Single-molecule live-cell fluorescence in situ hybridization uses an RNA-targeting CRISPR–Csm complex to image and track endogenous RNAs go.nature.com/3EJPKsM rdcu.be/eUK9K

After two decades of sustained growth, cancer diagnostics patents peaked in 2020 and have since stabilized, with a broad set of public and private players driving innovation go.nature.com/490ZTNn rdcu.be/eV2A9

In-body manufacturing promises a faster, cheaper and simpler alternative to CAR-T cell therapy — if the field can deliver clinical readouts that prove long-term safety and efficacy www.nature.com/articles/s41... rdcu.be/eV2Dy

An integrated experimental and deep learning pipeline reveals cell-level targeting of nanocarriers in whole bodies go.nature.com/4gNLjeC rdcu.be/eUK6B

In Brief: @fda.gov approves Arrowhead Pharmaceuticals' #Redemplo for treating familial chylomicronemia syndrome www.nature.com/articles/s41... rdcu.be/eVTl4

FOCUS: an AI-assisted reading workflow for information overload go.nature.com/49pa7YY

The brief digital edition of @natbiotech.nature.com December issue is live now! 🎉 Check it out here👉 mp.weixin.qq.com/s/s9rh4chmdT...

Out in Nature Biotechnology from IGI's Patrick Shih — a new "speed scanner" can test 1000s of plant gene activators at once. Read here: https://ow.ly/foy650XLAxh P.S. The image is in fact not a watermelon radish slice from Berkeley Bowl, but a tobacco cell with fluorescent reporters!

Congratulations @jcstark.bsky.social and the team, antibody-lectin chimeras (AbLecs), a new modality for cancer immune therapy, now published @natbiotech.nature.com. These bispecifics can block glyco-immune checkpoint receptor ligands directly at the immune synapse/activate immune effector functions

Out now: We present antibody-lectin chimeras (AbLecs) as a molecular platform to target sugars, or glycans, for cancer immunotherapy. www.nature.com/articles/s41... www.nature.com/articles/s41... @mitkochinstitute.bsky.social @mitdeptofbe.bsky.social @mitcheme.bsky.social @stanford-chemh.bsky.social

Machine learning enables scalable and systematic hierarchical virus taxonomy - @sullivan-lab.bsky.social go.nature.com/4qoPli9

This year’s most popular stories are a testament to biotech ingenuity and a cause for celebration: the gene editing triumph that cured ‘baby KJ’ of a rare genetic disorder in record time; the bispecific molecules that trick HIV out of cells to destroy them... www.nature.com/articles/s41...

Targeting T cells by delivering mRNAs encoding DLL1, FLT3L and IL-7 to liver improved peptide vaccine responses and restored anti-tumour immunity in aged mice. #NBThighlight www.nature.com/articles/s41...

Human periportal liver assembloids containing hepatocytes, cholangiocytes, and mesenchymal cells offer a potential system to model liver fibrosis. #NBThighlight www.nature.com/articles/s41...

Mapping the metabolic effects of drugs helps define their mode of action go.nature.com/3CreANg rdcu.be/eUK7o

The import of biological research material is a silent barrier to biotechnology in the Global South go.nature.com/48ZIPHr

Computational prediction of human genetic variants in the mouse genome - @fsrmit.bsky.social @mitkochinstitute.bsky.social go.nature.com/4qbEfg1

Engineered base editors with reduced bystander editing through directed evolution - @geochurch.bsky.social @harvardmed.bsky.social @wyssinstitute.bsky.social go.nature.com/4qmupbv

Adipose manipulation transplantation can reduce tumor growth and proliferation in vitro and in mouse models go.nature.com/4gqhxvw rdcu.be/eUK5T

Exploring the use of AI authors and reviewers at Agents4Science - @jameszou.bsky.social go.nature.com/4j1O7a3

A language model predicts the effects of genetic variants in the human genome go.nature.com/4gWppWg rdcu.be/eUK6Z

In Brief: @fda.gov pitches a new pathway for moving individualized genetic technologies into clinical practice, tacitly acknowledging that the traditional scheme does not meet rare disease treatment needs in a timely way nature.com/articles/s41... rdcu.be/eUYs9

Mapping the patent landscape of cancer diagnostics - @cambridgelaw.bsky.social go.nature.com/490ZTNn

Antibody-lectin chimeras for glyco-immune checkpoint blockade - @jcstark.bsky.social @carolynbertozzi.bskyverified.social go.nature.com/4aRDpk8

The suitability of different AAV capsids for gene therapy is assessed in human livers go.nature.com/3PWpD4o rdcu.be/eUK3m

In vivo CAR-Ts captivate big pharma www.nature.com/articles/s41...

Building synthetic chromosomes one yeast at a time: insights from Sc2.0 - @arccoesb.bsky.social go.nature.com/48Fqxwi

Predicting better lipids: In a cover-winning @natbiotech.nature.com paper, the Anderson & Langer Labs screened 1.6M lipids in silico to speed up successful designs for mRNA delivery to lungs. www.nature.com/articles/s41...

Our @natbiotech.nature.com editorial team picks our favorite research articles from 2025. We’ve also posted a Chinese version here 👉 mp.weixin.qq.com/s/fY10zwuljH...

Five questions with Pranam Chatterjee @pranam.bsky.social go.nature.com/4pzXi3P

Our editors pick their favorite research articles from 2025 go.nature.com/4oCK84L

The December issue is live nature.com/nbt/volumes/... Hybrid quantum computing for drug design. Ghazi Vakili et al. present a hybrid quantum–classical generative model to design molecules to inhibit KRAS activity. Two candidates are synthesized and further characterized go.nature.com/3EitbLm

The outlook for patients with certain forms of fibrosis has finally started to brighten, after a string of clinical trial setbacks over the past decade. In October @US_FDA approved @Boehringer's oral drug Jascayd (nerandomilast) for idiopathic pulmonary fibrosis www.nature.com/articles/s41...

Obituary: David Baltimore (1938–2025) go.nature.com/4959dRm

A scaffold-free bioprinting approach achieves physiological cell densities, and is used to print in vitro models of heart and liver structures, and neural circuits #NBThighlight www.cell.com/cell/fulltex...

Top ten news stories in 2025 www.nature.com/articles/s41...

RNA sequestration in P-bodies stabilizes cell-fate transitions by repressing past identities — a process that can be harnessed to control cell fate #NBTNV go.nature.com/4iyZmGv rdcu.be/eTR4A

2025: research in review go.nature.com/4oCK84L

In vivo gene editing of human hematopoietic stem and progenitor cells using envelope-engineered virus-like particles - @uclpophealthsci.bsky.social go.nature.com/4a39S6X

By creating a network of early-career principal investigators, Gianvito Scaringi and his colleagues have enacted change and battled bureaucracy. You can read more about how a group of novice lab leaders are supporting each other: spklr.io/63329B5TIW #AcademicSky

Thanks @natbiotech.nature.com for the shoutout and supporting our work at attempting QC in this emerging field of #spatial #transcriptomics @lgmartelotto.bsky.social @christophermason.bsky.social

Harmful debris and inflammation in the brain caused by hemorrhagic stroke are treated by ultrasound therapy in a mouse model #NBTNV go.nature.com/4hWkUwE rdcu.be/eSP1Q

Obituary: Pedro Cuatrecasas (1936–2025) go.nature.com/4pHtmCC

A deep learning model trained on experimental data from high-throughput screening identifies structurally novel antimicrobial compounds #NBTNV go.nature.com/47fxSSv rdcu.be/eSIvL

A statistical framework quantifies single-cell batch variation and recovers meaningful biological signals go.nature.com/4hZnzW5 rdcu.be/eRy6o

Biotech news from around the world: Uganda, UK, Brazil, India nature.com/articles/s41... rdcu.be/eSP9B

Standardized metrics for assessment and reproducibility of imaging-based spatial transcriptomics datasets - @jasmineplummer.bsky.social @lgmartelotto.bsky.social go.nature.com/4rBC1Z0

Mapping single-cell diploid chromatin fiber architectures using DAF-seq - @uwgenome.bsky.social @uwdeptmedicine.bsky.social go.nature.com/4rFTAHy

Recent patents relating to mRNA vaccine compositions and methods of use go.nature.com/48dVmb4 rdcu.be/eSP7I

Beyond the unprecedented efficacy of GLP-1s in obesity and type 2 diabetes, evidence that they improve comorbidities has been accumulating at an impressive pace in recent years go.nature.com/49aN7gR