Not just passengers! Perspective by Colin Hill & Co examines role of phages in fecal microbiota transplants (FMTs). Phages may actively reshape the recipient’s gut by transferring genes between microbes, potentially influencing treatment success www.cell.com/cell-host-mi...

Phages as ecosystem engineers of plant microbiomes Forum highlighting role of phages in plant health via their eco-evolutionary effects on plant-associated bacteria, which can determine balance between mutualistic &antagonistic plant-bacteria interactions www.cell.com/cell-host-mi...

Potential impacts of antivirals on the virome In this Forum, @tao-zuo.bsky.social & Co discuss the potential effects of antivirals on the commensal virome, a crucial player in microbiome homeostasis and mammalian health. www.cell.com/cell-host-mi...

Forum: Making room for gut prophages in human health @luisadesordi.bsky.social examines evidence that prophages regulate bacterial fitness & microbe-host interactions, arguing that prophage biology is important to understand microbiota functions in health/disease www.cell.com/cell-host-mi...

Forum: The gut phageome:Friend or foe? @naamagz.bsky.social examines how gut phages defy classification as beneficial or harmful, instead shifting in roles that stabilize or destabilize communities. Framework to navigate phage functions & virome-targeted therapeutics www.cell.com/cell-host-mi...

Review: The human skin virome Che & Kong examine virome dynamics across the human lifespan, their roles in skin disorders & emerging therapeutic opportunities, while also highlighting key methodological and translational challenges in the field www.cell.com/cell-host-mi...

Focus Issue on The Virome! Forums, Perspectives and Reviews examining the latest insights and open questions. www.cell.com/cell-host-mi...

Gut microbes may shape drug delivery. A new preview in @cp-cellhostmicrobe.bsky.social by Gerard Clarke & @jfcryan.bsky.social explains how microbial control of #serotonin may affect liver clearance of synthetic & viral vectors. 📰 Read the preview: buff.ly/eQQzo0N #Microbiome #DrugDelivery

I had fun writing a short commentary on the importance of integrating prophage biology into microbiome research 🦠 Now out in @cp-cellhostmicrobe.bsky.social #microbiomesky #phagesky www.cell.com/cell-host-mi...

Weekend read! Microbiota extends reproductive lifespan Germ-free female mice undergo accelerated primordial follicle loss & reduced reproductive capacity that are restored upon post-natal colonization. Microbial SCFAs & fiber mitigates ovarian dysfunction www.cell.com/cell-host-mi...

Abs powering MMR efficacy against MeV New work IDs human antibodies against measles virus. Abs potently and broadly neutralize, target conserved sites, & protect animals even after exposure, opening means to prevent/treat measles as outbreaks re-emerge www.cell.com/cell-host-mi...

Breaking #measles study: 👩‍🔬 LJI scientists are the first to describe human antibodies that target measles virus and block infection. 🤒 These antibodies could serve as the first-ever measles treatments. bit.ly/42lQ2P7 @cp-cellhostmicrobe.bsky.social #Immunology #ImmuneSystem #Health #Medicine

Huge cheers to LJI's Saphire Lab for their groundbreaking, NIH-funded #measles study! The antibodies they discovered may serve as the world's first measles treatment. 🏥 Learn more: bit.ly/42lQ2P7 @cp-cellhostmicrobe.bsky.social #Health #Medicine #SanDiego #Immunology

S. copri keeps pace with modern lifestyles Subset of Segatella copri strains have acquired an additional oxygen regulator via horizontal gene transfer, which confers increased oxygen tolerance. These strains are more prevalent in industrialized countries www.cell.com/cell-host-mi...

New paper out in @cp-cellhostmicrobe.bsky.social! Microbes evolving with modern lifestyles 🧬🦠 S. copri uses PerR to manage oxygen stress, but some strains acquired OxyR via HGT, boosting oxygen tolerance. These strains are enriched in industrialized populations. www.cell.com/cell-host-mi...

Mom’s helminths rewire microbiota to protect offspring Maternal helminths confer lasting protection against respiratory viruses in offspring. Helminth-induced changes in microbiota increase indole-3-propionic acid, which induces lung IFN-I responses www.cell.com/cell-host-mi...

Great turnout for an inspiring seminar hosted by @bahtiyil.bsky.social, the MCID and @dbmr-unibe.bsky.social in Bern this week! We had the pleasure of welcoming Dr Yingyu Liu, Scientific Editor at @cp-cellhostmicrobe.bsky.social, who shared a behind-the-scenes look at the publication process.

One year ago! Co-habitation shifts your microbiome to protective state Sharing gut bacteria via cohabitation, ie Rikenellamicrofusus, boosts isoflavone conversion to biochanin-A, reducing liver injury from acetaminophen by enhancing liver cell metabolism www.cell.com/cell-host-mi...

Vaginal bacteria turn newborn skin into a beneficial ‘bioreactor’ for lipid promoting brain development. Vaginal fluid swab can provide this to C-section babies @science.org commentary on @cp-cellhostmicrobe.bsky.social report www.science.org/content/arti... www.cell.com/cell-host-mi...

Childhood immunological imprinting impacts influenza Ab specificity H1/H3 cross-reactive antibodies targeting epitope in HA head isolated in people born in 1990s & vaccinated w/2021–22 seasonal vaccine. Similar Abs elicited in ferrets w/ H3➡️H1 exposures www.cell.com/cell-host-mi...

Childhood immunological imprinting of cross-subtype antibodies targeting the hemagglutinin head domain of influenza viruses @cp-cellhostmicrobe.bsky.social www.cell.com/cell-host-mi... @stanforduniversity.bsky.social @upenn.edu @scripps.edu

Weekend read! Cadaverine rewires macrophages: Gut-microbiota-derived cadaverine reprograms macrophage energy metabolism, altering inflammatory immunophenotypes. In IBD, cadaverine is associated w/increased flare risk & regulated by Enterobacteriaceae www.cell.com/cell-host-mi...

Highlight of new Cell Host & Microbe paper! Vaginal bacteria turn newborn skin into a beneficial ‘bioreactor’ www.science.org/content/arti...

Not just passengers! Perspective by Colin Hill & Co examines role of phages in fecal microbiota transplants (FMTs). Phages may actively reshape the recipient’s gut by transferring genes between microbes, potentially influencing treatment success www.cell.com/cell-host-mi...

VMT & infant neurodevelopment Vaginal microbiota transfer after cesarean birth restores skin lipid signal (N-bc2S1P) linked to neurodevelopment. In mice, engineered skin bacteria sustain N-bc2S1P & prolong rescue of cesarean-associated deficits www.cell.com/cell-host-mi...

In faecal microbiota transplantation, it may not just be bacteria that matter. A new review in @cp-cellhostmicrobe.bsky.social argues that donor #phages may drive gene exchange between gut bacteria after #FMT, widening how we think about engraftment and function. Read the paper: buff.ly/icbIzqU

"Vaginal microbiota transfer ameliorates cesarean-associated neurodevelopmental deficits in mice via microbial N-bc2S1P synthesis on neonatal skin" spkl.io/63323A4yYx Yuhang Zhang, Ri-hua Xie & colleagues @cp-cellhostmicrobe.bsky.social

Microbiota mitigate antipsychotic-induced cognitive impairment Antipsychotics deplete Cyanobacteria & ergothioneine, leading to cognitive impairment. Ergothioneine treatment rescues cognitive deficits by inhibiting hippocampal oxidative stress & PTP1B www.cell.com/cell-host-mi...

Early-life interventions & airway microbiome Nasal microbial gene atlas in infants -/+ cystic fibrosis. Hypertonic saline inhalation reshapes airway microbiome, selects salt-tolerant H. influenzae & induces transporters linked to antibiotic tolerance www.cell.com/cell-host-mi...

Weekend read! Plant microbiome & drought resistance Drought stress promotes specific microbial & metabolite enrichments in the wheat rhizosphere. These changes enhance plant drought resistance via plant-microbe interactions & have lasting legacy effects www.cell.com/cell-host-mi...

#WeekendRead! #EveryCellIsAnImmuneCell! #InflammasomePower! #ImmunometabolismPower! Zhao &co show @cp-cellhostmicrobe.bsky.social that a clostridium enriched in #IBD exacerbates colitis via boosting #glycolysis & IL1b by macrophages & activating NLRP3 in enteric #neurons, causing their loss!

Gut phage ACRs Type II CRISPR-Cas systems dominate human gut w/diverse phage Acrs targeting these systems. Widespread family, GutAcraca, adopts similar structures to inhibit Cas9 & regulate its own expression, highlighting phage adaptation to gut ecology www.cell.com/cell-host-mi...

Microbes that chew allergens mitigate anaphylaxis Preview of work demonstrating that oral & small intestinal bacteria can modulate IgE-mediated anaphylaxis through metabolic degradation of immunodominant peanut allergens. www.cell.com/cell-host-mi...

Microbes impact peanut allergy Mouth & gut contain peanut-degrading bacteria(Rothia) that metabolize PN allergens. Mice colonized w/Rothia show decreased anaphylaxis & allergic patients w/better PN tolerance have higher abundance of these bacteria www.cell.com/cell-host-mi...

Crisping up Lactobacillus vaginal live biotherapeutics Highlight of 2 papers reporting clinical trials evaluating 3 vaginal live biotherapeutic products containing different Lactobacillus crispatus strain combinations for treatment of bacterial vaginosis. www.cell.com/cell-host-mi...

Lactobacillus crispatus live biotherapeutic for BV Vaginal live biotherapeutic product containing health-associated bacterium L. crispatus prevents bacterial vaginosis recurrence & reduces inflammation. Success depends on pre-treatment vaginal microbiota www.cell.com/cell-host-mi...

VIBRANT: Phase 1 trial of multi-strain L. crispatus for BV Women w/bacterial vaginosis receiving multi-strain vaginal L. crispatus live biotherapeutic 3–7 days post antibiotics showed vaginal colonization up to 12 wks, reducing risk of recurrent BV www.cell.com/cell-host-mi...

How to measure microbiome health? Commentary proposes adaptive coherence: capacity of host-microbiome systems to sustain integrated function via reorganization. Reframes health as emergent & relational, w/measurements of adaptability/functional integrity www.cell.com/cell-host-mi...

Skin microbiota drives cutaneous ICI toxicity Checkpoint inhibitor toxicity is driven by skin microbiota in genetically autoimmune-susceptible mice. Topical antibiotics mitigate ICI averse events w/out compromising anti-tumor efficacy www.cell.com/cell-host-mi...

Leveraging intratumoral probiotics in PDAC B. longum colonizes pancreatic tumors. Rapamycin-induced xenophagy enables B. longum to drive probiotic neoantigen presentation & CD4 T cell-mediated tumor killing, thereby enhancing immune checkpoint blockade www.cell.com/cell-host-mi...

Microbes as architects of colonic patterning Highlight of @cp-cell.bsky.social paper discovering regionalization of colonic epithelium depends on microbes, with proximal identity regulated by microbial nicotinic acid-induced PPARα activation in the epithelium. www.cell.com/cell-host-mi...

C. symbiosum promotes enteric neuron loss in IBD C. symbiosum-derived succinate rewires macrophages to sustain IL-1β, thereby activating neuronal NLRP3 & driving neuron loss. Targeting C. symbiosum w/phage endolysin preserves neurons &dampens inflammation www.cell.com/cell-host-mi...

‘Insane in the membrane’: 2′,3′-cGAMP triggers filamentous phage defense Preview of work reporting bacteria produce 2′,3′-cGAMP, activating SAVED effector that polymerizes into membrane-disrupting filaments, inducing abortive infection www.cell.com/cell-host-mi...

Featured Article: Bacterial 2′,3′-cGAMP triggers membrane disruption to restrict phage In response to phage, CdnB enzymes in CBASS systems synthesize 2′,3′-cGAMP, which activates Cap14 that induces filament formation & premature cell lysis www.cell.com/cell-host-mi...

No sugar, no problem Preview highlighting how neutrophils, which require glucose to combat C. albicans, have a work-around for glucose depletion by fungi. Neutrophils utilize glycogenolysis to generate energy to deploy antifungal effectors www.cell.com/cell-host-mi...

Featured Article: Metabolic flexibility allows neutrophils to fight Candida Upon C. albicans glucose consumption, neutrophils upregulate PYGL-mediated glycogenolysis through a dectin-1/PKA axis, thus sustaining antifungal function in glucose-low tissues www.cell.com/cell-host-mi...

Don’t keep this endopeptidase on the DL Preview highlighting work identifying delayed gut microbiome development in preterm infants as a risk factor for late onset sepsis & proposing a protective regulatory response by NOD2 www.cell.com/cell-host-mi...

Featured Article: Preterm microbiota & sepsis Delayed microbiome maturation in preterm infants mediates Abx-induced late-onset sepsis susceptibility. DL-endopeptidase-producing bacteria prevent murine sepsis via NOD2 & probiotic enhances NOD2 in infants www.cell.com/cell-host-mi...

Female urogenital microbiome: Review by Sarah Lebeer & Co In urogenital tract, dominant lactobacilli shape vaginal immunity & community stability. Review examines molecular strategies & rational design of next-generation microbiome-based therapies www.cell.com/cell-host-mi...

Our April issue is now live! On the cover: Peanut allergy & microbes Bacteria in the oral cavity & small intestine can degrade immunodominant peanut allergens, limiting anaphylaxis www.cell.com/cell-host-mi...