.bsky.social

Unstructured transcription factor interactions enable emergent specificity | Science www.science.org/doi/10.1126/...

AP-1 mediates cellular adaptation and memory formation @natcomms.nature.com @pennmedicine.bsky.social @arjunraj.bsky.social @penngenetics.bsky.social www.nature.com/articles/s41...

Today we report single-cell APEX-seq (scAPEX-seq)—a method for unbiased mapping of subcellular transcriptomes at single-cell resolution. It reveals cell states invisible to standard scRNA-seq and identifies regulators of CAR T function that improve solid tumor killing. tinyurl.com/32pf6b8p

Our exciting collaboration paper is out 👇and investigates how chronic inflammation in the skin (psoriasis) prevents tumor development. 🔝👏👏Have a look 👀. Thanks for involving us in this important study 🙏🏾 Center for Cancer Research Medizinische Universität Wien www.pnas.org/doi/10.1073/...

🚨 New paper from our lab just published in Nature🚨 www.nature.com/articles/s41... Discover how 🌱 tumour formation is shaped by tissue context from the very beginning. Cancer is not driven by genetics alone ✨Fantastic team led by Greta Skrupskelyte, Eduardo Rojo, @hariajith.bsky.social

Ridges under the skin - paper in @nature.com www.nature.com/articles/s41...

🎉Proud to present our latest paper, out now in Nature Communications: www.nature.com/articles/s41... RNA Binding Proteins (RBPs) are often full of intrinsically disordered regions (IDRs), but what these regions do during RNA recognition is often unclear. 1/10 #RNA #IDR #RBP

I am thrilled to share our paper introducing RBPscan, a novel approach to profile RNA–protein interactions in living cells. Free access link at the end ⬇️ 🧵 1/ www.cell.com/molecular-ce...

Excited to highlight a new preprint about mechanical contributions to tissue homeostasis, from the Manning group in collaboration with the amazing Carien Niessen and Sara Wickstrom @sarawickstrom.bsky.social labs, spearheaded by Dr. Somiealo Azote: www.biorxiv.org/content/10.6...

Single-cell susceptibility to viral infection is driven by variable cell states www.sciencedirect.com/science/arti... #MicroSky

Our review “A competition model of multilineage priming and cell-fate decisions” is out: www.cell.com/cell-reports...

Check out our review on epithelial–microbiome interactions and their disruption in inflammatory skin disorders. + computational tools to study host–microbe crosstalk + ecological memory (epithelial and microbial memories) in barrier tissues. www.nature.com/articles/s41...

The G3BP stress-granule proteins reinforce the integrated stress response translation programme www.nature.com/articles/s41...

Can one map the genome-wide binding (1) and its protein partners (2) simultaneously from the same sample? Yes, one can. with CUT&ID ✂️🪪 Spearheaded — singlehandedly — by @annanordin.bsky.social No need of transgenesis, cloning and overexpression. Check it out, it's fast and its works.

🚨 New paper out! A human epiblast model reveals how dynamic TGF‑β signalling controls epithelial identity in early mammalian development Here is the full paper: rdcu.be/eSWEs 🧵 A twittorial: THREAD

So proud to share this beautiful work developed in collaboration with @lorealfrance.bsky.social Using 3D imaging at an outstanding level of resolution, we have uncovered the intricate cellular dynamics of human hair follicles - and the movies are stunning! More details here: tinyurl.com/4vrywf3z

An amazing preprint on molecular evolution (p63-Notch) of Epithelial Multilayering Cross-organ (14 in🐭), Cross-species (7🪰🐟x2🐸🐥🐭👤) single-cell transcriptomics p63+Jag2+ basal signal sendor▶️ p63-Hes1+ suprabasal receivers🐭 bioRxiv 2025 www.biorxiv.org/content/10.1...

Human epidermal Langerhans cells induce tolerance and hamper T cell function upon tick-borne pathogen transmission @natcomms.nature.com www.nature.com/articles/s41...

I am thrilled to share the latest manuscript from the Shain lab, describing the genetic changes that transform a keratinocyte into cutaneous squamous cell carcinoma (and everything in between). www.nature.com/articles/s41...

The latest in my favorite love triangle: Chromatin <-(💜)-> Condensates <-(💚)-> Mechanics

Selective RNA sequestration in biomolecular condensates directs cell fate transitions - @distefanolab.bsky.social @brumbaugh-lab.bsky.social go.nature.com/3X215du

Now online! Stress-induced sympathetic hyperactivation drives hair follicle necrosis to trigger autoimmunity

Finally announcing our new study in @cp-immunity.bsky.social! We show that IL-17RA fulfills dual tumor suppressor function in late-stage colorectal cancer (CRC)! #immunosky #cancer #immunology @loewe-fci.bsky.social @cellpress.bsky.social @goetheuni.bsky.social Read here🧵👇: tinylink.net/OS41F

Messenger RNA is made in the nucleus before it is exported to the cytoplasm for translation. But how are only correctly made mRNAs chosen and remodeled in the nucleus for export? Our new paper investigates the nuclear events leading to human mRNA export. www.nature.com/articles/s41.... (1/4)

Last but not least, we are thrilled to have representatives from academia, industry, foundations and publishers to share with us their take during the roundtable discussion on Bridging Sectors for Translational Impact!

The 2nd @eurocancerdepmap.bsky.social meeting is starting with introduction from @francescoiorio.bsky.social ! Full day of exciting talks ahead. Stay with us for live updates @humantechnopole.bsky.social

Our latest paper has just been published in Cell! doi.org/10.1016/j.ce... We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.

Great collaboration on uncovering how ER organisation, curvature and mechanics are regulating collective cell migration. Experiments by Simran, Tamal and collaborators and a model by Pradeep.

Regulatory T cells in skin utilize the Cxcr4-Cxcl12 axis to promote hair follicle regeneration @cp-cellreports.bsky.social www.cell.com/cell-reports...

Multimodal learning enables chat-based exploration of single-cell data - @bocklab.bsky.social @cemm.oeaw.ac.at @meduniwien.ac.at go.nature.com/3WPGJnW

How does aging alter the translational landscape of stem cells and how do these changes impact their regenerative capacity? Here we developed an in vivo single-cell ribosome profiling strategy to monitor translational landscapes of the mouse epidermis 1/6 www.biorxiv.org/content/10.1...

Fibroinflammatory skin diseases are characterized by interferon independent fibroblast EGFR-STAT1 signaling that controls expression of fibrotic genes @natcomms.nature.com @yalepress.bsky.social www.nature.com/articles/s41...

My recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...

Latest from @ivaskalab.bsky.social @jrwconway.bsky.social in NCB. We find that SHP-2 inhibition stops TNBC invasion and limits metastasis by blocking integrin dephosphorylation! Read more at: www.nature.com/articles/s41...

Clinically-normal skin harbours widespread, sub-clinical fields of BRAF V600E-mutant melanocytes, which are oncogene-primed but apparently dormant. These fields concentrated around naevi & melanomas may represent a field cancerization. @thestarklab.bsky.social url: academic.oup.com/bjd/article/...

Programmable promoter editing for precise control of transgene expression - @mitcheme.bsky.social @mitdeptofbe.bsky.social go.nature.com/4h9wlR1

Pleased to share our review on “Synthetic Mechanotransduction” — now live at Nature Reviews Bioengineering. May the force be with you! www.nature.com/articles/s44...

We found that the ECM composition underlying the stem cells affects wound healing speed!

Proximity-specific ribosome profiling using light induced BirA. 😎 #Ribosome #RNASky

Check out our new RAEFISH spatial transcriptomics technology published in Cell! This work represents the first time that transcripts from more than 20,000 genes were directly imaged in situ with any technology, and the first time numerous gRNAs were directly probed in an image-based CRISPR screen.

What would happen if cells would express more molecular motors ? They would break all microtubules 😱 As shown by recent great work from @kjverhey1.bsky.social rupress.org/jcb/article-...

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

1/12 A very special moment for me! 🎉 My first paper as corresponding author—a @jcb.org Perspective on how contact-based decision-making in collective cell migration can itself encode blueprints for complex patterns and shapes. rupress.org/jcb/article/... #cellbio #devbio #science 🧵for details