Join us!! 👇👇👇

I am excited to present our long-overdue lab website. Please visit us to learn who we are, our past work, and our current lines of research! ahidalgolab.com Thank you to Gerardo Barcia for his beautiful design and constant support in building it

#WeekendRead! #ImmunometabolismPower! #InflammasomePower! Liu, Yin &co show @cp-cellchembiol that lactate downstream of aerobic glycolysis is used to directly lactylates NLRP3 increasing ASC recruitment and inflammasome activation, which exacerbates lethality in sepsis! www.cell.com/cell-chemica...

Too much data, too little thinking. A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read. @Yale www.nature.com/articles/s41...

Excited to be giving my first seminar of 2026 tomorrow @cedars-sinai.bsky.social! Stop by if you are around, it will be all about how we respond to microbial or sterile threats & the paramount roles played by PAMPs & DAMPs, with lot of unpublished data 😉

#WeekendRead! #SharingIsCaring! Ji, Xu &co show @nature.com that glia transfers mitochondria to sensory neurons via tunneling nanotubes, which are altered in #diabetes causing neuropathy! doi.org/10.1038/s415...

#WeekendRead! #FirstLove #IL2power #IL10power #InterferonPower! Delaloy, Gauthier &co show @cp-immunity.bsky.social that IL2 favors a regulatory program in B cells that, together IFNg, induces IL10 production, protecting against neuroinflammation! Exciting paper 🤗! www.cell.com/immunity/ful...

Excited to have the one and only @labwaggoner.bsky.social posting our @annualreviews.bsky.social Immunology paper on the biology of #Type_3_Interferons!! Check it out! www.annualreviews.org/content/jour...

#Epithelialmechanics fans...interferons protect against viruses but also impair recovery post-infection. In new work @plosbiology.org we show that interferons block epithelial repair by co-opting the Hippo pathway #innateimmunity #lungs #respiratory journals.plos.org/plosbiology/...

#DirtyIsBetter! @rmedzhitov.bsky.social, Erickson &co show @nature.com that pet shop mice are protected from #allergy thanks to cross reactive type I (or tolerogenic) immune memory that prevents type II allergen-driven responses! doi.org/10.1038/s415...

Science update from my postdoc Peiyuan Chai - his work “glycoRNA complexed with heparan sulfate regulates VEGF-A signaling” is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX

A new function for GlycoRNAs!! The GlycoRNA-Heparan sulfate complex on the cell surface controls VEGF-A signaling and angiogenesis. Superexciting findings from Ryan Flynn's lab. Congratulations to all authors!! @raflynn5.bsky.social www.nature.com/articles/s41...

#InterferonFriendsOrFoes? Another cool one @ellenfoxman.bsky.social &friends out @plosbiology.org about how excessive #IFNs delay repair by activating LATS & degrading YAP/TAZ in the Hippo 🦛 pathway! journals.plos.org/plosbiology/... 👇👇👇

#WeekendRead! #LocationLocationLocation! Sng, Andoniou, @the-de-lab.bsky.social &co show @nature.com that fibrobalstic reticular cell (FRC) CD44 interacts with hyaluronic acid to correctly position dendritic cells within the spleen allowing anti-viral CD8T cell responses! doi.org/10.1038/s415...

Great story from the Nieswandt lab in Science: uncovering a non-classical platelet mechanism that drives inflammation via integrin- and tetraspanin-rich tethers. A fresh angle on thrombo-inflammation. Happy to be part of this work! www.science.org/doi/10.1126/...

Excited to share: We show that basal IFNλ2/3 signaling helps human intestinal epithelial cells stay ready for viral infections, even before an acute infection. A reminder that a lot of innate immune defense happens quietly in the background. journals.plos.org/plospathogen...

Fantastic work @ellenfoxman.bsky.social &co! If you block the #InterferonPower, Rhinovirus activates NFkB & NLRP1 #inflammasome leading to IL1b secretion & excessive mucus production!

#NoTimeToDie! Ayres &co show @nature.com that young & aged mice initiate different disease tolerance mechanisms to survive #sepsis. Dying young mice have cardiomegaly while aged mice cardiac atrophy. Opposite in surviving mice, with Foxo1 🦊 being protective in young & detrimental in aged mice!

#WeekendRead #MicrobiotaPower! Tsai, @diehllab.bsky.social &co show @ Science Immunology that E. coli flagellin is recognized by TLR5 on intestinal epithelial stem cells to recruit gut protective CCR2+ monocyte-derived macrophages, decreasing colitis! #IBDs doi.org/10.1126/sciimmunol.adr4057

#WeekendRead! #SmartTumor! #SharingIsCaring! #InterferonFriendOrFoe?! Lot in this @cp-cellmetabolism.bsky.social paper from Okwan-Duodu &co showing that tumor cells steal #mitochondria from immune cells to impair their activity & to produce immune suppressive type I #IFNs via cGAS-STING!

Registration for the 2026 Henry Kunkel Society Meeting is well underway! 📍 @rockefeller.edu | 🗓 April 16–18 Join us for three days focused on “Autoantibodies Against Cytokines”. 🔗 Register now: henrykunkelsociety.app.neoncrm.com/eventReg.jsp... 🤝 Meeting in partnership with @jem.org

Another superb study of human TLR7 GOF: Novel TLR7 gain-of-function variant and review of the associated disease spectrum url: rupress.org/jhi/article/...

An intriguing observation: Increased prevalence of autoantibodies neutralizing IFNλ2/3 in young individuals with cystic fibrosis url: rupress.org/jhi/article/...

#WeekendRead! #SameSameButDifferent! #FirstLove! Its discovery changed our understanding of the functioning of innate immunity and of the immune response in general, but actually not all TLR4s are equal, check this out @jimmunol.bsky.social 👇👇👇 academic.oup.com/jimmunol/art...

#WeekendRead! #SmartTumor! Liu, Kroemer, Tang, Wang &co show @cp-cell.bsky.social that ferroptotic tumor cells release GPX4 dampening anti-tumor responses by signaling in DCs via ZP3 receptors, thus blocking glycolysis & impairing cytotoxic T cell activation! www.cell.com/cell/abstrac...

#CyclopsPower👁️ Lu, Choi, Huh &co describe @cp-cell.bsky.social a new reporter system to detect cells that respond to a cytokine & utilize it to identify ileal epithelial cells that respond to IL17 or IFNg responsive CD8 T cell within tumors which are hypofunctional!

Highly recommended 👇, be fast 😉

A must read! Highly recommend.

💥New paper alert!💥 What’s better than starting 2026 with an @annualreviews.bsky.social #Immunology, often a once-in-a-life honor ❤️?! Check it out if you want to know everything about type III interferons #IFN! Thanks to my wonderful team for their amazing work 🤗 doi.org/10.1146/annu...

💥New paper alert!💥 What’s better than starting 2026 with an @annualreviews.bsky.social #Immunology, often a once-in-a-life honor ❤️?! Check it out if you want to know everything about type III interferons #IFN! Thanks to my wonderful team for their amazing work 🤗 doi.org/10.1146/annu...

#WeekendRead! #DendriticCellPower! @reisesousalab.bsky.social @drjonlim.bsky.social &co show @natimmunol.nature.com that cDC1s exploit DNGR1 to crosspresent #tumor #neoantigens derived from F-actin binding proteins protecting against tumorigenesis but favoring cancer immunoediting!

Harvard profiles the discovery of how inflammatory caspases detect bacterial infection. And how our own lipids bind caspases in the same manner. Kudos to Anh Cao, who made these discoveries. @harvardmed.bsky.social @harvard.edu gsas.harvard.edu/news/crackin...

#WeekendRead! #NeutrophilPower! @drusqui.bsky.social Aroca &co show @jem.org that neutrophil intrinsic circadian clock can be exploited by targeting CXCR4 to decrease vascular & myocardial damage by relocating neutrophils within the wound core, thus sparing injury to healthy neighboring cells!

#JEMLegacy @jem.org goes back to 1930 with the first description by William Tillett and Thomas Francis Jr. of C-reactive protein (CRP) in the sera of patients during the acute phase of pneumococcal pneumonia. @RockUPress @RockefellerUniv rupress.org/jem/article/...

#WeekendRead! #SmartTumor #EveryCellIsAnImmuneCell! Levy & (many) friends show @cp-cell.bsky.social that melanoma tumors release large extracellular vesicles #melanosomes decorated with MHC-I & high affinity tumor associated antigens which subvert cytotoxic T cells! www.cell.com/cell/fulltex...

9/ Read the paper here 👉 onlinelibrary.wiley.com/doi/10.1002/... And stay tuned — exciting new discoveries on liver Tregs are coming soon 👀🧬

Highly recommended 👇👇👇

#WeekendRead! #EveryCellIsAnImmuneCell! #MysterySolved! Clevers &co reveal @nature the differentiation trajectory of human intestinal M cells & show they respond to GM-CSF, express PRRs, & present antigen via MHC-II as dendritic cells, contributing to anti-gluten responses! doi.org/10.1038/s415...

I am excited to share our new paper @JExpMed led by our one and only #Alejandra_Aroca

Always fun to spend time outside the lab with such an amazing & passionate group of scientists. #LabHolydaysParty #SecretSanta🎅🏼 #LoveMyLab #LoveScience #LoveImmunology

#WeAreWhatWeEat! Jones &co show @natmetabolism.nature.com that dietary restriction empowers CD8+ T cells within the #tumor microenvironment by potentiating #mitochondrial metabolism via ketone body utilization, limiting T cell exhaustion, & synergizing with anti-PD1 immunotherapy!

#SharingIsCaring, not always! Lou &co show @cp-cellmetabolism.bsky.social that lactate driven by excessive exercise leads to release of muscle mitochondria-derived vesicles that impair cognitive functions by disrupting hippocampal neuron bioenergy via cGAS/STING activation & via PAF!

#WeekendRead! #FriendOrFoe? Yu, Lozinski, Dong, &co show @natneuro.nature.com that host-derived oxidized lipid deposition in the brain supports multiple sclerosis development via microglia dysfunction/replacement by monocyte-derived macrophages & interleukin-1 #IL1 signaling! doi.org/10.1038/s415...

#NeutrophilPower! @dcerezowallis.bsky.social, Rubio-Ponce, Ballesteros, Ng, @drusqui.bsky.social &co present @nature.com NeuMap, a neutrophil atlas across health & disease states in mice (& humans)! So happy to see this out! 💪💪💪 doi.org/10.1038/s415...

#WeekendRead! #FroendsOrFoes?! Benamar, Chatila &co identify @cp-immunity.bsky.social a #GutBrain axis leading to microbiota- & TLR-dependent induction of Notch3+ Tregs in the gut that in multiple sclerosis migrate to the CNS & interacting with microglia become pathogenic Th17 cells!

#NoTimeToDie! Welcome mitoxyperiosis! ⁦‪Kanneganti, Wang‬⁩ &co show ⁦‪@cp-cell.bsky.social that energy starvation via carbon deprivation in the presence of innate immune stimuli triggers a new form of cell death dependent on mitochondria-driven plasma membrane oxidative damage!

Honored to be included in Clarivate's Highly Cited Researcher list for 2025. Working with the best people in the business makes the discoveries easier, and more fun. Cheers to my lab (present and former). @clarivatelsh.bsky.social @bostonchildrens.bsky.social @harvardmed.bsky.social

We're hiring for tenure-track faculty! Please apply if you have interests in immune responses to microbes and/or cancer, immune regulation, microbial infections (bacteria, viruses, parasites, fungi), the microbiota, and/or interests that span these disciplines. arizona.csod.com/ux/ats/caree...

#WeekendRead! #LocationLocationLocation! #EveryCellIsAnImmuneCell! Turley Muller Wu Lane &co show @natimmunol.nature.com that fibroblastic reticular cells in lymph nodes produce Flt3l to support survival & proliferation of dendritic cells allowing T cell responses during immunization or infection!!

Very excited to announce that the first paper from the lab is now live @natcomms.nature.com #mitochondria #immunometabolism This work was led by postdoc Eloise marques with many important contributions from all of our co-authors. Please check it out! www.nature.com/articles/s41...