A 49-year-old man with acute myeloid leukemia was evaluated for prolonged neutropenic fever. On examination, there were crackles at the lung bases. CT of the chest revealed a reversed halo sign. Read the full case details: nej.md/3MAEwuS #MedSky #Hematology #IDSky

New in the February 12, 2026, issue of NEJM: Interim Analysis of Sibeprenlimab in IgA Nephropathy (phase 3 VISIONARY trial) nej.md/493Xtza Atacicept in Patients with IgA Nephropathy (ORIGIN 3 trial) nej.md/3JEq8QL #MedSky

VITT is caused by a somatic hypermutation of an anti–adenovirus pVII antibody that generates more avid binding of platelet factor 4 than of adenovirus pVII, its original target, which results in platelet activation. Full study results: nej.md/3MBnaOx #MedSky #Hematology

Mucormycosis is a rapidly progressive, invasive fungal infection that causes severe disease. The latest epidemiologic data, risk factors, diagnostic strategies, and treatment approaches are reviewed. Read the Review Article “Mucormycosis”: nej.md/3ZsLZ21 #MedSky @mdanderson.bsky.social

In this report from Singapore, the release of wolbachia-infected, irradiated male 𝘈𝘦𝘥𝘦𝘴 𝘢𝘦𝘨𝘺𝘱𝘵𝘪 mosquitoes resulted in a reduction in the vector population and in the risk of dengue infection. Full report: nej.md/4atd2iN #MedSky #IDSky

In a new Perspective, Melissa Arguello Belli, MD, argues that U.S. clinicians, health systems, and policymakers should recognize immigration enforcement as a social determinant of health currently implicated in a public health crisis and act accordingly. Read the full Perspective: nej.md/4rcAhVw

MGUS is a common, asymptomatic plasma-cell disorder in older adults that can progress to cancer or systemic illness. NEJM Editorial Fellow Katerina Lin, MD, shares some key points from a review published in October. Read the full article: nej.md/473uOsj #MedSky #Hematology

In high-risk biochemically recurrent prostate cancer, enzalutamide plus leuprolide significantly improved overall survival as compared with leuprolide alone. Enzalutamide monotherapy had no significant benefit for survival. Full phase 3 EMBARK trial results and Research Summary: nej.md/4h8QpDc

A 𝐬𝐢𝐧𝐠𝐥𝐞-𝐧𝐮𝐜𝐥𝐞𝐨𝐭𝐢𝐝𝐞 𝐩𝐨𝐥𝐲𝐦𝐨𝐫𝐩𝐡𝐢𝐬𝐦 (𝐒𝐍𝐏) is a type of variation affecting a single nucleotide in a DNA sequence, in which the nucleotide (for example, cytosine) is substituted with a different type of nucleotide (for example, thymidine). #MedSky #ScienceSky #Genetics

NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD, explains a recent study on weight regain after stopping obesity medications showing projected return to baseline weight within 2 years. Read the full context and comment by Sarah E. Post, MD: jwat.ch/4a91gtO #MedSky #GLP1

As an obstetrician, would you support an elective cesarean section if requested by the mother or recommend vaginal delivery unless medical indications for a cesarean section arise? Vote on the best option: nej.md/4toAzKz #MedSky #MedEd #OBGYN

Phase 3 DESTINY-Breast09 trial: In untreated HER2-positive metastatic breast cancer, trastuzumab deruxtecan + pertuzumab extended progression-free survival to 40.7 months, vs. 26.9 months with standard first-line therapy, with a similar incidence of high-grade adverse events. nej.md/3JrVYjC

HIV testing is based on the interplay of several virologic and immunologic events. Immediately after infection, the “eclipse period” begins, during which HIV replicates in local lymphoid tissue and is not detectable in the bloodstream by diagnostic tests. Learn more: nej.md/4ql7ehk

In a meta-analysis involving 17,801 patients with myocardial infarction and preserved LVEF (≥50%), beta-blockers did not reduce death, MI, or heart failure over a median 3.6 years of follow-up. Full trial results and Research Summary: nej.md/43U5Ppo

Phase 3 EMBARK trial: Patients with high-risk biochemical recurrence of prostate cancer face an increased risk of disease progression. Findings about long-term survival with enzalutamide are summarized in a new Quick Take video. nej.md/4atcZVk

Coronary artery disease develops from an interplay of behavioral, environmental, genetic, and stochastic factors. A new review focuses on recent discoveries regarding coronary atherosclerosis and discusses current and potential clinical uses of this information. Learn more: nej.md/4tmGZtI

DESTINY-Breast09: For patients with HER2-positive metastatic breast cancer, standard first-line therapy includes a taxane plus trastuzumab and pertuzumab. Research evaluating trastuzumab deruxtecan plus pertuzumab as initial treatment is summarized in a Quick Take video. nej.md/4rzbdb9

In the phase 3 CORALreef Lipids trial, the oral PCSK9 inhibitor enlicitide reduced LDL cholesterol by 57% at 24 weeks and also lowered non-HDL cholesterol, apolipoprotein B, and lipoprotein(a). Adverse events were similar in the two groups. Full trial results and Research Summary: nej.md/4qhQPtQ

A 49-year-old man with acute myeloid leukemia who had been admitted to the hospital for induction chemotherapy was evaluated for prolonged neutropenic fever. On physical examination, crackles were identified at the lung bases. 1/2 #MedSky

For patients with a preserved left ventricular ejection fraction after myocardial infarction, the benefit of beta-blockers is unclear. Research findings from a meta-analysis of five trials are summarized in a Quick Take video. nej.md/3MoSjoj #MedSky #CardioSky

Shift work disorder (SWD), which is characterized by excessive sleepiness during nocturnal wakefulness, affects 26.5% of shift workers. This RCT tests a new agent for treating excessive sleepiness among early-morning shift workers with SWD. Full results in NEJM Evidence: eviden.cc/3ZpGHnU

A 39-year-old woman with obesity presented with a 6-week history of foreign-body sensation and tearing in both eyes. She reported daytime fatigue and snoring. Examination showed marked laxity of the upper eyelids. Read the full case details: nej.md/4rnbM7y #MedSky #Ophthalmology

Phase 3 CORALreef Lipids trial: PCSK9 inhibitors are an effective alternative to statins for lowering LDL cholesterol, but current formulations are available only in an injectable form. Research findings on an oral PCSK9 inhibitor are summarized in a new Quick Take video. nej.md/4a8fxXz #MedSky

Presented at #WORLDSymposia: In nine patients with GM1 gangliosidosis, a fatal neurodegenerative disease, AAV9 β-galactosidase gene therapy was associated with short-lived adverse events, increased β-galactosidase levels, and delayed progression. Full trial results: nej.md/4rxOZpP #MedSky

A rare case of spontaneous heparin-induced thrombocytopenia occurred after hip arthroplasty despite no heparin exposure. Severe thromboses developed, but the patient recovered with bivalirudin and IVIG. Full case details: nej.md/3ZOKprn #MedSky #Hematology #Surgery

A 29-year-old woman with active opioid, alcohol, benzodiazepine, tobacco, and cocaine use disorders and recent intravenous drug use presented with acute onset of chills and increased pain and drainage of chronic wounds in both legs. Read the full case details: nej.md/4ql7ehk

New in the February 5, 2026, issue of NEJM: A Placebo-Controlled Trial of Enlicitide (phase 3 CORALreef Lipids trial) nej.md/4qhQPtQ Beta-Blockers after Myocardial Infarction nej.md/43U5Ppo #MedSky

A 63-year-old man presented with a 3-month history of chest tightness, palpitations, and abdominal pain. Laboratory studies showed an elevated erythrocyte sedimentation rate and an elevated C-reactive protein level. Read the full case details: nej.md/4keccuG #MedSky #Rheumatology #CardioSky

Genetic analyses of coronary artery disease have led to advances in therapy, prevention, and risk prediction. Genetic risk scores may guide prevention, but questions remain about implementation. Learn more in a new Review Article: nej.md/4tmGZtI #MedSky #CardioSky #Genetics

In the phase 3 CORALreef Lipids trial, the oral PCSK9 inhibitor enlicitide reduced LDL cholesterol by 57% at 24 weeks and also lowered non-HDL cholesterol, apolipoprotein B, and lipoprotein(a). Adverse events were similar in the two groups. Full trial results: nej.md/4qhQPtQ #MedSky #CardioSky

Peripheral artery disease is linked to cardiovascular risk and impaired mobility. Diagnosis relies on ankle–brachial index testing, and management involves cardiovascular risk reduction, exercise, and selective revascularization. Learn more: nej.md/4sZujsh #MedSky #CardioSky

In mobile stroke units, a teleneurologist model of care is superior to an onboard neurologist model based on a composite hierarchical outcome of safety, timeliness, and physician efficiency. Learn more in an article published in 𝘕𝘌𝘑𝘔 𝘌𝘷𝘪𝘥𝘦𝘯𝘤𝘦: eviden.cc/4pYer7x #MedSky #NeuroSky

In metastatic hormone-receptor–positive, HER2-positive breast cancer, maintenance palbociclib plus anti-HER2 and endocrine therapies extended progression-free survival but increased toxic effects such as neutropenia. Full phase 3 PATINA trial results and Research Summary: nej.md/3ZEyWdO

Our latest video in our partnership with @glaucomflecken.bsky.social summarizes the POTCAST trial, which assessed a strategy of actively increasing plasma potassium levels to the high-normal range in patients at high risk for ventricular arrhythmias. Read the full study for free: nej.md/DrG35

NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD, explains recent research into routine antibiotics for hospitalized patients with community-acquired pneumonia and a positive respiratory viral assay. Full context and comment by Dr. Aaron J. Calderon: jwat.ch/4t1rNC5 #MedSky

𝐍𝐨𝐰 𝐚𝐯𝐚𝐢𝐥𝐚𝐛𝐥𝐞 𝐢𝐧 𝑵𝑬𝑱𝑴 𝑬𝒗𝒊𝒅𝒆𝒏𝒄𝒆! A new Public Health Alerts report, published in partnership with @cidrap.bsky.social: 𝘗𝘢𝘦𝘯𝘪𝘣𝘢𝘤𝘪𝘭𝘭𝘶𝘴 𝘥𝘦𝘯𝘥𝘳𝘪𝘵𝘪𝘧𝘰𝘳𝘮𝘪𝘴 as a Cause of Destructive Meningitis in Infants eviden.cc/4tdRdw5 #MedSky #IDSky #PedSky

𝐕𝐚𝐬𝐜𝐮𝐥𝐚𝐫 𝐞𝐧𝐝𝐨𝐭𝐡𝐞𝐥𝐢𝐚𝐥 𝐠𝐫𝐨𝐰𝐭𝐡 𝐟𝐚𝐜𝐭𝐨𝐫 𝐀 (𝐕𝐄𝐆𝐅-𝐀) is a dimeric glycoprotein, commonly referred to as VEGF, that binds (i.e., it is a ligand of) vascular endothelial growth factor receptor 2 (VEGF-R2) on endothelial cells. Full definition of this NEJM Illustrated Glossary term: nej.md/3NCrAVI #MedSky

In acute central retinal artery occlusion treated within 4.5 hours after onset, intravenous tenecteplase did not result in greater recovery of vision at 30 days than aspirin and was associated with serious safety concerns. Full phase 3 TenCRAOS trial results and Research Summary: nej.md/3NU6BgZ

Parents’ firearm injuries were associated with increases in rates of psychiatric disorders and mental health visits among their children. Read the full results of a new claims-based study involving 3790 affected youths: nej.md/4aiAiB4 #MedSky #PedSky #Psychiatry

Peripheral artery disease in the legs refers to atherosclerotic blockages of arteries in the legs. The disease affects approximately 12.5 million persons 40 years of age or older in the United States and approximately 236 million persons worldwide. Learn more: nej.md/4sZujsh #MedSky

Case Record of the Massachusetts General Hospital: An 80-year-old woman was admitted to the hospital because of cough and hypoxemia (oxygen saturation, 83%). CT of the chest showed diffuse ground-glass opacities in both lungs. A diagnosis was made. Full case details: nej.md/4a2WKgv

In the phase 3 CORE-TIMI 72a and CORE2-TIMI 72b trials involving patients with severe hypertriglyceridemia, olezarsen led to a significantly greater reduction in the triglyceride level and in acute pancreatitis events than placebo. Full results and Research Summary: nej.md/491XG5V #MedSky

In metastatic hormone-receptor–positive, HER2-positive breast cancer, resistance to maintenance therapy often develops. Findings from the phase 3 PATINA trial evaluating palbociclib are summarized in a new Quick Take video. nej.md/45zIJFy #MedSky #Oncology

Rare disease in an adolescent who lived more than 12,000 years ago, along with her burial embrace by a first-degree relative, may reflect the importance of care for survival. Ancient DNA analysis led to a genetic diagnosis. Read the full report: nej.md/49WnAqo #MedSky #Genetics

A 55-year-old woman with invasive ductal carcinoma presented with a rash that had developed after a round of chemotherapy and had worsened and spread to her axillae, groin, and popliteal fossae after several additional rounds. Read the full case details: nej.md/3Z12cvc #MedSky

Phase 3 TenCRAOS trial: Central retinal artery occlusion carries a high risk of permanent blindness if prompt reperfusion is not achieved. Research findings evaluating the efficacy and safety of tenecteplase for this condition are summarized in a new Quick Take video. nej.md/4qFINvS

Shown are the relative effects of therapies that improve walking performance in persons with peripheral artery disease. Learn more in a new Clinical Practice article: nej.md/4sZujsh #MedSky #CardioSky

A 39-year-old woman with obesity presented to an ophthalmology clinic with a 6-week history of a foreign-body sensation and tearing in both eyes. Symptoms were worse upon awakening. She also reported daytime fatigue, snoring, and difficulty sleeping at night. 1/2 #MedSky

CORE-TIMI 72a and CORE2-TIMI 72b trials: Patients with severe hypertriglyceridemia have an increased risk of pancreatitis despite the use of lipid-lowering therapy. Research findings on the safety and efficacy of olezarsen in this population are summarized in a new video. nej.md/4bkpa7S

A new Case Study in NEJM Catalyst Innovations in Care Delivery reports an initiative that has reduced the number of orders for vitamin D tests in the first 12 months post intervention, which supports best practice guidelines and reduces overtesting. Full study results: nej.md/4pHZ0iY #MedSky