Noah Fierer
@noahfierer.bsky.social
📤 2542
📥 203
📝 84
Microbial ecologist
https://www.fiererlab.org/
New preprint led by Matt Gebert focused on the environmental reservoirs of nontuberculous mycobacterial (NTM) pathogens. NTM disease is environmentally acquired, but routes of exposure unclear. Our work implicates premise plumbing as the main culprit!
www.biorxiv.org/content/10.1...
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A cross-environment comparison of nontuberculous mycobacterial diversity
Nontuberculous mycobacteria (NTM) are a group of environmental bacteria that encompass nearly 200 described species, some of which can cause chronic pulmonary infection in humans. What makes these inf...
https://www.biorxiv.org/content/10.1101/2025.08.04.668438v1
about 2 months ago
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After 15 years, the authors of the infamous 'arsenic life' paper are still trying to argue that their findings are legit and not just a product of 'major errors'? Unbelievable. The authors' response to the retraction is infuriating. Time to let it go.
www.science.org/doi/10.1126/...
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https://www.science.org/doi/10.1126/science.adu5488
about 2 months ago
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New pre-print from my group - project led by PhD student Michael Hoffert. We set out on a daunting mission to generate a 'periodic table' of bacterial diversity (1/6)
www.biorxiv.org/content/10.1...
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A periodic table of bacteria?: Mapping bacterial diversity in trait space
Bacterial diversity can be overwhelming. There is an ever-expanding number of bacterial taxa being discovered, but many of these taxa remain uncharacterized with unknown traits and environmental prefe...
https://www.biorxiv.org/content/10.1101/2025.07.11.664459v1
2 months ago
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Hope this is useful - consensus statement "Guidelines for preventing and reporting contamination in low-biomass microbiome studies"
rdcu.be/er3Io
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Guidelines for preventing and reporting contamination in low-biomass microbiome studies
Nature Microbiology - In this Consensus Statement, the authors outline strategies for processing, analysing and interpreting low-biomass microbiome samples, and provide recommendations to minimize...
https://rdcu.be/er3Io
3 months ago
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New study out - we developed a pipeline for targeted assembly of genomes from (complex) soil metagenomes to examine the strain-level diversity and ecology of a dominant soil bacterial genus (Bradyrhizobium). Feedback appreciated.
www.biorxiv.org/content/10.1...
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Continent-wide assessment of the strain-level diversity of Bradyrhizobium, a dominant soil bacterial genus
Global surveys of soil bacteria have identified several taxa that are nearly ubiquitous and often the most abundant members of soil bacterial communities. However, it remains unclear why these taxa ar...
https://www.biorxiv.org/content/10.1101/2025.05.29.656829v1
4 months ago
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This is cool - bacteria wrap their flagella to propel themselves through narrow passages
www.biorxiv.org/content/10.1...
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Bacteria break through one-micrometer-square passages by flagellar wrapping
Confined spaces are omnipresent in the micro-environments, including soil aggregates and intestinal crypts, yet little is known about how bacteria behave under such conditions where movement is challe...
https://www.biorxiv.org/content/10.1101/2025.02.12.637796v1.abstract
4 months ago
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Just your regular reminder that 'sterile' doesn't mean 'DNA-free'! (this rant brought to you by yet another published DNA-based study conducted in a low biomass system where appropriate controls do not appear to have been included)
5 months ago
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Dear fellow olds - recognize that the term 'next generation sequencing' is confusing to those that never had experience with the first generation. Also - what 'generation' are we on anyways?
5 months ago
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So happy it is still winter here in Colorado
5 months ago
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reposted by
Noah Fierer
Julian Resasco
6 months ago
Excited to share PhD student Claire Winfrey’s (w/
@noahfierer.bsky.social
& me) new paper in
@esajournals.bsky.social
Ecology! She examines how edge effects in habitat fragments shape soil microbial communities. Check it out 🦠 🧪 🌎
esajournals.onlinelibrary.wiley.com/doi/full/10....
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New study out from my group showing how the volatile geosmin (the wonderful 'smell of dirt') serves as a cue to influence the behavior of soil protists
rdcu.be/edCJj
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Effects of Geosmin on the Behavior of Soil Protists
https://rdcu.be/edCJj
6 months ago
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New paper out that (we hope) will be useful to anyone with an interest in Antarctic soil microbial communities:
link.springer.com/article/10.1...
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A comprehensive survey of soil microbial diversity across the Antarctic continent - Polar Biology
Antarctic soils are unique from those found nearly anywhere else on Earth yet can still harbor a broad diversity of microorganisms able to tolerate the challenging conditions typical of the continent....
https://link.springer.com/article/10.1007/s00300-025-03372-y
7 months ago
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We are trying to recruit folks from across the US that might be willing to be involved in a beta test of a new project to quantify airborne allergen loads in their homes. If interested (no cost), sign up here:
boulderblue.com
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Air Quality Testing Services – Allergen Detection with Boulder Blue
Ensure a healthier space with cutting-edge air quality testing services from Boulder Blue. Our genomic tests help detect indoor allergens.
https://boulderblue.com/
7 months ago
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Both the porcupine and I enjoyed the powder today
8 months ago
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For years I've heard it said by univ admins that 'research is a net cost to the univ'. I guess we are about to find out if that is really true....
8 months ago
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reposted by
Noah Fierer
Neal Henderson
8 months ago
Lovely day to get out and XC ski in North Boulder Park. I recognized three Olympians out there during my 1 hour ski…one gold medalist, and one other medalist. There were probably other Olympians out there I didn’t recognize. Thanks to Boulder Nordic Club for grooming!
bouldernordic.org
#Boulder
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Yet another reminder that RNA levels are not necessarily predictive of growth rate in mixed microbial communities (from this paper:
www.pnas.org/doi/10.1073/...
)
8 months ago
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Lucky to be able to spend the morning skiing in Rocky Mt Natl Park
8 months ago
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Another day with a SciEnCV-induced headache. Who thought just preparing a biosketch should be turned into a major time sink and source of frustration?
9 months ago
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Cool work by
@mattolm.bsky.social
identifying the specific bacteria targeted by gut antibodies
www.nature.com/articles/s41...
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Metagenomic immunoglobulin sequencing reveals IgA coating of microbial strains in the healthy human gut - Nature Microbiology
Metagenomic immunoglobulin sequencing (MIg-seq) uncovered patterns of IgA antibody binding of bacterial strains in the healthy human gut microbiome.
https://www.nature.com/articles/s41564-024-01887-4
9 months ago
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Damn - these cookies slap
cooking.nytimes.com/recipes/1023...
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Gochujang Caramel Cookies Recipe
Gochujang, the fermented Korean chile paste, offers intrigue in this otherwise classic chewy sugar cookie A gentle amount of ground cinnamon lends snickerdoodle vibes, and the dough is raked through w...
https://cooking.nytimes.com/recipes/1023675-gochujang-caramel-cookies?smid=ck-recipe-android-share
9 months ago
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Yikes - large earthquake in Port Vila, Vanuatu. Wonderful people and beautiful place (spent 2 weeks there in 2023). Hoping for the best...
9 months ago
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Basically every ecology paper: "We found a strong link between X and Y at this site, so this is how the world works." The plot.
9 months ago
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Why are Punnett squares still a thing? (asks the guy currently helping his daughter with 9th grade biology homework)
9 months ago
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Dear microbial ecologists - I don't care how many MAGs you generated - what matters is what new insights you can glean from all those genomes (rant over)
9 months ago
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In recognition of World Soils Day, here are 3 kitties snuggling together on a Namibian soil
10 months ago
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Friendly welcoming party in Namibia
10 months ago
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Cool to see that pH is not only an important determinant of microbiome structure in soil and freshwater environments, but also the human gut!
www.nature.com/articles/s41...
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Gut physiology and environment explain variations in human gut microbiome composition and metabolism - Nature Microbiology
An observational longitudinal clinical trial, incorporating a SmartPill and metabolomics, reveals the role of host factors in shaping the gut microbiome in healthy human adults.
https://www.nature.com/articles/s41564-024-01856-x
10 months ago
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Phytophthora takes down an indoor farming company:
pitchbook.com/news/article...
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Wilted greens: How a leaf-eating pathogen, failed deals brought down Bowery Farming - PitchBook
A pathogen decimated crop yields at both of Bowery's farms, former employees said. They never fully recovered.
https://pitchbook.com/news/articles/bowery-farming-collapse-leaf-eating-pathogen-failed-acquisition
10 months ago
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Anyone have an alternate protocol suitable for ONT genomic/metagenomic library preps? The 'official' ONT protocol is kind of a pain in the ass....
10 months ago
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With the recent improvements in ONT sequencing, I don't think we'll ever go back to Illumina for most of our sequencing work
10 months ago
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Summary of our recent paper using Twitter data (primarily) to track seasonal allergies across the US:
cires.colorado.edu/news/social-...
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Social media posts reveal regional patterns in seasonal allergies
https://cires.colorado.edu/news/social-media-posts-reveal-regional-patterns-seasonal-allergies
10 months ago
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New paper out - social media (namely Twitter) is good for something - tracking spatial/temporal patterns in seasonal allergies across the US:
academic.oup.com/pnasnexus/ar...
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Internet-based surveillance to track trends in seasonal allergies across the United States
Abstract. Over a quarter of adults in the United States suffer from seasonal allergies, yet the broader spatiotemporal patterns in seasonal allergy trends
https://academic.oup.com/pnasnexus/article/3/10/pgae430/7828924
10 months ago
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Yesterday vs today - gotta love Colorado
11 months ago
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I have a request: Can you send me your 'tips & tricks' for managing/organizing research projects? I ask as I'm teaching a grad class next week on this topic. Any and all suggestions much appreciated.
11 months ago
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This is a cool paper by
@nonresidentdesi.bsky.social
et al. Bacteria feeding off the carcasses of their prey.
www.biorxiv.org/content/10.1...
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Antagonism as a foraging strategy in microbial communities
In natural habitats, nutrient availability often limits bacterial growth. We discovered that bacteria can overcome this limitation by acquiring nutrients through lysing neighboring cells via contact-d...
https://www.biorxiv.org/content/10.1101/2024.11.04.621785v1?s=03
11 months ago
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This is really cool. Nematodes use siderophores to locate their bacterial prey:
www.pnas.org/doi/abs/10.1...
over 1 year ago
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Opening for an asst professor in environmental geochemistry at UC Berkeley:
aprecruit.berkeley.edu/JPF04075
over 1 year ago
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Maybe not everything is everywhere - the bacterial equivalent of a kiwi bird is discovered in New Zealand
www.nature.com/articles/s41...
over 1 year ago
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New paper out from my group - a practical guide to machine learning in microbial ecology. Hope it is useful!
journals.asm.org/doi/10.1128/...
almost 2 years ago
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Finally got a photo of nearly everyone in the lab group! Using pizza as bait was the key.
almost 2 years ago
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Maybe scheduling a shut down of Canvas for maintenance during the last week of classes wasn't a great idea
almost 2 years ago
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This was a fun study to work on - what we know (or think we know) about bacterial amino acid auxotrophies
www.nature.com/articles/s41...
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Taxonomic and environmental distribution of bacterial amino acid auxotrophies - Nature Communication...
Many microorganisms are auxotrophic, that is, unable to synthesize the compounds they require for growth. Here, Ramoneda et al. predict amino acid biosynthetic capabilities of over 26,000 bacterial ge...
https://www.nature.com/articles/s41467-023-43435-4
almost 2 years ago
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An important (and useful) paper that uses data to actually quantify the 'peer review crisis':
journals.asm.org/doi/10.1128/...
almost 2 years ago
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Unpopular opinion: using structural equation modeling to analyze microbiome data is rarely very useful. It is not a 'magic bullet' that can be used to infer causality from correlations.
almost 2 years ago
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This is really cool - using the distribution of cells in a pipette tip for CFU quantification:
www.nature.com/articles/s41...
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A high-throughput and low-waste viability assay for microbes - Nature Microbiology
Using agar media suspended in pipette tips and a standard camera, the geometric viability assay provides a user-friendly and scalable update to standard colony-forming-unit-count approaches.
https://www.nature.com/articles/s41564-023-01513-9#Sec10
almost 2 years ago
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Lots of papers examining how microbes are influenced by soil properties. Here we flip that around and ask how microbes can influence the soil environment. Fun paper to write with Laurent Philippot, Claire Chenu,
@mrillig.bsky.social
and Andreas Kappler
www.nature.com/articles/s41...
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The interplay between microbial communities and soil properties - Nature Reviews Microbiology
In this Review, Philippot et al. explore how soil microorganisms can affect the physical and chemical properties of soil and discuss the ecological and evolutionary consequences of these microbially d...
https://www.nature.com/articles/s41579-023-00980-5
almost 2 years ago
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reposted by
Noah Fierer
Stephen Heard
almost 2 years ago
This, from Ken Hughes, is really good. Is science like a jigsaw puzzle? Climbing a mountain? Building a shelter in the woods? In search of a good analogy:
brushingupscience.com/2023/10/18/s...
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Science is a like a …
Improving public understanding of science would be a good thing, right? Right? Not so much, argued professor of communication Leon Trachtman 40 years ago, because it's difficult to communicate to the ...
https://brushingupscience.com/2023/10/18/science-is-a-like-a/
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New job opening at CU Boulder: Asst. Professor of Environmental Data Science. A great opportunity at a great place
jobs.colorado.edu/jobs/JobDeta...
almost 2 years ago
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Incredible weekend backpacking with kids in WY. Look at that sky!
almost 2 years ago
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