Thomas Clavel
@tclavel.bsky.social
📤 204
📥 161
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Passoniate microbiome research; www.clavel.ukaachen.de
reposted by
Thomas Clavel
Emma Slack
10 days ago
We are recruiting a lab manager for my group in Oxford. This is a lovely team doing great things, and you could be an important part of it! See here:
www.path.ox.ac.uk/vacancy/lab-...
Please spread the word!
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Lab Manager - Molecular Immunology - Dunn School
Laboratory Manager/Senior Scientist position in the Molecular Mucosal Immunology group at Oxford
https://www.path.ox.ac.uk/vacancy/lab-manager-molecular-immunology/
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Thomas Clavel
Cell Host & Microbe
16 days ago
Universal microbiome signature for CRC Large gut microbiome meta-analysis of colorectal cancer uncovers CRC microbiome signatures universal across ages & sequencing methods & modifiable by dietary interventions, ie fiber.
www.cell.com/cell-host-mi...
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Meta-analysis reveals microbiome signatures for colorectal cancer that are universal across age groups and sequencing methods
Pekel, Karcher, et al. present the largest gut microbiome meta-analysis of colorectal cancer to date, integrating 6,779 amplicon and shotgun sequencing profiles. They establish a robust microbiome sig...
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(26)00223-4
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Excellent work by our one and only
#CharliePauvert
. We use it in all our high-throughput anaerobic cultivation projects. More to come... 💫
add a skeleton here at some point
16 days ago
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Gut epithelium responses to bile acids 👉
rdcu.be/fmcUe
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Modulation of intestinal bile acids influences colonic mucosal responses
Scientific Reports - Modulation of intestinal bile acids influences colonic mucosal responses
https://rdcu.be/fmcUe
about 1 month ago
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Thomas Clavel
NFDI4Microbiota
about 1 month ago
📝 Only a few days left to submit your abstract! Take the opportunity to present your research, workflows, tools, and
#FAIR
data management approaches at the Boosting Biodata Bootcamp 2026! 👉 Abstract submission:
events.hifis.net/event/3702/a...
📅 Submission deadline: 1 June
#biology
#rdm
#nfdi
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Thomas Clavel
Anna S. Weiss
about 2 months ago
So happy to see this out 🎉 it all started with a discussion group of ECR brought together by the NCCR Microbiomes and cumulated in this primer on microbial community ecology. This was such a fun group project, where I learned a lot about how cool both microbial and human communities are 🤩
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Thomas Clavel
RuthLeyMicro
2 months ago
Come and work with us in a beautiful corner of Germany: 5 years of funding for your microbiology research and lots of great colleagues 🦠🧫
add a skeleton here at some point
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Thomas Clavel
Nature Microbiology
3 months ago
Out Now! Benchmarking shotgun metagenomics
#MicroSky
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Benchmarking shotgun metagenomics
Nature Microbiology, Published online: 24 April 2026; doi:10.1038/s41564-026-02344-0Shotgun metagenomic sequencing is a comprehensive untargeted next-generation sequencing method that enables culture-independent analysis of complex microbial communities. Comparing the results of several metagenome-based analyses at various sequencing depths for known input illustrates which methods and amounts of data are most suitable for determining microbial composition, accuracy of metagenome-assembled genomes and functional coverage.
https://go.nature.com/4d41ipn
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Thomas Clavel
Elisabetta Cacace
3 months ago
Check out our work on E. coli capsules! Including a 3x extended catalog of capsule loci from >37K genomes, a scalable tool to type them in silico (kTYPr) and new associations with ecology and disease! A joint effort from
@microbiomeresearch.bsky.social
@mucosalimmunology.bsky.social
at
@ethz.ch
.
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Strain diversity influences microbiome functions, and can be assessed with metagenome-assembled genomes (MAGs). But many MAGs are inaccurate! Benchmarking of shotgun sequencing by ⭐
@treichelnicole.bsky.social
⭐ with
@nfdi4microbiota.bsky.social
, in
@natmicrobiol.nature.com
👉
rdcu.be/feAWc
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Benchmarking of shotgun sequencing depth reveals the potential and limitations of shallow metagenomics and strain-level analysis
Nature Microbiology - A comparison of sequencing of complex mock communities performed at multiple depths and analysed using different methods establishes minimum standards that can ensure the...
https://rdcu.be/feAWc
3 months ago
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Thomas Clavel
Steven Salzberg
3 months ago
In my latest column, I explain some of my reasons for being deeply skeptical about AI models that claim to understand DNA, genes, and genomes:
stevensalzberg.substack.com/p/ai-is-star...
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AI is starting to look like pseudoscience
Not all of it, but some scientists are too eager to believe their own hype
https://stevensalzberg.substack.com/p/ai-is-starting-to-look-like-pseudoscience
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Thomas Clavel
NFDI4Microbiota
4 months ago
📢 Are you at
#VAAM2026
? 👉 Stop by the NFDI4Microbiota booth to learn how we can support you with training, data analysis, and making your microbiome research easier to share, reuse, and scale. And don’t miss today’s panel discussion at 1:30 in Lecture Hall B! We’d love to meet you 👋!
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Thomas Clavel
NFDI4Microbiota
4 months ago
Are you at
#DGE26
? 👋 So are we! Stop by the NFDI4Microbiota booth to explore how we can help make your microbiome research FAIR and easier to share, reuse, and amplify. Let’s connect, exchange ideas, and talk data. We’d love to meet you!
#microbiome
#NFDI
#FAIR
#rdm
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Thomas Clavel
Joel Selkrig
5 months ago
Registration for the 18th Annual Seeon Conference on Microbiota, Probiotics and Host is now open! 🎉 We’re looking forward to welcoming you in Seeon! When: June 24-26 Where: Seeon Monastery, Germany (near Munich) Program:
www.dghm.org/seeon/
Registration:
app1.edoobox.com/SPP1656/Seeo...
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Seeon - Deutsche Gesellschaft für Hygiene und Mikrobiologie
Microbiota, Probiotics and Host Seeon- Save the date 2026 Registration Abstract Template 2026 We are looking forward to meeting you there! Don’t forget your swimwear, sunscreen and running gear ...
https://www.dghm.org/seeon/
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Thomas Clavel
NFDI4Microbiota
5 months ago
☕ Join our next NFDI4Microbiota Tandem Coffee Talk! 📅 Mon, 23 Feb 2026 | 14:00–15:00 CET 🎙️ Prof. Dr. Bas E. Dutilh & Dr. Noriko Cassman 💬 “Learning phage-host interactions from curated big data” & “VirJenDB: a FAIR (meta)data and analysis platform for viruses” 👉 More info here:
tinyurl.com/5y7h6wfh
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Thomas Clavel
RWTH Aachen University
5 months ago
Prof. Carolin Schneider von der Uniklinik RWTH Aachen forscht mit KI-Fachleuten zur Krebsprävention. Ziel ist die personalisierte Strategie: "Wir glauben, dass wir gute Modelle entwickeln können, die die Einzel-Faktoren berücksichtigen, die jemand mitbringt." ➡️
www1.wdr.de/mediathek/au...
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Krebsforscherin: "Prävention ins Zentrum stellen"
Ärztin Carolin Schneider forscht mit KI-Experten an der RWTH Aachen zur Krebsprävention. Ziel ist die personalisierte Strategie: "Wir glauben, dass wir gute Modelle entwickeln können, die die Einzel-F...
https://www1.wdr.de/mediathek/audio/wdr5/wdr5-morgenecho-interview/audio-wie-weit-ist-die-krebsforschung-100.html
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Thomas Clavel
Lisa Maier Lab | Tübingen
7 months ago
We’re hiring 2 Postdocs (f/m/d) in Drug–Microbiome–Host Interactions 🦠💊 Focus: how non-antibiotic drugs shape the gut microbiome, drug efficacy & side effects.
#PostdocJobs
#Microbiome
#AcademicJobs
Full job ad:
lisamaierlab.com/wp-content/u...
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https://lisamaierlab.com/wp-content/uploads/2025/12/2025_Postdoc_Job-Ad.pdf
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Now published 🔥 Feeding your gut microbes with complex carbohydrates can help preventing colorectal cancer by reducing the production of secondary bile acids. Perhaps NiMe diet
@jenswalter15.bsky.social
? THX team & Sören Ocvirk ⭐ Thx
www.sfb.tum.de/1371/microbi...
. Article 👉
doi.org/10.1136/gutj...
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Secondary bile acid production by gut bacteria promotes Western diet-associated colorectal cancer
Background Western diet and associated production of secondary bile acids (BAs) have been linked to the development of sporadic colorectal cancer (CRC). Despite observational studies showing that seco...
https://doi.org/10.1136/gutjnl-2024-332243
7 months ago
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Thomas Clavel
NFDI4Microbiota
7 months ago
Save the Date! 📅 The NFDI4Microbiota Annual Conference 2026 will take place 15–17 September 2026 and will be a joint event with other biodata-related NFDI consortia. Stay tuned for more details!
#onenfdi
#NFDI4Microbiota
#rdm
#microbiota
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Thomas Clavel
Michael Zimmermann Lab
7 months ago
📍Our paper is out!📍 Here, we show the development of a GC-MS/MS method for the quantification of 120 compounds produced by gut bacteria, including short-chain fatty acids, indols, nucleotides, organic acids, and amino acid derivatives. Check it out!
link.springer.com/article/10.1...
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Development of a GC-MS/MS method to quantify 120 gut microbiota-derived metabolites - Analytical and Bioanalytical Chemistry
The gut microbiota produces metabolites that are important for host physiology and have critical roles in the development of diseases, such as metabolic disorders, cardiovascular diseases, and cancer....
https://link.springer.com/article/10.1007/s00216-025-06256-6
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Thomas Clavel
Jörg Vogel
7 months ago
Franziska Faber and I are recruiting shared postdocs, PhD students to work on Fusobacterium & new BGCs.
www.helmholtz-hiri.de/fileadmin/HI...
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Thomas Clavel
Lisa Maier Lab | Tübingen
7 months ago
New paper from the lab! Led by Patrick Müller: we show that non-antibiotic compounds — but not macrolide antibiotics — can induce an efflux pump that protects Bacteroidaceae from macrolides. A neat twist on drug–microbe interactions...
www.tandfonline.com/doi/full/10....
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Thomas Clavel
DSMZ Digital Diversity
8 months ago
📣 Open position: We are looking for a new
#ScientificLead
for the
#SILVA
database 🧬🖥️ You will be responsible for guiding the development of this important resource and for curating the SILVA taxonomy🌳and more! 👉
www.dsmz.de/dsmz/career/...
Read and share ‼️
#sciencejobs
🦠🧪
#career
#taxonomy
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Thomas Clavel
Tom Hitch
8 months ago
Want to delineate genera? We have been optimising POCP, and propose POCPu, which stops the 'double counting' of proteins in POCP by only allowing unique matches. We also speed up, and benchmarked, the analysis using DIAMOND;
peerj.com/articles/202...
(now implemented in Protologger)
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Fast and robust estimate of bacterial genus novelty using the percentage of conserved proteins with unique matches (POCPu)
Accurate taxonomic assignment of bacterial genomes is essential for identifying novel taxa and for stable classification to enable robust comparison between studies. Bacterial genus delineation relies...
https://peerj.com/articles/20259/
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Great work from our FAIR science master Charlie (
www.linkedin.com/in/charliepa...
) to delineate bacterial genera:
peerj.com/articles/202...
. We hope this will help many. The POCPu calculation is now implemented in
protologger.bi.denbi.de
by
@tcahitch.bsky.social
. Thanks for the hard work you 2 ⭐⭐
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Fast and robust estimate of bacterial genus novelty using the percentage of conserved proteins with unique matches (POCPu)
Accurate taxonomic assignment of bacterial genomes is essential for identifying novel taxa and for stable classification to enable robust comparison between studies. Bacterial genus delineation relies...
https://peerj.com/articles/20259/
8 months ago
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Thomas Clavel
NFDI4Microbiota
8 months ago
Need a hand with your #Nextflow or #nfcore pipeline? Join our weekly drop-in session — every Friday 10–11 CET with Daniel Straub (Uni Tübingen). Ask questions, get tips, and connect with the community! 📍 Zoom:
tinyurl.com/mwz84xvb
#Nextflow
#nfcore
#Bioinformatics
#OpenScience
#NFDI4Microbiota
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A place to be 👇 Highly recommended ⭐⭐⭐⭐⭐
add a skeleton here at some point
8 months ago
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Thomas Clavel
Emma Slack
8 months ago
We have an opening for a postdoctoral researcher in my group at the Botnar Institute for Immune Engineering in Basel, Switzerland. The project is aimed at developing novel mucosal adjuvants for application in oral vaccines. Deadline to apply 16.11.25! Please re-post 🔬🧬
join.com/companies/im...
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Botnar Institute of Immune Engineering - BIIE (Zürich): Postdoctoral Researcher (100%): Mechanisms of action of mucosal adjuvants
Botnar Institute of Immune Engineering - BIIE has a job opening for Postdoctoral Researcher (100%): Mechanisms of action of mucosal adjuvants in Zürich (published: 30.10.2025). Apply now or check the ...
https://join.com/companies/immune1/15114497?utm_medium=social_sharing&utm_source=copy_link
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Thomas Clavel
NFDI4Microbiota
9 months ago
☕ Grab your coffee and join our next NFDI4Microbiota Coffee Talk! 📅 Mon, 27 Oct 2025 | 14:30–15:30 CET 🎙️ Daniel Straub (QBiC Tübingen) 💬 “Meta-omics Analysis at a Bioinformatics Core Facility – As FAIR as Possible”. More info here:
nfdi4microbiota.de/c...
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Thomas Clavel
bioRxiv Microbiology
9 months ago
A toolkit for transposon libraries and functional genomics in intestinal Bacteroidales
https://www.biorxiv.org/content/10.1101/2025.10.10.681549v1
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Thomas Clavel
Michael Zimmermann Lab
10 months ago
📍Paper alert 📍 Our new preprint is available on:
chemrxiv.org/engage/chemr...
Here, we show the development of a GC-MS/MS method for the quantification of 120 compounds produced by gut bacteria, including SCFA, indols, organic acids, and amino acid derivatives.
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Development of a GC-MS/MS method to quantify 120 gut microbiota-derived metabolites
The gut microbiota produces metabolites that are important for host physiology and have critical roles in the development of diseases, such as metabolic disorders, cardiovascular diseases, and cancer....
https://chemrxiv.org/engage/chemrxiv/article-details/68c723ae9008f1a4677dc87d
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Thomas Clavel
Tom Hitch
10 months ago
The main work from my time in Aachen is now out 🎉 if you have wanted to make a SynCom that captures the functional-landscape of microbiota, MiMiC2 makes that possible based on metagenomic data! 1/7
doi.org/10.1093/isme...
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Function-Based Selection of Synthetic Communities Enables Mechanistic Microbiome Studies
Abstract. Understanding the complex interactions between microbes and their environment requires robust model systems such as synthetic communities (SynCom
https://doi.org/10.1093/ismejo/wraf209
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Interested in the design of defined microbial communities for fundamental research and applications? Hope this work & tool will help you 👇 As always
@tcahitch.bsky.social
has been a driving factor ⭐⭐⭐!
github.com/ClavelLab/Mi...
;
academic.oup.com/ismej/advanc...
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Validate User
https://academic.oup.com/ismej/advance-article/doi/10.1093/ismejo/wraf209/8256658?login=false
10 months ago
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Thomas Clavel
Emma Slack
10 months ago
Come and be my colleague at the Dunn School! It‘s a brilliant place to work and exciting to be building up our immunology team. Do apply. Do pass on the news 💉🧬🦠🔬🧫
add a skeleton here at some point
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Thomas Clavel
NFDI4Microbiota
10 months ago
We’re heading to Jena for two exciting events! 📍 DGHM 2025 – 24 Sept Workshop: Data madness: Navigating Host Microbiomes Featuring VirJenDB – virus sequence discovery & analysis Details 👉
programme.conventus....
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Thomas Clavel
Steven Salzberg
10 months ago
We're still not finding any good evidence for a microbiome in any cancer type: see our new paper in @ScienceTM led by PhD student Yuchen (Peter) Ge
www.science.org/doi/10.1126/...
and the accompanying news piece,
www.science.org/content/arti...
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Comprehensive analysis of microbial content in whole-genome sequencing samples from The Cancer Genome Atlas project
An analysis of TCGA whole-genome sequencing samples yields a comprehensive resource for investigating the role of microbes in cancer.
https://www.science.org/doi/10.1126/scitranslmed.ads6335
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Thomas Clavel
Carolin Wendling
10 months ago
Interested in exploring prophages in your (meta)genomes, but don't know how and where to start? We've put together a beginners guide to exploring viral diversity in prokaryotes
@marievasse.bsky.social
@sebwielgoss.bsky.social
@oxunipress.bsky.social
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Thomas Clavel
NFDI4Microbiota
11 months ago
Planning, sequencing… and now analysis. 📊 ☕ Coffee Talk: Getting Your Microbiome Research on the Road – Managing Your Data using Qiita 🗓️ Aug 25, 2025 | 14:30 CEST 👉 More info:
tinyurl.com/2m9jpf2p
👉 Workshop (Oct 22–24, Gießen):
tinyurl.com/4w8mczh7
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Thomas Clavel
Geraldine Zimmer-Bensch
11 months ago
🌍 Open Call! RWTH Aachen University invites postdocs from outside the EU to apply for the “Port to Europe” Fellowship (24 months funding, all disciplines). Start your research journey at one of Europe’s top universities! 🚀 Deadline: Oct 5, 2025. 👉https://rwth-aachen.de/go/id/botjje/lidx/1
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Thomas Clavel
Michael Zimmermann Lab
11 months ago
Do you have experience in metabolomics/lipidomics/exposomics? Check out the EMBL ARISE2 Fellowship Programme! 🔗
www.embl.org/training/ari...
📩 Contact: Juan Antonio Vizcaíno — Team Leader, EMBL-EBI 🔗
www.ebi.ac.uk/people/perso...
📌 Applications close soon! 📆 30/09/2025 More info below👇
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Thomas Clavel
Typas Lab
12 months ago
Ready to lead pioneering research that bridges systems-level investigations of biological systems to molecular mechanism? The EMBL Molecular Systems Biology Unit in Heidelberg is hiring a Group Leader!
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Group Leader – Molecular Systems Biology Unit
Are you ready to lead groundbreaking research in Molecular Systems Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group, addressing original biological ...
https://embl.wd103.myworkdayjobs.com/en-US/EMBL/details/Group-Leader----Molecular-Systems-Biology-Unit_JR2062
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Thomas Clavel
Lisa Maier Lab | Tübingen
12 months ago
Finally online! Our latest research is out
@nature.com
: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG
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Non-antibiotics disrupt colonization resistance against enteropathogens
Nature - Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens, a previously underappreciated side effect of...
https://rdcu.be/ewwrG
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Thomas Clavel
François Leulier
12 months ago
A pure « délice » to have followed this story unfolding under our eyes. Congrats
@ameliejoly.bsky.social
brilliantly followed-up by
@lucasrebiffe.bsky.social
.
@filipedevadder.bsky.social
and I were/are so lucky to work with gifted Ph’D candidates like you!
add a skeleton here at some point
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Thomas Clavel
NFDI4Microbiota
about 1 year ago
Try cloud-based microbiome workflows with CloWM—no installation needed! 📍 4th NFDI4Microbiota Annual Conference |Cologne 📆 Oct 2 | Registration is free 🔗
events.hifis.net/eve...
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Congrats
@baerboletta.bsky.social
👏 Highly deserved & best possible ambassador for the field
www.embo.org/press-releas...
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Outstanding life scientists elected to the EMBO Membership – Press releases – EMBO
Sixty-nine new members join the community of leading life scientists in Europe and beyond
https://www.embo.org/press-releases/outstanding-life-scientists-elected-to-the-embo-membership/
about 1 year ago
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Thomas Clavel
Nature Microbiology
about 1 year ago
#NewResearch
🚨Out now! Human gut bacteria bioaccumulate forever chemicals, in intracellular aggregates and colonization of gnotobiotic mice with these bioaccumulating bacteria increases faecal PFAS excretion.
@kiranrpatil.bsky.social
#MicroSky
#MicrobiomeSky
🦠
www.nature.com/articles/s41...
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Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances - Nature Microbiology
Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances (PFAS), commonly known as forever chemicals, in intracellular aggregates. Colonization of gnotobiotic mice with bioaccumulating bac...
https://www.nature.com/articles/s41564-025-02032-5?utm_source=bluesky&utm_medium=social&utm_campaign=nmicrobiol
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Thomas Clavel
NFDI4Microbiota
about 1 year ago
Join our NFDI4Microbiota Coffee Talk: Ivan Belyaev
@microverse.bsky.social
presents BEXIS2, a flexible platform for microbiology metadata. June 30 at 14:30 CEST. More info here:
tinyurl.com/mudhdnra
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Thomas Clavel
NFDI4Microbiota
about 1 year ago
🧫 Registration is open! Join the 4th NFDI4Microbiota Conference in Cologne 📅 Sept 30–Oct 2 | Theme: From Lab to Publication Hands-on workshops, keynotes, posters | Registration is free 📝 Register by Aug 31:
events.hifis.net/eve...
#FAIRdata
#Microbiome
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Thomas Clavel
Noah Fierer
about 1 year ago
Hope this is useful - consensus statement "Guidelines for preventing and reporting contamination in low-biomass microbiome studies"
rdcu.be/er3Io
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Guidelines for preventing and reporting contamination in low-biomass microbiome studies
Nature Microbiology - In this Consensus Statement, the authors outline strategies for processing, analysing and interpreting low-biomass microbiome samples, and provide recommendations to minimize...
https://rdcu.be/er3Io
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Thomas Clavel
NFDI4Microbiota
about 1 year ago
The #NFDI4Microbiota Flex Funds Call 2026 opens June 16! Support for infrastructure, workflows, training & more in microbiology. Deadline: Aug 11. Details:
nfdi4microbiota.de/n...
#NFDI4Microbiota
#OpenScience
#FAIRdata
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