Cell Reports
@cp-cellreports.bsky.social
š¤ 1032
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š 1064
Identification of molecular markers and exploration of the oncogenic role of exomeres in hepatocellular carcinoma
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Identification of molecular markers and exploration of the oncogenic role of exomeres in hepatocellular carcinoma
This study isolates extracellular vesicles and particles (EVPs) from hepatocellular carcinoma (HCC) cells. Biophysical and proteomic analyses demonstrate that sEVs and exomeres are distinctive entities. GALNS and MAN2B1 are identified as potential EM markers. HCC-derived EMs promote oncogenesis via several mechanisms, including PI3K/AKT/mTOR activation, cell cycle progression, and lipidomic dysregulation.
http://dlvr.it/TP6wRv
about 4 hours ago
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Chromatin remodeling activity of EP400 safeguards chromosomal stability by preventing CENP-A mislocalization
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Chromatin remodeling activity of EP400 safeguards chromosomal stability by preventing CENP-A mislocalization
Sethi et al. define a molecular role for the ATP-dependent chromatin remodeler EP400, a core subunit of the NuA4 HAT complex, in preventing CENP-A mislocalization for chromosomal stability. Cells defective for EP400 function cause mislocalization of CENP-A to non-centromeric regions in a DAXX-dependent manner, leading to CIN phenotypes.
http://dlvr.it/TP6n0K
about 7 hours ago
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Siderophore-mediated iron enrichment in the biofilm matrix enhances plant iron nutrition
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Siderophore-mediated iron enrichment in the biofilm matrix enhances plant iron nutrition
Tan et al. reveal that Bacillus velezensis biofilms accumulate Fe on roots, serving as Fe reservoirs to make Fe more accessible to the host plant. The bacterial siderophore bacillibactin plays a dual role by promoting Fe accumulation in the biofilms and activating plant Fe-deficiency responses.
http://dlvr.it/TP6SmW
about 13 hours ago
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Oncogenic Ras activation in permissive somatic cells triggers rapid-onset phenotypic plasticity and elicits a tumor-promoting neutrophil response
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Oncogenic Ras activation in permissive somatic cells triggers rapid-onset phenotypic plasticity and elicits a tumor-promoting neutrophil response
Ras mutations drive tumorigenesis yet persist in normal tissues. Elliot et al. explore this paradox, finding that HRASG12V induces bifurcating cell fates in the zebrafish larval epidermis, with lamc2+krt18+ cancer stem cell-like cells emerging from permissive cells at the preneoplastic stage and expressing neutrophil-modulating cytokines that instigate reciprocal tumor-supportive crosstalk.
http://dlvr.it/TP6KlZ
about 15 hours ago
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Bacterial metabolite patterns of infants receiving multi-strain probiotics and risk of late-onset sepsis
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Bacterial metabolite patterns of infants receiving multi-strain probiotics and risk of late-onset sepsis
Waschina et al. explored how multi-strain probiotic supplementation influenced the gut microbiome and metabolome in very-low-birth-weight infants at high risk of late-onset sepsis. Probiotics promote colonization with beneficial microbes and reduce antibiotic-resistant pathobionts. Late-onset sepsis is associated with lower levels of key fermentation products (lactate and acetate) of probiotics.
http://dlvr.it/TP5m2d
1 day ago
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Health-associated key gut microbiota drives the variation in community metabolic interactions in non-human primates
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Health-associated key gut microbiota drives the variation in community metabolic interactions in non-human primates
Gao et al. reveal that the metabolic interactions of gut microbial community are driven by the key competitive and cooperative microbiota, which are potentially associated with non-human primate health. The study improves our understanding of the complex interactions in microbial community, providing potential avenues to therapeutic implications.
http://dlvr.it/TP5cpp
1 day ago
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Expansion of secreted cystine knot proteins reveals virulence factors in the human fungal pathogen Histoplasma
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Expansion of secreted cystine knot proteins reveals virulence factors in the human fungal pathogen Histoplasma
Rodriguez et al. employ bioinformatic analyses to discover effectors involved in the virulence of the understudied human fungal pathogen Histoplasma and uncover an expansion of knottins (inhibitor cystine knot proteins). Their algorithms are broadly applicable to other organisms and uncover virulence effectors with diverse predicted structures.
http://dlvr.it/TP5JMR
1 day ago
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PreTA-mediated metabolism of 5-fluorouracil by intratumoral Citrobacter freundii drives chemoresistance in pancreatic cancer
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PreTA-mediated metabolism of 5-fluorouracil by intratumoral Citrobacter freundii drives chemoresistance in pancreatic cancer
Xu et al. report that intratumoral Citrobacter enrichment correlates with poor overall survival in pancreatic cancer patients. An intratumoral Citrobacter freundii strain metabolizes 5-fluorouracil (5-FU) into inactive products via PreTA. Gimeracil, an inhibitor of human dihydropyrimidine dehydrogenase, preserves 5-FU efficacy by blocking PreTA activity.
http://dlvr.it/TP58hj
1 day ago
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Cyclin switch tailors a cell cycle variant to orchestrate multiciliogenesis
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Cyclin switch tailors a cell cycle variant to orchestrate multiciliogenesis
(Cell Reports 44, 115103, January 28, 2024)
http://dlvr.it/TP4Y9Y
2 days ago
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Integrating mutation, copy number, and gene expression data to identify driver genes of recurrent chromosome-arm losses
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Integrating mutation, copy number, and gene expression data to identify driver genes of recurrent chromosome-arm losses
Saad et al. present a comprehensive framework that combines mutation, copy number, and expression data to identify 322 candidate genes driving recurrent chromosome-arm losses across 20 cancer types. Additionally, the study links these drivers to altered cellular pathways, providing a resource for understanding how aneuploidy promotes cancer.
http://dlvr.it/TP4PYm
2 days ago
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Optimal CXCR5 expression during Tfh maturation involves the Bhlhe40-Pou2af1 axis
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Optimal CXCR5 expression during Tfh maturation involves the Bhlhe40-Pou2af1 axis
The Bcl6-Blimp-1 axis plays a critical role in follicular T helper (Tfh) cell fate determination; however, the regulation of CXCR5 expression during Tfh maturation is still elusive. Zhu et al. report that the Bhlhe40-Pou2af1 pair regulates optimal expression of CXCR5 and Tfh cell migration into germinal centers without affecting Bcl6 induction.
http://dlvr.it/TP44xl
3 days ago
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Distinct immunity protein families mediate compartment-specific neutralization of a bacterial toxin
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Distinct immunity protein families mediate compartment-specific neutralization of a bacterial toxin
Alcock et al. show that the Staphylococcus aureus type VII-secreted toxin EsxX has membrane depolarizing activity and is toxic to S. aureus from both the cytoplasmic and periplasmic sides of the membrane. Two distinct families of immunity proteins protect against the cytoplasmic and periplasmic forms of the toxin, respectively.
http://dlvr.it/TP3xZQ
3 days ago
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Nuclear U1 snRNA facilitates the dimerization of hnRNPA2B1 to enhance anti-DNA viral innate immunity
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Nuclear U1 snRNA facilitates the dimerization of hnRNPA2B1 to enhance anti-DNA viral innate immunity
Zhang et al. report that nuclear U1 snRNA promotes antiviral innate immunity against HSV-1 infection by facilitating hnRNPA2B1-mediated IFN-I and ISG induction. This study demonstrates an important role of nuclear U1 snRNA in boosting anti-DNA viral innate immunity and provides strategies for restricting DNA virus infection.
http://dlvr.it/TP3L1v
3 days ago
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BET family BRD3 initiates DSB-induced chromatin remodeling with TIP60 to promote R-loop-mediated HR
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BET family BRD3 initiates DSB-induced chromatin remodeling with TIP60 to promote R-loop-mediated HR
We provide the mechanisms of genomic stability on actively transcribed loci to prevent cancer development. BRD3 initiates DSB-induced chromatin remodeling by CHD4 and TIP60 on actively transcribed loci to promote R-loop-mediated HR. Thus, BRD3 deficiency reduces HR and increases the potential mutagenic NHEJ pathway and is linked to HRD cancer.
http://dlvr.it/TP3BhV
3 days ago
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Muscle spindles provide flexible sensory feedback for movement sequences
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Muscle spindles provide flexible sensory feedback for movement sequences
Olson et al. show mixed encoding of kinematics and task-related variables in jaw muscle spindle afferents of mice performing a complex licking sequence task. Flexible feedback of orofacial kinematics may help achieve task-related behavioral goals.
http://dlvr.it/TP2tXg
4 days ago
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Biphasic inflammation control by fibroblasts enables spinal cord regeneration in zebrafish
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Biphasic inflammation control by fibroblasts enables spinal cord regeneration in zebrafish
Fibrosis and persistent inflammation are interconnected processes that inhibit axon regeneration in the mammalian central nervous system. John et al. show that in zebrafish, the regulatory interplay between fibroblasts and immune cells is required for regeneration.
http://dlvr.it/TP2lLk
4 days ago
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A bacterial exotoxin-triggered plant immune response restricts pathogen growth
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A bacterial exotoxin-triggered plant immune response restricts pathogen growth
Thoms et al. demonstrate that perception of a bacterial exotoxin allows plants to distinguish between closely related microbiota, which has consequences for rhizosphere microbiome structure and function. These results suggest that recognition of toxins or the damage they cause may allow plants to distinguish helpful from harmful microbiota.
http://dlvr.it/TP2C64
4 days ago
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Regulatory T cells in skin utilize the Cxcr4-Cxcl12 axis to promote hair follicle regeneration
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Regulatory T cells in skin utilize the Cxcr4-Cxcl12 axis to promote hair follicle regeneration
Cohen et al. show that glucocorticoid receptor-dependent Cxcr4 expression by skin Tregs is partially required for accumulation to Cxcl12-expressing isthmic/infundibular regions of the hair follicle. The Cxcr4/Cxcl12 axis is required for optimal hair growth in mice and is an evolutionally conserved chemotactic pathway in human skin.
http://dlvr.it/TP268c
4 days ago
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Metabolic regulation of immunity in the tumor microenvironment
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Metabolic regulation of immunity in the tumor microenvironment
Tumors exploit metabolic stress to exhaust immune cells, while suppressors thrive. In this review, Li et al. highlight how targeting metabolic immune checkpoints may unlock durable immunotherapy.
http://dlvr.it/TP1vZ0
5 days ago
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Non-conjugative plasmids limit their mobility to persist in nature
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Non-conjugative plasmids limit their mobility to persist in nature
Sabnis et al. explain why non-conjugative plasmids move at a low rate in nature. While increased mobility can easily evolve by incorporating phage DNA into plasmids, this is disadvantageous because it reduces diversity in populations. This ultimately leaves bacterial populations more vulnerable to being killed, for example by antibiotics.
http://dlvr.it/TP1q1F
5 days ago
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Targeting the hepatic circadian clock concomitant with tyrosine kinase inhibition reverses late-stage hepatocellular carcinoma
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Targeting the hepatic circadian clock concomitant with tyrosine kinase inhibition reverses late-stage hepatocellular carcinoma
Fekry et al. demonstrate that BMAL1-deficient hepatocellular carcinoma (HCC) is highly sensitive to the clock-activating flavonoid nobiletin. When combined with tyrosine kinase inhibitors, nobiletin most effectively halts tumor progression, underscoring the promise of circadian-based chronotherapy to enhance treatment efficacy in HCC.
http://dlvr.it/TP1QNz
5 days ago
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Missense variants in human forkhead transcription factors reveal determinants of forkhead DNA bispecificity
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Missense variants in human forkhead transcription factors reveal determinants of forkhead DNA bispecificity
Most forkhead (FH) transcription factors (TFs) recognize either FKH or FHL DNA binding site motifs, while some FHs bind both motifs. By screening a library of naturally occurring variants and designed mutant FHs for DNA binding activity, King et al. reveal non-DNA-contacting residues that control TF DNA-binding mono-versus bispecificity.
http://dlvr.it/TP1Jgd
5 days ago
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Enhancing pre-sexual and sexual differentiation of Toxoplasma gondii using retinal epithelial cells and intestinal organoids
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Enhancing pre-sexual and sexual differentiation of Toxoplasma gondii using retinal epithelial cells and intestinal organoids
Cancela, S. and Sena, F. et al. establish a non-feline in vitro model that enhances pre-sexual and sexual development of T. gondii. By integrating environmental conditions with genetic manipulation, they achieve synergistic stage conversion, providing an optimized platform to study the parasiteās sexual cycle without relying on feline hosts.
http://dlvr.it/TP14hm
6 days ago
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Med20 regulates myelination in the peripheral nervous system by modulating ferroptosis of Schwann cells
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Med20 regulates myelination in the peripheral nervous system by modulating ferroptosis of Schwann cells
Med20 safeguards peripheral myelination by suppressing Schwann cell ferroptosis. Loss of Med20 in Schwann cells triggers ferroptosis via the DDB1-UHRF1-BACH1-Hmox1 axis, disrupting myelin sheath formation. Pharmacological inhibition of HO-1 (ZnPP) or ferroptosis (Fer-1) rescues myelination defects, revealing a therapeutic strategy for PNS disorders linked to Med20 dysfunction.
http://dlvr.it/TP0zvY
6 days ago
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Sound preferences in mice are sex dependent
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Sound preferences in mice are sex dependent
Sehrawat et al. find that sound preferences, brain responses, and the relationships between them in adulthood in mice are shaped by experience during infancy. These effects were sex dependent.
http://dlvr.it/TP0ZKW
6 days ago
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Multi-environment deep mutational scanning reveals the distribution of temperature-sensitive variants in a bacterial kinase
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Multi-environment deep mutational scanning reveals the distribution of temperature-sensitive variants in a bacterial kinase
Ghose et al. perform multi-temperature deep mutational scanning to provide a comprehensive accounting of variants with altered temperature-dependent behavior in a model kinase, challenging previous assumptions surrounding temperature sensitivity and adaptation. Heat-sensitive variants were distributed across the protein structure and affected expression, whereas heat-resistant variants showed increased enzymatic activity, not stability.
http://dlvr.it/TP0Rjv
6 days ago
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Heat shock induces silent ribosomes and reorganizes mRNA turnover
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Heat shock induces silent ribosomes and reorganizes mRNA turnover
Rahaman et al. show that heat shock leads to monosome accumulation without a corresponding increase in monosome-associated mRNAs, indicating that most monosomes are silent rather than elongation paused. This reduces the median rate of mRNA association with ribosomes, except for mRNAs encoding heat shock proteins, which maintain steady association.
http://dlvr.it/TP08h9
7 days ago
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Regulation of epigenetics and chromosome structure by human ORC2
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Regulation of epigenetics and chromosome structure by human ORC2
(Cell Reports 44, 115816; June 24, 2025)
http://dlvr.it/TP02Ft
7 days ago
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Medullary stromal cells define small intestinal lymph node identity in humans and mice
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Medullary stromal cells define small intestinal lymph node identity in humans and mice
Fatkhullina et al. discover that in humans and mice, the dominant difference between lymph nodes draining the small intestine versus colon and other sites is their stromal cell and macrophage composition. This difference is induced by dietary vitamin A and amplified by the microbiota.
http://dlvr.it/TNzXs3
7 days ago
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Modulation of speed-dependent acetylcholine release in the hippocampus by spatial task engagement
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Modulation of speed-dependent acetylcholine release in the hippocampus by spatial task engagement
Xuan et al. measure release of the brain modulation chemical acetylcholine in the mouse hippocampus with micron scale and sub-second resolution. They find increases in release related to heightened attention states and decreases related to task disengagement. Their findings point to a potential mechanism for spatial memory encoding, storage, and recall.
http://dlvr.it/TNzPC1
7 days ago
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Targeting the UFL1-PARP1 axis amplifies anti-tumor immunity
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Targeting the UFL1-PARP1 axis amplifies anti-tumor immunity
Song et al. demonstrate that UFL1-mediated UFMylation upregulates PARP1 stability and suppresses the cGAS-STING signaling pathway in PDAC. Inhibition of PARP1 UFMylation disrupts DNA repair, activates anti-tumor immunity, and enhances the efficacy of immunotherapy, highlighting UFMylation as a promising therapeutic target in PDAC.
http://dlvr.it/TNz4z6
8 days ago
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STBD1 mediates the crosstalk between glycogen and lipid droplets in clear cell renal cell carcinoma
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STBD1 mediates the crosstalk between glycogen and lipid droplets in clear cell renal cell carcinoma
Wang et al. discover that the glycogen-binding protein STBD1 localizes to lipid droplets (LDs) through myristoylation and mediates the interaction between LDs and glycogen. STBD1 promotes LD biogenesis and lipophagic degradation, and its depletion enhances ferroptosis sensitivity and suppresses tumor growth, serving as a potential therapeutic target in ccRCC.
http://dlvr.it/TNyy9Y
8 days ago
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Deciphering genomic evolution of metastatic organotropism with 535 paired primary lung cancers and metastases
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Deciphering genomic evolution of metastatic organotropism with 535 paired primary lung cancers and metastases
Xie et al. systematically analyzed large genomic datasets of paired primary lung cancers and metastases. They identified two candidate drivers in primary tumors that may promote brain metastases and revealed that brain metastases seed in relatively monoclonal and late fashion, highlighting the distinct genomic evolution trajectory of brain metastasis.
http://dlvr.it/TNyRVN
8 days ago
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Adipose m6A reader YTHDF2 promotes obesity, insulin resistance, and liver steatosis by suppressing Ī²-adrenergic signaling and lipolysis
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Adipose m6A reader YTHDF2 promotes obesity, insulin resistance, and liver steatosis by suppressing Ī²-adrenergic signaling and lipolysis
Zhou et al. identify YTHDF2 as an epitranscriptomic regulator of adipose expansion and dysfunction. YTHDF2 binds to m6A-modified transcripts encoding the Ī²3-receptor, ATGL, and CGI-58, promoting their degradation and, thereby, inhibiting Ī²-adrenergic signaling and lipolysis. YTHDF2 emerges as a long-sought mediator underlying adipose catecholamine resistance and impaired lipolysis in obesity.
http://dlvr.it/TNyJHG
8 days ago
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CCL26 and CXCL12 preserve insulin-sensitizing macrophages in subcutaneous adipose tissue in obesity
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CCL26 and CXCL12 preserve insulin-sensitizing macrophages in subcutaneous adipose tissue in obesity
Jeelani et al. find that subcutaneous adipose tissue (SAT)-specific CCL26 and CXCL12 expression collectively favors the retention of insulin-sensitizing, resident adipose tissue macrophages (ATMs) in SAT compared with visceral adipose tissue (VAT) in obese mice. This helps preserve the protective effect of SAT against insulin resistance in obesity.
http://dlvr.it/TNy0QJ
9 days ago
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Long noncoding RNA-dependent control of Myc transcriptional bursting
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Long noncoding RNA-dependent control of Myc transcriptional bursting
Li et al. show that the chromatin-associated long noncoding RNA Pvt1 is a negative regulator of Myc transcription by increasing local RNA concentration and limiting bursting from the Myc promoter. This mechanism serves to restrain Myc levels and restrict its proliferative and oncogenic activities.
http://dlvr.it/TNxsnl
9 days ago
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The m6A reader IGF2BP2 promotes homologous recombination-mediated DNA repair by eliminating DNA-RNA hybrids
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The m6A reader IGF2BP2 promotes homologous recombination-mediated DNA repair by eliminating DNA-RNA hybrids
DNA-RNA hybrids at double-strand breaks are regulated to ensure efficient homologous recombination. Sun et al. show that IGF2BP2 and DHX9 remove hybrids in an m6A-dependent manner, enabling RAD51 loading and promoting DNA repair, with implications for improving cancer therapy.
http://dlvr.it/TNxM7G
9 days ago
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The olivocerebellar system differentially encodes the effect sensory events exert on behavior
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The olivocerebellar system differentially encodes the effect sensory events exert on behavior
By directly imaging climbing fibers, Scheer and Prsa show that they flexibly encode sensory events, reflecting stimulus identity, behavioral outcome, and even context during idle periods. The value of encoded information scales with event modality and cellās complexity. These findings highlight adaptive, context-sensitive olivocerebellar signaling for organizing multifaceted behavior.
http://dlvr.it/TNxDH6
9 days ago
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DEAD-box helicase DDX24 is essential for endothelial mitochondrial function to maintain the blood-brain barrier
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DEAD-box helicase DDX24 is essential for endothelial mitochondrial function to maintain the blood-brain barrier
Li et al. demonstrate that the RNA helicase DDX24 is essential for maintaining blood-brain barrier (BBB) homeostasis by regulating mitochondrial function in cerebral endothelial cells. Specifically, DDX24 regulates the expression of PPFIA4 by binding to its mRNA and enhancing its stability. This offers a potential therapeutic strategy for BBB-related diseases.
http://dlvr.it/TNwwyj
10 days ago
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Hippocampal sequences represent working memory and implicit timing
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Hippocampal sequences represent working memory and implicit timing
Dorian et al. develop a differential-delayed-non-match-to-sample (dDNMS) task for rodents. Using this olfactory working memory and implicit timing task, they demonstrate that sequential activity in hippocampal CA1 is a shared mechanism for the encoding of working memory and timing.
http://dlvr.it/TNwp29
10 days ago
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Nitrate starvation inhibits stomatal opening via the long-distance CEP1-CEPR2 signaling cascade
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Nitrate starvation inhibits stomatal opening via the long-distance CEP1-CEPR2 signaling cascade
Carbon and nitrogen metabolisms are two fundamental metabolic processes in plants, and their coordination is crucial for optimizing plant growth and development. Wang et al. demonstrate that nitrate starvation interrupts light-induced stomatal opening through a long-distance CEP1-CEPR2-BIK1 signaling cascade, which induces H2O2 accumulation in guard cells, ultimately inhibiting photosynthesis.
http://dlvr.it/TNwJRJ
10 days ago
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Contextual regulation of T follicular helper cell expansion and differentiation into T regulatory type 1 cells by multiple transcription factors
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Contextual regulation of T follicular helper cell expansion and differentiation into T regulatory type 1 cells by multiple transcription factors
Garnica et al. interrogate the role of 20 transcription factors in the differentiation of autoreactive TFH cells into TR1 cells upon repetitive antigen encounters. Eleven of these factors play key roles in cell conversion events along this pathway and regulate the expression of subset-specific signature genes in a context-dependent manner.
http://dlvr.it/TNw9Vs
10 days ago
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Stomach encyclopedia: Combined single-cell and spatial transcriptomics reveal cell diversity and homeostatic regulation of human stomach
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Stomach encyclopedia: Combined single-cell and spatial transcriptomics reveal cell diversity and homeostatic regulation of human stomach
(Cell Reports 42, 113236; October 31, 2023)
http://dlvr.it/TNvt8x
11 days ago
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P-Rex1 limits the agonist-induced internalization of GPCRs independently of its Rac-GEF activity
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P-Rex1 limits the agonist-induced internalization of GPCRs independently of its Rac-GEF activity
P-Rex1 activates Rac downstream of GPCRs to regulate processes ranging from innate immunity to neuronal plasticity, its deregulation contributing to cancer. Here, Baker et al. show that P-Rex1 also controls GPCR trafficking, limiting agonist-induced GPCR internalization through an adapter function. Thus, P-Rex1 promotes GPCR responses in a dual manner.
http://dlvr.it/TNvlcF
11 days ago
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Normal circadian period length requires repression of Npas2 by REV-ERB nuclear receptors
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Normal circadian period length requires repression of Npas2 by REV-ERB nuclear receptors
Loss of REV-ERB nuclear receptors shortens the free-running circadian period. Tackenberg et al. show that the period-shortening phenotype is conserved between the master circadian pacemaker, the SCN, and the peripheral clocks of the liver. The period-shortening phenotype requires the depression of Npas2, a REV-ERB target gene.
http://dlvr.it/TNvJ72
11 days ago
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Algal carbon concentrating drives fatty acid biosynthesis beyond photosynthesis
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Algal carbon concentrating drives fatty acid biosynthesis beyond photosynthesis
You et al. reveal a moonlighting function for the Chlamydomonas reinhardtii carbon-concentrating mechanism (CCM) in lipid biosynthesis. They demonstrate that the pyrenoid, the central organelle of the CCM, supplies a concentrated stream of inorganic carbon to neighboring acetyl-CoA carboxylase condensates, thereby enhancing fatty acid production.
http://dlvr.it/TNvChr
11 days ago
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Antibody evasion and receptor binding of SARS-CoV-2 LP.8.1.1, NB.1.8.1, XFG, and related subvariants
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Antibody evasion and receptor binding of SARS-CoV-2 LP.8.1.1, NB.1.8.1, XFG, and related subvariants
Mellis et al. show that the SARS-CoV-2 JN.1 sublineage has different virological features associated with its recently dominant subvariants. LP.8.1 has greater receptor-binding affinity than earlier strains but not increased antibody evasion, while the more recently dominant XFG and NB.1.8.1 have greater antibody evasion than LP.8.1.1.
http://dlvr.it/TNv2Wx
12 days ago
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CMTR1 directs mitochondrial dynamics during T cell activation through epitranscriptomic regulation of splice isoforms
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CMTR1 directs mitochondrial dynamics during T cell activation through epitranscriptomic regulation of splice isoforms
T cell activation requires increased biosynthesis, which depends on mitochondrial function. Galloway et al. demonstrate that mitochondrial function is regulated by cap methyltransferase CMTR1 during T cell activation. By methylating RNA Pol II-transcribed RNAs, including the spliceosomal U2 snRNA, CMTR1 controls a splicing program that impacts mitochondrial dynamics.
http://dlvr.it/TNtydT
12 days ago
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Glycation-lowering compounds inhibit ghrelin signaling to reduce food intake, lower insulin resistance, and extend lifespan
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Glycation-lowering compounds inhibit ghrelin signaling to reduce food intake, lower insulin resistance, and extend lifespan
Wimer et al. identify Gly-Low, a combination of glycation-reducing compounds, as a promising therapeutic to reduce food intake and extend lifespan in mice by targeting glycolytic detoxification and appetite-regulating pathways. These findings suggest a strategy for combating obesity and age-associated decline, offering an alternative to traditional caloric restriction.
http://dlvr.it/TNtdZZ
12 days ago
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A VIPP1-associated protein VIA1 involved in thylakoid membrane biogenesis diversifies the chloroplast ESCRT landscape
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A VIPP1-associated protein VIA1 involved in thylakoid membrane biogenesis diversifies the chloroplast ESCRT landscape
Yilmazer et al. identify the VIPP1 interactome in Arabidopsis. VIPP1-Associated 1 (VIA1) emerges as a significant, evolutionarily conserved VIPP1-interacting partner. Mutants lacking VIA1 show delayed chloroplast development in newly emerging leaf tissue. This study establishes VIA1 as a critical regulator of thylakoid membrane formation in coordination with VIPP1.
http://dlvr.it/TNtY7T
12 days ago
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