How could the United States save ~$184 billion per year on outpatient prescription medications? Use international reference pricing @pnas.org www.pnas.org/doi/10.1073/...

Paging Dr. Freud and giving the science of aging a bad name @vanityfair.com by @sarahdigregorio.bsky.social www.vanityfair.com/news/story/l...

President Trump is taking 325 mg of aspirin a day to prevent heart disease. His doctors advise him to take 81 mg. Both are wrong. Here’s why. New edition of Ground Truths, open-access erictopol.substack.com/p/the-lowdow...

Challenging dogma: Functional iron deficiency could, ironically, be at the core of Parkinson's disease jci.org/articles/vie...

The gut<->brain axis impact on health and disease is far more important than anticipated, as reflected by GLP-1 effects, modulating the immune system, direct neural circuits, the microbiome, and more. A stellar new, open-access review www.jci.org/articles/vie...

New @nature.com Detection of Alzheimer's pathology from a dried blood spot derived from capillaries with capability of quantifying p-tau217 and other neuromarker levels www.nature.com/articles/s41...

"COVID-19 burden continued to have a large impact in the US, particularly among adults 65 years and older, underscoring the ongoing importance of prevention measures." jamanetwork.com/journals/jam...

“But the techies were the first on this because of the willingness to take ridiculous risks.” h/t @katebevan.com

Prospects for a universal flu vaccine are picking up, from a San Diego start-up. Would have helped reduce the toll of the current very bad flu season, >7.5 million Americans hit www.sandiegouniontribune.com/2025/12/31/h...

Hoping the pivotal finding of increased inflammation with #LongCovid will be responsive to tirzepatide (Zepbound) in our ongoing 1,000+ participant randomized, placebo-controlled trial (full enrollment completed in <1 month!) www.nature.com/articles/s41... @natimmunol.nature.com

In people age 70+ without prior heart attack, bypass surgery, or stenting, the risk of major bleeding events w/ low dose aspirin markedly exceeds benefit. There was an increase in MACE in follow-up of ASPREE. A full review of the data here erictopol.substack.com/p/the-lowdow...

The Peptide Craze in the US. It's reckless and unfounded. erictopol.substack.com/p/the-peptid... Today @nytimes.com @jasmine.bsky.social goes deep into the use in Silicon Valley, the supply from China, and the reasons this biohacking is popular t.co/lQXUBHNEaG

This is so true. The more data we get, the more we're important, unanticipated protection www.nytimes.com/2026/01/03/h...

Cardiologist and best-selling author Eric Topol has spent years studying what it takes to become a super ager — someone who lives beyond their 80s without debilitating chronic conditions. His research suggests that almost anyone can do it.

This could become the 1st approved induced pluripotent stem cell (iPSC) treatment in the United States www.washingtonpost.com/technology/2...

A.I. detecting early pancreatic cancer in China, based on @naturemedicine.bsky.social validation publication "I think you can 100% say AI saved their lives." gift link www.nytimes.com/2026/01/02/w...

President Trump is taking 325 mg of aspirin a day to prevent heart disease. His doctors advise him to take 81 mg. Both are wrong. Here’s why. New edition of Ground Truths, open-access erictopol.substack.com/p/the-lowdow...

What I eat and avoid gift link wapo.st/4piAKUk

There's a lot packed into your ~3 billion lifetime heartbeats www.nature.com/articles/s41...

People age 70+ should not be taking aspirin at any dose for prevention. Results of randomized trials show higher risk of all-cause mortality, major bleeding events and deaths from cancer. p 153, SUPER AGERS book

New @science.org today Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging) @bloodgenes.bsky.social @kharaslab.bsky.social science.org/doi/10.1126/...

—“They say aspirin is good for thinning out the blood, and I don’t want thick blood pouring through my heart,” Trump said. “I want nice, thin blood pouring through my heart. Does that make sense?” —No. www.wsj.com/us-news/as-s...

The vaccine takedown wapo.st/49zDc43

A tally of the damage www.nytimes.com/2025/12/30/o...

And, finally, our favorite interviews we did this year (including with @maryroach.bsky.social, @erictopol.bsky.social and @karenhao.bsky.social) (by @breezybrik.bsky.social)

98 million Americans have prediabetes. A recent landmark paper showed normalization of glucose in people with prediabetes is linked to halving of major cardiovascular adverse events over ensuing decades thelancet.com/journals/lan...

Do you know about LVA surgery that is being done to increase brain waste product drainage, with intent to treat or prevent neurodegenerative diseases? In conversation with @jonykipnis.bsky.social erictopol.substack.com/p/how-our-br...

Neuroscience cartoon inspired by a interview by a @erictopol.bsky.social interview. In my latest (FREE) newsletter, learn how the brain gets washed while you sleep. Also, exciting reports about the potential of brain-drain-expanding surgery to combat dementia. himelblau.substack.com/p/brain-washed

Generative AI, 3 years in

"The U.S. Bureau of Labor Statistic projects nearly two million open health care jobs each year for the next decade." nytimes.com/2025/12/27/o...

The Future @wsj.com including extending healthspan www.wsj.com/health/welln...

On Super Agers gift link wapo.st/4q1nsNk

How to keep the heart young? Preserve the integrity of its connection to the right vagus nerve! www.science.org/doi/10.1126/... V Interesting findings, minipig model To simplify, I made this Infographic via @notebooklm.bsky.social

For Alzheimer's disease, it's no longer a debate of amyloid (Aβ) versus tau. They are interactive drivers and this new, optimistic review maps out a path towards disease-halting therapies @cellcellpress.bsky.social cell.com/cell/fulltex...

More accurate and individualized health predictions will allow for preventative factors to be implemented well in advance. www.wired.com/story/data-h...

Brain food on our brain drainage system to help keep you healthy, with @jonykipnis.bsky.social erictopol.substack.com/p/how-our-br...

The Department of Government Efficiency (DOGE) led a path of gutting and destruction of public, global health, and medical research resources, among others. How much did it save in federal spending? Nothing...it led to an increase www.nytimes.com/2025/12/23/u...

At this cognitively-intense season your brain is BUSY🧠 ✨🎄!! Fascinating insights from @erictopol.bsky.social & @jonykipnis.bsky.social how our brains deal with waste products & the incredible way our waking & sleeping hours are affected. Take time for your mind & #BrainHealth #spéirghorm #Xmas

Great podcast on the state of the science on brain fluid clearance and immune surveillance, by @jonykipnis.bsky.social discussing with @erictopol.bsky.social. They break down how sleep and our immune cells influence cognitive function and risk for dementia for 🧠 geek and lay audiences alike!👏

MAHA Country if only it was a joke www.newyorker.com/magazine/202...

Such an illuminating and accessible discussion weaving new science and research and insights into the elaborate systems driving our immune response, brain function, sleep importance and much more. Tune in to @erictopol.bsky.social and @jonykipnis.bsky.social

How Our Brain Drains Its Waste Products and its relevance to our sleep quality and risk of neurodegenerative diseases A podcast with @jonykipnis.bsky.social and illustrative text summary of 3 of his recent review articles erictopol.substack.com/p/how-our-br...

The one validated intervention to slow aging and extend healthspan is not for sale. It's exercise. sciencedirect.com/science/arti...

Natural killer (NK) cells are primarily being assessed to treat cancer, but they have substantial potential for Rx of neurodegenerative diseases, viral infections, and autoimmune conditions. A first-rate review, open-access rupress.org/jem/article/...

The common MTHFR gene allele (C677T) plus methionine metabolites may predict the severity of Covid and risk of #LongCovid @pnas.org www.pnas.org/doi/10.1073/...

The takedown of the US system of childhood vaccines which worked exceedingly well for decades for preventing diseases and major adverse outcomes

This about sums it up, folks. www.thelancet.com/journals/lan...

What does it take to achieve the highest level of human performance? Across athletics, science, chess, and music @science.org science.org/doi/10.1126/...

Breakdown of the year @science.org www.science.org/doi/10.1126/...

Natural daylight and improved glucose control in Type 2 diabetes cell.com/cell-metabol...