🌟Online today Hu and colleagues report that a micropeptide encoded by the lncRNA USP30-AS1 promotes tumor growth by undergoing phase separation with TBK1 and attenuating cGAS–STING–type I IFN signaling in tumor-associated macrophages. www.nature.com/articles/s43...

In first-in-human phase 1 NOA16 trial, @michael-platten.bsky.social and colleagues report the long-term clinical and immunological follow-up outcomes of a vaccine targeting mutant IDH1 in persons with astrocytoma. @platten-lab.bsky.social www.nature.com/articles/s43...

🌻Check out our June issue ! ✅Metastatic dissemination in CRC ✅Immunotherapy in GBM ✅BH3 mimetics sensitization in AML ✅ctDNA and PSA to monitor prostate cancer ✅Methylation-based CNS tumor classification and more... www.nature.com/natcancer/vo...

Now online! Zemp at al. found GPNMB as a targetable antigen for MiT/TFE-family fusion-driven soft-part sarcoma and translocation RCC and tested GPNMB-directed CAR T cell therapy in preclinical models and in first-in-human trial Read the N&Vs: nature.com/articles/s43... nature.com/articles/s43...

⭐️Online now Iron level and ferroptosis impair antitumor efficacy of CAR-T cells. by Dongrui Wang, Yongxian Hu, Pengxu Qian, He Huang & colleagues www.nature.com/articles/s43...

📢Online now! @moritzgerstung.bsky.social, Felix Sahm & co developed an AI algorithm that leverages H&E slides to classify central nervous system tumors into methylation-based subtypes reducing turnaround time to 12 min in prospective evaluation. www.nature.com/articles/s43...

⭐️Now online In a large cohort of patients with ICB-treated glioblastoma, Catherine J. Wu & colleagues show that baseline mesenchymal transcriptional state predicts therapy response, and transition to non-mesenchymal state results in acquired resistance. www.nature.com/articles/s43...

Impressive new study by the Wu lab in @natcancer.nature.com investigating the tumor cell features associated with #immunotherapy response in #glioblastoma Tumor transcriptional state predicts survival in immune-checkpoint-blockade-treated glioblastoma | Nature Cancer www.nature.com/articles/s43...

🍓☀️Check out our May Issue, now live! Including: ☑️Oncolytic virus and cytokine-based gene therapies ☑️Myeloid plasticity, part of our Series on Tumor Heterogeneity and Plasticity ☑️DeepFAN, a model for human-AI collaboration and more! www.nature.com/natcancer/vo...

New Article out today! CD300ld, upregulated in pathologically activated neutrophils, mediates contact-dependent suppression of cytotoxic CD8+ T cells by binding to phosphatidylserine, inhibiting antitumor immune responses and revealing a targetable checkpoint pathway. www.nature.com/articles/s43...

Registration and abstract submissions are now open for Next Generation Cancer Therapeutics. This Nature Conference will bring together leading global researchers who are transforming the landscape of cancer therapies for discussions and networking. go.nature.com/4eHSlnc #STEMConference

🌟 Online now! Read the Review on myeloid cell plasticity in cancer therapy by Dmitry Gabrilovich & colleagues 🔗 www.nature.com/articles/s43... Check out the rest of our Series on Tumor Heterogeneity and Plasticity here: www.nature.com/collections/...

⭐Out today! Read the phase I clinical trial on neoantigen DNA vaccine for patients with glioblastoma www.nature.com/articles/s43...

⭐️Check out the Perspective on cellular neighborhoods in cancer by Lichun Ma, @kaitanlab.bsky.social & co 🔗 www.nature.com/articles/s43... Part of our Series on Tumor Heterogeneity and Plasticity: www.nature.com/collections/...

A phase 1 clinical trial now published @natcancer.nature.com 'Tumor-localized CD40 agonism with MP0317, a FAP x CD40 DARPin, reprograms the tumor microenvironment in patients with advanced solid tumors' ✒️By Hilde De Winter & colleagues 🔗 www.nature.com/articles/s43...

⭐️Don't miss this Review published @natcancer.nature.com as part of our Series on Tumor Heterogeneity and Plasticity 'Heterogeneity and plasticity of cancer-associated fibroblasts' ✒️By Ruth Scherz-Shouval, Mara Sherman and co-authors 🔗 www.nature.com/articles/s43...

🔥Online now, a Review on EMT as driver of tumor cell plasticity By @nietoangela.bsky.social and @ruljcz.bsky.social Part of our Series on Tumor Heterogeneity and Plasticity: nature.com/collections/... nature.com/articles/s43...

🌷Our April Issue is out! Featuring: ☑️Our Series on Tumor Heterogeneity and Plasticity ☑️CAR T cell therapy in solid tumors ☑️An erythrocyte–anti-PD1 conjugate ☑️Mitigation of immune-related toxicities ☑️Pediatric tumors classification using cfDNA methylation and more! www.nature.com/natcancer/vo...

NEW CALL FOR PAPERS 📣 @natcomms.nature.com, @nature.com, @natcancer.nature.com, @natneuro.nature.com, Nature Progress Oncology, Nature Progress Brain Health and @commsbio.nature.com invite submissions on #CancerNeuroscience 👇 www.nature.com/collections/...

📢Today we launch our Series on Tumor Heterogeneity and Plasticity featuring commissioned Reviews and a selection of articles published in Nature Cancer! Read about EMT, CAF plasticity, immune cell plasticity, cellular neighborhoods and more here: 🔗 www.nature.com/collections/...

🌟New study in Nature Cancer evaluates the clinical significance of early PSMA upregulation in patients with metastatic castrate-resistant prostate cancer treated with enzalutamide with or without 177Lu-PSMA-617. by @drlouiseemmett.bsky.social & colleagues www.nature.com/articles/s43...

🌟Now in Nature Cancer, multi-omics analysis of nasopharyngeal carcinoma identifies molecular subtypes with distinct immune profiles and responses to induction chemotherapy. 🖊️by Jia-Xing Yue, Na Liu, Aihua Sun, Jun Ma & Fuchu He and colleagues www.nature.com/articles/s43...

🌟New Perspective out today presents the recent advances in predicting TCR–epitope recognition and the therapeutic applications in cancer immunotherapy. by @dgfeller.bsky.social and colleagues www.nature.com/articles/s43...

New REVIEW published @natcancer.nature.com ! 'Single-cell and spatial profiling in cancer biology and clinical oncology' ✏️By Benjamin Izar, Elham Azizi and co-authors 🔗 www.nature.com/articles/s43...

Article now online @natcancer.nature.com 'Leptomeningeal metastatic cancer cells induce a permissive choroid plexus vasculature through extracellular-vesicle-derived 5-HIAA signaling' ✒️By Yudan Chi and colleagues 🔗 www.nature.com/articles/s43...

Technical Report now published @natcancer.nature.com 'PRET is a few-shot system for pan-cancer recognition without example training' By Xiaomeng Li, Kang Zhang, Qingling Zhang & colleagues 🔗 www.nature.com/articles/s43...

🌟Today in Nature Cancer! Stromal cells and chemokine gradients organize the loss of tissue architecture in lymph nodes in B cell lymphoma ✒️Judith B. Zaugg, Daniel Hübschmann, Simon Haas & Sascha Dietrich & colleagues www.nature.com/articles/s43...

Now in Nature Cancer! @rkmurthy.bsky.social and colleagues provide evidence suggesting clinical benefit with the combination of tucatinib, capecitabine and trastuzumab as systemic regimen for women with HER2+ leptomeningeal metastasis www.nature.com/articles/s43...

📢Come join our editorial team @natcancer.nature.com We're hiring an Associate or Senior Editor! Apply to join our team in Shanghai, Beijing, Nanjing or Madrid. ⏲️Application deadline: March 29th Details: 👉 springernature.wd3.myworkdayjobs.com/SpringerNatu...

📣Hot off the press @natcancer.nature.com Don’t miss these 3 new Articles along with the accompanying News&Views on the use of AI in breast cancer screening!

🌟New Resource article Read about the pancancer landscape of cancer-specific cell-free DNA methylation and fragmentomic features from plasma samples from 1,294 patients ✒️Yong Zeng, @matlupien.bsky.social, @pughlab.bsky.social, Housheng Hansen He & colleagues www.nature.com/articles/s43...

PERSPECTIVE hot off the press @natcancer.nature.com ! 'Setting higher standards for reports of microbial species in human cancers' 🔗 www.nature.com/articles/s43... ✒️By Steven Salzberg, Jacques Neefjes & Niranjan Nagarajan and co-authors #tumormicrobiome

🌟Out today in Nature Cancer, two automated tools to analyze prognostic spatial features of TNBC by Michael Angelo & co @joleneranek.bsky.social @noahgreenwald.bsky.social QUICHE detects differentially enriched cellular niches, including low-prevalence niches. www.nature.com/articles/s43...

⭐Technical Report out today at Nature Cancer The deep neural network M-PACT uses low-input cell-free DNA methylation profiles to classify pediatric brain tumors @doctorpauln77.bsky.social www.nature.com/articles/s43...

Join us on Tuesday, Feb. 17 as Luca Danelli @natcomms.nature.com @natcancer.nature.com presents, "Understanding the editorial process at Nature journals" at 12:30pm in Boyer 130. The seminar is open to all UCLA faculty, students and staff! 🐻

📢Don't miss this recently published @natcancer.nature.com Article! ✒️By Housheng Hansen He, Xin Xu and colleagues 🔗 www.nature.com/articles/s43...

❄️Our January Issue is out! Featuring: ☑️Review on GBM immunity ☑️immune atlas in multiple myeloma ☑️tumor microbiome in head & neck cancer ☑️MEK–RAF molecular glue against RAS/BRAF-mutant cancers ☑️atypical EMT ☑️CheckMate 77T phase 3 trial in patients with NSCLC and more! www.nature.com/natcancer/vo...

🌟New Perspective at Nature Cancer Read about the recent advances in spatial omics and computational models that inform the classification and clinical relevance of cellular neighborhoods in cancer. by Kai Tan and colleagues @kaitanlab.bsky.social 🔗 www.nature.com/articles/s43...

Our editor Heathcliff Dorado Garcia will be attending Spotlight on the #CancerCell: Vulnerabilities for Therapy, this January in Cary. If you want to connect with him, you can reach him per email! @keystoneSymposia.bsky.social keysym.us/KSCancerCell26 #KSCancerCell26

New Perspective to read at Nature Cancer Learn about the current clinical and preclinical evidence of the effects of GLP-1 medicines on cancer outcomes and their mechanism in cancer cells and the TME. ✏️Julian M. Yabut & @danieljdrucker.bsky.social www.nature.com/articles/s43...

⭐New Article at Nature Cancer Chen et al. report the design and characterization of a systemically injectable oncolytic virus with tumor-targeting and low-immunogenic properties, engineered to induce tumor cell pyroptosis under local mild hyperthermia. www.nature.com/articles/s43...

🚨Don't miss this window-of-opportunity phase 2 RCT now published @natcancer.nature.com: 'Evaluating progesterone receptor agonist megestrol plus letrozole for women with early-stage estrogen-receptor-positive #breastcancer' ✒️By Richard Baird and colleagues 🔗 www.nature.com/articles/s43...

🚨New Article now published at Nature Cancer 'TGFβ induces an atypical #EMT to evade #immune mechanosurveillance in #lungadenocarcinoma dormant #metastasis' ✏️By Joan Massagué and colleagues 🔗 www.nature.com/articles/s43...

📣Check out this Article published at Nature Cancer 'The MEK–RAF molecular glue IK-595 has potent antitumor activity across RAS/MAPK pathway-altered cancers' ✏️By Jeffrey Ecsedy and colleagues 🔗 www.nature.com/articles/s43...

🎆New year, new papers at Nature Cancer! The amount of tumor bacteria is now shown to influence immunotherapy outcomes in head and neck cancer in two papers out today: 🔗 www.nature.com/articles/s43... 🔗 www.nature.com/articles/s43... With the associated N&Vs: www.nature.com/articles/s43...

🚨New Clinical Outlook published as part of the 2025-in-review Nature Cancer content! ✏️By Sandra Misale 'The evolving landscape of RAS-targeted therapies' 🔗 www.nature.com/articles/s43...

⭐Check out this Comment published in the 2025 year-in-review @NatureCancer Focus Issue ✏️By Michelle Monje & Frank Winkler 'Key developments in the cancer neuroscience field' 🔗 www.nature.com/articles/s43...

Take a look at this Article now out at Nature Cancer! ✏️By Christophe Quéva, Francisco Quintana and colleagues 'Retargeted oncolytic viruses engineered to remodel the tumor microenvironment for glioblastoma immunotherapy' 🔗 www.nature.com/articles/s43...

🚨Check out this Technical Report from Nature Cancer ✒️By Tieliang Gong, Chen Li, Mireia Crispin-Ortuzar and colleagues 'SMMILe enables accurate spatial quantification in digital pathology using multiple-instance learning' 🔗 www.nature.com/articles/s43...