A new, tour de force review on the future approaches to treat and potentially cure Type 1 diabetes @thelancet.com thelancet.com/journals/lan...

2 decades after the first GLP-1 drug, we're still in the early stages for where this is headed. Nice, succinct summary and graphic by a pioneer of the field: @danieljdrucker.bsky.social jamanetwork.com/journals/jam...

Today is World #AlzheimersDay A note of optimism @science.org www.science.org/doi/10.1126/...

Which one is it going to be? www.economist.com/leaders/2025... www.nytimes.com/2025/09/14/m...

What are the implications of a new A.I. model that predicts the risk of a person's disease(s) 20 years ahead and when they will appear? erictopol.substack.com/p/dawn-of-a-...

Independent, comprehensive reviews of the data on protein intake led us to the same conclusions youtube.com/watch?app=de... erictopol.substack.com/p/our-preocc...

That's right. It could have been worse. Brace for more to come.

How sugary drinks loaded with fructose and glucose may promote colon cancer metastatic potential www.nature.com/articles/s42...

New extended definition of Remote Control @newyorker.com new issue

Don't underestimate the effect of the arts—music, dance, visual, gardening, crafts, theater—for promoting health, a systematic review @naturemedicine.bsky.social www.nature.com/articles/s41...

A consensus report on the cardiovascular manifestations, diagnosis, prevention and treatment from Covid and #LongCovid academic.oup.com/eurjpc/advan...

@erictopol.bsky.social has a really nice breakdown of the paper on his substack if you want to learn more: bsky.app/profile/eric...

Low dose aspirin (160mg/d) reduced recurrence in people with colon cancer and PI3K mutations. Emblematic of precision, individualized medicine since the data for aspirin across all colon cancer has been mixed. www.nejm.org/doi/full/10....

Major advance for refractory lupus by engineering the T cells in the patient's body (in vivo) and achieving success in 5 patients @nejm.org (uses mRNA/nanoparticle package) www.nejm.org/doi/full/10....

Who is vulnerable to a breakthrough infection after Covid mRNA vaccination? Especially those with rapid decline of antibodies or low spike-specific IgA titers early after a booster www.science.org/doi/full/10....

A groundbreaking paper published @nature.com today—the first large health language model—predicts >1,000 diseases for a person and when. Implications here: erictopol.substack.com/p/dawn-of-a-...

Senate hearing today, Dr. Monarez testified: Kennedy directed her to commit to approving every recommendation "regardless of the scientific evidence" and also directed her to "dismiss career officials responsible for vaccine policy, w/o cause" "He said if I was unwilling to do both, I should resign"

Big randomized trial of a GLP- pill (vs placebo) achieves significant weight loss www.nejm.org/doi/full/10....

"At breathtaking speed, the Trump administration is enacting policies that will be difficult to reverse and could disrupt population health for years or decades to come. Time is running out to intervene." www.thelancet.com/journals/lan... @thelancet.com

Current read out for a mammogram leaves a lot on the table. A new study shows how risk of cardiovascular disease can be predicted as well as traditional cardiovascular risk scores (aka opportunistic A.I.) heart.bmj.com/content/earl...

Coming tomorrow. Something that's been talked about for many decades, but not done. That's changing. Subscribe; it's free, and you'll get the link by email and future posts. erictopol.substack.com

A two-fer of beneficial associations with the planetary, primarily plant-based diet journals.plos.org/plosmedicine...

Why do we sleep? And how? The 2 theories, broken down cell.com/neuron/fullt...

A clever way to activate the immune system against cancer via the STING pathway www.nature.com/articles/s41...

A new review of multicancer early detection tests (MCED). Without any controlled studies in people without symptoms (and at increased risk), they are "not ready for popular use." @annalsofim.bsky.social www.acpjournals.org/doi/10.7326/... www.acpjournals.org/doi/epdf/10....

A simple way to help reduce obesity and stroke? Stop the shifts in our clocks twice a year www.pnas.org/doi/abs/10.1...

p-tau 217 as a stand-alone blood marker establishes risk of Alzheimer's disease in cognitively unimpaired individuals (again) jamanetwork.com/journals/jam...

On #ScienceUnderSeige BY @peterhotezmdphd.bsky.social @michaelemann.bsky.social @latimes.com @hiltzikm.bsky.social www.latimes.com/business/sto...

I've been following the field of biosensors for nearly 2 decades. This may well turn out to be the most important advance yet erictopol.substack.com/p/biosensors...

We've seen protein organ clocks that indicate the pace of aging for each in a person. Now there's 11 organ/system methylation clocks from a single blood sample www.nature.com/articles/s43...

Two new randomized trials testing higher dose semaglutide (Ozempic) for obesity, obesity + diabetes: some further weight loss, similar safety profile www.thelancet.com/journals/lan... www.thelancet.com/journals/lan...

The youthful immune system signature of centenarians vs controls with balance of natural killer and T cell adaptations, as seen by single-cell RNA sequencing www.thelancet.com/journals/ebi...

Some good tips for reducing the consumption of unhealthy, pro-inflammatory, ultraprocessed foods By @andreaapetersen www.wsj.com/health/welln...

I've been following the field of biosensors for nearly 2 decades. This may well turn out to be the most important advance yet erictopol.substack.com/p/biosensors...

We know GLP-1 drugs reduce brain inflammation. But I didn't anticipate bipolar disorder as a possible indication in the future www.nature.com/articles/s41...

Our A.I. times ;-)

"We will never know what diseases might have been cured or what advances in technology might have been invented had the lights not gone out in the labs." www.nytimes.com/2025/09/08/o...

On the consequences of our pervasive exposure to micro- and nanoplastics A new stellar review @naturemedicine.bsky.social www.nature.com/articles/s41...

Partitioning obesity by genomics, proteomics and health outcomes from >450,000 UK Biobank @naturemedicine.bsky.social —A protective subtype vs cardiometabolic diseases (GRS BFP) and —A risk subtype for these diseases (GRS uncoupling) GRS-genomic risk score nature.com/articles/s41...

In the new issue of @science.org, @yoshuabengio.bsky.social on the implications (illusions) of accepting A.I.'s consciousness science.org/doi/10.1126/...

Where we're headed with many layers of data for a person to prevent age-related diseases www.genomeweb.com/genetic-rese...

A conversation on Healthy Aging with @hmkyale.bsky.social and @thehowie.bsky.social @yaleschoolofmed.bsky.social insights.som.yale.edu/podcasts/hea...

The CDC is in the ICU (<-good diagnosis) www.thelancet.com/journals/lan...

Why are older people more vulnerable to flu? A new report finds age-related high expression of ApoD as a culprit that reduces the first line interferon immune response www.pnas.org/doi/epdf/10....

Is "consumer genetics privacy" an oxymoron? www.science.org/doi/10.1126/... @science.org "A databank [23andMe] of this type and magnitude requires heightened protection for privacy and security."

“Everyone thinks their genes are the cause for them getting an age-related disease, it’s actually your immune system.” - @erictopol.bsky.social the author of Super Agers on #HealthandVeritas podcast pod.link/1588414491/e... @thehowie.bsky.social @hmkyale.bsky.social

Really?

Exercise and suppression of cancer wapo.st/47EINFQ

? Such a Thing as Longevity Supplements My thoughts (based on evidence) are included www.nytimes.com/2025/09/11/w...

Chronic "non-communicable disease mortality declined in all high-income western countries, with Denmark experiencing the largest decline for both sexes and the USA experiencing the smallest decline." www.thelancet.com/journals/lan... open-access @thelancet.com