New study shows the promise of Cell Painting, an AI-powered, scalable cell-imaging method, to make drug toxicity testing faster, cheaper, and more information-rich in human cells—potentially reducing failed clinical trials and animal testing.

The first ever large scale study of whole genomes from Anopheles darlingi -- a key malaria vector in the Americas -- reveals signs of emerging insecticide resistance. @jacobphd.bsky.social

Team #PROSPECT has revealed how the epigenome “remembers” inflammation, priming cells for cancer risk in mice. We spoke with @snaga13.bsky.social and Jason Buenrostro about what these findings mean for patients, and what the future holds. Learn more: www.cancergrandchallenges.org/news/the-epi...

Chronic gut inflammation leaves behind “molecular scars” that may raise the risk for developing cancer, according to a new study showing that epigenetic memory of colitis, along with a cancer-promoting mutation, can accelerate tumor growth in mice. @jbuenrostro.bsky.social

By analyzing DNA data from over 900,000 people, a new study found that some of the most common viruses hiding in the body vary with age, sex, and the seasons — and that genes influence the long-term effects these viruses have on our health.

The Stanley Family Foundation has renewed its commitment to psychiatric research at Broad Institute, bringing its total investment to more than $1 billion. This funding has advanced schizophrenia/bipolar disorder research, opening new paths to therapies. broad.io/SC-News

Join us March 18 at 6PM ET in Cambridge, MA (or online) for a Broad Discovery Series talk with Heidi Greulich and Matthew Meyerson, “The story behind a new therapy for lung cancer patients.” Register: broadinstitute.swoogo.com/Discovery26

A genetic variation has a big impact on who develops aortic stenosis, UCSF/@broadinstitute.org researchers found using a deep learning-based model. “These findings demonstrate the power of jointly analyzing cardiovascular structure and function.” Dr. James Pirruccello says. https://ucsfh.org/4bhJ3ea

Attention science/health reporters and editors: applications are open for Broad’s 2026 Media Boot Camp! Join us in Cambridge April 30–May 1 for a deep dive into emerging stories in biomedicine. Hotel & meals provided. Apply by Friday, March 20: broad.io/mediabootcamp

The recording of "New approaches and data sources for coding variant interpretation" by @ccassa.bsky.social is now available: youtu.be/8YiHnealbEc. This talk is part of @broadinstitute.org's MPG Primer series. For more info, check out broad.io/MPGPrimer.

New study, in collaboration with Kenya Honda, out now in @nature.com. We show how a low protein diet drives a microbiota-dependent induction of thermogenic brown adipocytes via FXR & FGF21 pathways. www.nature.com/articles/s41...

New research from @thexavierlab.bsky.social finds that the gut microbiome fine-tunes fat tissue in mice in response to diet, converting it from energy-storing fat to more energy-burning fat when dietary protein is low.

Rescheduled to March 18 at 6 pm ET. Register: broadinstitute.swoogo.com/discovery26

The Catalyst program, led by Alabama nonprofit Southern Research, Broad Clinical Labs, and MyOme, Inc., provides free genetic testing to adult residents across Alabama to improve medical care and address chronic disease.

Large-scale FinnGen-based study by Reeve et al., just published in Nature Genetics, provides the most detailed genetic map of autoimmune hypothyroidism to date and reveals a surprising inverse relationship between hypothyroidism risk and skin cancer risk. www.broadinstitute.org/news/study-r...

Check out this great write-up of a recent study between the @broadinstitute.org , University of Helsinki, and other institutions which has found more than 400 genetic markers that are linked to autoimmune hypothyroidism (AIHT). (1/4) www.broadinstitute.org/news/study-r...

How do genes impact disease risk? By rapidly testing hundreds of thousands of #DNA sequences, scientists at JAX, @broadinstitute.org and @yale.edu#DNAhave identified specific genetic variations that contribute to blood pressure, cholesterol, blood sugar, and more.🧪🧬 https://go.jax.org/gene-maps-health

The same genetic variants that heighten the risk of autoimmune hypothyroidism — the most common autoimmune disorder — may also lower cancer risk, according to a new study led by scientists at Broad, @helsinki.fi, and @mgbresearch.bsky.social. broad.io/AIHT-news

Pinpointing the exact noncoding variants driving locus-disease associations is an enduring challenge. Using MPRA, a @jacksonlab.bsky.social, Broad & @yaleschoolofmed.bsky.social team tested >220,000 variants in 5 cell types, resolving >13,000 and revealing mechanisms behind several disease traits.

Research in Science Advances by @danafarbernews.bsky.social’s Sabrina Camp, Kevin Bi and Eli Van Allen, MD, revealed loss of the gene BAP1 activates a tumor-intrinsic interferon signaling program, highlighting immune evasion pathways as potential treatment targets. @broadinstitute.org bit.ly/4cEOFBl

📢Caroline Uhler and colleagues from Eric and Wendy Schmidt Center at @broadinstitute.org present APOLLO, a framework to integrate diverse data modalities, enabling predicting missing data modalities and identifying the influence of each modality on a phenotype. www.nature.com/articles/s43... 🖥️ 🧬

1/ Our paper is out today in @cp-cellsystems.bsky.social. We used protein language models and deep learning to identify candidate protease allergens in the human microbiome. www.cell.com/cell-systems...

(1/2) New paper out now in Cell Systems @cellpress.bsky.social describing development of a deep learning framework to predict allergenic microbial proteases! www.sciencedirect.com/science/arti... @broadinstitute.org @mgbresearch.bsky.social

Due to inclement weather, the Broad Discovery Series talk scheduled for Tuesday, February 24 has been postponed. We will share the rescheduled date soon.

Join us this Tuesday, February 24 at 6PM ET in Cambridge, MA (or online) for a Broad Discovery Series talk with Heidi Greulich and Matthew Meyerson, “The story behind a new therapy for lung cancer patients.” Register: broadinstitute.swoogo.com/Discovery26

Can we accurately map cell family trees using mtDNA? Excited to share MitoDrift, a high-precision single-cell lineage inference tool, enabling reliable mapping of lineage history to cell phenotypes. doi.org/10.64898/202... Joint with @gaoteng.bsky.social. @bloodgenes.bsky.social @jswlab.bsky.social🧵

Applications are open for Broad’s 2026 Media Boot Camp! Science/health reporters and editors: Join us in Cambridge (April 30–May 1) for a deep dive into emerging stories in biomedicine. Hotel & meals provided. Applications due March 20. Learn more here: broad.io/mediabootcamp

A clinical trial is exploring whether a new genetic test can improve prostate cancer detection. Developed by Broad Clinical Labs & the US Department of Veterans Affairs, the low-cost test uses BCL’s blended genome-exome method and could help diagnose men earlier and help low-risk men avoid biopsies.

Sensitive detection of cancer antigens enabled by user-defined peptide libraries - @broadinstitute.org go.nature.com/4kvvwUC

On Tuesday, February 24 at 6PM ET join us in Cambridge, MA (or online) for a Broad Discovery Series talk with Heidi Greulich and Matthew Meyerson, “The story behind a new therapy for lung cancer patients.” Register: broadinstitute.swoogo.com/Discovery26

How did the latest targeted lung cancer drug, and the first FDA-approved treatment born of Broad science, come about? Come find out at the next talk in the Broad Discovery Series!

Congratulations to @zhangf.bsky.social for being inducted into the National Inventors Hall of Fame!

Join us on Tuesday, February 24 at 6PM ET in Cambridge, MA (or online) for a Broad Discovery Series talk with Heidi Greulich and Matthew Meyerson, “The story behind a new therapy for lung cancer patients.” Register: broadinstitute.swoogo.com/Discovery26

Our genes play a role in determining the microbial community living in our mouths, according to a new study that analyzed over 12,500 oral microbiome profiles. Researchers found interactions between human & bacterial DNA that could influence dental health.

A new gen-AI model, called DNA-Diffusion, creates short DNA sequences capable of turning genes on or off in specific cells. The researchers hope that the technology could one day be part of gene therapies to treat disease.

SciShow Field Trips is here! For the first episode, we traveled to Feng Zhang's lab at the @broadinstitute.org. The MIT biochemist and HHMI Investigator is studying a set of microbial genes called TIGR, potentially the key to developing CRISPR's successor. 🎥 youtube.com/watch?v=_UimlaolxiA

Excited to share our latest study in Cell Genomics, combining single-nucleus RNA-seq, spatial transcriptomics, and histology to dissect the molecular determinants of lung fibrosis! www.cell.com/cell-genomic... #fibrosis #lung #ILD

First stop on our Field Trip tour is Dr. Feng Zhang's lab at the Broad Institute. You may already be familiar with Dr. Zhang’s work if you’ve ever heard of CRISPR… but how do you follow up a hit like that? That’s a story big enough to tell in person. youtu.be/_UimlaolxiA?...

New study shows a human genetics-to-medicines pipeline that worked in finding new drug candidates for Crohn’s disease. The molecules mimic the effects of a gene variant that protects against chronic inflammation.

In 2021 @janewit-thekidgene.bsky.social joined our lab & decided to define the prevalence & clinical correlates of known genetic forms of nephrotic syndrome among an unselected group of adults. 5 yrs later, we're excited to share what he found; a 🧵 kidney-international.org/article/S008...

Very excited to share our latest work in @Nature integrating single-cell & spatial transcriptomics with bidirectional CRISPR screens to unravel an immune–stromal cell circuit dependent on the transcription factor GLIS3 that regulates intestinal fibrosis during chronic inflammation. Congrats, Vlad!

Newly uncovered pathway behind tissue scarring, or fibrosis, in inflammatory bowel disease suggests new treatment strategies for the dangerous condition.

A new study led by #NASmember Feng Zhang suggests a way to rejuvenate the immune system. By temporarily programming cells in the liver, researchers at MIT and @broadinstitute.org were able to improve T-cell function and enhance vaccine response. Read more: news.mit.edu/2025/new-stu...

📣 We’re hiring! My team at Mass General Brigham / @broadinstitute.org is growing: • Postdoc (PhD; human 🧬 & multi-omics) • Research fellow (clinical trials & epi; 2-yr) • Computational associate Join a collaborative, high-impact 🫀 precision medicine team. DM or email [email protected]

Out today in @cp-cell.bsky.social! We studied how environmental stresses like high-fat diets today can prime tumorigenesis months to years in the future (1/n)

Study by @ragoninstitute.bsky.social, @mitkochinstitute.bsky.social, @broadinstitute.org team - including @constantine-sci.bsky.social, @drshay.bsky.social, and @shaleklab.bsky.social - suggests a high-fat diet puts liver cells in a state that makes them more susceptible to cancer-causing mutations

Our immune system declines with age. Now the lab of @zhangf.bsky.social has found a way to overcome this decline by temporarily programming liver cells to improve T cells’ ability to fight infection.

Broad and @mgbresearch.bsky.social scientists discovered a potential new drug target for Friedreich’s ataxia, a rare but devastating genetic disorder.

Drs. Matthew Meyerson and Heidi Greulich from the @broadinstitute.org sit down and discuss how they and Bayer scientists developed the first FDA-approved #CancerDrug to come from a Broad scientific discovery. 🤝 Learn more about their academic-industry alliance: https://bit.ly/4ruQNRl

Congratulations to the recipients of the 2025 BroadIgnite Awards: Pierre Ankomah, Fabio Cunial, Jordan Doman, Ana Gonzalez Ramos, Sarah Pierce, Avanthi Raghavan, and Jackson Weir! Learn how BroadIgnite helps early-career scientists drive biology forward: broad.io/BI2025.