Interesting to see my Asian colleagues are suggesting ideas for constructing synthetic cells, while my JCVI coworkers are almost finishing up the last touch to achieve the Holy Grail goal. @natbiotech.nature.com www.nature.com/articles/s41...

Targeting IL-33 could act more widely on COPD inflammatory pathways than current therapies - my latest for @natbiotech.nature.com rdcu.be/fld8G

Our machine learning driven quantification algorithm for proteomics now published in Nature Biotechnology. Optimal protein quantification and, for the first time, error estimates for individual quantities. Paper link in comments below.

🧬📜 SDN classification as a regulatory trigger no longer makes sense. New genome editing tools defy these old boxes. Regulate the product, not the method. A science‑based, outcome‑focused path forward for plant breeding. #plantscience @natbiotech.nature.com www.nature.com/articles/s41...

Optically detected and radio wave-controlled spin chemistry in flavoproteins - @bucherlab.bsky.social @tum.de @mcqst.bsky.social go.nature.com/4nYgTuG

Research Highlight: An in vivo electromagnetic field-responsive gene switch www.nature.com/articles/s41...

In Brazil, podcasts, live sessions, artificial intelligence and non-peer conversations serve as pedagogical tools to train biotechnology students for dialog go.nature.com/4dXiPjr rdcu.be/fkccr

TopoVelo infers cell differentiation stages and rate parameters of gene expression using spatially coupled differential equations go.nature.com/4lyR02w rdcu.be/fjOvI

Improving multimodal wearable sensing for healthcare with artificial intelligence - @ucsandiego.bsky.social @ethz.ch @stanfordmedicine.bsky.social go.nature.com/3RudjMJ

Scoring gene importance by interpreting single-cell foundation models go.nature.com/3RyZ6hs

Accurate quantification in proteomics with QuantUMS - @vadim-demichev.bsky.social @tuberlin.bsky.social go.nature.com/4wPiE1j

A combination of engineering approaches is used to improve the function of IscB for a variety of editing activities in vivo go.nature.com/44XVBph rdcu.be/fjOtb

In Brief: Shanghai-based Excalipoint Therapeutics launches with $68.7M from HongShan Capital Group, Lilly Asia Ventures and Eisai Innovation to develop next-generation T cell-engaging antibodies against solid tumors and autoimmune diseases www.nature.com/articles/s41...

Research Highlight: Programming B cell immunity from hematopoietic stem cells www.nature.com/articles/s41...

A framework for building a synthetic cell from the SynCell Asia Initiative go.nature.com/4tW9FZg

Fetal monitoring for high-risk pregnancies using a wearable ultrasound patch - @ucsandiego.bsky.social @stanfordmedicine.bsky.social go.nature.com/3PKl7cr

This research solves a major open problem in post-translational modification search for de novo peptide sequencing. It will help enable the development of new diagnostic tests and treatments.

Learn more about the work that established the world’s first system that uses DNA, rather than RNA, to guide CRISPR enzymes to its target.

A Brazilian approach to training stakeholder engagement skills in biotechnology undergraduates through curricular innovation go.nature.com/4dXiPjr

In Brief: The most advanced clinical trial for an in vivo gene editor, @intelliatx.bsky.social's lonvoguran ziclumeran (lonvo-z), reported positive phase 3 results in hereditary angioedema www.nature.com/articles/s41...

Photosynthesis in mammalian corneal cells boosts energy production and reduces inflammation #NBThighlight www.cell.com/cell/fulltex...

Colorectal cancer is discriminated by measuring cell-free RNA methylation in plasma bit.ly/3TYj96P rdcu.be/fjOqz

AI-guided redesign of laboratory-evolved reverse transcriptases enhances prime editing - @broadinstitute.org @hhmi-science.bsky.social go.nature.com/49yUr5t

Novel antivenoms bite back www.nature.com/articles/s41... [🔓read free with login]

Engineered E. coli trapped in a hydrogel scaffold release antibacterial proteins to clear a Pseudomonas infection in mice #NBThighlight www.science.org/doi/10.1126/...

Hughes and colleagues present a developmentally inspired tissue engineering strategy to overcome barriers in kidney tissue generation, enhancing prospects for renal replacement therapies go.nature.com/46tacJq rdcu.be/fjOmA

A science-based, outcome-focused regulatory approach in plant breeding would future-proof the risk-proportionate oversight of innovations and enable a more efficient delivery of improved crops amid growing concerns of climate change and evolving pests and diseases go.nature.com/4rhghjQ rdcu.be/fjPR1

Research Highlight: MitoCatch targets healthy mitochondria to diseased cells www.nature.com/articles/s41...

Directed evolution of small RNA-stabilizing motifs that improve prime-editing efficiency - @broadinstitute.org @hhmi-science.bsky.social go.nature.com/4wLWKMu

In Brief: UK issues regulatory approval for @rothamsted.bsky.social's gene-edited barley, the first under its new rules for precision breeding. The landmark approval marks a shift away from the EU's restrictive approach toward GMOs www.nature.com/articles/s41...

How biotech companies evolve intellectual property management capabilities: lessons from Cambridge Antibody Technology - @eng.cam.ac.uk go.nature.com/4fBhTCy

Zero-shot de novo peptide sequencing with open posttranslational modification discovery - @uwcheritoncs.bsky.social go.nature.com/4ujx08d

AstraZeneca’s IL-33 antibody tozorakimab targets two distinct signaling pathways engaged in COPD: inflammation and epithelial dysfunction www.nature.com/articles/s41... [🔓read free with login]

While circRNA is often framed as a more stable, longer-lasting alternative to linear mRNA, its real-world advantages remain largely theoretical, and it is unclear whether greater molecular stability will translate into meaningful clinical gains go.nature.com/3RzqxHN

The May issue is live nature.com/nbt/volumes/... On the cover, Zhang et al. describe an antibody-based therapy against drug-resistant S. aureus. The antibody conjugate selectively binds to the wall teichoic acid of the bacteria and enriches calcium on the cell envelope go.nature.com/3UaGItg

Now out @natbiotech.nature.com ! Do lncRNAs commonly bind 1000s of genomic sites? Maybe they do, but the dozens of studies that report genomic binding maps of lncRNAs are deeply flawed, with probes binding suprious DNA sites rather than RNA-bound ones.

New in @natbiotech.nature.com from Aly Khan: a platform combining yeast display with fine-tuned protein language models to identify antigens driving autoimmune disease. In collaboration with Chris Garcia at @stanfordpress.bsky.social / @hhmi-science.bsky.social 🧵

DNA-guided CRISPR–Cas12 for cellular RNA targeting - @ufresearch.bsky.social go.nature.com/49SP29d

Widespread DNA off-targeting confounds RNA chromatin occupancy studies - @igorulitsky.bsky.social go.nature.com/3Pvbf6e

Evidence linking thymic function with health and longevity is piling up, and a cluster of biotechnology companies is trying to regenerate the thymus directly or recapitulate its function to reinvigorate patients’ immunity www.nature.com/articles/s41... [🔓read free with login]

Immune-remodeling mRNAs expressing IRF8 or NIK generate durable antitumor immunity in multiple cancer models - @mitkochinstitute.bsky.social go.nature.com/42td2fh

Are you joining us at the 2026 HCA General Meeting in 5 week’s time in Boston? If so, you’ll have the opportunity to engage directly with editors from scientific journals during ‘meet-the-editors’ sessions. buff.ly/gnFdhAL #HCA2026GM

Deep peptide recognition profiling decodes TCR specificity and enables disease-associated antigen discovery - @stanfordmedicine.bsky.social go.nature.com/3QWMRet

As measurement resolution, depth and throughput improve in single-cell and spatial proteomics, progress is increasingly constrained not by experimental sensitivity but by the ability to integrate proteomic data across experiments, modalities and spatial contexts go.nature.com/3NHDkGP rdcu.be/fij7N

The US Supreme Court’s decision in Loper Bright, along with federal spending cuts, may limit the potential of synthetic biology to provide innovative solutions for environmental challenges, medicine and biomanufacturing go.nature.com/4cE794D rdcu.be/fikex

A new translational research unit at the Weizmann Institute of Science complements the work of the tech transfer office and bridges the translation gap with strategic, operational and resource frameworks that go beyond traditional commercialization infrastructure go.nature.com/4cJwcn4 rdcu.be/fh6eL

Circling back to RNA vaccines go.nature.com/3RzqxHN

How can we translate our growing understanding of the dark genome into therapeutics? We asked experts in the field for their thoughts go.nature.com/4tQ1zTn rdcu.be/e8Eci

Sharing of big data is a vital driver of innovation in the agri-food sector. @novo-nordisk.bsky.social scientists discuss the main challenges and propose steps to enhance data sharing and exploration from a research funder’s perspective go.nature.com/4raUN86 rdcu.be/fh6mr

A builder and problem solver at heart, she is developing technologies to understand and engineer the roles of cell-surface sugars, called glycans, in the immune system go.nature.com/42sA99y rdcu.be/fh6cx