Out today in @cp-cell.bsky.social! We studied how environmental stresses like high-fat diets today can prime tumorigenesis months to years in the future (1/n)

Study by @ragoninstitute.bsky.social, @mitkochinstitute.bsky.social, @broadinstitute.org team - including @constantine-sci.bsky.social, @drshay.bsky.social, and @shaleklab.bsky.social - suggests a high-fat diet puts liver cells in a state that makes them more susceptible to cancer-causing mutations

Our immune system declines with age. Now the lab of @zhangf.bsky.social has found a way to overcome this decline by temporarily programming liver cells to improve T cells’ ability to fight infection.

Broad and @mgbresearch.bsky.social scientists discovered a potential new drug target for Friedreich’s ataxia, a rare but devastating genetic disorder.

Drs. Matthew Meyerson and Heidi Greulich from the @broadinstitute.org sit down and discuss how they and Bayer scientists developed the first FDA-approved #CancerDrug to come from a Broad scientific discovery. 🤝 Learn more about their academic-industry alliance: https://bit.ly/4ruQNRl

Congratulations to the recipients of the 2025 BroadIgnite Awards: Pierre Ankomah, Fabio Cunial, Jordan Doman, Ana Gonzalez Ramos, Sarah Pierce, Avanthi Raghavan, and Jackson Weir! Learn how BroadIgnite helps early-career scientists drive biology forward: broad.io/BI2025.

LAST CALL! Nominations close Friday, December 5 for the 2026 Merkin Prize in Biomedical Technology 🏆. Nominate: merkinprize.org The 2025 Merkin Prize was awarded to the pioneering scientists behind CAR T-cell therapy. Learn more: youtube.com/watch?v=YM9R... Video credit: HPN Health

A just-published study by Elinor Karlsson, PhD, and Kathryn Lord, PhD, in @pnas.org found no evidence of behavior-associated genetic variations in dogs: direc.to/oaxf Genetic tests only revealed strong associations for traits like height & leg length. #dogs @elinork.bsky.social @broadinstitute.org

Nominations are open for the $400,000 Merkin Prize in Biomedical Technology! Do you know a team or individual whose novel device or method has improved diagnosis, treatment, or prevention of human disease? Nominate them today. Deadline: Dec. 5, 2025 merkinprize.org

Broad scientists Matthew Meyerson and Heidi Greulich discuss the challenges and lessons learned in developing a new lung cancer medicine from Bayer Healthcare Pharmaceuticals that is based on Broad genetic discoveries. @danafarber.bsky.social

The @fda.gov approved sevabertinib for HER2-mutant non-small-cell lung cancer, supported by a multi-year research collaboration with colleagues at the @broadinstitute.org. Learn more: bit.ly/49Q2vjd

The US FDA approved the first cancer drug based on Broad discoveries. Developed by Bayer Healthcare Pharmaceuticals through its research alliance with Broad, this drug is approved for a type of lung cancer that previously had few treatment options. @danafarber.bsky.social

A team at the Broad Institute co-led by Sarah Pierce, Steven Erwood, and David Liu has developed a new genome-editing strategy that could potentially lead to a one-time treatment for multiple unrelated genetic diseases.

The MacArthur Foundation today announced the winner of this year’s 100&Change award: Sentinel at @broadinstitute.org. Sentinel is an outbreak surveillance framework that prevents pandemics through local community empowerment. Congrats to the Sentinel team, incl. foundation trustee, Pardis Sabeti!

It is a rare thing to be able to award a $100 million grant but today we do so @macfound.org. I’m thrilled to share the Broad Institute’s Sentinel project is @macfound 100&Change Award Recipient! www.macfound.org/press/press-...

We're thrilled that Sentinel, a pandemic prevention and response program jointly led by @sabetilab.bsky.social and Christian Happi of the Institute of Genomics and Global Health (IGH), Redeemer’s University in Nigeria, is the Award Recipient for @macfound.org’s #100andChange!

Join us in Cambridge, MA (or online) on Wednesday, November 19 at 6PM ET for a Broad Discovery Series talk with Niall Lennon, “Entering the Genomic Medicine era: How technology, data, and biology can improve healthcare throughout our lives.” Register: broadinstitute.swoogo.com/Discovery25

The 2026 Merkin Prize is now accepting nominations! The Prize is a $400,000 award for transformative technologies and pioneering innovators. The Merkin Prize recognizes: 🔹 Real-world impact 🔹 Innovation 🔹 Teams and individuals Nominate by December 5, 2025: merkinprize.org

On Wednesday, November 19 at 6PM ET, join us in Cambridge, MA (or online) for a Broad Discovery Series talk with Niall Lennon, “Entering the Genomic Medicine era: How technology, data, and biology can improve healthcare throughout our lives.” Register: broadinstitute.swoogo.com/Discovery25

Announcing our new preprint! We built SPICE, a framework that combines large-scale experiments and generative AI to design RNA sequences that control cell type-specific gene expression using alternative splicing – a powerful, underexplored modality. Preprint: www.biorxiv.org/content/10.1... (1/10)

New research published in @natchembio.nature.com by @danafarber.bsky.social’s William Gibson, MD, PhD, reveals a general strategy for TP53 missense mutant cancers (majority) with prototype small molecules. @broadinstitute.org Read more at bit.ly/4onnFJO

We’re proud to be part of this new @broadinstitute.org effort! In this Q&A Picower researchers Sara Prescott and Ravi Raju describe the project, how they’re involved, and the research they’re doing: picower.mit.edu/news/qa-pico...

Broad has launched the Biology of Adversity Project, led by @jbuenrostro.bsky.social a 2023 @macfound.org fellow, to uncover how adverse life experiences can inflict molecular “scars” in the genome and body and increase risk of heart disease and other disorders. Learn more: broad.io/BAP

Congrats to Jinjin Xu & co-authors – an image from their recent @jem.org article that describes Ankrd55 as a modulator of T cell metabolism impacting Th17 responses was selected for the cover! Read the study here: rupress.org/jem/article-... @broadinstitute.org @mgbresearch.bsky.social

A new @natgenet.nature.com study by Broad, @mgbresearch.bsky.social, and VA Boston collaborators reveals a genetic variant that helps explain the high dilated cardiomyopathy risk in people of African ancestry.

Excited to share new work in @NatureMicrobio! Using metagenomics, we show how #HIV infection and treatment shape the gut microbiome across geographic regions & find ART-induced phageome changes linked to inflammation and atherosclerosis. www.nature.com/articles/s41...

Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation @science.org @thexavierlab.bsky.social @broadinstitute.org www.science.org/doi/10.1126/...

Tissue and cellular spatiotemporal dynamics in colon aging - @nygenome.org @flatironinstitute.org @broadinstitute.org @cancerdynamics.bsky.social go.nature.com/47I1RBF

Now accepting nominations for the 2026 Merkin Prize — a $400,000 international award recognizing advances that improved human health through diagnosis, treatment or prevention of disease. Submit by Dec 5, 2025: merkinprize.org

A new drug candidate for a difficult-to-treat type of lung cancer, developed by scientists in the Broad-Bayer oncology research alliance, targets HER2 mutations in lung cancer and shrinks tumors in mice and humans.

We’re so excited with this accomplishment of fastest genome sequencing. Major efforts from BCL and Roche to make this happen. Can’t wait to launch this service clinically so patients can benefit! Paper here www.nejm.org/doi/full/10....

Predicting functions of uncharacterized gene products from microbial communities - @hutlab.bsky.social @hsph.harvard.edu @broadinstitute.org go.nature.com/435C4lp

Broad Clinical Labs, Roche Sequencing Systems, and @bostonchildrens.bsky.social have set a new @guinnessworldrecords.com for the sequencing and analysis of the whole human genome in less than 4 hours — potentially enabling faster results in critical medical settings. Learn more: broad.io/BCLGWR

Enrollment has now completed for most Count Me In projects, though a few remain open. Patient-partnered research will now be supported through Broad Clinical Labs, and interested researchers can learn more here: broad.io/CMInextphase.

Leading epigenetics researcher and longtime Broad member @jbuenrostro.bsky.social has been named core institute member of the Broad. His lab will study how cells change in response to life experiences, and how those alterations affect health and disease.

New research from Microsoft, Drexel, and the Broad explores how generative AI could support genetic professionals in rare disease diagnosis. msft.it/6019sS3P5

Xu, @thexavierlab.bsky.social et al @harvardmed.bsky.social @broadinstitute.org reveal an important role of the ANKRD55 protein in TH17 biology, where its deletion impairs T cell proliferation & effector cytokine production through metabolic dysregulation. rupress.org/jem/article/... #Autoimmunity

In her new role as an alliance manager, former drug discovery scientist Gail Guo keeps research projects moving forward for the Broad-Bayer Oncology collaboration. Learn more about her evolving role in a new #WhyIScience Q&A.

A human-mouse atlas of intrarenal myeloid cells identifies conserved disease-associated macrophages in #lupus #nephritis. New study from Paul Hoover, Nir Hacohen @broadinstitute.org, Anne Davidson @northwellhealth.bsky.social and colleagues: rupress.org/jem/article/... #InnateImmunity #Autoimmunity

Antibody–bottlebrush prodrug conjugates for targeted cancer therapy - @mitchemistry.bsky.social @broadinstitute.org go.nature.com/46d1T3t

In a Broad Q&A, Broad scientists Kristin Ardlie and Brad Bernstein talk about AlphaGenome, artificial intelligence, and how foundational datasets like ENCODE and @GTEx are fueling biomedical science in the AI age.

The lab's first sim pub of #ESC2025 is now online in @jaccjournals.bsky.social #JACC! jacc.org/doi/10.1016/... Led by 🇧🇪⭐️ @danielezzat.bsky.social , we examined clonal hematopoiesis (CHIP) 🩸 & CV 🫀 outcomes in older women 👵 using deep targeted 🧬 sequencing in the WHI Long Life Study 👇 (1/X)

Funded by the NIH Common Fund, @smahtnetwrk.bsky.social will map somatic mutations across human tissues with #SingleCell sequencing. Their work will uncover the causes, patterns, and consequences of somatic mutations in normal cells—providing a vital baseline for disease research. 🧪 🧬

Now online in Cancer Discovery @aacrjournals.bsky.social: Integrative Proteogenomics & Forward Genetics Reveals a Novel Mitotic Vulnerability in TNBC - by Nicholas Neill, Shankha Satpathy, Trey Westbrook and colleagues doi.org/10.1158/2159... @bcmfromthelabs.bsky.social @broadinstitute.org

Tomorrow, August 14 at 6 PM ET, join us in Cambridge, MA – or tune in online – for a Broad Discovery Series talk with @soumya-boston.bsky.social: "Arthritis, autoimmunity, and how the genome works." Register: broadinstitute.swoogo.com/DiscoverySeries25

New research from a collaborative study between Dana-Farber and @broadinstitute.org shows promise for targeted therapies for pediatric gliomas, the most common form of pediatric brain tumor. The research was published in @natcomms.nature.com. Learn more: bit.ly/45meNf6

Next week! Join us on Thursday, August 14 at 6PM ET in Cambridge, MA (or online) for a Broad Discovery Series talk with @soumya-boston.bsky.social, “Arthritis, autoimmunity, and how the genome works.” Register: broadinstitute.swoogo.com/DiscoverySeries25

New findings show low-oxygen air reverses Parkinson’s symptoms in mouse model, suggesting possible new way to treat this neurodegenerative disorder: a pill that mimics low oxygen.

Join us on Thursday, August 14 at 6 PM ET in Cambridge, MA, or online, for a Broad Discovery Series talk with @soumya-boston.bsky.social: “Arthritis, autoimmunity, and how the genome works.” Register: broadinstitute.swoogo.com/DiscoverySer...

Scientists find new factors linked to poor outcomes in the most common lung cancer type cancer, hinting at how certain chemical exposures may contribute to lung cancer risk in people who have never smoked.