President Trump is taking 325 mg of aspirin a day to prevent heart disease. His doctors advise him to take 81 mg. Both are wrong. Here’s why. New edition of Ground Truths, open-access erictopol.substack.com/p/the-lowdow...

What I eat and avoid gift link wapo.st/4piAKUk

There's a lot packed into your ~3 billion lifetime heartbeats www.nature.com/articles/s41...

People age 70+ should not be taking aspirin at any dose for prevention. Results of randomized trials show higher risk of all-cause mortality, major bleeding events and deaths from cancer. p 153, SUPER AGERS book

New @science.org today Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging) @bloodgenes.bsky.social @kharaslab.bsky.social science.org/doi/10.1126/...

—“They say aspirin is good for thinning out the blood, and I don’t want thick blood pouring through my heart,” Trump said. “I want nice, thin blood pouring through my heart. Does that make sense?” —No. www.wsj.com/us-news/as-s...

The vaccine takedown wapo.st/49zDc43

A tally of the damage www.nytimes.com/2025/12/30/o...

And, finally, our favorite interviews we did this year (including with @maryroach.bsky.social, @erictopol.bsky.social and @karenhao.bsky.social) (by @breezybrik.bsky.social)

98 million Americans have prediabetes. A recent landmark paper showed normalization of glucose in people with prediabetes is linked to halving of major cardiovascular adverse events over ensuing decades thelancet.com/journals/lan...

Do you know about LVA surgery that is being done to increase brain waste product drainage, with intent to treat or prevent neurodegenerative diseases? In conversation with @jonykipnis.bsky.social erictopol.substack.com/p/how-our-br...

Neuroscience cartoon inspired by a interview by a @erictopol.bsky.social interview. In my latest (FREE) newsletter, learn how the brain gets washed while you sleep. Also, exciting reports about the potential of brain-drain-expanding surgery to combat dementia. himelblau.substack.com/p/brain-washed

Generative AI, 3 years in

"The U.S. Bureau of Labor Statistic projects nearly two million open health care jobs each year for the next decade." nytimes.com/2025/12/27/o...

The Future @wsj.com including extending healthspan www.wsj.com/health/welln...

On Super Agers gift link wapo.st/4q1nsNk

How to keep the heart young? Preserve the integrity of its connection to the right vagus nerve! www.science.org/doi/10.1126/... V Interesting findings, minipig model To simplify, I made this Infographic via @notebooklm.bsky.social

For Alzheimer's disease, it's no longer a debate of amyloid (Aβ) versus tau. They are interactive drivers and this new, optimistic review maps out a path towards disease-halting therapies @cellcellpress.bsky.social cell.com/cell/fulltex...

More accurate and individualized health predictions will allow for preventative factors to be implemented well in advance. www.wired.com/story/data-h...

Brain food on our brain drainage system to help keep you healthy, with @jonykipnis.bsky.social erictopol.substack.com/p/how-our-br...

The Department of Government Efficiency (DOGE) led a path of gutting and destruction of public, global health, and medical research resources, among others. How much did it save in federal spending? Nothing...it led to an increase www.nytimes.com/2025/12/23/u...

At this cognitively-intense season your brain is BUSY🧠 ✨🎄!! Fascinating insights from @erictopol.bsky.social & @jonykipnis.bsky.social how our brains deal with waste products & the incredible way our waking & sleeping hours are affected. Take time for your mind & #BrainHealth #spéirghorm #Xmas

Great podcast on the state of the science on brain fluid clearance and immune surveillance, by @jonykipnis.bsky.social discussing with @erictopol.bsky.social. They break down how sleep and our immune cells influence cognitive function and risk for dementia for 🧠 geek and lay audiences alike!👏

MAHA Country if only it was a joke www.newyorker.com/magazine/202...

Such an illuminating and accessible discussion weaving new science and research and insights into the elaborate systems driving our immune response, brain function, sleep importance and much more. Tune in to @erictopol.bsky.social and @jonykipnis.bsky.social

How Our Brain Drains Its Waste Products and its relevance to our sleep quality and risk of neurodegenerative diseases A podcast with @jonykipnis.bsky.social and illustrative text summary of 3 of his recent review articles erictopol.substack.com/p/how-our-br...

The one validated intervention to slow aging and extend healthspan is not for sale. It's exercise. sciencedirect.com/science/arti...

Natural killer (NK) cells are primarily being assessed to treat cancer, but they have substantial potential for Rx of neurodegenerative diseases, viral infections, and autoimmune conditions. A first-rate review, open-access rupress.org/jem/article/...

The common MTHFR gene allele (C677T) plus methionine metabolites may predict the severity of Covid and risk of #LongCovid @pnas.org www.pnas.org/doi/10.1073/...

The takedown of the US system of childhood vaccines which worked exceedingly well for decades for preventing diseases and major adverse outcomes

This about sums it up, folks. www.thelancet.com/journals/lan...

What does it take to achieve the highest level of human performance? Across athletics, science, chess, and music @science.org science.org/doi/10.1126/...

Breakdown of the year @science.org www.science.org/doi/10.1126/...

Natural daylight and improved glucose control in Type 2 diabetes cell.com/cell-metabol...

"Higher intake of high-fat cheese and high-fat cream was associated with a lower risk of all-cause dementia." Results of a 25-year prospective study of ~27,000 participants. The purported benefit was not linked to APOE4 carriers or low-fat cheese intake www.neurology.org/doi/full/10....

The p-tau217 biomarker by age and prevalence of Alzheimer's disease in the community of ~12,000 people in Norway www.nature.com/articles/s41...

About 1 in 10 people have an autoimmune disease. There's great news here on current efforts that are achieving cures. erictopol.substack.com/p/the-exhili...

What predicts protection from Covid in the real-world household transmission setting among exposed individuals? Pre-existing, Variant-specific #SARS-CoV-2 antibodies www.sciencedirect.com/science/arti...

Enhanced understanding of the biologic basis for ME/CFS www.sciencedirect.com/science/arti...

How exercise decreases the risk of cancer and cancer- related mortality by reducing immunosenescence and inflammaging www.sciencedirect.com/science/arti...

Evidence for a detrimental causal effect of social isolation on cognitive function in older adults academic.oup.com/psychsocgero...

A new jump forward in cancer immunotherapy blocking glycan sugar molecules (antibodies to lectin, AbLec) that releases the immune system brakes against many types of tumors @carolynbertozzi.bskyverified.social @jcstark.bsky.social www.nature.com/articles/s41...

I love how @erictopol.bsky.social has framed these advancements in autoimmune disease treatment as cancer's mirror biology. A bit dense for lay public, but well worth the read and powers of concentration needed: erictopol.substack.com/p/the-exhili...

Reinventing modern medicine My interview with the European Medical Journal @emjreviews.bsky.social www.emjreviews.com/innovations/...

My top 10 books for 2025

Controlling our immune system like a rheostat is not only helping to treat cancer (dialing it up) but now leading to cures of autoimmune diseases (dialing it down). Mirror images. Shared technologies. erictopol.substack.com/p/the-exhili...

About 1 in 10 people have an autoimmune disease. There's great news here on current efforts that are achieving cures. erictopol.substack.com/p/the-exhili...

How to Save A Life "Supporting full federal funding for medical research is one of the most certain ways to ensure a healthy future for these children. It’s also one of the best ways to save a life." @nejm.org www.nejm.org/doi/full/10....

Normalization of glucose in people with prediabetes, i.e. achieving remission, is linked to halving of major cardiovascular adverse events over ensuing decades www.thelancet.com/journals/lan...

"One small molecule for man, one giant leap for mankind with obesity" sciencedirect.com/science/arti... But the very high amounts of drug in pills relative to injectable peptides, due to such poor bioavailability, means we need to be watchful for new side effects when these pills get widely used