#JEMLegacy @jem.org goes back to 1930 with the first description by William Tillett and Thomas Francis Jr. of C-reactive protein (CRP) in the sera of patients during the acute phase of pneumococcal pneumonia. @RockUPress @RockefellerUniv rupress.org/jem/article/...

#WeekendRead! #SmartTumor #EveryCellIsAnImmuneCell! Levy & (many) friends show @cp-cell.bsky.social that melanoma tumors release large extracellular vesicles #melanosomes decorated with MHC-I & high affinity tumor associated antigens which subvert cytotoxic T cells! www.cell.com/cell/fulltex...

9/ Read the paper here 👉 onlinelibrary.wiley.com/doi/10.1002/... And stay tuned — exciting new discoveries on liver Tregs are coming soon 👀🧬

Highly recommended 👇👇👇

#WeekendRead! #EveryCellIsAnImmuneCell! #MysterySolved! Clevers &co reveal @nature the differentiation trajectory of human intestinal M cells & show they respond to GM-CSF, express PRRs, & present antigen via MHC-II as dendritic cells, contributing to anti-gluten responses! doi.org/10.1038/s415...

I am excited to share our new paper @JExpMed led by our one and only #Alejandra_Aroca

Always fun to spend time outside the lab with such an amazing & passionate group of scientists. #LabHolydaysParty #SecretSanta🎅🏼 #LoveMyLab #LoveScience #LoveImmunology

#WeAreWhatWeEat! Jones &co show @natmetabolism.nature.com that dietary restriction empowers CD8+ T cells within the #tumor microenvironment by potentiating #mitochondrial metabolism via ketone body utilization, limiting T cell exhaustion, & synergizing with anti-PD1 immunotherapy!

#SharingIsCaring, not always! Lou &co show @cp-cellmetabolism.bsky.social that lactate driven by excessive exercise leads to release of muscle mitochondria-derived vesicles that impair cognitive functions by disrupting hippocampal neuron bioenergy via cGAS/STING activation & via PAF!

#WeekendRead! #FriendOrFoe? Yu, Lozinski, Dong, &co show @natneuro.nature.com that host-derived oxidized lipid deposition in the brain supports multiple sclerosis development via microglia dysfunction/replacement by monocyte-derived macrophages & interleukin-1 #IL1 signaling! doi.org/10.1038/s415...

#NeutrophilPower! @dcerezowallis.bsky.social, Rubio-Ponce, Ballesteros, Ng, @drusqui.bsky.social &co present @nature.com NeuMap, a neutrophil atlas across health & disease states in mice (& humans)! So happy to see this out! 💪💪💪 doi.org/10.1038/s415...

#WeekendRead! #FroendsOrFoes?! Benamar, Chatila &co identify @cp-immunity.bsky.social a #GutBrain axis leading to microbiota- & TLR-dependent induction of Notch3+ Tregs in the gut that in multiple sclerosis migrate to the CNS & interacting with microglia become pathogenic Th17 cells!

#NoTimeToDie! Welcome mitoxyperiosis! ⁦‪Kanneganti, Wang‬⁩ &co show ⁦‪@cp-cell.bsky.social that energy starvation via carbon deprivation in the presence of innate immune stimuli triggers a new form of cell death dependent on mitochondria-driven plasma membrane oxidative damage!

Honored to be included in Clarivate's Highly Cited Researcher list for 2025. Working with the best people in the business makes the discoveries easier, and more fun. Cheers to my lab (present and former). @clarivatelsh.bsky.social @bostonchildrens.bsky.social @harvardmed.bsky.social

We're hiring for tenure-track faculty! Please apply if you have interests in immune responses to microbes and/or cancer, immune regulation, microbial infections (bacteria, viruses, parasites, fungi), the microbiota, and/or interests that span these disciplines. arizona.csod.com/ux/ats/caree...

#WeekendRead! #LocationLocationLocation! #EveryCellIsAnImmuneCell! Turley Muller Wu Lane &co show @natimmunol.nature.com that fibroblastic reticular cells in lymph nodes produce Flt3l to support survival & proliferation of dendritic cells allowing T cell responses during immunization or infection!!

Very excited to announce that the first paper from the lab is now live @natcomms.nature.com #mitochondria #immunometabolism This work was led by postdoc Eloise marques with many important contributions from all of our co-authors. Please check it out! www.nature.com/articles/s41...

November is a big month for the lab with *two* new papers by @ehartenian.bsky.social and @alexandraboegli.bsky.social ++ co authors now online. www.embopress.org/doi/full/10....

#InflammasomePower! #EveryCellIsAnImmuneCell! #MysterySolved! @brozlab.bsky.social @alexandraboegli.bsky.social &co show @embojournal.org that in intestinal epithelial cells, NLRP6 senses endosomal damage to trigger GSDMD-dependent IL1 release & pyroptosis against bacterial invasion & more!

New review out in @cp-trendsimmuno.bsky.social! With @valentinavenzin.bsky.social, we revisit IL-27 as a central regulator of CD8⁺ T cell fate — integrating insights from infection, cancer, and autoimmunity, and outlining its therapeutic potential. www.sciencedirect.com/science/arti...

#WeekendRead! #FriendOrFoes?! Zhang &co show @cp-immunity.bsky.social that herpes simplex virus #HSV1 exploits changes in membrane integrity to activate a GPI-anchored hydrolase which degrades cGAMP preventing #cGAS/#STING activation & favoring virus infection www.cell.com/immunity/ful...

#WeekendRead! #EveryCellIsAnImmuneCell! Riedel, Mattavelli, Helal &co show @cp-immunity.bsky.social that fibroblasts in breast cancer metastatic lymph nodes sense tumor-derived TLR4 agonists to attract monocytes & form an immunosuppressive niche, favoring lung metastasis! dlvr.it/TPCYjz

Thank you for your contribution, Ivan. It was great working with you!✨

Fantastic @ Nature Biotechnology by @bocklab.bsky.social &co, link to go and whisper to your cells 👉 doi.org/10.1038/s415...

#ToPrimeOrNotToPrime, this is the question! Excited for our new review @cp-trendsimmuno.bsky.social with @oceanedufies.bsky.social in which we discuss what is “priming” for the #NLRP3 #inflammasome & how we can harness this knowledge to better control human diseases! #InflammasomePower! #Free 👇👇👇

#WeekendRead! #EveryCellIsAnImmuneCell! #SmartTumors. Ji Zhang &co show @cp-cell.bsky.social that tumor cells undergo ER stress under immune pressure leading to activation of nociceptive neurons which signal in draining lymph node driving immune suppression via decreased CCL5 & favoring tumor growth

Fascinating as always @reisesousalab.bsky.social &co! 1 aminoacid makes the difference between a CLR that drives cross-presentation or immune activation!! Kudos to all authors of this cool paper! 👇👇👇

#cytokines2025 Day 2 starts with a major symposium with Charlie Rice as the keynote! This session highlights my favorite cytokine -interferons! #interferons #seattle #conference

#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇

#Cytokines2025 will kick off with two special symposia! Check in early, get your badges, to attend these sessions.

Welcome to #Cytokines2025! We are thrilled to have you in Seattle for cytokines2025. Check in starts at 11 am, join us for cutting-edge scientific sessions, celebrate excellence at the award ceremony, and connect at the welcome reception. Enjoy the meeting and Seattle! 🌲🧬✨ #Cytokines25 #Immunology

#WeekendRead! #SmartTumor Zhao, Huang &co show @natimmunol.nature.com that within tumormicro environment, sensing of dead cells by macrophages via TIM4 inhibits a mitochondrial chaperone protein enhancing mitochondrial functions & epigenetically enforcing immunesuppression doi.org/10.1038/s415...

So blessed to have the possibility to work with some of the smartest & nicest people I ever met. #LoveMyLab #LoveScience #LoveImmunology #Halloween #LabParty

An authoritative review on phagosome immunobiology by David Underhill and Kai Li. Highly recommend for anyone interested in innate immunity, antigen presentation, infection and host defense. @cedarssinai.bsky.social rdcu.be/eNIFY

#SpookyInflammasome 🎃 With @lozanzi.bsky.social &co, we show that sustained NRF2 activation by endogenous oxidized phospholipids primes and activates the NLRP3 inflammasome 🔥 to drive atherosclerosis. ... more to come on the priming !

#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇

The UofA is hiring for a Principal Scientist in cancer immunology! This isn’t a typical academic position—we're looking for a scientist with a great idea but needs time/resources to translate and commercialize. Please repost and apply if interested! arizona.csod.com/ux/ats/caree...

#WeekendRead! #InterferonPower! Lin, Sayour, Grippin &co show @nature.com that SARSCoV2 #mRNAvaccines potentiate in cancer patients & mouse models immune checkpoint blockade anti-tumor therapy thanks to increased type I interferon signaling! www.nature.com/articles/s41...

#WeekendRead! #ImmunometabolismPower! #MoreThanItaconate! Wang, Tang, Kang &co show @cp-devcell.bsky.social that BRD3 induces ACOD1 via its kinase, rather than epigenetic, activity to potentiate inflammation during sepsis in a -partially- itaconate-independent manner! www.cell.com/developmenta...

#FirstLove! Donner &co show @jaccjournals.bsky.social that after myocardial infarction, #CD14 blockade rewires immune response of infiltrating monocytes & macrophages, blocking detrimental inflammation & leaving unaltered their repair functions! #MasterRegulator www.jacc.org/doi/epdf/10....

Deadline for the underrepresented trainee travel grant is tomorrow!!

#EveryCellIsAnImmuneCell! Luchetti @rauchlab.bksy.social Dixit &co show @nature.com that enteropathogenic bacteria evolved a virulence factor that degrades non-canonical #inflammasome & targets ROCKs necessary for luminal extrusion of infected intestinal #epithelial cells, favoring bacterial growth!

We hiring! Please share this post with your talented ECRs We're looking for a postdoc interested in the formation and function of tertiary lymphoid structures - project funded by Wellcome Based at @lmcb-ucl.bsky.social at University College London Apply here: www.jobs.ac.uk/job/DPD418/r...

Join us for this exciting meeting! @embo.org Workshop "Pathogen Immunity and Signalling", 8-12 June, 2026, Leiden, The Netherlands meetings.embo.org/event/26-pat...

#WeekendRead! #ToSenseOrNotToSense! #MysterySolved! Berouti, Wagner, Carell, @v-hornung.bsky.social &co show @cp-cell.bsky.social that RNase T2 & PLDs generate #TLR7 & #TLR8 agonistic ligands only if RNA does not contains pseudouridines explaining avoidance of self RNA sensing!

What an amazing week of great immunology @ SBI The Brazilian Society of Immunology, IMMUNO 2025. Thanks to Dario Zamboni & to the organizers for inviting me & thanks to all trainees & other speakers for cool discussions! #LoveScience #LoveImmunology

#WeekendRead! #EveryCellIsAnImmuneCell! Kolter, Doring, Henneke &co show @cp-immunity.bsky.social that during development or after injury, skin sensory neurons provide TGFb & CGRP to macrophages which become neuron-associated macrophages helping nerve regeneration! doi.org/10.1016/j.im...

Your immune system remembers skin inflammation long after it resolves because of #interferon alpha! Check out our new paper describing these findings just published at @jimmunol.bsky.social 👇👇👇 It was amazing working on this with my role model @drshrutinaik.bsky.social

#DAMPsPower! Balachandran, Yin &co show @nature.com that upon influenza #IAV or herpes #HSV1 virus infection, ZBP1 induces cell death by sensing #host-derived endogenous retroelement Z-RNAs produced in response to virulence factors! www.nature.com/articles/s41...

Must read for #InnateImmunity, #MucosalImmunology #RespiratoryTract lovers, & more! 👇👇👇