New research in Nature Methods from Project Ex Vivo shows AI models learn more from diverse cell states than from scaled datasets alone, a finding that could reshape how therapies are matched to patients. msft.it/6013vgE8l

The 2026 Richard N. Merkin Prize in Biomedical Technology honors Graeme Clark, Erwin Hochmair, Ingeborg Hochmair, Michael Merzenich, and Blake Wilson for developing the modern cochlear implant — a device used by more than 1 million people worldwide.

In three new studies, the David Liu lab has optimized key prime editing components (guide pegRNA motifs, reverse transcriptase stability, and delivery via lipid nanoparticles), addressing key bottlenecks that previously impeded its use in animals and human patients.

Won-Seok Lee @broadinstitute.org, receives the 2026 Nancy S. Wexler Young Investigator Prize, which is awarded annually to an early career researcher whose work reflects the highest caliber of excellence, diligence & creative thinking. Learn more: tinyurl.com/nswprize #curehd #huntingtonsdisease

New research in @natmed.nature.com by @danafarber.bsky.social’s Dr. Suzanne George and Dr. Bradley Bernstein reveals the clinical activity of FGFR inhibition in SDH-deficient GIST. ➡️bit.ly/497QeW8 @broadinstitute.org

My May 20 (next Wednesday!) lecture at Broad: Turns out humans don't have all the answers. There is an untapped opportunity for innovation in medicine by exploring why other species are protected from diseases common in humans. Come and find out more!

Join us in Cambridge, MA (or online) for a Broad Discovery Series talk, “What Animal Superpowers Can Teach Us About Our Own DNA,” on Wednesday, May 20, at 6 pm ET with @elinork.bsky.social of @darwinsark.org. Register: broadinstitute.swoogo.com/Karlsson

NHP-dGTEx V1 derived data is available for download from @GTExPortal. NHP-dGTEx V1 contains 421 Macaque samples (372 RNA-seq and 49 WGS) from 50 subjects and 333 Marmoset samples (314 RNA-seq and 19 WGS) from 20 subjects. bit.ly/4lV8tmI

dGTEx V1 open access data is now available for download from @GTExPortal. dGTEx V1 contains 379 samples from 40 subjects. bit.ly/4rHwa3A #rnaseq

Broad researchers used their single-molecule tracking technology to reveal unexpected patterns of dimerization among EGFR family receptors, shedding light on their role in cancer. Learn more: broad.io/Peng-EGFR

Other mammals have so many abilities that we don't, but which could teach us a lot about health and disease. Join us for what promises to be a talk filled to the brim with great science and super-cute animal pictures!

Excited to share our paper out today in @science.org! We directed high-content, single-cell genetic screens to ask how a disordered adapter protein orchestrates the complex process of T cell activation. (1/4) www.science.org/doi/10.1126/...

Have you ever wondered what animal superpowers can teach us about our own DNA? Join us in Cambridge, MA (or online) for a Broad Discovery Series talk on Wednesday, May 20 at 6 pm ET with Elinor Karlsson. Register: broadinstitute.swoogo.com/Karlsson

A new drug candidate designed to slow the progression of prion disease is entering a phase 1 clinical trial. The trial, led by Eric Minikel, codirector of Broad’s Prion Therapeutic Science program, will evaluate a divalent small interfering RNA (siRNA) drug candidate for safety and tolerability.

Out now in @cp-cellhostmicrobe.bsky.social! In collaboration with Swiss clinicians, we built the largest nasal microbial gene atlas in infants w/ and w/o cystic fibrosis to date (cont.)

The Cancer Dependency Map Consortium is entering its third phase, accelerating the next generation of cancer therapies. (1/4)

The recording of "Network-based rare variant association for complex diseases" by @snz20.bsky.social is now available: youtu.be/KO-6M5lXTlI. This talk is part of @broadinstitute.org's MPG Primer series. For more info, check out broad.io/MPGPrimer.

The recording of "Epigenomic profiling and AI-guided cancer diagnostics" by @sbenfatto.bsky.social is now available: youtu.be/eO4ywdRGDN4. This talk is part of @broadinstitute.org's MPG Primer series. For more info, check out broad.io/MPGPrimer.

Scientists corrected a genetic mutation that causes a rare, life-threatening condition, Zellweger spectrum disorder, in mice. The study points toward an optimal base editor enzyme with implications for other genetic diseases. broad.io/ZSD-News

Leukemia and possibly other cancers could be using sugary proteins on their cell surface to shield themselves from immune attack. New study points to potential cancer immunotherapy target. broad.io/CD43 @danafarbernews.bsky.social @mgbresearch.bsky.social

New study shows the promise of Cell Painting, an AI-powered, scalable cell-imaging method, to make drug toxicity testing faster, cheaper, and more information-rich in human cells—potentially reducing failed clinical trials and animal testing.

The first ever large scale study of whole genomes from Anopheles darlingi -- a key malaria vector in the Americas -- reveals signs of emerging insecticide resistance. @jacobphd.bsky.social

Team #PROSPECT has revealed how the epigenome “remembers” inflammation, priming cells for cancer risk in mice. We spoke with @snaga13.bsky.social and Jason Buenrostro about what these findings mean for patients, and what the future holds. Learn more: www.cancergrandchallenges.org/news/the-epi...

Chronic gut inflammation leaves behind “molecular scars” that may raise the risk for developing cancer, according to a new study showing that epigenetic memory of colitis, along with a cancer-promoting mutation, can accelerate tumor growth in mice. @jbuenrostro.bsky.social

By analyzing DNA data from over 900,000 people, a new study found that some of the most common viruses hiding in the body vary with age, sex, and the seasons — and that genes influence the long-term effects these viruses have on our health.

The Stanley Family Foundation has renewed its commitment to psychiatric research at Broad Institute, bringing its total investment to more than $1 billion. This funding has advanced schizophrenia/bipolar disorder research, opening new paths to therapies. broad.io/SC-News

Join us March 18 at 6PM ET in Cambridge, MA (or online) for a Broad Discovery Series talk with Heidi Greulich and Matthew Meyerson, “The story behind a new therapy for lung cancer patients.” Register: broadinstitute.swoogo.com/Discovery26

A genetic variation has a big impact on who develops aortic stenosis, UCSF/@broadinstitute.org researchers found using a deep learning-based model. “These findings demonstrate the power of jointly analyzing cardiovascular structure and function.” Dr. James Pirruccello says. https://ucsfh.org/4bhJ3ea

Attention science/health reporters and editors: applications are open for Broad’s 2026 Media Boot Camp! Join us in Cambridge April 30–May 1 for a deep dive into emerging stories in biomedicine. Hotel & meals provided. Apply by Friday, March 20: broad.io/mediabootcamp

The recording of "New approaches and data sources for coding variant interpretation" by @ccassa.bsky.social is now available: youtu.be/8YiHnealbEc. This talk is part of @broadinstitute.org's MPG Primer series. For more info, check out broad.io/MPGPrimer.

New study, in collaboration with Kenya Honda, out now in @nature.com. We show how a low protein diet drives a microbiota-dependent induction of thermogenic brown adipocytes via FXR & FGF21 pathways. www.nature.com/articles/s41...

New research from @thexavierlab.bsky.social finds that the gut microbiome fine-tunes fat tissue in mice in response to diet, converting it from energy-storing fat to more energy-burning fat when dietary protein is low.

Rescheduled to March 18 at 6 pm ET. Register: broadinstitute.swoogo.com/discovery26

The Catalyst program, led by Alabama nonprofit Southern Research, Broad Clinical Labs, and MyOme, Inc., provides free genetic testing to adult residents across Alabama to improve medical care and address chronic disease.

Large-scale FinnGen-based study by Reeve et al., just published in Nature Genetics, provides the most detailed genetic map of autoimmune hypothyroidism to date and reveals a surprising inverse relationship between hypothyroidism risk and skin cancer risk. www.broadinstitute.org/news/study-r...

Check out this great write-up of a recent study between the @broadinstitute.org , University of Helsinki, and other institutions which has found more than 400 genetic markers that are linked to autoimmune hypothyroidism (AIHT). (1/4) www.broadinstitute.org/news/study-r...

How do genes impact disease risk? By rapidly testing hundreds of thousands of #DNA sequences, scientists at JAX, @broadinstitute.org and @yale.edu#DNAhave identified specific genetic variations that contribute to blood pressure, cholesterol, blood sugar, and more.🧪🧬 https://go.jax.org/gene-maps-health

The same genetic variants that heighten the risk of autoimmune hypothyroidism — the most common autoimmune disorder — may also lower cancer risk, according to a new study led by scientists at Broad, @helsinki.fi, and @mgbresearch.bsky.social. broad.io/AIHT-news

Pinpointing the exact noncoding variants driving locus-disease associations is an enduring challenge. Using MPRA, a @jacksonlab.bsky.social, Broad & @yaleschoolofmed.bsky.social team tested >220,000 variants in 5 cell types, resolving >13,000 and revealing mechanisms behind several disease traits.

Research in Science Advances by @danafarbernews.bsky.social’s Sabrina Camp, Kevin Bi and Eli Van Allen, MD, revealed loss of the gene BAP1 activates a tumor-intrinsic interferon signaling program, highlighting immune evasion pathways as potential treatment targets. @broadinstitute.org bit.ly/4cEOFBl

📢Caroline Uhler and colleagues from Eric and Wendy Schmidt Center at @broadinstitute.org present APOLLO, a framework to integrate diverse data modalities, enabling predicting missing data modalities and identifying the influence of each modality on a phenotype. www.nature.com/articles/s43... 🖥️ 🧬

1/ Our paper is out today in @cp-cellsystems.bsky.social. We used protein language models and deep learning to identify candidate protease allergens in the human microbiome. www.cell.com/cell-systems...

(1/2) New paper out now in Cell Systems @cellpress.bsky.social describing development of a deep learning framework to predict allergenic microbial proteases! www.sciencedirect.com/science/arti... @broadinstitute.org @mgbresearch.bsky.social

Due to inclement weather, the Broad Discovery Series talk scheduled for Tuesday, February 24 has been postponed. We will share the rescheduled date soon.

Join us this Tuesday, February 24 at 6PM ET in Cambridge, MA (or online) for a Broad Discovery Series talk with Heidi Greulich and Matthew Meyerson, “The story behind a new therapy for lung cancer patients.” Register: broadinstitute.swoogo.com/Discovery26

Can we accurately map cell family trees using mtDNA? Excited to share MitoDrift, a high-precision single-cell lineage inference tool, enabling reliable mapping of lineage history to cell phenotypes. doi.org/10.64898/202... Joint with @gaoteng.bsky.social. @bloodgenes.bsky.social @jswlab.bsky.social🧵

Applications are open for Broad’s 2026 Media Boot Camp! Science/health reporters and editors: Join us in Cambridge (April 30–May 1) for a deep dive into emerging stories in biomedicine. Hotel & meals provided. Applications due March 20. Learn more here: broad.io/mediabootcamp

A clinical trial is exploring whether a new genetic test can improve prostate cancer detection. Developed by Broad Clinical Labs & the US Department of Veterans Affairs, the low-cost test uses BCL’s blended genome-exome method and could help diagnose men earlier and help low-risk men avoid biopsies.

Sensitive detection of cancer antigens enabled by user-defined peptide libraries - @broadinstitute.org go.nature.com/4kvvwUC

On Tuesday, February 24 at 6PM ET join us in Cambridge, MA (or online) for a Broad Discovery Series talk with Heidi Greulich and Matthew Meyerson, “The story behind a new therapy for lung cancer patients.” Register: broadinstitute.swoogo.com/Discovery26