Fascinating as always @reisesousalab.bsky.social &co! 1 aminoacid makes the difference between a CLR that drives cross-presentation or immune activation!! Kudos to all authors of this cool paper! 👇👇👇

#cytokines2025 Day 2 starts with a major symposium with Charlie Rice as the keynote! This session highlights my favorite cytokine -interferons! #interferons #seattle #conference

#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇

#Cytokines2025 will kick off with two special symposia! Check in early, get your badges, to attend these sessions.

Welcome to #Cytokines2025! We are thrilled to have you in Seattle for cytokines2025. Check in starts at 11 am, join us for cutting-edge scientific sessions, celebrate excellence at the award ceremony, and connect at the welcome reception. Enjoy the meeting and Seattle! 🌲🧬✨ #Cytokines25 #Immunology

#WeekendRead! #SmartTumor Zhao, Huang &co show @natimmunol.nature.com that within tumormicro environment, sensing of dead cells by macrophages via TIM4 inhibits a mitochondrial chaperone protein enhancing mitochondrial functions & epigenetically enforcing immunesuppression doi.org/10.1038/s415...

So blessed to have the possibility to work with some of the smartest & nicest people I ever met. #LoveMyLab #LoveScience #LoveImmunology #Halloween #LabParty

An authoritative review on phagosome immunobiology by David Underhill and Kai Li. Highly recommend for anyone interested in innate immunity, antigen presentation, infection and host defense. @cedarssinai.bsky.social rdcu.be/eNIFY

#SpookyInflammasome 🎃 With @lozanzi.bsky.social &co, we show that sustained NRF2 activation by endogenous oxidized phospholipids primes and activates the NLRP3 inflammasome 🔥 to drive atherosclerosis. ... more to come on the priming !

#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇

The UofA is hiring for a Principal Scientist in cancer immunology! This isn’t a typical academic position—we're looking for a scientist with a great idea but needs time/resources to translate and commercialize. Please repost and apply if interested! arizona.csod.com/ux/ats/caree...

#WeekendRead! #InterferonPower! Lin, Sayour, Grippin &co show @nature.com that SARSCoV2 #mRNAvaccines potentiate in cancer patients & mouse models immune checkpoint blockade anti-tumor therapy thanks to increased type I interferon signaling! www.nature.com/articles/s41...

#WeekendRead! #ImmunometabolismPower! #MoreThanItaconate! Wang, Tang, Kang &co show @cp-devcell.bsky.social that BRD3 induces ACOD1 via its kinase, rather than epigenetic, activity to potentiate inflammation during sepsis in a -partially- itaconate-independent manner! www.cell.com/developmenta...

#FirstLove! Donner &co show @jaccjournals.bsky.social that after myocardial infarction, #CD14 blockade rewires immune response of infiltrating monocytes & macrophages, blocking detrimental inflammation & leaving unaltered their repair functions! #MasterRegulator www.jacc.org/doi/epdf/10....

Deadline for the underrepresented trainee travel grant is tomorrow!!

#EveryCellIsAnImmuneCell! Luchetti @rauchlab.bksy.social Dixit &co show @nature.com that enteropathogenic bacteria evolved a virulence factor that degrades non-canonical #inflammasome & targets ROCKs necessary for luminal extrusion of infected intestinal #epithelial cells, favoring bacterial growth!

We hiring! Please share this post with your talented ECRs We're looking for a postdoc interested in the formation and function of tertiary lymphoid structures - project funded by Wellcome Based at @lmcb-ucl.bsky.social at University College London Apply here: www.jobs.ac.uk/job/DPD418/r...

Join us for this exciting meeting! @embo.org Workshop "Pathogen Immunity and Signalling", 8-12 June, 2026, Leiden, The Netherlands meetings.embo.org/event/26-pat...

#WeekendRead! #ToSenseOrNotToSense! #MysterySolved! Berouti, Wagner, Carell, @v-hornung.bsky.social &co show @cp-cell.bsky.social that RNase T2 & PLDs generate #TLR7 & #TLR8 agonistic ligands only if RNA does not contains pseudouridines explaining avoidance of self RNA sensing!

What an amazing week of great immunology @ SBI The Brazilian Society of Immunology, IMMUNO 2025. Thanks to Dario Zamboni & to the organizers for inviting me & thanks to all trainees & other speakers for cool discussions! #LoveScience #LoveImmunology

#WeekendRead! #EveryCellIsAnImmuneCell! Kolter, Doring, Henneke &co show @cp-immunity.bsky.social that during development or after injury, skin sensory neurons provide TGFb & CGRP to macrophages which become neuron-associated macrophages helping nerve regeneration! doi.org/10.1016/j.im...

Your immune system remembers skin inflammation long after it resolves because of #interferon alpha! Check out our new paper describing these findings just published at @jimmunol.bsky.social 👇👇👇 It was amazing working on this with my role model @drshrutinaik.bsky.social

#DAMPsPower! Balachandran, Yin &co show @nature.com that upon influenza #IAV or herpes #HSV1 virus infection, ZBP1 induces cell death by sensing #host-derived endogenous retroelement Z-RNAs produced in response to virulence factors! www.nature.com/articles/s41...

Must read for #InnateImmunity, #MucosalImmunology #RespiratoryTract lovers, & more! 👇👇👇

#WeekendRead! #MomIsAlwaysMom! #EveryCellIsAnImmuneCell! Serhan, Gaudenzio &co show @nature.com that elevated corticosterone in stressed moms alters #skin mast cells & mechanosensing #neurons causing fetal immunedysregulation & eczema after birth. doi.org/10.1038/s415...

#LiveForever! Chen, Mao &co show @science.org that not all #cGAS are equals & that naked mole-rats one bears a 4 amino acid mutation which enhances DNA repair & when transferred in aged mice dampens frailty, hair graying, inflammatory & senescence markers! www.science.org/doi/10.1126/...

Late to the party, but: Host-oxidized phospholipids (oxPLs) form during infection & epigenetically silence IL-10 via AKT→EZH2→H3K27me3, driving lethal inflammation. Blocking oxPLs boosts IL-10 + survival. Kudos, @lozanzi.bsky.social; out in @cp-immunity.bsky.social: doi.org/10.1016/j.im... 🧪

Exciting #science as always @raflynn5.bsky.social &friends 👇👇👇 Thrilled to be part of this 🤗

#WeekendRead! #ImmunometabolismPower! Formiga, Sokol &co show @cp-cellhostmicrobe.bsky.social that #microbiota derived cadaverine 🧟‍♂️ controls macrophage metabolism & gut inflammation. Low 🧟‍♂️ activates NRF2 promoting OXPHOS & homeostasis, while high 🧟‍♂️ drives glycolysis & intestinal inflammation 🔥 !!

#Microbiota #FriendOrFoe? Our own @bostonchildrens.bsky.social Chatila, Benamar &co show @cp-immunity.bsky.social that #gut microbiota drives Notch3+ Tregs which migrate to brain & interacts with microglia becoming Th17 cells, subvert CNS resident neuropetide-responsive Tregs, supporting MS/EAE!

We are currently in the process of recruiting a technician. 🥼🐭🔬 If you know anyone with enthusiasm to learn new skills and stamina to hear me go on and on about IFNs, please have them reach out to me for more details!

What a fantastic day to start the Immunobiology of #PRRs Symposium in beautiful Lausanne! Much looking forward to being part of an amazing line up of speakers, & to presenting a brand new story on a 100-year old protein whose function remains poorly understood! 😉

#WeekendRead! #MicrobiotaPower! Jang, Jung &co show @natmetabolism.nature.com that dietary fibre protects against dietary fructose-driven insulin resistance & liver steatosis via promoting fructose utilization by small intestine microbiota & favoring anti-oxidant responses in the liver!

What a fantastic day spent @ Brown University talking about all things inflammation & innate immunity! Thanks Sanghyun Lee for hosting me, and to all faculties, postdocs & students for exciting discussions!

🚨 We are #recruiting! 🚨My lab is looking for a highly motivated Research Technician to join us for the next 3 years. 👉 Apply via the link www.imperial.ac.uk/jobs/search-... or feel free to reach out for more information!

#WeekendRead! #MicrobiotaPower! Wang, Lin &co reveal @immunity-cp.bsky.social that a #GutSkinAxis that drives skin inflammation in psoriatic prone mice & patients caused by indole-producing gut bugs that increase host I3S driving AHR-dependent skin Th17 activation! www.cell.com/immunity/abs...

Original report on the regulators of TLR4 endocytosis and its importance in TRIF-IFN signaling. @lozanzi.bsky.social @harvardmed.bsky.social @harvardmicro.bsky.social www.cell.com/fulltext/S00...

This work derives from prior studies on the structure-function relationship between Bacteroides LPS and TLR4 endocytosis and signaling. www.sciencedirect.com/science/arti...

Fascinating discussion about cell death by several leaders in the field. If we get to understand cell death better, can we #LiveForever 😉?!👇👉 doi.org/10.1038/s41594-025-01646-x

Thank you @jem.org for the invite to participate in this Viewpoint alongside such inspiring scientists 🤩🤩

So happy to see the final version of our paper out today @jclinical-invest.bsky.social 🤗

How diet influences atherosclerosis in obesity… @aweinstock.bsky.social & team show short-term caloric restriction resolves atherosclerosis inflammation in obese mice, but weight regain accelerates its adverse effects: buff.ly/ieqwQ3O

An amazing resource written by the great Ivan Zanoni and Daniel Boehmer! 👏🏻

#InterferonPower! Li, Park &co show @cp-immunity.bsky.social that IL-15 negatively regulates CD103 expression on CD8 T cells allowing formation of effector T cells & that engagement of CD103 on CD8 T cells by E-cadherin+ dendritic cells is necessary to drive memory formation via type I IFNs & IL-12

#WeekendRead #InterferonPower! Hegde, @miriammerad.bsky.social &co show @nature.com that #tumor-derived factors drive NRF2 activation in bone marrow myeloid progenitors, dampening IFN-I/-III responses & favoring emergence of immunosuppressive monocyte-derived macrophages!

Pleased to update this - The paper is published in Cell Reports! A long road for this one, the paper grew exponentially and evolved over a couple of years. Thanks to @makris1.bsky.social for sticking with it to untangle all the new data! @cp-cellreports.bsky.social www.cell.com/cell-reports...

💥 #ImmunometabolismPower! Excited to have this officially out @cp-immunity.bsky.social 💥 We show that pathogens induce the host to produce oxidized lipids which rewire the #metabolism of #macrophages, causing #epigenetic modifications which dampen anti-inflammatory IL-10, exacerbating #inflammation!

Fantastic new story @jkagan1.bsky.social & friends showing that human dendritic cells can become hyperactive activating the inflammasome without dying, & that this approach can be used in mice and NHPs to potentiate anti-influenza vaccine responses! 👇👇👇

#WeekendRead! #LiveForever! Gonzalez-Hurtado, Leveau, Dixit &co show @nataging.nature.com that adipose tissue macrophages #ATMs are central drivers of #inflammaging & loss of a sub population of nerve-associated ATMs in aging disrupts fat homeostasis impairing lipolysis!

#NoTimeToDie! Matthias Nahrendorf, Nina Kumowski &co show @science.org that after myocardial infraction, #neutrophils release antimicrobial resistin RELMg which forms pores in cardiomyocytes causing cell death & driving arrhythmias! www.science.org/doi/10.1126/...