Tao et al. show that SCRN1 acts as a scaffold to facilitate GPX4 phosphorylation by STK38, thereby preventing chaperone-mediated autophagy of GPX4 and subsequent ferroptosis in patient-derived organoids and mouse models for hepatocellular carcinoma. www.nature.com/articles/s43...

🚨Don't miss this Resource published now at Nature Cancer, as part of the #HTAN initiative! 'A cellular and spatial atlas of TP53-associated tissue remodeling defines a multicellular tumor ecosystem in lung adenocarcinoma' ✏️By Alexander Tsankov and colleagues 🔗 www.nature.com/articles/s43...

🚨Check out this Article published at Nature Cancer! 'Aberrant expression of SLAMF6 constitutes a targetable immune escape mechanism in acute myeloid leukemia' ✏️By Thoas Fioretos, Carl Sandén and colleagues 🔗 www.nature.com/articles/s43...

Save the date! We are hosting the webinar "Inflammatory cell death and anti-tumor immunity". Join our speakers Dmitri Krysko, Judy Lieberman, Lorenzo Galluzzi and Pascal Meier @deadoc80.bsky.social @meierlabicr.bsky.social 📅 Tuesday 14th Oct 2025 ⏰ 16.00 PM (GMT+1) cassyni.com/events/QAERn...

🚨Check out this article published now at Nature Cancer! ✏️By Scott Lowe and colleagues 'SMAD4 induces opposite effects on metastatic growth from pancreatic tumors depending on the organ of residence' 🔗 www.nature.com/articles/s43...

🍂Our September issue is OUT NOW! Featuring, among others: - A Perspective on #drugconjugates - #immunotherapy studies - research on GBM invasion - method for #singlecell analyses of #CTCs 🔗 www.nature.com/natcancer/vo...

Check out this recent Review published at Nature Cancer! ✒️By Dario Neri and colleagues 'Past, present and future of #drugconjugates for #cancertherapy' 🔗 www.nature.com/articles/s43...

🚨Our Senior Editor Elena Skourti will be at the #ESMO Molecular Analysis for Precision Oncology Congress over the next two days. Find her and talk to her about your research!

Shao et al. developed an MRI–pathology-based foundation model to assess the pathology of prostate cancer for diagnosis and grading of tumors. The model is noninvasive and outperforms current pathological assessments. www.nature.com/articles/s43...

🤩Just started your lab as a #newPI in cancer research? Let us know about your exciting news, reach out to Nature Cancer -we'd love to connect with the new generations 👀

Resource article published now @NatureCancer 'Spatiotemporal analyses of the pan-cancer single-cell landscape reveal widespread profibrotic ecotypes associated with tumor immunity' ✒️By Qiu Wu, Chenfei Wang and colleagues 🔗 www.nature.com/articles/s43...

Article now ONLINE @at Nature Cancer! 'A sphingolipid-derived paclitaxel nanovesicle enhances efficacy of combination therapies in triple-negative breast cancer and pancreatic cancer' ✏️By Jianqin Lu and colleagues 🔗 www.nature.com/articles/s43...

📢New Article now published at Nature Cancer! 'Colorectal cancer cells hijack a brain–gut polysynaptic circuit from the lateral septum to enteric neurons to sustain tumor growth' ✏️By Tian-Ming Gao, Jian-Ming Li and colleagues 🔗 www.nature.com/articles/s43...

⭐️New Article published at Nature Cancer! 'Evolutionary trajectories of IDH-mutant astrocytoma identify molecular grading markers related to cell cycling' ✒️By Wies Vallentgoed and colleagues 🔗 www.nature.com/articles/s43...

🚨New REVIEW article online at Nature Cancer! 'Prospects for ferroptosis therapies in cancer' ✒️By Jessalyn Ubellacker & Scott Dixon 🔗 www.nature.com/articles/s43...

Our August issue is OUT NOW! ☀️ Check it out here: 🔗 www.nature.com/natcancer/vo... ⭐️Featuring: - review on #nanotechnology for immuno-oncology - review on #ferroptosis for #cancertherapy - AI in clinical oncology - cancer #cachexia - #immunotherapy clinical trial

🌟Review online! Dotti and colleagues review CAR-engineered cell-based cancer therapy and overview its transition for solid tumors from CAR-T to CAR-engineered innate immune cells, discussing strengths and limitations for clinical application. www.nature.com/articles/s43...

🚨Don't miss the July issue of Nature Cancer! Check it out here: 🔗 www.nature.com/natcancer/vo... Featuring: ⭐️Review on clonal hematopoiesis in cancer ⭐️Review on CAR engineering for cancer therapy ⭐️immunotherapy ⭐️AI for tumour classification ⭐️single-cell analyses in B-ALL

🚨ARTICLE now published at Nature Cancer ! ✏️By Valsamo Anagnostou and colleagues 'Combination of pembrolizumab and radiotherapy induces systemic antitumor immune responses in immunologically cold non-small cell lung cancer' 🔗 www.nature.com/articles/s43...

📢New Article published at Nature Cancer! ✒️By Christopher Klebanoff and colleagues 'CAR-engineered lymphocyte persistence is governed by a FAS ligand–FAS autoregulatory circuit' 🔗 www.nature.com/articles/s43...

Our Senior Editor Elena Skourti is attending the AACR Special Conference in Artificial Intelligence & Machine Learning this week. If you are there, find her and connect!

Thanks Nature Cancer for the chance to reflect on some factors that led me to study cancer metabolism. For the trainees and other young scientists: the critical events that shape your career might not be obvious while they are happening. Keep an open mind and trust your instincts. rdcu.be/evi4I

🌟Review at Nature Cancer Chalabi and colleagues summarize the current clinical landscape of neoadjuvant immunotherapy in solid tumors www.nature.com/articles/s43...

Will it be a turning point? I recently came back from a research sabbatical funded by @fwovlaanderen.bsky.social & #KULeuven in the lab of @mafdawson.bsky.social @petermaccc.bsky.social and I am happy to share my experience @natcancer.nature.com www.nature.com/articles/s43... @vib-ccb.bsky.social

Out today! www.nature.com/articles/s43...

🚨 Clinical Trial published at Nature Cancer! David Cibula and colleagues report on the final outcome of the SENTIX international trial, assessing sentinel LN biopsy without systematic pelvic lymphadenectomy in early-stage cervical cancer. 🔗 www.nature.com/articles/s43...

🚨New Article Alert from Nature Cancer ! 'Self-amplifying NRF2–EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer' ✏️ By Michael Karin and colleagues 🔗 www.nature.com/articles/s43...

📢Another Article ONLINE at Nature Cancer! 'Profiling antigen-binding affinity of B cell repertoires in tumors by deep learning predicts immune-checkpoint inhibitor treatment outcomes' ✒️By Junzhou Huang, David Gerber, Tao Wang and colleagues 🔗 www.nature.com/articles/s43...

🚨New Article ONLINE at Nature Cancer! 'Multipotent lineage potential in B cell acute lymphoblastic leukemia is associated with distinct cellular origins and clinical features' ✒️ By John Dick, Charles Mullighan and colleagues 🔗 www.nature.com/articles/s43...

📢We’ve partnered with MD Anderson to explore recent breakthroughs in understanding the tumor ecosystem and how its various components influence cancer development, progression, diagnosis, and treatment. Learn more and save your seat! 🔗 go.nature.com/44cJT9Z

🚨Our JUNE Issue is OUT NOW! ☀️ Check it out here: 🔗 www.nature.com/natcancer/vo...

Another REVIEW now ONLINE at Nature Cancer 'Advancing therapeutics in small-cell lung cancer' ✒️By Anish Thomas, Chirayu Mohindroo & Giuseppe Giaccone 🔗 www.nature.com/articles/s43...

🚨Read this REVIEW published at Nature Cancer! 'The tumor microenvironment’s role in the response to immune checkpoint blockade' ✏️By Vassiliki Boussiotis and co-authors 🔗 www.nature.com/articles/s43...

New Article published! 'p95HER2, a truncated form of the HER2 oncoprotein, drives an immunosuppressive program in HER2+ breast cancer that limits trastuzumab deruxtecan efficacy' ✒️By Linda McAllister-Lucas, Peter Lucas, Dong Hu and colleagues 🔗 www.nature.com/articles/s43...

⭐️New Article ONLINE at NatureCancer ! Concurrent inhibition of tumor growth and metastasis by a lipidated nanophotosensitizer tracing and disabling tumor extracellular vesicles ✏️By Xiaorui Wang and colleagues 🔗 www.nature.com/articles/s43...

📢New Article published at Nature Cancer! 'Innate immunity and the NF-κB pathway control prostate stem cell plasticity, reprogramming and tumor initiation' ✒️By Cédric Blanpain and colleagues 🔗 www.nature.com/articles/s43...

Applications are now open for the 2026 Takeda Innovators in Science Award with Nature. Early-career researchers in GI & inflammatory disease, neuroscience or oncology: Win a share of US$400K and earn global recognition. Apply today: go.nature.com/4jBp3oM #Academicsky

Our Senior Editor Elena Skourti is attending the Pezcoller Symposium this week. If you are there, find her and connect!

🚨Join us for this webinar TODAY!

🛎️LAST CHANCE to register for tomorrow's webinar on Liquid Biopsies in Clinical Oncology hosted by Nature Cancer & @natbiotech.nature.com 🔗 cassyni.com/events/5evgf... ⏰Wednesday 11th June 2025 10am ET/3pm BST ⭐️Speakers: Caroline Dive Lillian Siu Chairs: Eleni Skourti & Barbara Cheifet

New article online! by @jnkt.bsky.social and team www.nature.com/articles/s43...

🌟Check out our May Issue now! Read about: - The circadian clock in cancer - TIL therapy in lung cancer - A 4-1BB co-stimulated anti-CD19 CAR-NK cell therapy - TME dynamics of neoadjuvant therapy in esophageal adenocarcinoma - a SCLC organoid biobank and more! www.nature.com/natcancer/vo...

The atypical protein kinase RIOK1 phase separation leads to PTEN mRNA sequestration and pentose phosphate pathway activation resolving cellular stress in hepatocellular carcinoma. Targeting RIOK1 enhances response to tyrosine kinase inhibitors. by Lianxin Liu & team www.nature.com/articles/s43...

Myocardial CCDC25 detects doxorubicin-induced NET DNA and activates autophagy, leading to cardiotoxicity. Targeting CCDC25 exerts a cardioprotective effect without impacting doxorubicin antitumor activity in lymphoma and breast cancer models. www.nature.com/articles/s43...

📣Don't miss this recent REVIEW published at Nature Cancer: 'The diverse roles of the circadian clock in cancer' ✏️By Nicholas Pannunzio, Selma Masri @ masrilab.bsky.social and colleagues 🔗 www.nature.com/articles/s43...

🚨REVIEW ARTICLE JUST OUT at Nature Cancer! 'The current and emerging #immunotherapy paradigm in small-cell #lungcancer' ✏️By Lauren Byers, Jianjun Zhang and colleagues 🔗 www.nature.com/articles/s43...

Thrilled to share this publication from our lab on muscle wasting in #Cancer and #vascularbiology, spearheaded by Young-Mee Kim in @natcancer.nature.com nature.com/articles/s43.... Bluetorial on #cachexia, #cancer, #cardiovascular health @uicancercenter.bsky.social @uofilsystem.bsky.social

Super happy to share our latest in @natcancer.nature.com co-led by @pannunziolab.bsky.social! We review the complex role of the circadian clock in genome integrity, DNA repair, immunity, metabolism, and cancer with a specific focus on early-onset cancer. Check it out! www.nature.com/articles/s43...

🛎️Register NOW for the webinar on Liquid Biopsies in Clinical Oncology hosted by Nature Cancer and Nature Biotechnology! 🔗 cassyni.com/events/5evgf... ⭐️Speakers: Caroline Dive Lillian Siu ⏰Wednesday 11th June 2025, 10am ET/3pm UK time Chairs: Eleni Skourti & Barbara Chiefet