The rise in US health care costs related to more treatment www.economist.com/united-state...

With the help of @statto.bsky.social and @erictopol.bsky.social (🙏) I have delved a little into the often bizarre efforts of tech billionairres to live forever. Is there anything at all in it? My column for @thenewworldmag.bsky.social www.thenewworld.co.uk/philip-ball-...

On Ground Truths, I'll be talking with Dr. Susan Monarez today, her first interview since leaving her post as CDC Director 1 PM PT (4 PM ET) Join us, subscribe (it's free) erictopol.substack.com

The inside story of COVAX, started in January 2020, and led to 2 billion doses of Covid vaccines given in 146 countries, with 2.7 million lives saved. FAIR DOSES, by @drsethberkley.bsky.social A clip from our Ground Truths conversation today Link to full: erictopol.substack.com/p/seth-berkl...

For children and teens, heart and blood vessel complications of Covid overshadow the very rare and short-term risk of vaccinations, a new report from nearly 14 million kids www.thelancet.com/journals/lan...

Aging biomarkers for prediction of diseases, a systematic review of 39 biomarkers in >20,000 people. GrimAge2 best for healhspan prediction nature.com/articles/s43...

Many clinical studies have shown reduced cancer risk in people with diabetes of obesity taking GLP-1 family of drugs. A new JCI piece makes the case these drugs should be studied to reduce cancer in people without metabolic disease jci.org/articles/vie...

GLP-1 drugs have intrinsic potent anti-inflammatory action beyond their metabolic beneficial impact on glucose regulation and weight loss www.jci.org/articles/vie...

Join Lee Hood and I for a conversation about Super Agers, tomorrow 10 AM PT isbscience.zoom.us/webinar/regi...

Physical activity and risk of Alzheimer's disease. In older adults (mean age 72) with elevated Aβ amyloid, 5,000-7,500 steps/day (<-a plateau) were associated with less Tau accumulation, improved cognition @naturemedicine.bsky.social nature.com/articles/s41...

Good and accurate summary of data for creatine supplements wapo.st/4nGIHSt

A word that has become a euphemism for promoting and selling things without data or evidence

This week's @nature.com cover highlights a report of A.I.- mediated distortion When #ChatGPT was asked to rate 40,000 résumés, it ranked the older male candidates as better quality than the younger female applicants nature.com/articles/s41...

The 1st pregnancy via A.I. detected sperm (by finding 5 motile sperm in 2.5 million images) from a 39-year-old man with infertility. @thelancet.com thelancet.com/journals/lan...

Participants are now enrolling in our #longCovid randomized, controlled trial of tirzepatide. The largest trial to test a treatment for this condition. Home-based—no sites. In today's @sandiegouniontribune.com www.sandiegouniontribune.com/2025/11/01/c...

Bottom line of systematic assessment of studies on Covid vaccinations/boosters: ~50% reduction of hospitalization, across all adults (not just older) who are not immunocompromised Real data on vaccine-induced myocarditis: occurred in 1-3 per 100,000 male adolescents www.nejm.org/doi/full/10....

We've just launched the first large, site-less (home, direct to participant) randomized trial for treatment of #LongCovid, testing tirzepatide (a GLP-1 drug) vs placebo. Please help spread the word www.scripps.edu/news-and-eve...

The supplement Urolithin A, in a small randomized, placebo-controlled clinical trial of adults (mean age 53 years), shifted the immune system away from age-related decline nature.com/articles/s43...

Even chimpanzees think rationally and weigh the evidence when making a choice ;-) @science.org www.science.org/doi/10.1126/...

The Long COVID Treatment Trial – Tirzepatide (LoCITT-T) is officially open for enrollment for people with Long COVID in: Alabama, Alaska, California, Florida, Illinois, Indiana, Michigan, Ohio, Pennsylvania, Texas, Utah longcovid.scripps.edu/locitt-t/?ut... 1/16

On our #LongCovid clinical trial launched today! thesicktimes.org/2025/10/30/w... @julialmv.bsky.social @scripps.edu

The collateral benefits of the Covid pandemic response was a marked decrease in airborne and aerosol-transmitted infections via masking and non-pharmaceutical interventions @science.org www.science.org/doi/10.1126/...

On the nominee..."as they seek to dismantle the system that awarded them" www.nytimes.com/2025/10/30/o...

Discovery of a way to regenerate the thymus gland through mesenchymal cells, with implications for enhancing the T cell immune response in multiple medical conditions and with aging www.nature.com/articles/s41... www.nature.com/articles/s41...

It worked. Stem cells (mesenchymal) given to patients with a large heart attack reduced major adverse events in a randomized trial vs standard care www.bmj.com/content/391/...

The prostate cancer PSA screening story over 23 years of follow-up for >166,000 participants: more detection, small reduction of mortality www.nejm.org/doi/full/10....

What do the naked mole rat and bowhead whale (lives to ~200 years) have in common to explain their remarkable longevity? Enhanced DNA repair www.nature.com/articles/s41... erictopol.substack.com/p/a-long-awa...

What happens to our immune system with aging, reducing vaccine response? Our memory T cells undergo a dramatic shift resulting in dysregulated B cell antibody production @alleninstitute.org @nature.com www.nature.com/articles/s41...

Acute and chronic viral infections, including Herpes Zoster (Shingles), Hepatitis C, HIV, CMV, influenza, and SARS-CoV-2, are linked with a substantial increased risk of cardiovascular events, from a systematic review. Figure for SARS-CoV-2 below newsroom.heart.org/news/some-ac...

Why fundamental research is fundamental to progress, seeding major breakthroughs Editorial @nature.com this week And 7 basic science discoveries that changed the world nature.com/articles/d41... nature.com/articles/d41...

On NAD+ supplement: "The science is almost nonexistent." www.nytimes.com/2025/10/23/w...

How do you change a cold, immune evasive tumor into a hot one? erictopol.substack.com/p/how-mrna-v...

"It's Clinical" No it isn't. There are no published data for this. Full page ad in NY Times today

The prominent role of circadian rhythm in cardiovascular and metabolic health and disease ahajournals.org/doi/10.1161/...

The body of evidence for persistent activation of the immune system in #LongCovid and related post-infective syndromes www.thelancet.com/journals/ebi...

The longevity craze side benefit, oped by @dshaywitz.bsky.social www.wsj.com/opinion/nobo...

Longer walks linked with less mortality and cardiovascular risk compared with short bouts of physical activity @annalsofim.bsky.social www.acpjournals.org/doi/10.7326/...

Women derive more benefit from physical activity than men with respect to reduction of cardiovascular risk and related mortality, and can achieve protection at lower levels of engagement. From ~85,000 participants, open-access (blue=men) nature.com/articles/s44...

Exposure to sugar early in life: a natural experiment among >63,000 @uk_biobank participants: rationing of sugar was associated with less cardiovascular risk in adulthood www.bmj.com/content/391/...

The benefit of Ozempic (semaglutide) for protection from major adverse cardiovascular events (MACE) is independent of weight loss magnitude and baseline adiposity, likely related to the GLP-1 anti-inflammatory effect thelancet.com/journals/lan...

Common diseases can be misdiagnosed as actually being due to rare, disease-causing genome variants. DNA and RNA sequencing can make the true diagnosis, which affects response to therapy @nejm.org www.nejm.org/doi/full/10....

A meta-analysis of 13 studies comparing health care professionals vs generative A.I. showed the latter was more likely to be perceived as more empathetic in all but 1 study academic.oup.com/bmb/article/...

How do mRNA vaccines help fight cancer? A @nature.com paper today tells the story, one with big implications, as reviewed here erictopol.substack.com/p/how-mrna-v...

In a cohort of over 13,500 women with mean age ~72 years, >4,000 steps per day, at least 1-2 days per week, was associated with reduction in all-cause mortality and lower risk of cardiovascular disease bjsm.bmj.com/content/earl...

From a new @thelancet.com article today entitled "Health care in the USA: money has become the mission" www.thelancet.com/journals/lan...

First proof of synthetic DNA-encoded antibodies vs SARS-CoV-2 with expression lasting at least 72 weeks from 1-dose, scalable vs other pathogens www.nature.com/articles/s41...

Despite concerns that A.I. will worsen inequities, there's growing evidence it can be used to reduce them. Latest today jamanetwork.com/journals/jam... My summary Table of some examples

What did the largest trial of an early detection of cancer blood test show? erictopol.substack.com/p/the-larges...

Cancer stem cells (CSC) are elusive and one of the reasons for resistance to treatment. Machine learning led to discovery of a way to promote their self-destruction (apoptosis) cell.com/cell-reports...

Several years before onset of symptoms of multiple sclerosis, there is evidence of central nervous system myelin injury nature.com/articles/s41...