Iris
@irismarchal.bsky.social
📤 69
📥 54
📝 12
Associate Editor Reviews @Nature Biotechnology. Views are my own.
reposted by
Iris
Eliza Loo
about 2 months ago
How do you detect transgenes in genome-edited crops? We tested several methods and report our findings in 2 back-to-back papers:
onlinelibrary.wiley.com/doi/10.1111/...
rdcu.be/eLgUi
loading . . .
Ensuring effective removal of transgenes before release of genome-edited crops
Nature Biotechnology - Genome editing technology is evolving fast, and many labs worldwide are generating crop plants with improved traits. If transgenes were used to generate the edits, foreign...
https://rdcu.be/eLgUi
2
24
14
reposted by
Iris
Nature Biotechnology
2 months ago
The COP16 decision established a multilateral mechanism for digital sequence information benefit-sharing. DSI researchers assess what has been accomplished so far and identify remaining challenges
go.nature.com/4nBE4t8
rdcu.be/eJnid
0
0
2
reposted by
Iris
Nature Biotechnology
4 months ago
Redefining druggable targets with artificial intelligence -
@wcmenglanderipm.bsky.social
@aihealthmit.bsky.social
go.nature.com/4fHNMYi
1
13
4
How can we engineer B cells to treat diseases? Read about the latest developments of this exciting field in this new Review out now in
@natbiotech.nature.com
www.nature.com/articles/s41...
loading . . .
Engineering B cells to treat and study human disease - Nature Biotechnology
Recent developments in B cell engineering expand our ability to study human disease and drive progress toward new B cell therapies, balancing challenges in clinical implementation with emerging opport...
https://www.nature.com/articles/s41587-025-02757-y
4 months ago
0
17
7
reposted by
Iris
Eric Topol
5 months ago
Can senolytics reverse or slow aging? Table of companies pursuing this goal. So far the results are questionable.
@natbiotech.nature.com
www.nature.com/articles/s41...
5
46
14
Gene regulatory networks are crucial for understanding complex gene regulation in plants and could help improve crops for more sustainable and climate-resilient agriculture. Read about it in this Review out now in
@natbiotech.nature.com
www.nature.com/articles/s41...
loading . . .
Unlocking gene regulatory networks for crop resilience and sustainable agriculture - Nature Biotechnology
Gene regulatory networks are crucial for understanding complex gene regulation in plants and could advance crop improvement for more sustainable and climate-resilient agricultural practices.
https://www.nature.com/articles/s41587-025-02727-4
5 months ago
1
5
3
This Review presents a classification system of hybrid engineered biological systems to support researchers in making design choices, out now in
@natbiotech.nature.com
www.nature.com/articles/s41...
loading . . .
Improving engineered biological systems with electronics and microfluidics - Nature Biotechnology
A classification of hybrid engineered biological systems is presented to support researchers in making design choices that expand their use.
https://www.nature.com/articles/s41587-025-02709-6
5 months ago
0
1
1
reposted by
Iris
Nature Biotechnology
6 months ago
Base editors model mitochondrial disease
#NBTNV
-
@mikrobenjaeger.bsky.social
go.nature.com/45O9PJM
loading . . .
Base editors model mitochondrial disease - Nature Biotechnology
Optimized TALE base editors are used to generate a rat model of mitochondrial disease and then revert the disease mutation in the next generation.
https://go.nature.com/45O9PJM
0
2
2
reposted by
Iris
Nature Biotechnology
6 months ago
Anatomy of the 23andMe fall and implications for consumer genomics
go.nature.com/3Hf6sBE
loading . . .
Anatomy of the 23andMe fall and implications for consumer genomics - Nature Biotechnology
23andMe’s bankruptcy serves as a moment of reflection for the direct-to-consumer (DTC) genomics industry. We analyzed 23andMe financial data and business practices to reveal the factors behind the fal...
https://go.nature.com/3Hf6sBE
0
5
3
Overcoming key hurdles for the development of next-generation anaerobic cultivation methods could have major impacts on microbial community research and applications. Read how in this new Perspective in
@natbiotech.nature.com
www.nature.com/articles/s41...
loading . . .
Enabling next-generation anaerobic cultivation through biotechnology to advance functional microbiome research - Nature Biotechnology
Overcoming key hurdles for the development of next-generation anaerobic cultivation methods could have major impacts on microbial community research and applications.
https://www.nature.com/articles/s41587-025-02660-6
7 months ago
0
4
2
reposted by
Iris
Nature Biotechnology
7 months ago
A call for built-in biosecurity safeguards for generative AI tools
go.nature.com/3GIpTlR
loading . . .
A call for built-in biosecurity safeguards for generative AI tools - Nature Biotechnology
Nature Biotechnology - A call for built-in biosecurity safeguards for generative AI tools
https://go.nature.com/3GIpTlR
1
10
6
reposted by
Iris
Thomas Clavel
7 months ago
Here we share thoughts on next-gen cultivation:
rdcu.be/ejPSb
. Hope it helps 😄 Was fun to write with great colleagues
@lisamaierlab.bsky.social
@jselkrig.bsky.social
@baerboletta.bsky.social
@typaslab.bsky.social
@mmmicrobiomelab.bsky.social
@leibniz-dsmz.bsky.social
@westermannlab.bsky.social
loading . . .
Enabling next-generation anaerobic cultivation through biotechnology to advance functional microbiome research
Nature Biotechnology - Overcoming key hurdles for the development of next-generation anaerobic cultivation methods could have major impacts on microbial community research and applications.
https://rdcu.be/ejPSb
1
27
22
reposted by
Iris
Milo Lab @WIS
8 months ago
1/ We need new ways of producing foods and fuels to minimise our impact on our planet. Our new paper now in
@natbiotech.nature.com
examines whether microbes hold the key to producing foods and fuels in the future Open access:
rdcu.be/eiIUu
nature.com/articles/s41...
2
15
9
The development of therapeutic cancer vaccines is seeing exciting progress recently. Curious how researchers are dealing with challenges to translate new technologies to the clinic?
@natbiotech.nature.com
asked experts for an update.
www.nature.com/articles/s41...
loading . . .
Cancer vaccines: the experts speak - Nature Biotechnology
The development of therapeutic cancer vaccines has long been a promising yet challenging field of research. While early efforts were impeded by limited efficacy and immune escape, recent advances in i...
https://www.nature.com/articles/s41587-025-02606-y
8 months ago
0
4
2
Cell therapies are transforming our ability to treat cancer but are out of reach for many patients.
@natbiotech.nature.com
asked experts to share their insights into pressing challenges and promising strategies to make these therapies more broadly accessible
www.nature.com/articles/s41...
loading . . .
Making cell therapy accessible: challenges and opportunities - Nature Biotechnology
Despite major advances in bringing cancer cell therapies to the clinic, their widespread accessibility remains a substantial challenge. High manufacturing costs, lack of funding and varying regulatory...
https://www.nature.com/articles/s41587-025-02625-9
8 months ago
0
7
5
reposted by
Iris
Kristen Panthagani, MD, PhD
8 months ago
A look back at what vaccines have done.
loading . . .
1
48
24
reposted by
Iris
Elana Fertig, PhD
8 months ago
Proud of our new perspective describing the role of mathematical biology for immunotherapy
www.nature.com/articles/s41...
@natbiotech.nature.com
loading . . .
Virtual cells for predictive immunotherapy - Nature Biotechnology
Synergizing advances in artificial intelligence with mathematical modeling will improve our ability to computationally predict immunotherapy outcomes.
https://www.nature.com/articles/s41587-025-02583-2
1
41
7
reposted by
Iris
Rong
8 months ago
This month, we've focused on recent developments as well as challenges in cancer immunotherapy, including cancer vaccines, immune checkpoint inhibitors, and CAR-engineered cells. Please read more👇
add a skeleton here at some point
0
2
1
Innate immune cells are promising candidates for cancer immunotherapy and various engineering strategies can be employed to set them up for success. Read about is in this Review in
@natbiotech.nature.com
and don't forget to check out our full Focus Issue!
www.nature.com/articles/s41...
loading . . .
Engineering innate immune cells for cancer immunotherapy - Nature Biotechnology
The unique attributes of innate immune cells position them as attractive candidates for cancer immunotherapy, with engineering strategies to enhance their antitumor potential, offering notable therape...
https://www.nature.com/articles/s41587-025-02629-5
8 months ago
0
11
3
reposted by
Iris
Itai Yanai
8 months ago
🔥New Night Science paper!! Discovery happens when your initial plans fall apart but it requires you to have a particular mindset: it's not extraverted, orderly, neurotic or agreeable that's the most important – discovery requires an OPENNESS to new ideas and unexpected insights.
7
166
66
reposted by
Iris
Nature Biotechnology
8 months ago
Shares of US drugmakers fell after reports that
@fda.gov
top vaccine official, Peter Marks, had been forced to resign, as the Trump administration undertakes an overhaul of federal health agencies
#NBTNewsBeat
www.reuters.com/business/hea...
loading . . .
Pharma stocks sink after ouster of top FDA vaccine regulator
Shares of U.S. drugmakers fell on Monday after reports that the Food and Drug Administration's top vaccine official, Peter Marks, had been forced to resign, the most high-profile exit at the regulator as the Trump administration undertakes an overhaul of federal health agencies.
https://www.reuters.com/business/healthcare-pharmaceuticals/biotech-stocks-tumble-reports-fdas-top-vaccine-regulator-leave-2025-03-31/
0
5
3
Check out the state of the field of engineered bacteria for cancer therapy in this Comment in
@naturebiotech.bsky.social
www.nature.com/articles/s41...
loading . . .
The emerging landscape of engineered bacteria cancer therapies - Nature Biotechnology
Our ability to use engineered bacteria for cancer therapy is rapidly expanding. A survey of preclinical, clinical and commercial efforts provides an overview of the state of the field, revealing trend...
https://www.nature.com/articles/s41587-025-02623-x
8 months ago
0
7
3
Modulating induced proximity at the cell surface is a powerful engineering strategy that can find diverse applications in basic and translational science. Curious to learn about emerging modalities in this space? Read this review out now in
@naturebiotech.bsky.social
www.nature.com/articles/s41...
loading . . .
Induced proximity at the cell surface - Nature Biotechnology
Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses.
https://www.nature.com/articles/s41587-025-02592-1
9 months ago
0
7
1
Nanopore technology might be able to sequence proteins soon! Read about the road ahead in this exciting Perspective
rdcu.be/edWPi
in
@naturebiotech.bsky.social
loading . . .
Toward single-molecule protein sequencing using nanopores
Nature Biotechnology - Maglia and colleagues discuss advances in nanopore technology en route to single-molecule protein sequencing
https://rdcu.be/edWPi
9 months ago
2
87
33
The program of the CiRT2025 meeting is out:
meeting2025.cirt-net.org/program.html
. I will be sharing my top 10 tips on publishing with
@naturebiotech.bsky.social
. See you there?
loading . . .
Program
https://meeting2025.cirt-net.org/program.html
10 months ago
0
2
2
reposted by
Iris
David R. Martinez
about 1 year ago
Our article is now out in Nature Biotechnology. Here we outline challenges for developing broad-based mucosal vaccines for respiratory viruses. Check it out! Congrats to Junghwa and Jordan from my lab and to other co-authors!
www.nature.com/articles/s41...
loading . . .
Challenges for developing broad-based mucosal vaccines for respiratory viruses - Nature Biotechnology
Nature Biotechnology - Challenges for developing broad-based mucosal vaccines for respiratory viruses
https://www.nature.com/articles/s41587-024-02486-8
1
29
6
Natural and engineered Cas12 and TnpB variants offer diverse applications in genome editing and diagnostics - read all about it in this Review in
@naturebiotech.bsky.social
www.nature.com/articles/s41...
loading . . .
Biology and applications of CRISPR–Cas12 and transposon-associated homologs - Nature Biotechnology
Natural and engineered Cas12 and TnpB variants offer diverse applications in genome editing and diagnostics.
https://www.nature.com/articles/s41587-024-02485-9
about 1 year ago
0
2
0
you reached the end!!
feeds!
log in