Culturing microbiome therapeutics with big data go.nature.com/4akDuef

Sensitive detection of cancer antigens enabled by user-defined peptide libraries - @broadinstitute.org go.nature.com/4kvvwUC

👏👏 to our own Pragati Sharma, Vince Smeraglia, & Michael Zwick, & Rutgers Health's Reynold Panettieri, as their article 𝙎𝙪𝙨𝙩𝙖𝙞𝙣𝙖𝙗𝙞𝙡𝙞𝙩𝙮 𝙤𝙛 𝙂𝙖𝙥 𝙁𝙪𝙣𝙙𝙞𝙣𝙜 𝙋𝙧𝙤𝙜𝙧𝙖𝙢𝙨 𝘼𝙞𝙢𝙚𝙙 𝙖𝙩 𝘾𝙤𝙢𝙢𝙚𝙧𝙘𝙞𝙖𝙡𝙞𝙯𝙞𝙣𝙜 𝘼𝙘𝙖𝙙𝙚𝙢𝙞𝙘 𝙄𝙣𝙣𝙤𝙫𝙖𝙩𝙞𝙤𝙣 was published by Nature Biotechnology! ➡️ www.nature.com/articles/s41... #RutgersResearch

The time is ripe for transitioning the field of immunotherapy to in vivo engineering as ex vivo engineering is now mature, with extensive knowledge on the safety & lifesaving aspect of these immunotherapies especially in blood cancers, solid tumors & autoimmunity go.nature.com/4r732m4 rdcu.be/e2yJa

Single-round evolution of RNA aptamers with GRAPE-LM go.nature.com/4bFDI22

@fda.gov headlines from 2025 were about people and policies, rather than new drugs. Both CDER and CBER cycled through multiple leadership changes. Several senior positions across the FDA remain unfilled and over a fifth of the agency workforce has been cut go.nature.com/3LDdG50 rdcu.be/e2yI5

Two recent studies describe the most advanced islet cell implants for type 1 diabetes and how they fared in the clinic. The results are encouraging but open up a discussion of whether freedom from insulin will soon become a reality for patients www.nature.com/articles/s41...

Recent patents relating to compositions and methods for preventing or treating diseases and conditions associated with mitochondrial dysfunction go.nature.com/4tjp1YG rdcu.be/e2nw5

DNA repair activity of reverse transcriptase may negatively affect prime editing precision go.nature.com/3X6mOBv rdcu.be/e1bDk

Insights into regulatory T cell biology are accelerating therapeutic innovation in cancer immunotherapy, autoimmune diseases and transplant rejection go.nature.com/4qNezXD

Balancing innovation and integrity: the biomedical research ecosystem at a crossroads - @fralinbiomed.bsky.social @virginiatech.bsky.social go.nature.com/3MqlHdP

Accurate plasmid reconstruction from metagenomics data using assembly–alignment graphs and contrastive learning - @ucph.bsky.social @novo-nordisk.bsky.social go.nature.com/4qcOb8H

Pilot phase clinical trial of a wearable, electrochemical aptamer-based patch for continuous drug concentration measurement - @sydney.edu.au @ucsantabarbara.bsky.social go.nature.com/46q2uQ7

Profiling transcriptional crosstalk between promoters and cell-type-specific enhancers allows large gene cargo delivery go.nature.com/4kFUnEO rdcu.be/e1bCR

Research Highlight: Gene drives tested against real-world malaria diversity www.nature.com/articles/s41...

San Diego based Debut Biotechnology creates a lab version of orris, a floral scent that can cost as much as gold, that has been used in perfume making and in medicine since the time of the Ancient Greeks www.nature.com/articles/s41... rdcu.be/e18Vl

Placement of an m7G cap internally on circular RNAs promotes their translation in vivo go.nature.com/4b37Thj rdcu.be/e1bAD

Biotech news from around the world: India, South Korea, Brazil, Belgium www.nature.com/articles/s41... rdcu.be/e1Zaj

Building an effective and sustainable technology commercialization fund emphasizes getting industry input early to improve outcomes in the short and long term go.nature.com/4bRcKo3 rdcu.be/e0PlI

Customizing CRISPR–Cas PAM specificity with protein language models - @thisismadani.bsky.social go.nature.com/4a4G9Zy

First-in-human studies provide hope that islet replacement therapies derived from stem cells will prove safe and effective in people with type 1 diabetes, but hurdles remain www.nature.com/articles/s41... rdcu.be/e1x9M

A neural network model improves time-lapse super-resolution imaging of live cells go.nature.com/3EjfqMQ rdcu.be/e1bwv

A systematic, prospective analysis of the interplay between science and technology in biomedicine can illuminate the pathway for translating scientific insights into tangible innovations for societal benefit go.nature.com/4bbgxfR rdcu.be/e0sgz

Obituary: John Gurdon (1933–2025) - @zernickagoetz.bsky.social go.nature.com/3Mf8SD0

Fancy smelling like a Greek goddess? www.nature.com/articles/s41...

In Brief: @gsk.bsky.social selects its first two biotech collaborators from venture capital Flagship Pioneer’s bioplatform companies, part of a $7.2 billion pact between the pharma and VC forged in 2024 www.nature.com/articles/s41... rdcu.be/eZ8Ah

Biologics are delivered to the gut using phage that infects resident commensal bacteria go.nature.com/4jWgRAW rdcu.be/e1buG

Recent moves of note in and around the biotech and pharma industries go.nature.com/4q6Xxmv rdcu.be/e1bFi

Lipid nanoparticles carrying plasmid DNA and an inflammation inhibitor enable longer transgene expression than mRNA nanoparticles go.nature.com/3EkClak rdcu.be/eZ8DO

China’s innovation in translational medicine: rethinking early-stage clinical development - @caidyacro.bsky.social go.nature.com/4agbEkG

Single-cell proteomic landscape of the developing human brain - @ucsfstemcell.bsky.social @stanfordmedicine.bsky.social go.nature.com/4rfSn8A

Sidewinder uses DNA three‑way junctions (3WJs) to construct long, complex, and highly diverse synthetic DNA sequences. #NBThighlight www.nature.com/articles/s41...

Careful selection of Cas13 variants and delivery methods minimizes collateral RNA degradation go.nature.com/4gEn95x rdcu.be/eZ8CF

Sustainability of gap funding programs aimed at commercializing academic innovation go.nature.com/4bRcKo3

In Brief: Merck pays $9.2 billion for Cidara Therapeutics and its phase 3 antiviral designed to prevent influenza A and B infection in people at high risk of complications nature.com/articles/s41... rdcu.be/e0O8c

@fda.gov leadership changes, staff cuts and a raft of new policies marked an agency in transition. New drug approvals featured more follow-on products than firsts go.nature.com/3LDdG50

The brief digital edition of @natbiotech.nature.com’s first issue of 2026 is now live! Check it out here: mp.weixin.qq.com/s/CCnzwsGlQR...

Mapping the science–technology translational landscape in biomedicine - @pku1898.bsky.social go.nature.com/4bbgxfR

Patients with Parkinson’s disease treated with fetal tissue are assessed 3 years after surgery go.nature.com/44TCQ6u rdcu.be/eZ8Cj

Lab-made islet cell implants sail through diabetes trials, but are they ready yet? www.nature.com/articles/s41...

The dawn of in vivo immune cell engineering in oncology - @fredhutch.org @pennmedicine.bsky.social go.nature.com/4r732m4

Metabolites can be quantified using a combination of aptamers and DNA barcodes go.nature.com/42BbXTQ rdcu.be/eZ8BP

In Brief: The first two clinical trials to look at the effect of GLP-1s on Alzheimer’s disease deliver disappointing results www.nature.com/articles/s41... rdcu.be/eZ8yE

Fresh from the biotech pipeline: FDA turmoil overshadows 2025 approvals go.nature.com/3LDdG50

An engineered UGA suppressor tRNA gene for disease-agnostic AAV delivery go.nature.com/3LziXdP

Engineered living glues secrete therapeutic proteins for treatment of inflammatory bowel disease go.nature.com/4pJHFpL

TimeVault transforms vault particles into transcriptome recording devices, which are applied to uncover transcriptional heterogeneity in drug-tolerant persister cancer cells #NBThighlight www.science.org/doi/10.1126/...

Balancing immunity with Tregs Insights into regulatory T cell biology are accelerating therapeutic innovation in cancer immunotherapy, autoimmune diseases and transplant rejection go.nature.com/4qNezXD

The January issue is live nature.com/nbt/volumes/44 /issues/1 On the cover, Luebbert et al. present a method to detect viral sequences in bulk and single-cell transcriptomic data using conserved amino acid domains instead of annotated reference genomes go.nature.com/4lGrSY3

The persistent challenge of importing biological research materials to the Global South at a reasonable cost, within acceptable timeframes, and with manageable regulatory complexity stalls progress before research and innovation can even begin go.nature.com/48ZIPHr rdcu.be/eZond