A clinical trial is exploring whether a new genetic test can improve prostate cancer detection. Developed by Broad Clinical Labs & the US Department of Veterans Affairs, the low-cost test uses BCL’s blended genome-exome method and could help diagnose men earlier and help low-risk men avoid biopsies.

Sensitive detection of cancer antigens enabled by user-defined peptide libraries - @broadinstitute.org go.nature.com/4kvvwUC

On Tuesday, February 24 at 6PM ET join us in Cambridge, MA (or online) for a Broad Discovery Series talk with Heidi Greulich and Matthew Meyerson, “The story behind a new therapy for lung cancer patients.” Register: broadinstitute.swoogo.com/Discovery26

How did the latest targeted lung cancer drug, and the first FDA-approved treatment born of Broad science, come about? Come find out at the next talk in the Broad Discovery Series!

Congratulations to @zhangf.bsky.social for being inducted into the National Inventors Hall of Fame!

Join us on Tuesday, February 24 at 6PM ET in Cambridge, MA (or online) for a Broad Discovery Series talk with Heidi Greulich and Matthew Meyerson, “The story behind a new therapy for lung cancer patients.” Register: broadinstitute.swoogo.com/Discovery26

Our genes play a role in determining the microbial community living in our mouths, according to a new study that analyzed over 12,500 oral microbiome profiles. Researchers found interactions between human & bacterial DNA that could influence dental health.

A new gen-AI model, called DNA-Diffusion, creates short DNA sequences capable of turning genes on or off in specific cells. The researchers hope that the technology could one day be part of gene therapies to treat disease.

SciShow Field Trips is here! For the first episode, we traveled to Feng Zhang's lab at the @broadinstitute.org. The MIT biochemist and HHMI Investigator is studying a set of microbial genes called TIGR, potentially the key to developing CRISPR's successor. 🎥 youtube.com/watch?v=_UimlaolxiA

Excited to share our latest study in Cell Genomics, combining single-nucleus RNA-seq, spatial transcriptomics, and histology to dissect the molecular determinants of lung fibrosis! www.cell.com/cell-genomic... #fibrosis #lung #ILD

First stop on our Field Trip tour is Dr. Feng Zhang's lab at the Broad Institute. You may already be familiar with Dr. Zhang’s work if you’ve ever heard of CRISPR… but how do you follow up a hit like that? That’s a story big enough to tell in person. youtu.be/_UimlaolxiA?...

New study shows a human genetics-to-medicines pipeline that worked in finding new drug candidates for Crohn’s disease. The molecules mimic the effects of a gene variant that protects against chronic inflammation.

In 2021 @janewit-thekidgene.bsky.social joined our lab & decided to define the prevalence & clinical correlates of known genetic forms of nephrotic syndrome among an unselected group of adults. 5 yrs later, we're excited to share what he found; a 🧵 kidney-international.org/article/S008...

Very excited to share our latest work in @Nature integrating single-cell & spatial transcriptomics with bidirectional CRISPR screens to unravel an immune–stromal cell circuit dependent on the transcription factor GLIS3 that regulates intestinal fibrosis during chronic inflammation. Congrats, Vlad!

Newly uncovered pathway behind tissue scarring, or fibrosis, in inflammatory bowel disease suggests new treatment strategies for the dangerous condition.

A new study led by #NASmember Feng Zhang suggests a way to rejuvenate the immune system. By temporarily programming cells in the liver, researchers at MIT and @broadinstitute.org were able to improve T-cell function and enhance vaccine response. Read more: news.mit.edu/2025/new-stu...

📣 We’re hiring! My team at Mass General Brigham / @broadinstitute.org is growing: • Postdoc (PhD; human 🧬 & multi-omics) • Research fellow (clinical trials & epi; 2-yr) • Computational associate Join a collaborative, high-impact 🫀 precision medicine team. DM or email [email protected]

Out today in @cp-cell.bsky.social! We studied how environmental stresses like high-fat diets today can prime tumorigenesis months to years in the future (1/n)

Study by @ragoninstitute.bsky.social, @mitkochinstitute.bsky.social, @broadinstitute.org team - including @constantine-sci.bsky.social, @drshay.bsky.social, and @shaleklab.bsky.social - suggests a high-fat diet puts liver cells in a state that makes them more susceptible to cancer-causing mutations

Our immune system declines with age. Now the lab of @zhangf.bsky.social has found a way to overcome this decline by temporarily programming liver cells to improve T cells’ ability to fight infection.

Broad and @mgbresearch.bsky.social scientists discovered a potential new drug target for Friedreich’s ataxia, a rare but devastating genetic disorder.

Drs. Matthew Meyerson and Heidi Greulich from the @broadinstitute.org sit down and discuss how they and Bayer scientists developed the first FDA-approved #CancerDrug to come from a Broad scientific discovery. 🤝 Learn more about their academic-industry alliance: https://bit.ly/4ruQNRl

Congratulations to the recipients of the 2025 BroadIgnite Awards: Pierre Ankomah, Fabio Cunial, Jordan Doman, Ana Gonzalez Ramos, Sarah Pierce, Avanthi Raghavan, and Jackson Weir! Learn how BroadIgnite helps early-career scientists drive biology forward: broad.io/BI2025.

LAST CALL! Nominations close Friday, December 5 for the 2026 Merkin Prize in Biomedical Technology 🏆. Nominate: merkinprize.org The 2025 Merkin Prize was awarded to the pioneering scientists behind CAR T-cell therapy. Learn more: youtube.com/watch?v=YM9R... Video credit: HPN Health

A just-published study by Elinor Karlsson, PhD, and Kathryn Lord, PhD, in @pnas.org found no evidence of behavior-associated genetic variations in dogs: direc.to/oaxf Genetic tests only revealed strong associations for traits like height & leg length. #dogs @elinork.bsky.social @broadinstitute.org

Nominations are open for the $400,000 Merkin Prize in Biomedical Technology! Do you know a team or individual whose novel device or method has improved diagnosis, treatment, or prevention of human disease? Nominate them today. Deadline: Dec. 5, 2025 merkinprize.org

Broad scientists Matthew Meyerson and Heidi Greulich discuss the challenges and lessons learned in developing a new lung cancer medicine from Bayer Healthcare Pharmaceuticals that is based on Broad genetic discoveries. @danafarber.bsky.social

The @fda.gov approved sevabertinib for HER2-mutant non-small-cell lung cancer, supported by a multi-year research collaboration with colleagues at the @broadinstitute.org. Learn more: bit.ly/49Q2vjd

The US FDA approved the first cancer drug based on Broad discoveries. Developed by Bayer Healthcare Pharmaceuticals through its research alliance with Broad, this drug is approved for a type of lung cancer that previously had few treatment options. @danafarber.bsky.social

A team at the Broad Institute co-led by Sarah Pierce, Steven Erwood, and David Liu has developed a new genome-editing strategy that could potentially lead to a one-time treatment for multiple unrelated genetic diseases.

The MacArthur Foundation today announced the winner of this year’s 100&Change award: Sentinel at @broadinstitute.org. Sentinel is an outbreak surveillance framework that prevents pandemics through local community empowerment. Congrats to the Sentinel team, incl. foundation trustee, Pardis Sabeti!

It is a rare thing to be able to award a $100 million grant but today we do so @macfound.org. I’m thrilled to share the Broad Institute’s Sentinel project is @macfound 100&Change Award Recipient! www.macfound.org/press/press-...

We're thrilled that Sentinel, a pandemic prevention and response program jointly led by @sabetilab.bsky.social and Christian Happi of the Institute of Genomics and Global Health (IGH), Redeemer’s University in Nigeria, is the Award Recipient for @macfound.org’s #100andChange!

Join us in Cambridge, MA (or online) on Wednesday, November 19 at 6PM ET for a Broad Discovery Series talk with Niall Lennon, “Entering the Genomic Medicine era: How technology, data, and biology can improve healthcare throughout our lives.” Register: broadinstitute.swoogo.com/Discovery25

The 2026 Merkin Prize is now accepting nominations! The Prize is a $400,000 award for transformative technologies and pioneering innovators. The Merkin Prize recognizes: 🔹 Real-world impact 🔹 Innovation 🔹 Teams and individuals Nominate by December 5, 2025: merkinprize.org

On Wednesday, November 19 at 6PM ET, join us in Cambridge, MA (or online) for a Broad Discovery Series talk with Niall Lennon, “Entering the Genomic Medicine era: How technology, data, and biology can improve healthcare throughout our lives.” Register: broadinstitute.swoogo.com/Discovery25

Announcing our new preprint! We built SPICE, a framework that combines large-scale experiments and generative AI to design RNA sequences that control cell type-specific gene expression using alternative splicing – a powerful, underexplored modality. Preprint: www.biorxiv.org/content/10.1... (1/10)

New research published in @natchembio.nature.com by @danafarber.bsky.social’s William Gibson, MD, PhD, reveals a general strategy for TP53 missense mutant cancers (majority) with prototype small molecules. @broadinstitute.org Read more at bit.ly/4onnFJO

We’re proud to be part of this new @broadinstitute.org effort! In this Q&A Picower researchers Sara Prescott and Ravi Raju describe the project, how they’re involved, and the research they’re doing: picower.mit.edu/news/qa-pico...

Broad has launched the Biology of Adversity Project, led by @jbuenrostro.bsky.social a 2023 @macfound.org fellow, to uncover how adverse life experiences can inflict molecular “scars” in the genome and body and increase risk of heart disease and other disorders. Learn more: broad.io/BAP

Congrats to Jinjin Xu & co-authors – an image from their recent @jem.org article that describes Ankrd55 as a modulator of T cell metabolism impacting Th17 responses was selected for the cover! Read the study here: rupress.org/jem/article-... @broadinstitute.org @mgbresearch.bsky.social

A new @natgenet.nature.com study by Broad, @mgbresearch.bsky.social, and VA Boston collaborators reveals a genetic variant that helps explain the high dilated cardiomyopathy risk in people of African ancestry.

Excited to share new work in @NatureMicrobio! Using metagenomics, we show how #HIV infection and treatment shape the gut microbiome across geographic regions & find ART-induced phageome changes linked to inflammation and atherosclerosis. www.nature.com/articles/s41...

Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation @science.org @thexavierlab.bsky.social @broadinstitute.org www.science.org/doi/10.1126/...

Tissue and cellular spatiotemporal dynamics in colon aging - @nygenome.org @flatironinstitute.org @broadinstitute.org @cancerdynamics.bsky.social go.nature.com/47I1RBF

Now accepting nominations for the 2026 Merkin Prize — a $400,000 international award recognizing advances that improved human health through diagnosis, treatment or prevention of disease. Submit by Dec 5, 2025: merkinprize.org

A new drug candidate for a difficult-to-treat type of lung cancer, developed by scientists in the Broad-Bayer oncology research alliance, targets HER2 mutations in lung cancer and shrinks tumors in mice and humans.

We’re so excited with this accomplishment of fastest genome sequencing. Major efforts from BCL and Roche to make this happen. Can’t wait to launch this service clinically so patients can benefit! Paper here www.nejm.org/doi/full/10....

Predicting functions of uncharacterized gene products from microbial communities - @hutlab.bsky.social @hsph.harvard.edu @broadinstitute.org go.nature.com/435C4lp

Broad Clinical Labs, Roche Sequencing Systems, and @bostonchildrens.bsky.social have set a new @guinnessworldrecords.com for the sequencing and analysis of the whole human genome in less than 4 hours — potentially enabling faster results in critical medical settings. Learn more: broad.io/BCLGWR