Cell Reports
@cp-cellreports.bsky.social
📤 1118
📥 6
📝 1255
A histone H2A and H2B point mutant library defines essential in vivo functions in Drosophila
loading . . .
A histone H2A and H2B point mutant library defines essential in vivo functions in Drosophila
Sun et al. present a systematic Drosophila histone H2A/H2B point mutant library, enabling residue-specific functional analysis in vivo. Screening 30 conserved residues reveals essential roles in development, fertility, genome stability, and immunity, providing a foundational resource for chromatin biology in multicellular organisms.
http://dlvr.it/TPzkkm
about 6 hours ago
0
0
0
VIP interneuron activity during sleep conveys the cortical infraslow oscillation
loading . . .
VIP interneuron activity during sleep conveys the cortical infraslow oscillation
Sleep promotes memory by reorganizing cortical circuits. Rolle et al. discovered that VIP interneurons, which regulate inhibition, are suppressed during slow-wave sleep but activated during spindles and slow oscillations. Their unique infraslow coupling to spindles, absent in SST and PV interneurons, suggests a specialized role in memory consolidation.
http://dlvr.it/TPzcn7
about 9 hours ago
0
0
0
Mutualist-pathogen co-colonization modulates phosphoinositide signatures at host intracellular interfaces
loading . . .
Mutualist-pathogen co-colonization modulates phosphoinositide signatures at host intracellular interfaces
Using phosphoinositide biosensors in Nicotiana benthamiana, Guyon et al. show that mutualist and pathogen interfaces display distinct membrane lipid signatures. During co-colonization, host phosphatidylinositol-4-phosphate is recruited to pathogen structures, and resistance is enhanced, revealing dynamic remodeling of host membrane identity that shapes interaction outcomes.
http://dlvr.it/TPzMNp
about 14 hours ago
0
2
1
DEC1 regulates human β cell functional maturation and circadian rhythm
loading . . .
DEC1 regulates human β cell functional maturation and circadian rhythm
Preza et al. show that DEC1, a circadian clock regulator, promotes mature insulin responses to glucose stimulation in human stem cell-derived islet organoids. DEC1 is restricted to maturing β cells, where it regulates circadian insulin responsiveness, respiration, and mitochondrial turnover, highlighting circadian control as a lever to enhance islet organoid functionality.
http://dlvr.it/TPzFcM
about 16 hours ago
0
2
0
Paracrine stimulation of brown adipose tissue vascularization by adipocyte O-GlcNAc signaling
loading . . .
Paracrine stimulation of brown adipose tissue vascularization by adipocyte O-GlcNAc signaling
Brown adipose tissue is extensively vascularized, which is essential for its physiological activities. Li et al. show that nutrient/stress-sensing O-GlcNAc signaling in brown adipocytes dynamically adapts to environmental stimuli to stimulate brown adipose tissue vascularization and thermogenesis via a KCP-mediated paracrine mechanism.
http://dlvr.it/TPyns7
1 day ago
0
0
0
Mycobacteria trehalose dimycolate interactions with host Mincle remodel blood-brain barrier junctions for brain invasion
loading . . .
Mycobacteria trehalose dimycolate interactions with host Mincle remodel blood-brain barrier junctions for brain invasion
Using a zebrafish model of brain infection, Hayes et al. find that mycobacteria infect the brain not within macrophages, but as extracellular bacteria that attach to endothelial cells of the blood-brain barrier. Using a glycolipid, mycobacteria trigger the opening of gaps in endothelial cell junctions, allowing transit into the brain.
http://dlvr.it/TPygb3
1 day ago
0
1
0
Q&A with Laura B. Duvall
loading . . .
Q&A with Laura B. Duvall
Cell Reports' editor Jorge Santos spoke with Dr. Laura B. Duvall about her research focusing on the regulation of innate behaviors in mosquitoes, namely feeding and reproduction. In this conversation, Dr. Duvall spotlights her recent work in Cell Reports that describes the circadian control of egg laying in Aedes aegypti females.
http://dlvr.it/TPyPkR
1 day ago
0
0
0
Cancer cells transfer invasive properties through microRNAs contained in collagen tracks
loading . . .
Cancer cells transfer invasive properties through microRNAs contained in collagen tracks
Rouyer et al. reveal that cancer cells leave behind collagen-bound membrane debris during migration along collagen fibrils, which can transfer invasive traits to nearby non-invasive cells. These structures, named collagen tracks, represent a previously unknown way of communication between tumor cells, highlighting a potential target to limit cancer progression.
http://dlvr.it/TPyHhb
1 day ago
0
2
0
Tracing the origin of testosterone-producing Leydig cells during pubertal development, homeostasis, and regeneration
loading . . .
Tracing the origin of testosterone-producing Leydig cells during pubertal development, homeostasis, and regeneration
Leydig cells are central to the development and homeostasis of male reproductive functions. Yu et al. identify a postnatal Gli1+ progenitor population that gives rise to Leydig cells during puberty and also contributes to their turnover and response to injury, providing a framework for understanding postnatal Leydig cell dynamics.
http://dlvr.it/TPxqfp
2 days ago
0
1
0
Aryl hydrocarbon receptor-induced activation of AIM2 inflammasome is mediated by MOMP and MPT: A vital therapeutic pathway for inflammation
loading . . .
Aryl hydrocarbon receptor-induced activation of AIM2 inflammasome is mediated by MOMP and MPT: A vital therapeutic pathway for inflammation
Chen et al. demonstrate that AHR activation by 8:2 FTOH triggers MOMP/MPT via F1F0ATPase inhibition and BAX/BAK upregulation, inducing mtDNA leakage and AIM2 inflammasome activation. This study establishes AHR as a mitochondrial DAMP signaling hub and proposes therapeutic targets for PFAS-induced inflammation.
http://dlvr.it/TPxkwg
2 days ago
0
1
0
Microglial macrophage-derived ds-HMGB1 in DRG orchestrates neuropathic pain through immune-neural signaling
loading . . .
Microglial macrophage-derived ds-HMGB1 in DRG orchestrates neuropathic pain through immune-neural signaling
Oxaliplatin-induced peripheral neuropathy (OIPN) arises when DRG M-TRMφs oxidize and release disulfide HMGB1. This alarmin activates neuronal TLR4 to upregulate TRPV1 and drive allodynia. Inhibiting PDIA3 or GSDMD or neutralizing ds-HMGB1 reduces pain without impairing chemotherapy. Patient serum ds-HMGB1 correlates with neuropathic pain severity in OIPN, suggesting a biomarker and target.
http://dlvr.it/TPxYYG
3 days ago
0
0
0
Chimeric human organoid and mouse brain slice co-cultures to study microglial function
loading . . .
Chimeric human organoid and mouse brain slice co-cultures to study microglial function
Panagiotakopoulou et al. developed a co-culture system combining human cerebral organoids and mouse brain slices. The model supports long-term study of human microglia, enhances cortical marker expression and CSF1 release in organoids, and is associated with the preferential migration of human microglia into organoids within a structured neural environment.
http://dlvr.it/TPxTR6
3 days ago
0
0
0
Neuronal hyperactivity becomes mTORC1 independent due to transcriptional changes in tuberous sclerosis complex disease models
loading . . .
Neuronal hyperactivity becomes mTORC1 independent due to transcriptional changes in tuberous sclerosis complex disease models
Tuberous sclerosis complex is a genetic disorder associated with neurological symptoms that have been attributed to mTOR signaling. In this work, Afshar-Saber et al. demonstrate that altered mTOR activity disrupts neuronal differentiation and changes in DNA methylation. This results in rapamycin, an mTOR inhibitor, being ineffective in rescuing neuronal hyperactivity after maturation.
http://dlvr.it/TPx7F6
3 days ago
0
3
2
Post-biting behavioral reprogramming underlies reproductive efficiency in Aedes aegypti mosquitoes
loading . . .
Post-biting behavioral reprogramming underlies reproductive efficiency in Aedes aegypti mosquitoes
Population growth of pathogen-spreading mosquitoes relies on efficient egg laying. Dong et al. report the behavioral reprogramming that occurs after a blood meal: daytime-biting Aedes aegypti mosquitoes becomes hyperactive and show nocturnal humidity-seeking and egg-laying activity. The clock gene cycle is required for the proper timing and efficiency of egg laying.
http://dlvr.it/TPx2TN
3 days ago
0
3
1
The lifespan evolution of individualized neurophysiological traits
loading . . .
The lifespan evolution of individualized neurophysiological traits
da Silva Castanheiro et al. examine the development of individualized brain activity across a person’s life. Rhythmic brain activity distinguishes individuals across age groups, with activity in sensory and motor regions becoming increasingly distinctive in early adulthood. These developmental changes in individualized brain activity align with specific patterns of cortical gene expression.
http://dlvr.it/TPwrV0
4 days ago
0
0
0
The exit of naive pluripotency contains a metabolism-induced checkpoint for telomere homeostasis
loading . . .
The exit of naive pluripotency contains a metabolism-induced checkpoint for telomere homeostasis
de Souza et al. uncover a telomere length checkpoint triggered by metabolic remodeling during the transition from naive to formative pluripotency in mouse ESCs. Acute shifts in mitochondrial respiration and lipid biosynthesis induce transient telomere shortening and ZSCAN4 activation, linking metabolic state to telomere homeostasis in early development.
http://dlvr.it/TPwlps
4 days ago
0
0
0
Extrachromosomal circular miRNA-gene amplifications contribute to the renal cancer phenotype
loading . . .
Extrachromosomal circular miRNA-gene amplifications contribute to the renal cancer phenotype
Han et al. show that small extrachromosomal circular DNAs carrying miRNA genes are recurrently formed in renal cancer and promote tumor cell proliferation. These findings reveal that small eccDNAs act as functional genetic elements contributing to cancer progression.
http://dlvr.it/TPwMxc
4 days ago
0
1
1
Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia
loading . . .
Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia
Trinh et al. show that mutant GNAS promotes pyloric-type differentiation and reprograms glycosylation in pancreatic cystic precancerous lesions. This indolent program slows progression, and glycan signatures distinguish low- from high-grade IPMN.
http://dlvr.it/TPwFM3
4 days ago
0
0
0
Age- and cell-type-specific effects of histone variant H2BE in the brain
loading . . .
Age- and cell-type-specific effects of histone variant H2BE in the brain
Louzon et al. demonstrate that the histone variant H2BE is highly expressed in astrocytes and accumulates in both neurons and astrocytes with age. H2BE is required in both neurons and astrocytes for proper synaptic function and has divergent effects on gene expression and mouse cognition in young and old mice.
http://dlvr.it/TPvyjj
5 days ago
0
0
0
Revisiting the dispersal history of walnut by analyzing the ancient DNA of walnut remains in Xinjiang, China
loading . . .
Revisiting the dispersal history of walnut by analyzing the ancient DNA of walnut remains in Xinjiang, China
Zhang et al. use ancient genomes from Xinjiang walnuts to reveal their earliest genetic diversity and connections to modern accessions for phylogenetic analysis. The study re-clarifies walnut origins, dispersal routes, and gene flow, highlights Xinjiang as a key hub, and demonstrates the value of ancient plant genomes for understanding crop evolution.
http://dlvr.it/TPvrHS
5 days ago
0
0
0
Cancer-associated fibroblast-derived fibulin-5 promotes radioresistance in non-small-cell lung cancer
loading . . .
Cancer-associated fibroblast-derived fibulin-5 promotes radioresistance in non-small-cell lung cancer
(Cell Reports 44, 116018; August 26, 2025)
http://dlvr.it/TPvJnc
5 days ago
0
0
0
ESAT-6 and CFP-10 reactive IgG in patients with tuberculosis inhibits intracellular bacteria
loading . . .
ESAT-6 and CFP-10 reactive IgG in patients with tuberculosis inhibits intracellular bacteria
Antibodies represent a well-established arm of immunity in many infectious diseases, but their role in tuberculosis is underappreciated. This study identifies key characteristics of antibodies in human TB that target the mycobacterial virulence factors ESAT-6 and CFP-10 and restrict intracellular Mycobacterium tuberculosis, showing the potential for humoral immunity to protect.
http://dlvr.it/TPv9jP
5 days ago
0
0
0
Linking functional activity and connectivity of neuronal circuits via fast cross-layer all-optical physiology
loading . . .
Linking functional activity and connectivity of neuronal circuits via fast cross-layer all-optical physiology
Liu et al. present a cross-layer all-optical physiology (CLAOP) system enabling simultaneous cross-plane imaging and optogenetic stimulation with high temporal resolution. The system links activity patterns during behavior to functional connectivity across cortical layers in the visual and somatosensory cortex, advancing functional activity-connectivity coupling analysis with high temporal precision.
http://dlvr.it/TPttnL
6 days ago
0
1
0
eIF3d and eIF3e mediate selective translational control of hypoxia that can be inhibited by small molecules
loading . . .
eIF3d and eIF3e mediate selective translational control of hypoxia that can be inhibited by small molecules
Purdy et al. report that eIF3e/eIF3d are required for hypoxia-induced selective mRNA translation and induction of pro-metastatic phenotypes. eIF3e and eIF3d RNA signatures correlate with worsened overall survival in patients with breast cancer, and the acute translational hypoxic response mediated by eIF3e/eIF3d can be inhibited by novel small molecules.
http://dlvr.it/TPtlvx
6 days ago
0
2
1
Context-dependent inhibitory roles of RhoA in 3D invasive cell migration within the extracellular matrix
loading . . .
Context-dependent inhibitory roles of RhoA in 3D invasive cell migration within the extracellular matrix
Iwata et al. show that the small GTPase RHOA regulates cell invasion in 3D environments, with effects shaped by ECM composition and cellular context. They demonstrate that RHOA knockout slows pancreatic tumor progression in a mouse model, highlighting unique opportunities for therapeutic strategies targeting RHOA in cancer.
http://dlvr.it/TPtD8P
6 days ago
0
1
0
Nuclear exosome targeting complex safeguards hematopoietic stem cell self-renewal and genomic integrity through resolving R loops
loading . . .
Nuclear exosome targeting complex safeguards hematopoietic stem cell self-renewal and genomic integrity through resolving R loops
R loops form during transcription, threatening the genomic stability of hematopoietic stem cells (HSCs) and lymphoma cells. Pan et al. report that ZCCHC8 safeguards the genome integrity and self-renewal capacity of HSCs by resolving transcription-coupled R loops, and they also position ZCCHC8 as a potential therapeutic target for diffuse large B cell lymphoma.
http://dlvr.it/TPt59y
6 days ago
0
2
0
Keratinocyte differentiation transcription factor ZNF750 coordinates the development of epidermal immunocytes
loading . . .
Keratinocyte differentiation transcription factor ZNF750 coordinates the development of epidermal immunocytes
The coordinated development of immunocytes within the skin is a mystery. Adar et al. show that the epidermal transcription factor ZNF750, an essential driver of keratinocyte differentiation, also regulates epidermis-resident immunocyte development, coupling physical-immunological barrier formation.
http://dlvr.it/TPsp59
7 days ago
0
4
0
LL-37 transports immunoreactive cGAMP to activate STING signaling and enhance interferon-mediated host antiviral immunity
loading . . .
LL-37 transports immunoreactive cGAMP to activate STING signaling and enhance interferon-mediated host antiviral immunity
(Cell Reports 39, 110880; May 31, 2022)
http://dlvr.it/TPsgHf
7 days ago
0
1
0
circATF6 triggers calcium overload to synergize with EGFR-TKI in non-small cell lung cancer via modulation of proteostasis
loading . . .
circATF6 triggers calcium overload to synergize with EGFR-TKI in non-small cell lung cancer via modulation of proteostasis
Hu et al. identify circATF6 as a key regulator of drug-tolerant persister (DTP) cells, a crucial intermediate state leading to EGFR-TKI resistance in NSCLC. By binding BiP, this circRNA impairs the fragile protein homeostasis in DTP cells and selectively eliminates them, offering a new strategy to target DTP cells.
http://dlvr.it/TPs8Jc
7 days ago
0
0
0
Jub-induced phosphorylation of Warts inhibits its activity and recruitment into biomolecular condensates
loading . . .
Jub-induced phosphorylation of Warts inhibits its activity and recruitment into biomolecular condensates
This study identifies the phosphorylation of the disordered N-terminal region of Warts as a mechanism that reduces its activity by limiting its recruitment into protein condensates formed by upstream activators, including Expanded and Kibra, thereby offering new insights into how post-translational modifications can influence Hippo signaling through biomolecular phase separation.
http://dlvr.it/TPs1ww
7 days ago
0
0
0
In toto imaging shows intravascular proliferation promotes transmigration of daughter cells during brain invasion of Cryptococcus neoformans
loading . . .
In toto imaging shows intravascular proliferation promotes transmigration of daughter cells during brain invasion of Cryptococcus neoformans
Wang et al. develop an in toto imaging approach to reveal the major route of blood-brain barrier transmigration by a brain-invading fungal pathogen Cryptococcus neoformans. They find that capillary-residing fungal mother cells proliferate intravascularly to send their daughter cells to the abluminal side.
http://dlvr.it/TPrlLk
8 days ago
0
0
0
Post-translational switch of DHCR24 acetylation sustains sterol synthesis and promotes HCC via the 7-ketocholesterol/p62 axis
loading . . .
Post-translational switch of DHCR24 acetylation sustains sterol synthesis and promotes HCC via the 7-ketocholesterol/p62 axis
Zhou et al. identify DHCR24 acetylation at Lys254 as a key metabolic switch in hepatocellular carcinoma. This modification stabilizes DHCR24, enhances cholesterol synthesis, and promotes 7-ketocholesterol-p62 signaling to drive tumor growth. Pharmacologic inhibition of DHCR24 with irbesartan suppresses DHCR24 acetylation and tumor progression, revealing a potential therapeutic target for HCC.
http://dlvr.it/TPrcxy
8 days ago
0
0
0
Quiescent ILC1 cells confer protection against MCMV infection during undernutrition
loading . . .
Quiescent ILC1 cells confer protection against MCMV infection during undernutrition
Tatematsu et al. show that, under caloric restriction, hepatic ILC1 cells preferentially survive by adopting an mTORC1-dependent quiescent state with enhanced glucose uptake and oxidative phosphorylation. This adaptation provides protection against MCMV infection during undernutrition.
http://dlvr.it/TPr68P
8 days ago
0
0
0
Sec61 translocon inhibitor flavitransin blocks selectively dengue virus polyprotein insertion in the ER with pan-orthoflavivirus antiviral potency
loading . . .
Sec61 translocon inhibitor flavitransin blocks selectively dengue virus polyprotein insertion in the ER with pan-orthoflavivirus antiviral potency
Verhaegen et al. demonstrate that Sec61 inhibitor flavitransin selectively targets translocon insertion and ER membrane integration of the first, N-terminal transmembrane domain of the dengue virus polyprotein. As a result, flavitransin inhibits viral replication and the production of infectious virus and also of related orthoflaviviruses such as Zika virus.
http://dlvr.it/TPr005
8 days ago
0
0
0
SRM1 phosphorylation coordinates plant immunity and growth in Arabidopsis
loading . . .
SRM1 phosphorylation coordinates plant immunity and growth in Arabidopsis
Liu et al. demonstrate that the MYB transcription factor SRM1 promotes plant growth by activating PORA expression and enhances plant disease resistance by triggering DFR and EDS1 expression. SRM1 coordinates growth defense through transcriptional regulation and post-translational modifications.
http://dlvr.it/TPqjv5
9 days ago
0
0
0
Purmorphamine exerts anti-obesity effects by enhancing secretin-activated brown fat thermogenesis
loading . . .
Purmorphamine exerts anti-obesity effects by enhancing secretin-activated brown fat thermogenesis
Zhang et al. show that purmorphamine reduces body weight in diet-induced obese mice by potentiating secretin-activated thermogenesis in brown adipose tissue. The compound acts synergistically with secretin to enhance mitochondrial respiration and lipolysis in brown adipocytes via the secretin receptor, thereby increasing energy expenditure.
http://dlvr.it/TPqbb7
9 days ago
0
1
0
Selective decoupling of IgG1 binding to viral Fc receptors restores antibody-mediated NK cell activation against HCMV
loading . . .
Selective decoupling of IgG1 binding to viral Fc receptors restores antibody-mediated NK cell activation against HCMV
Antibodies targeting human cytomegalovirus (HCMV) are undermined by viral immune evasion strategies, including capture of the Fc. Qerqez et al. engineer human Fc variants with markedly reduced binding to two viral Fc receptors. Engineered antibodies mediate enhanced CD16A-activation against HCMV-infected fibroblasts and limit viral spread more effectively than non-engineered antibodies.
http://dlvr.it/TPq5fc
9 days ago
0
3
1
Interleukin-1/Toll-like receptor signaling potentiates macrophage olfactory receptor 2-driven atherosclerosis
loading . . .
Interleukin-1/Toll-like receptor signaling potentiates macrophage olfactory receptor 2-driven atherosclerosis
Zhang et al. demonstrate that IL-1R1/TLR signaling enhances atherosclerosis by disrupting β-arrestin-2 (βarr2)-mediated OR6A2 internalization in macrophages. This shift, driven by βarr2K295 deSUMOylation-dependent TRAF6-βarr2 coupling, sustains NLRP3 inflammasome activation. Targeting this pathway may offer therapeutic strategies to mitigate inflammation-driven vascular disease.
http://dlvr.it/TPq1C1
9 days ago
0
2
1
DROSHA, DICER, and damage-induced long ncRNA control BMI1-dependent transcriptional repression at DNA double-strand break
loading . . .
DROSHA, DICER, and damage-induced long ncRNA control BMI1-dependent transcriptional repression at DNA double-strand break
Genes near DNA double-strand breaks are silenced through a BMI1-dependent mechanism, while transcription of damage-induced lncRNAs (dilncRNAs), processed by DROSHA and DICER, occurs at break sites. Esposito and Capozzo et al. reconcile these opposing events, showing that the dilncRNA-DROSHA-DICER axis directs BMI1 recruitment, chromatin remodeling, and gene repression.
http://dlvr.it/TPpr8P
10 days ago
0
1
1
NEMO recruitment at single cytokine-receptor complexes shows quantized dynamics independent of ligand affinity
loading . . .
NEMO recruitment at single cytokine-receptor complexes shows quantized dynamics independent of ligand affinity
Kim et al. leverage natural variation in IL-1β affinity across species to show that while ligand affinity sets activation thresholds, each IL-1 receptor signaling complex outputs a fixed, quantized burst of signal. This mechanism provides robustness and specificity to cytokine responses and further defines mechanisms of cytokine signal encoding.
http://dlvr.it/TPpmL5
10 days ago
0
2
1
Cadherin-1-mediated communication at the leader-follower boundary controls mouse breast tumor organoid collective migration
loading . . .
Cadherin-1-mediated communication at the leader-follower boundary controls mouse breast tumor organoid collective migration
Morikis et al. highlight the importance of communication between breast tumor leader cells and follower cells during directional collective migration. Differential roles for cadherin-1 in followers, cadherin-11 in cancer-associated fibroblasts, and cadherin-3 in leaders point to unique properties between cell populations in maintaining a cohesive structure to effectively migrate collectively.
http://dlvr.it/TPpR1q
10 days ago
0
2
1
Multi-site phosphorylation of a transcription factor orchestrates imidacloprid resistance in whitefly
loading . . .
Multi-site phosphorylation of a transcription factor orchestrates imidacloprid resistance in whitefly
Liu et al. show that upregulation of p38 within the MAPK pathway enhances phosphorylation of Eagle at Ser363, while downregulation of PKA_C1 in the PKA pathway reduces phosphorylation of Eagle at Y235 in insecticide resistant B. tabaci. These coordinated changes collectively elevate CYP306A1 transcription and conferring resistance.
http://dlvr.it/TPpLYN
10 days ago
0
2
1
Complement-producing adventitial fibroblasts form an IL-33 alarmin hub that maintains ILC2s during airway allergy
loading . . .
Complement-producing adventitial fibroblasts form an IL-33 alarmin hub that maintains ILC2s during airway allergy
Atakkatan et al. identify a distinct subset of C3+IL-33+ adventitial fibroblasts (AFs) that drives allergic inflammation by maintaining ILC2 responses. In turn, ILC2-derived IL-13 supports AF function, thus engaging in a pro-allergic dialogue that promotes type 2 immunity.
http://dlvr.it/TPp9Fn
11 days ago
0
8
4
Phosphorylation of MAP18 by MPK6 orchestrates microtubule reorganization in Arabidopsis during adaptation to salt stress
loading . . .
Phosphorylation of MAP18 by MPK6 orchestrates microtubule reorganization in Arabidopsis during adaptation to salt stress
MPK6 phosphorylates MAP18 to temporally coordinate microtubule disassembly-reassembly, thereby modulating root growth under salt stress.
http://dlvr.it/TPp54N
11 days ago
0
4
2
SLC44A1 deficiency impedes myelin development in the central nervous system
loading . . .
SLC44A1 deficiency impedes myelin development in the central nervous system
Chen et al. show that oligodendrocyte-enriched SLC44A1 is essential for CNS myelination by supporting choline metabolism and phosphatidylcholine synthesis. Its loss impairs oligodendrocyte maturation and myelin formation, while citicoline supplementation rescues these defects, offering a therapeutic strategy for SLC44A1-related myelin disorders.
http://dlvr.it/TPnjCP
11 days ago
0
1
0
Presynaptic GABAA receptors control integration of nicotinic input onto dopaminergic axons in the striatum
loading . . .
Presynaptic GABAA receptors control integration of nicotinic input onto dopaminergic axons in the striatum
Brill-Weil et al. show that axonal GABAA receptors regulate excitatory nicotinic input onto the axons of dopaminergic neurons. This regulation alters integration of the subthreshold nicotinic input to impact axonal action potential output in the striatum.
http://dlvr.it/TPnbDs
11 days ago
0
0
0
FoxP3 forms a head-to-head dimer in vivo and stabilizes its multimerization on adjacent microsatellites
loading . . .
FoxP3 forms a head-to-head dimer in vivo and stabilizes its multimerization on adjacent microsatellites
The transcription factor FoxP3 binds DNA through two modes: multimerization on TnG repeats to stabilize chromatin loops and head-to-head dimerization on inverted forkhead motifs. Pull-down sequencing reveals relaxed motifs enabling head-to-head binding, which seeds FoxP3 multimerization on adjacent microsatellites. This dual strategy expands FoxP3’s sequence repertoire and chromatin-architectural function.
http://dlvr.it/TPnKDV
12 days ago
0
1
0
CD8+MT+ effector T cells from enlarged tumor-draining lymph nodes enhanced anti-tumor immunity and improved prognosis in colorectal cancer
loading . . .
CD8+MT+ effector T cells from enlarged tumor-draining lymph nodes enhanced anti-tumor immunity and improved prognosis in colorectal cancer
Jiang et al. performed single-cell and bulk RNA-seq on tumor-draining lymph nodes from patients with CRC, revealing enlarged, non-metastatic TDLN-enriched CD8+MT+ effector T cells with a stress-adapted phenotype and heightened cytotoxicity. A high level of CD8+MT+ effector T cells within tumor is associated with better survival of patients.
http://dlvr.it/TPnC22
12 days ago
0
0
0
Potentiation of noncanonical NF-κB signaling and marginal zone B cell expansion by CARD11-mediated regulation of p100 processing
loading . . .
Potentiation of noncanonical NF-κB signaling and marginal zone B cell expansion by CARD11-mediated regulation of p100 processing
Ghosh et al. report that activated forms of the CARD11 signaling scaffold potentiate the noncanonical NF-κB pathway through post-transcriptional regulation of the p100 NF-κB subunit. They reveal a regulatory step in B cell homeostasis whose dysregulation likely contributes to the aberrant proliferation of lymphomas that harbor CARD11 gain-of-function mutations.
http://dlvr.it/TPmgZS
12 days ago
0
0
0
Inhibiting peripheral serotonin activates liver AMPK and reduces monocyte-derived macrophages and fibrosis
loading . . .
Inhibiting peripheral serotonin activates liver AMPK and reduces monocyte-derived macrophages and fibrosis
Using a new mouse model that mimics human MASH, Batchuluun et al. show that inhibiting peripheral serotonin synthesis prevents metabolic-dysfunction-associated steatohepatitis and liver fibrosis independently of body weight and adiposity. This protective effect occurs via AMPK-dependent suppression of monocyte release, reducing monocyte-derived liver macrophages and ameliorating obesity-associated liver fibrosis.
http://dlvr.it/TPmXs4
12 days ago
0
0
0
Load more
feeds!
log in
