Xu, @thexavierlab.bsky.social et al @harvardmed.bsky.social @broadinstitute.org reveal an important role of the ANKRD55 protein in TH17 biology, where its deletion impairs T cell proliferation & effector cytokine production through metabolic dysregulation. rupress.org/jem/article/... #Autoimmunity

In her new role as an alliance manager, former drug discovery scientist Gail Guo keeps research projects moving forward for the Broad-Bayer Oncology collaboration. Learn more about her evolving role in a new #WhyIScience Q&A.

A human-mouse atlas of intrarenal myeloid cells identifies conserved disease-associated macrophages in #lupus #nephritis. New study from Paul Hoover, Nir Hacohen @broadinstitute.org, Anne Davidson @northwellhealth.bsky.social and colleagues: rupress.org/jem/article/... #InnateImmunity #Autoimmunity

Antibody–bottlebrush prodrug conjugates for targeted cancer therapy - @mitchemistry.bsky.social @broadinstitute.org go.nature.com/46d1T3t

In a Broad Q&A, Broad scientists Kristin Ardlie and Brad Bernstein talk about AlphaGenome, artificial intelligence, and how foundational datasets like ENCODE and @GTEx are fueling biomedical science in the AI age.

The lab's first sim pub of #ESC2025 is now online in @jaccjournals.bsky.social #JACC! jacc.org/doi/10.1016/... Led by 🇧🇪⭐️ @danielezzat.bsky.social , we examined clonal hematopoiesis (CHIP) 🩸 & CV 🫀 outcomes in older women 👵 using deep targeted 🧬 sequencing in the WHI Long Life Study 👇 (1/X)

Funded by the NIH Common Fund, @smahtnetwrk.bsky.social will map somatic mutations across human tissues with #SingleCell sequencing. Their work will uncover the causes, patterns, and consequences of somatic mutations in normal cells—providing a vital baseline for disease research. 🧪 🧬

Now online in Cancer Discovery @aacrjournals.bsky.social: Integrative Proteogenomics & Forward Genetics Reveals a Novel Mitotic Vulnerability in TNBC - by Nicholas Neill, Shankha Satpathy, Trey Westbrook and colleagues doi.org/10.1158/2159... @bcmfromthelabs.bsky.social @broadinstitute.org

Tomorrow, August 14 at 6 PM ET, join us in Cambridge, MA – or tune in online – for a Broad Discovery Series talk with @soumya-boston.bsky.social: "Arthritis, autoimmunity, and how the genome works." Register: broadinstitute.swoogo.com/DiscoverySeries25

New research from a collaborative study between Dana-Farber and @broadinstitute.org shows promise for targeted therapies for pediatric gliomas, the most common form of pediatric brain tumor. The research was published in @natcomms.nature.com. Learn more: bit.ly/45meNf6

Next week! Join us on Thursday, August 14 at 6PM ET in Cambridge, MA (or online) for a Broad Discovery Series talk with @soumya-boston.bsky.social, “Arthritis, autoimmunity, and how the genome works.” Register: broadinstitute.swoogo.com/DiscoverySeries25

New findings show low-oxygen air reverses Parkinson’s symptoms in mouse model, suggesting possible new way to treat this neurodegenerative disorder: a pill that mimics low oxygen.

Join us on Thursday, August 14 at 6 PM ET in Cambridge, MA, or online, for a Broad Discovery Series talk with @soumya-boston.bsky.social: “Arthritis, autoimmunity, and how the genome works.” Register: broadinstitute.swoogo.com/DiscoverySer...

Scientists find new factors linked to poor outcomes in the most common lung cancer type cancer, hinting at how certain chemical exposures may contribute to lung cancer risk in people who have never smoked.

The Omics for Assessing Signatures for Integrated Safety (OASIS) consortium, launched by Broad, @hesiglobal.bsky.social & scientific partners, with @malifesciences.bsky.social support, is sharing data using cell-based omics tools to reduce reliance on animals in drug & agrochemical safety testing.

So excited to share our latest study on defining the function of disease variants by editing single cells, and assuming them with CRAFT-seq! Special thanks to @zpmu.bsky.social and @baglaenkolab.bsky.social! @broadinstitute.org www.nature.com/articles/s41...

Our study led by T. Bellomo and with @aniruddhpatelmd.bsky.social describes the relationship between lipoprotein(a) and incident & progressive extracoronary atherosclerotic vascular disease www.ahajournals.org/doi/10.1161/... @ahajournals.bsky.social @broadinstitute.org @mgbresearch.bsky.social

Using an image-based screening method, Broad and Boston University researchers found potential new drug targets for reducing Ebola infection severity, uncovering human genes that, when silenced, impaired Ebola’s ability to replicate. broad.io/Ebola-News-0724

Partnership between David Liu, @jacksonlab.bsky.social, and rare disease group RARE Hope leads to first use of prime editing for a brain disease that reduced symptoms, extended lifespan in mice, offering hope for other rare genetic diseases. #Science #PrimeEditing

I've always found @soumya-boston.bsky.social's research to be absolutely fascinating, and I'm excited to bring him on-stage for the next talk in the @broadinstitute.org's Broad Discovery Series. Join us in-person or online on 8/14!

We are thrilled to announce that Seth Klarman will become the next Chair of the Broad Institute Board of Directors, succeeding Eric Schmidt. We also welcome Aviv Regev as a new member of the Board.

Join us on Thursday, August 14 at 6 PM ET in Cambridge, MA – or online – for a Broad Discovery Series talk with @soumya-boston.bsky.social : “Arthritis, autoimmunity, and how the genome works.” Register: broadinstitute.swoogo.com/DiscoverySer...

Dr. Ramnik Xavier and Dr. Christopher Smillie from the @broadinstitute.org analyzed individual cells from the intestinal tissue of #Crohns disease patients, measuring gene activity and mapping the cells’ location: bit.ly/4nwuf0s 📃 @natgenet.nature.com: go.nature.com/45UEWDH

Very excited to share our latest work in @NatureGenet with the Smillie lab: a spatial transcriptomics atlas of stricturing #Crohns disease that offers new insights into mechanisms driving fibrotic complications in chronic gut inflammation...(cont.) www.nature.com/articles/s41...

New spatial maps of a key complication of Crohn’s disease reveal the cells and genes involved and lay the foundation for better treatments.

Gene editing pioneer David Liu discusses baby K.J. Muldoon, the first person treated with a customized gene editing therapy, what made K.J.'s treatment possible, and how on-demand treatments for rare genetic diseases could one day become routine. #GeneEditing #Science

Being a neuroscientist in a lab focused on protein trafficking in the kidney has given Giulia Monti a unique perspective on Alzheimer’s disease. Learn about the potential paradigm shift she sees in Alzheimer’s disease research in a new #WhyIScience Q&A: broad.io/WISGiulia

The GKS Work Stream held its second open house meeting this month. Hear an overview of the newly approved Variant Annotation Specification (VA-Spec) and how GA4GH Driver Project ClinGen is implementing GKS products. View the recording here: youtu.be/sap18DAG0aA

🚨Interested in which genes are the true effectors behind the scenes of the #gwas results? 🚨 This new publication in Nature Genetics, a collaboration between @broadinstitute.org @ebi.embl.org @opentargets.org focuses on approaches to predicted effector gene reporting tinyurl.com/98yxy4hf (1/3) 👇

Broad and Bayer extend their 10-year cardiovascular research collaboration by 5 more years, with aims to identify joint precision cardiology targets, leverage the established human cardiomyocyte platform, and discover novel therapeutic approaches. www.broadinstitute.org/node/5558906

Neat event (BIO-adjacent, in Boston next week) nference.com/bio-x-conver...

Post 2: Virtual attendees can also visit the #HCA2025GM virtual Exhibition Hall here: buff.ly/OoVEkjh

July 31, virtual and in person in NYC: Cell Biology at Scale. See what's next for the data generators that will power the next phase of bio discoveries! www.czbiohub.org/events/cell-...

Delighted to have our work on Polygenic Modifiers of #TelomereBiologyDisorders, led by Michael Poeschla, @sashagusevposts.bsky.social, @mitchiela.bsky.social, @sharonsavage.bsky.social, @tummalalab.bsky.social, + co, published in @jclinical-invest.bsky.social today: www.jci.org/articles/vie...

A new combination technique enables DNA sequencing and high-resolution imaging in intact cells — offering new insights into progeria and aging. broad.io/expansion-in-situ @jbuenrostro.bsky.social

A new pipeline could help scientists discover unique combinations of molecules that increase the effectiveness of antibiotics against drug-resistant bacteria. broad.io/CITADel-news @mit.edu @tuftsmedschool.bsky.social

Researchers have developed a way to edit the genetic sequences at the root of Huntington’s disease and Friedreich’s ataxia.

This collection describes a range of methods allowing access to neuronal and non-neuronal cell types, opening the door to targeting the nervous system in ways that were previously unimaginable 🧠 Check out our BRAIN Armamentarium Consortium🧵 www.cell.com/consortium/b...

🚨New paper with @thexavierlab.bsky.social @science.org on the critical role of 🔄neuroimmune crosstalk in immune defense in the gut🪱🪱. 🧪@genelayinstitute.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social @broadinstitute.org www.science.org/doi/10.1126/...

I am deeply honored and humbled to have received the 2025 Merkin Prize in Biomedical Technology along with my long term mentor and colleague Carl June, and Isabelle Rivière, and Michel Sadelain, w/ collaborative work of many scientists, clinicians, & patients. www.broadinstitute.org/news/2025-me...

Carl June (@upenn.edu), Bruce Levine (Penn), Isabelle Rivière (Takeda), Michel Sadelain (@columbiauniversity.bsky.social) have been awarded the 2025 Richard N. Merkin Prize in Biomedical Technology for developing CAR T-cell therapy for cancer.

A new cell line atlas of biliary tract cancers uncovers new subtypes and potential drug targets for better treatment of these deadly diseases. @mgbresearch.bsky.social @targetcancer.bsky.social

Eating disorders run in families and have a strong heritable component, especially anorexia nervosa, but the genetics underlying these conditions are not fully understood. A new direct-to-patient effort could help scientists develop better diagnostics & treatments. @hsph.harvard.edu

We’re thrilled that base editing, developed by researchers in the lab of Broad member David Liu, is having such a profound impact in the clinic. Congratulations to former Broad postdoc @kiranmusunuru.bsky.social & @childrensphila.bsky.social on their groundbreaking work. www.nejm.org/doi/full/10....

Using laboratory-evolved versions of enzymes called CASTs, researchers have achieved a long-standing goal of genome editing: inserting entire healthy genes into human cells efficiently enough for potential therapeutic applications. @isaacwitte.bsky.social @eitzingersimon.bsky.social

In a recent study, researchers from Dana-Farber, @mit.edu, and the @broadinstitute.org identified cryptic peptides in pancreatic cancer cells that immune cells can be trained to recognize, pointing to potential immunotherapy targets for future treatment strategies. bit.ly/3FbSEXK

TONIGHT!!! Join us in Kendall Square or tune into the livestream at 6pm!

Meet Bo Xia, a systems biologist using both AI tools and experimental technologies to understand how the genome controls cell fate in health and disease. Learn about Bo in a #WhyIScience Q&A: broad.io/WISBo

1/ Thrilled to share our TWO back-to-back papers published in Nature Genetics today! www.nature.com/articles/s41... , www.nature.com/articles/s41...

1/ Truly excited to share our new study that I had to privilege to co-lead during my PhD alongside great friends and collaborators @masashi-nomura.bsky.social, @kevin-johnson.bsky.social and Luciano Garofano, published at Nature Genetics @natureportfolio.nature.com! www.nature.com/articles/s41...