In collaboration with @mattevilab.bsky.social, we share in @naturecomms.bsky.social our work studying the mechanism of LSD1 covalent ‘formylators’. Many LSD1 inhibitors create a bulky FAD-drug adduct. Discovered by Takeda by phenotypic screening, these formylators serendipitously create formyl-FAD.

I’m excited to share the latest work from our lab, led by a group of three amazing scientists: Junbing Zhang, Yousuf Ali and Harrison Chong, who describe @nature the discovery of a ROS sensor, VPS35, which links cytosolic H2O2 levels to regulation of mitochondrial translation and

Interested in small molecule mechanism? If you’re at #ACSSpring2025, stop by the Eli Lilly Symposium Wed 9am–12pm @ Room 31A in the convention center. Cool talks from @michael-erb.bsky.social, Yuh Min Chook & @xiaoyuzhang.bsky.social. I’ll discuss our program on chemical genomics. Come check it out!

Delighted to share this work led by @mekedlawitts.bsky.social that investigates the delivery efficiency of various protein delivery vehicles! pubs.acs.org/doi/10.1021/...

Happy to share a @nature.com News and Views on the amazing discoveries by @brianliau.bsky.social & Ning Zheng labs on how a molecular glue unexpectedly mimics the effect of cancer mutations. Such cool science and with implications to drug discovery. Check it out. www.nature.com/articles/d41...

Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5