Looking forward to #SITC25 next week! Please get in touch if you’d like to discuss your upcoming submissions to Nature Biotechnology! @natbiotech.nature.com

New online in @natbiotech.nature.com : The interactions of CAT-T cells and solid tumors are modeled on a chip.

The brief digital edition of our Nature Biotechnology October issue is live now! 🎉 Check it out here: mp.weixin.qq.com/s/nZSLSSxF4s... @natbiotech.nature.com

The brief digital edition of our @natbiotech.nature.com September issue is live now! Check it out here: mp.weixin.qq.com/s/vDXak-Ph4k...

On our latest podcast, Barbara Cheifet talks with Zhenan Bao and John Rogers about the latest in electronic wearables and how they will complement and advance global health — from health monitoring in neonates to smart bandages for wounds shows.acast.com/forum/episod...

Stereo-cell is a DNA nanoball array-based method that enables scalable, spatially resolved single-cell sequencing across diverse cell types and sizes with multimodal integration capabilities. #NBThighlight www.science.org/doi/10.1126/...

The brief digital edition of our @natbiotech.nature.com August issue is live now! Check it out here: mp.weixin.qq.com/s/ZIDiPktIya...

The brief digital edition of our June issue is live now! Check it out here: mp.weixin.qq.com/s/S9nAe_uF0Z...

CD8-targeted lipid nanoparticles carrying anti-CD19 CAR mRNA were developed to generate CAR-T cells directly in vivo, demonstrating effective B cell depletion for potential treatment of B cell malignancies and autoimmune diseases. www.science.org/doi/10.1126/... #NBThighlight

The brief digital edition of our May issue is live now! Check it out here: mp.weixin.qq.com/s/Ph75nRcl02...

A gene-editing treatment used on a 9½-month-old boy with a rare condition has the potential to help people with thousands of other uncommon genetic diseases #NBTNewsBeat www.nytimes.com/2025/05/15/h...

This developer of cancer immunotherapies discusses her early fascination with cellular behavior, perseverance and deep desire to directly impact patient care go.nature.com/3RSlwqL rdcu.be/ej8IO

Cancer vaccines: the experts speak www.nature.com/articles/s41...

Synergizing advances in artificial intelligence with mathematical modeling will improve our ability to computationally predict immunotherapy outcomes go.nature.com/4jfqM3Y rdcu.be/eh1qR

Cell therapies are transforming our ability to treat cancer but are out of reach for many patients. We asked experts to share their insights into the challenges and strategies to make these therapies more broadly accessible go.nature.com/3YCJn1o rdcu.be/eiaZ4

The identification of novel targets together with technological advances is transforming our ability to effectively modulate the tumor microenvironment go.nature.com/42Bo9lT rdcu.be/eiiow

The brief digital edition of our 2025 Cancer Immunotherapy Focus Issue is live as well! Check it out here: mp.weixin.qq.com/s/i5t1sfgpL-...

Cell therapies are transforming our ability to treat cancer but are out of reach for many patients. @natbiotech.nature.com asked experts to share their insights into pressing challenges and promising strategies to make these therapies more broadly accessible www.nature.com/articles/s41...

Innate immune cells are promising candidates for cancer immunotherapy and various engineering strategies can be employed to set them up for success. Read about is in this Review in @natbiotech.nature.com and don't forget to check out our full Focus Issue! www.nature.com/articles/s41...

This month, we've focused on recent developments as well as challenges in cancer immunotherapy, including cancer vaccines, immune checkpoint inhibitors, and CAR-engineered cells. Please read more👇

Our 2025 Focus issue on Cancer Immunotherapy is live now! More details below

⭐ I'm hiring a new Chief editor for Nature Biomedical engineering, in New York, Beijing or Shanghai. Please apply here: springernature.wd3.myworkdayjobs.com/SpringerNatu...

Sonogenetic EchoBack-CAR T cells incorporate an ultrasensitive heat-shock promoter and synthetic positive feedback loop, enabling focused-ultrasound-controlled long-lasting CAR expression and enhanced anti-tumor efficacy. www.cell.com/cell/fulltex... #NBThighlight

Writing is the most essential activity of a scientist because without writing there is no thinking and no real opportunity for exchange in the marketplace of ideas go.nature.com/4iXlwRQ rdcu.be/ee4X5

2H24 biotech job picture go.nature.com/42hUCgY

The lasso peptide lariocidin functions as a broad-spectrum antibiotic by binding to a unique site on the bacterial ribosome, disrupting protein synthesis without affecting human cells, and demonstrating low potential for resistance development. www.nature.com/articles/s41... #NBThighlight

The brief digital edition of our March issue is live as well! Check it out here mp.weixin.qq.com/s/5MDvA1JHC0...

New online in @naturebiotech.bsky.social: Lipid nanoparticles carrying plasmid DNA and an inflammation inhibitor enable longer transgene expression than mRNA nanoparticles-by Manthan N. Patel, Jacob S. Brenner et al.

New online in @naturebiotech.bsky.social: Primary T cells with multiple genetic modifications are rapidly isolated by negative selection. -by Christopher R. Chang, Brian R. Shy, Justin Eyquem et al.

A platform for the biomedical application of large language models go.nature.com/4h6FokW

The brief digital edition of our @naturebiotech.bsky.social January issue is live as well! Check it out here mp.weixin.qq.com/s/GIMh7TzIzn...

New online in @naturebiotech.bsky.social: A strategy for combinatorial cancer immunotherapy uses Cas13d to knock down immunosuppressive genes in vivo—by Feifei Zhang, Ryan D. Chow, Guangchuan Wang and Sidi Chen et al.

Cuba’s Center for Genetic Engineering and Biotechnology has continued to shepherd the development of drugs and vaccines for cancer, infectious disease and other conditions and to date has obtained regulatory approvals in more than 50 countries go.nature.com/4gxkhYt rdcu.be/d4Z0N

Leveraging machine learning and big data techniques to map the global patent landscape of phage therapy go.nature.com/4iIFelb

You also can follow Nature Portfolio editors with the starter pack we have been sharing.

New online in @naturebiotech.bsky.social: An optical pooled screening method can correlate phenotypes and perturbations in any nucleated cell type.

Modular synthetic ‘SNIPR’ receptors can now be activated by soluble ligands, offering the potential to regulate the activity of engineered therapeutic cells, such as localizing CAR T cells to solid tumors #NBTHighlight nature.com/articles/s41...

In Brief: Over 10% of patients with a fatal neurodegenerative disease who received bluebird bio’s gene therapy #Skysona have developed hematological cancers, further highlighting the well-known risks of using lentiviral vectors www.nature.com/articles/s41... rdcu.be/d0A6I

Gene editing produces sweeter tomatoes without diminishing fruit yield or weight #NBTHighlight

Scientists are using ever more sophisticated AI algorithms trained on vast, unlabeled datasets to develop models that can ‘interpret’ biological data to help guide biomolecule design.

Directed evolution of engineered virus-like particles with improved production and transduction efficiencies go.nature.com/3YMR3h5

Pooled CRISPR screens with joint single-nucleus chromatin accessibility and transcriptome profiling go.nature.com/4hXER5O