BioContextAI is a community hub for agentic biomedical systems - @puellesv.bsky.social @biocontext.ai go.nature.com/3JmqKux

CRISPR live-cell imaging reveals chromatin dynamics and enhancer interactions at multiple non-repetitive loci - @tsinghuauniversity.bsky.social go.nature.com/49EhzA4

Site-specific DNA insertion into the human genome with engineered recombinases - @pdhsu.bsky.social @arcinstitute.org go.nature.com/43kdvBg

A nonsurgical brain implant enabled through a cell–electronics hybrid for focal neuromodulation - @deblina-sarkar.bsky.social @medialab.bsky.social go.nature.com/3JuSNYH

Research Highlight: Combining CRISPR perturbations with chromatin profiling www.nature.com/articles/s41...

Recent patents relating to directed evolution methods and products go.nature.com/3LqXHX6 rdcu.be/eOisD

While medical digital twins hold great promise for personalized healthcare—with promising applications in oncology, diabetes management and cardiovascular medicine—their implementation is no easy feat. We asked experts in the field for their thoughts go.nature.com/42YcE9c rdcu.be/eOir8

After decades-long struggles with microRNA-based therapeutics, Regulus hits paydirt in the clinic and in the marketplace. Is it the beginning of a trend or a one-off? www.nature.com/articles/s41...

Recent moves of note in and around the biotech and pharma industries go.nature.com/47ydRH3 rdcu.be/eOe77

KATMAP infers splicing factor activity and regulatory targets from knockdown data - @daspliceisright.bsky.social go.nature.com/47ycrMJ

New approaches to engineering plant immunity can more broadly protect crops against pathogens and disease, once they get through regulatory hurdles go.nature.com/475WgV7 rdcu.be/eN6q4

Biotech news from around the world: Ghana, Chile, India, Burkina Faso www.nature.com/articles/s41... rdcu.be/eN6mp

Growth-coupled microbial biosynthesis of the animal pigment xanthommatin - @pabnik.bsky.social go.nature.com/3Ll0VeT

Everyone talks about thymic epithelial cells when it comes to T cell development. They play a major role — just not the only one. Our new paper in @natbiotech.nature.com shows the mesenchyme has been quietly pulling strings: rdcu.be/eNF24

New publication in @natbiotech.nature.com! Wim de Lau and colleagues from @hansclevers.bsky.social group describe an integrin-activating antibody that enhances organoid growth also in, medical-grade, collagen. An important step toward more affordable and translational organoid culture systems.

Check out our @natbiotech.nature.com @natureportfolio.nature.com piece with Yumeng Zhang + Jiangning Song on @genentech.bsky.social's deep learning approach to accelerate antibiotic discovery. Congrats to Gabriele Scalia, Tommaso Biancalani, Man-Wah Tan, Aviv Regev, @yoshuabengio.bsky.social et al!

1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...

🤝 Bridging the gap between bench and bedside requires structured clinical engagement, mentorship and opportunities to observe how research is applied in clinical context. Access the full article in @natbiotech.nature.com: www.nature.com/articles/s41...

The brief digital edition of our Nature Biotechnology October issue is live now! 🎉 Check it out here: mp.weixin.qq.com/s/nZSLSSxF4s... @natbiotech.nature.com

Porphyrins are produced at scale through metabolic engineering and optimization of CPIII purification go.nature.com/3Ks4YCi rdcu.be/eNakD

In Brief: Vertex dives into covalent biologics with Enlaza Therapeutics in a multi-drug discovery collaboration worth up to $2 billion nature.com/articles/s41... rdcu.be/eNF2U

LeDNA: a cut-and-build toolkit to democratize CRISPR gene editing technology education go.nature.com/3Wybiyb

An antivenom combining eight alpaca- and llama-derived nanobodies neutralizes toxins from a broad range of snake venoms #NBThighlight www.nature.com/articles/s41...

Agrobacterium-mediated transformation of plants and fungi is enhanced by plasmid copy number variants go.nature.com/3CdewQS rdcu.be/eNaje

A virtual course provides an opportunity for early-career researchers to witness the translation of basic and preclinical research to inform clinical decisions related to precision oncology go.nature.com/4qlnjEI rdcu.be/eNwpt

Looking forward to #SITC25 next week! Please get in touch if you’d like to discuss your upcoming submissions to Nature Biotechnology! @natbiotech.nature.com

Ad hoc, post hoc and intrinsic-hoc in bioinformatics go.nature.com/4oJTzji

Mesenchymal thymic niche cells enable regeneration of the adult thymus and T cell immunity go.nature.com/3Jp6B72

High-plex spatial RNA imaging in one round with conventional microscopes using color-intensity barcodes - @pku1898.bsky.social go.nature.com/47yENVJ

Chromatin organization is measured in single cells using droplet microfluidics go.nature.com/3NCqwO1 rdcu.be/eNah5

Big pharma seduced by transcription factors again. What has changed? www.nature.com/articles/s41...

A protein platform rapidly develops peptide-focused major histocompatibility complex class I binders with high specificity go.nature.com/4gcLzn5 rdcu.be/eNagQ

A single-chain derivative of an integrin-activating antibody potentiates organoid growth in Matrigel and collagen hydrogels - @hansclevers.bsky.social @hubrechtinstitute.bsky.social go.nature.com/3Le6j3i

Selective RNA sequestration in biomolecular condensates directs cell fate transitions - @distefanolab.bsky.social @brumbaugh-lab.bsky.social go.nature.com/3X215du

Investigating gender disparities in patent citations reveals untapped potential go.nature.com/3WVW1HB

Specific binders to peptide–MHC class II are rapidly generated without laborious screening go.nature.com/4gj5OQk rdcu.be/eMYFS

In Brief: San Francisco–based startup Mission Barns begins selling its cultured pork fat to local restaurant diners, joining a handful of companies selling cell-cultivated meat products www.nature.com/articles/s41... rdcu.be/eMYDx

Overcoming barriers to the wide adoption of single-cell large language models in biomedical research - @lgarmire.bsky.social go.nature.com/4oACOqQ

Pleased to have contributed to this Genentech-led research with NVIDIA featured today in @natbiotech.nature.com presenting GNEprop, an AI model that identifies novel antimicrobial compounds beyond known chemical space. Mila’s contributions were led by @yoshuabengio.bsky.social & Michał Koziarski.

Thrilled to see this published! Well done Ahmed on spearheading a project revealing mitotic errors in human embryos arise much later than anticipated. Thank you to collaborators @bensteventon.bsky.social Leila Muresan and all of the wonderful teams at Bourn Hall and Create Fertility clinics!

Great work from our grad student Ben Larsen who tested this on flu coronavirus strains with collaborators @eakarlsson.bsky.social @jsiegers.bsky.social @dirkeggink.bsky.social

Big news: The Vicković Lab’s study on colon aging has been accepted by @natbiotech.nature.com! The team built a detailed atlas of aging colon tissue, using spatial transcriptomics + a new tool (cSplotch) to profile ~1,500 samples & 400k nuclei. 🔗 Read more: bit.ly/4hj3ry7 #SpatialTranscriptomics

Exciting collaboration combining multiplex epigenetic reprogramming and site-specific payload integration!

Deep-learning-based virtual screening of antibacterial compounds go.nature.com/47oIdKy

Democratizing protein language model training, sharing and collaboration go.nature.com/47lrRSX

Applications of digital twins in medicine go.nature.com/42YcE9c

ReChb is a Cas12a nuclease with expanded target access and substrate recognition go.nature.com/3AmzhJ8 rdcu.be/eLVuq

RNA structure modulates Cas13 activity and enables mismatch detection - @cambearon.bsky.social @princetonmolbio.bsky.social go.nature.com/4oglebG

Elucidating lipid nanoparticle properties and structure through biophysical analyses - @guptapenn.bsky.social @pennengineering.bsky.social @pennmedicine.bsky.social go.nature.com/4oTt639

Discovery and engineering of retrons for precise genome editing - @texasscience.bsky.social go.nature.com/4nkr7DE