Research Highlight: Integrating chromatin architecture and functional analysis www.nature.com/articles/s41...

The FDA’s drive to reduce animal testing in drug development has coincided with a boom in AI-powered biosimulation techniques such as multi-agent virtual scientists and digital twins, while organoids and other mature methods embrace AI to ramp up predictive power www.nature.com/articles/s41...

The global patent landscape of bispecific antibodies: technological innovations and therapeutic applications www.nature.com/articles/s41...

This Perspective positions cellular self-organization as a foundational principle for the origin of multicellular life and discusses how decoding this concept with stem cell-based models will advance biological engineering go.nature.com/4e1m3Br rdcu.be/ftZeL

Multiscale in vivo imaging of tumor evolution using a germline conditional triple-reporter mouse - @davidylewis.bsky.social @cruk-si.bsky.social www.nature.com/articles/s41...

High numerical aperture confocal volumetric mesoscope reveals mesoscale subcellular dynamics in vivo - @tsinghuauniversity.bsky.social @fudanuniversity.bsky.social www.nature.com/articles/s41...

High-fidelity fast fluorescence lifetime imaging by event-based denoising - @tsinghuauniversity.bsky.social www.nature.com/articles/s41...

In Brief: China’s drug regulator gives green light to CARsgen Therapeutics' satri-cel (satricabtagene autoleucel) for gastric cancer — the first chimeric antigen receptor (CAR) T cell therapy approved for solid tumors www.nature.com/articles/s41... rdcu.be/ftVq1

Quantum computing in transition Hybrid quantum–classical computers will achieve quantum advantage in biotechnology, bridging the time until a full quantum computer becomes available www.nature.com/articles/s41...

The July issue is live nature.com/nbt/volumes/... On the cover, @ycongzhang.bsky.social @efranzosa.bsky.social @hutlab.bsky.social introduce FUGAsseM, a method that uses microbial community data to infer the functions of previously uncharacterized gene products go.nature.com/435C4lp rdcu.be/ftNUV

AI-powered methods shake up animal testing www.nature.com/articles/s41... [🔓read free with login]

High-resolution reconstruction of cell-type-specific transcriptional regulatory processes from bulk sequencing samples - @weillinstitute.bsky.social @cornelluniversity.bsky.social www.nature.com/articles/s41...

So proud to see this study out — a real honor to be involved in work from my PhD lab!

Biotech’s digital twin dilemma www.nature.com/articles/s41... [🔓read free with login]

Engineered ADARs enable precision A-to-G base editing of DNA www.nature.com/articles/s41...

Efficient in vivo cytosine base editing using virus-like particles with uracil DNA glycosylase inhibition www.nature.com/articles/s41...

High-quality phage assembly from metagenomes with PALACE www.nature.com/articles/s41...

Efficient targeting of human glial progenitor cells in vivo with engineered AAV vectors and glymphatic delivery - @urmed.bsky.social @ucph.bsky.social www.nature.com/articles/s41...

Antibody–bottlebrush conjugates expand the options for drug cargos compared to antibody–drug conjugates go.nature.com/46d1T3t rdcu.be/fpOS5

Frontier AI companies as biotech acquirers www.nature.com/articles/s41...

Silhouette score is unsuitable as a metric for single-cell data integration go.nature.com/4fcQzZr rdcu.be/fpOKP

Quantum computing in transition www.nature.com/articles/s41...

Each year, we highlight companies that received sizeable early-stage funding in the previous year. Liberate Bio is developing a lipid nanoparticle toolbox to deliver genetic medicine to previously inaccessible cells inside the body www.nature.com/articles/s41...

The brief digital edition of @natbiotech.nature.com’s June issue is live now! Check it out here: mp.weixin.qq.com/s/eXJfskj-pG...

Read Frank Buchholz's latest Nature Biotechnology article! A must-read for researchers in functional genomics. lnkd.in/d98vhQwN

really great paper from Sangamo, now peer-reviewed over two years after the initial preprint! this paper used LI Integrase and a RoseTTAFold model of Bxb1. since the preprint, structures of Bxb1, PhiC31, and SP-beta LSRs have all been solved. tons of great work in the LSR field recently

An evaluation framework isolates perturbation-specific effects in perturbation datasets go.nature.com/4791kda rdcu.be/fpOWU

Each year, we highlight companies that received sizeable early-stage funding in the previous year. Trogenix's platform for generating ‘synthetic super-enhancers’ could drive highly cell-specific gene therapy-based treatment of solid tumors such as glioblastoma www.nature.com/articles/s41...

A plug-and-play system fine-tunes multiple targets simultaneously for secondary metabolite production in Streptomyces go.nature.com/3HdTOTV rdcu.be/fpOVH

With endless curiosity and persistence, this biologist is motivated by the prospect of developing stem cell technologies that could one day repair damaged organs or even create new organs for transplantation www.nature.com/articles/s41... rdcu.be/fpQOo

Biotech news from around the world: United Kingdom, Vietnam, United Arab Emirates, Brazil, Japan www.nature.com/articles/s41... rdcu.be/frxni

A genome-scale CRISPRi perturbation atlas of human induced pluripotent stem cells www.nature.com/articles/s41...

Genomic integration of DNA templates is made more precise through microhomology-focused design go.nature.com/41GoBiX rdcu.be/fpOUC

Recent patents relating to methods and systems for using artificial intelligence in drug discovery www.nature.com/articles/s41... rdcu.be/frihO

Prime editing for precise genome engineering and modulation of fungal metabolism - @pennengineering.bsky.social www.nature.com/articles/s41...

Mass spectrometry and wearable sensor technology are complementary approaches that, when integrated, can co-evolve to open new possibilities for noninvasive health monitoring go.nature.com/4rvOjAS rdcu.be/fpQNs

Experiment-guided AlphaFold3 resolves measurement-consistent protein ensembles - @istaresearch.bsky.social @alex-bronstein.bsky.social @paulschanda.bsky.social @sankethvedula.bsky.social www.nature.com/articles/s41...

Retargeted serine integrases for one-step, precise integration of large DNA sequences in human cells www.nature.com/articles/s41...

Sub-zero technologies that reduce ice damage in organs could extend donor-graft shelf life — offering transplant centers more time to match recipients www.nature.com/articles/s41... [🔓read free with login]

For years, the idea of targeted protein degradation stalled because PROTACs were too large and unstable for clinical use. However, in the beginning of May, @fda.gov approved the use of the first PROTAC for adults with a certain form of metastatic breast cancer go.nature.com/4x3NYt7

Spatially resolved profiling of extracellular vesicles in tissues with Spatial-EV-seq www.nature.com/articles/s41...

PepMLM designs peptide binders against diverse targets using masked language modeling go.nature.com/3UtVc7N rdcu.be/fpOQD

Recent moves of note in and around the biotech and pharma industries www.nature.com/articles/s41... rdcu.be/fqq4U

Toward mechanistic virtual immune cells - @winshipcancer.emory.edu www.nature.com/articles/s41...

In Brief: British startup Meatly will build what it says will be Europe’s largest cultivated meat factory, to produce bioreactor-grown chicken meat for the pet food market www.nature.com/articles/s41... rdcu.be/foKVH

Transcriptome-scale maps of RNA secondary structure ensembles in living cells detect candidate RNA structural switches go.nature.com/4lLtIX8 rdcu.be/fpOO7

Mapping and engineering the human cell–cell interactome - @uclasamueli.bsky.social www.nature.com/articles/s41...

Joint profiling of chromatin and splicing in the brain uncovers shared and distinct patterns go.nature.com/3IKlcJn rdcu.be/fpONd

If translational medicine is to fulfill its promise, educational programs must evolve to prepare a workforce not only capable of discovery, but capable of moving discovery toward the patients who need it www.nature.com/articles/s41... rdcu.be/foTHd

Five questions with Ya-Wen Chen www.nature.com/articles/s41...