Reduction of prime editing errors by engineered Cas9 variants with relaxed nick positioning. #NBThighlight www.nature.com/articles/s41...

In Brief: @novonordisk.bsky.social's #Wegovy gains accelerated FDA approval for treating metabolic dysfunction-associated steatohepatitis (MASH), also known as fatty liver disease www.nature.com/articles/s41... rdcu.be/eHgPo

Each year, we highlight companies that received sizeable early-stage funding in the previous year. City Therapeutics is using very small cityRNAs to broaden the range of siRNA therapeutics go.nature.com/3IwUyUy

From frameworks to finance: how sharing benefits from the use of digital sequence information can evolve to contribute to biodiversity conservation - @amberhscholz.bsky.social @leibniz-dsmz.bsky.social go.nature.com/4nBE4t8

CRISPR activation restores expression of a haploinsufficient neuronal sodium channel, rescuing neuronal deficits associated with multiple neurodevelopmental disorders. #NBThighlight www.nature.com/articles/s41...

Intellectual property rights in the cultivated meat industry: opportunities and challenges go.nature.com/3K5Aj0O

On our latest podcast, Barbara Cheifet talks with Zhenan Bao and John Rogers about the latest in electronic wearables and how they will complement and advance global health — from health monitoring in neonates to smart bandages for wounds shows.acast.com/forum/episod...

Regenerative cell therapy marches into corneal blindness www.nature.com/articles/s41...

Advancing antivirals Funding and public support for vaccines in the United States is at an all-time low. Promising research is resulting in effective antivirals, but they should not take the place of vaccines go.nature.com/4gijtYv

The September issue is live nature.com/nbt/volumes/... On the cover, a system for high-precision mutation detection of mRNA in extracellular vesicles. Song et al. present SCOPE, a method that uses Cas13 to recognize and amplify target RNA for liquid biopsy applications go.nature.com/47Yw8Mf

AI is challenging the idea that some cancer targets are ‘undruggable’, but researchers must collaborate more effectively to capitalize on this technology, argue drug-discovery scientist Karen Akinsanya and her co-authors in this @natbiotech.nature.com Comment: rdcu.be/eFeF1

Bioactive molecules unearthed by terabase-scale long-read sequencing of a soil metagenome - @rockefelleruniv.bsky.social go.nature.com/4606ozA

A systemic screen using programmable antisense oligomers to silence genes of DNA and RNA phages identifies proteins essential for phage propagation. This tool offers potential for optimizing phage therapy. #NBThighlight www.nature.com/articles/s41...

Considering the enormous human and economic toll Chagas disease inflicts, investment in R&D of medical innovations such as diagnostics, pharmaceuticals and vaccines remains disproportionately low go.nature.com/4lqNXZ6 rdcu.be/eALyf

A rapid imaging-based screen for induced-proximity degraders identifies a potent degrader of oncoprotein SKP2 go.nature.com/4mTBGhr

Efficient sequence alignment against millions of prokaryotic genomes with LexicMap - @shenwei356.bsky.social @zaminiqbal.bsky.social go.nature.com/3K09TgJ

Antibody–bottlebrush prodrug conjugates for targeted cancer therapy - @mitchemistry.bsky.social @broadinstitute.org go.nature.com/46d1T3t

Genome-wide mapping of RNA-protein associations through sequencing go.nature.com/4gmf1Ii

With this cross-journal Collection, the editors at @commseng.nature.com, @natbiotech.nature.com, @natcomms.nature.com & Scientific Reports invite manuscripts that highlight continual or real-time sensing systems, primarily for arable farming or crop production www.nature.com/collections/...

E. coli engineered to display cytokines destroy hard-to-treat tumors by boosting the activity of local native and adoptive immune effector cells #NBTNV go.nature.com/3XRyVSv rdcu.be/dWuJ3

An innovator of new genome editing technologies on the similarities between science and cooking, and the challenge of turning a new technology into a viable business go.nature.com/468Vasp rdcu.be/eDK3q

🚀 New publication alert! 🚀 We just published in @natbiotech.nature.com: 👉 Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes doi.org/10.1038/s415...

Non-profits wade in where for-profit life science investment fears to tread nature.com/articles/s41... rdcu.be/eyzXy

Women are still underrepresented in executive roles in French biotech startups, while outperforming men in merger and acquisition activities go.nature.com/4oHriuB rdcu.be/eDK2i

Phage genome engineering with retrons #NBTNV go.nature.com/47l5mgD rdcu.be/eDKZo

Advancing antivirals go.nature.com/4gijtYv

Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes - @helmholtz-hiri.bsky.social go.nature.com/4n7zDpG

Chemical proteomics has brought rigor to covalent drug discovery and drugs to the clinic. Can it deliver a new generation of drug targets? nature.com/articles/s41... rdcu.be/eycCa

Optogenetic ribosome profiling with codon-level precision under native conditions enables high spatial and temporal resolution, revealing a bimodal logic of mitochondrial translation. #NBThighlight www.cell.com/cell/fulltex...

Natural molecular glues spur next-gen small molecules for ‘undruggable’ targets www.nature.com/articles/s41... rdcu.be/eAC91

Biotech news from around the world: Slovenia, Rwanda, Saudi Arabia, Denmark www.nature.com/articles/s41... rdcu.be/eDKHb

A differentiation method informed by developmental biology converts human pluripotent stem cells to engraftable hematopoietic stem and progenitor cells without the use of transgenes #NBTNV go.nature.com/4enUz7u rdcu.be/eDKV2

Analogs of the pancreatic peptide hormone amylin are making strides in obesity as developers zoom in on oral drugs that can emulate or even improve on injectable GLP-1 agonists nature.com/articles/s41... rdcu.be/ezwbM

🚨New podcast alert🚨 Chief Editor Barbara Cheifet speaks with Zhenan Bao and John Rogers about electronic wearable technologies and how they will complement and advance global health, from health monitoring in neonates to smart bandages for wounds shows.acast.com/forum/episod...

Our study developing a skin metatranscriptomics protocol is now out in @natbiotech.nature.com! We finally have the ability to study microbial activity on skin and identify key functional genes playing a role in diseases. Amazing team of Chia Minghao and Amanda Ng 👏 nature.com/articles/s41...

Our Systema framework for evaluating genetic perturbation response prediction methods is now out in @natbiotech.nature.com ✨ Systema helps to evaluate perturbation response prediction methods by focusing on perturbation-specific effects rather than systematic variation 🎯

🎧#Podcast with Prof. Vasilis Ntziachristos about Photoacoustic Imaging: 👉https://t1p.de/o4n9t Learn more about groundbreaking medical imaging tools in the #HelmholtzMunich Highlight: "The Light that Listens to Health and Disease" 👉https://t1p.de/szrqp @munichimaging.bsky.social

A benchmarking competition improves tools that predict how regulatory regions control gene expression go.nature.com/3NnblYZ rdcu.be/eCbmL

Recent moves of note in and around the biotech and pharma industries go.nature.com/45WFeZc rdcu.be/eCTpZ

UK scientists announce the births of eight healthy children whose embryos were created using a pioneering in vitro fertilization technology to reduce the risk of incurable mitochondrial DNA diseases nature.com/articles/s41... rdcu.be/eCUvU

Skin metatranscriptomics reveals a landscape of variation in microbial activity and gene expression across the human body - @niranjantw.bsky.social @astar-gis.bsky.social go.nature.com/4fVg95j

The neoantigen discovery pipeline NeoDisc incorporates mass spectrometry immunopeptidomics data go.nature.com/4eEVVvo rdcu.be/eCbk3

Recent patents relating to antiviral compositions and methods of treatment go.nature.com/3VnTyVy rdcu.be/eCMrr

Five questions with Kevin Zhao go.nature.com/468Vasp

The microbial composition of metagenomes is identified in seconds by profiling against large databases go.nature.com/3BBVqDC rdcu.be/eCbj4

In Brief: A new center in San Francisco will offer tailor-made CRISPR therapies to cure children with rare diseases www.nature.com/articles/s41...

An optical pooled screening method can correlate phenotypes and perturbations in any nucleated cell type go.nature.com/3P35toD rdcu.be/eCbjX

Systema: a framework for evaluating genetic perturbation response prediction beyond systematic variation - @mariabrbic.bsky.social @mornitzan.bsky.social go.nature.com/4791kda

Precision gene editing medicine makes history, and it’s just getting started nature.com/articles/s41... rdcu.be/eCbm4

Grateful to @natbiotech.nature.com @natureportfolio.nature.com for highlighting our work. Using deep learning, we uncovered antibiotic molecules in archaea and showed anti-infective activity in mouse models.