Drs. @kylessmith.bsky.social, Yiran Li, and a team in @doctorpauln77.bsky.social's lab at @sjcenos.bsky.social analyzed previously published #scRNAseq data and found no evidence of transitional cerebellar progenitors. Read the article: go.nature.com/46iVgyl Listen to the discussion: bit.ly/3IGfUP1

Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5

The location and type of mutation in ZIC1 determines medulloblastoma subtype and can be targeted to suppress cancer growth. Read about the collaboration between the Northcott, Taylor, and Huang labs at St. Jude, Baylor, and Mayo: tinyurl.com/y9dbkrsw @stjuderesearch.bsky.social

Thrilled to share our recent work published in @naturegenet.bsky.social, where we uncover how ZIC1 is regulated by distinct genetic and epigenetic mechanisms in SHH vs. Group 4 medulloblastoma—revealing it as a context-dependent driver. tinyurl.com/2c3jnhn2