Ryan Potts - real
@pottslab.bsky.social
📤 1323
📥 1154
📝 33
VP & Head of Induced Proximity Platform, @Amgen | Scientist | Father
pinned post!
What if treating disease meant stabilizing biology, not blocking it? We explore that idea in @ScienceMagazine with LOCKTAC molecular glues, a new class of molecules that stabilize natural interactions to either boost or block biology.
science.org/doi/10.1126/sc…
shorturl.at/976
aj
#mycompnay
ay
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https://science.org/doi/10.1126/sc…
4 months ago
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Ryan Potts - real
Science Magazine
4 months ago
A new
#ScienceReview
looks at a different approach to drug discovery that may enable drugging of unconventional targets through stabilization of macromolecular complexes with molecules known as “LOCKTACs.” Learn more:
https://scim.ag/4lC2aCM
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Check out how the Amgen Induced Proximity team repurpose lysosomal membrane proteins for targeted protein relocalization and degradation using LYMTAC molecules. Now published in @NatureComms. Congrats to
@dnalawansha0509.bsky.social
and team!
#mycompany
www.nature.com/articles/s41...
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LYMTACs:chimeric small molecules repurpose lysosomal membrane proteins for target protein relocalization and degradation
Nature Communications - LYMTACs are heterobifunctional small molecules that take advantage of lysosomal membrane proteins to degrade membrane targets via relocalization and lysosomal degradation,...
https://www.nature.com/articles/s41467-025-63128-4.epdf
4 months ago
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What if treating disease meant stabilizing biology, not blocking it? We explore that idea in @ScienceMagazine with LOCKTAC molecular glues, a new class of molecules that stabilize natural interactions to either boost or block biology.
science.org/doi/10.1126/sc…
shorturl.at/976
aj
#mycompnay
ay
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https://science.org/doi/10.1126/sc…
4 months ago
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🎓 Recent STEM grad? Jump-start your PhD journey with Amgen’s new 2-yr paid Postbaccalaureate Research Fellowship in Thousand Oaks! Work with world-class scientists, publish your findings, and make a real impact for patients. Apply by July 15 ➡️
amgen.wd1.myworkdayjobs.com/Careers/job/...
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Postbaccalaureate Fellow - Research
Career Category Research Job Description Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients...
https://amgen.wd1.myworkdayjobs.com/Careers/job/US---California---Thousand-Oaks/Postbaccalaureate-Fellow---Research_R-216920
6 months ago
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Ryan Potts - real
Dan Nomura
7 months ago
Our latest paper w/
@pottslab.bsky.social
&
@amgen.bsky.social
in
@jacs.acspublications.org
by co-first authors
@cmzammit.bsky.social
& Cory Nadel on discovery of covalent destabilizing degrader of AR & AR-V7 in prostate cancer. Thanks also to
@themarkfdn.bsky.social
!
pubs.acs.org/doi/10.1021/...
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Ryan Potts - real
Carolyn Bertozzi
9 months ago
SCAM ALERT. This is a fake conference that ripped off my and other people’s names to trick people into registering. There is no such conference that I or the others shown were invited or agreed to. We are working to try to get this fraud taken down from the web.
chemsymposia.com
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Join Chemsymposia 2026: Research & Innovation | ChemSymposia 2026
Join us at Chemsymposia 2026 to discover groundbreaking research in physics applications. Connect with experts, engage in insightful discussions, and explore our venue, registration details, and speak...
https://chemsymposia.com/
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Carolyn Bertozzi
9 months ago
Now we’re finally talking!
www.politico.com/news/2025/03...
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https://www.politico.com/news/2025/03/27/california-democrat-states-nih-00252794
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Ryan Potts - real
Cell Chemical Biology
9 months ago
[email protected]
@amgen.bsky.social demonstrate proof-of-concept of disease-specific targeted degradation by redirecting virally encoded E3 ubiquitin ligases with VIPER-TACs.
http://dlvr.it/TJgF0r
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🚨 Rational discovery of VHL molecular glues. New Preprint from
@amgen.bsky.social
Induced Proximity group led by postdoc Jonathan Bushman reports the discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq. Read on for details. 🧵1/8
www.biorxiv.org/content/10.1...
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Discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq
Targeted protein degradation (TPD) is an emerging therapeutic modality in which small molecules are used to recruit targets to the natural protein degradation machinery of the cell. Molecular glue deg...
https://www.biorxiv.org/content/10.1101/2025.03.19.644003v1
9 months ago
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Check out this cover highlighting
@amgen.bsky.social
postdoc Kyle Mangano’s work on VIPER-TACs! 🐍
add a skeleton here at some point
9 months ago
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Ryan Potts - real
Sylvie Callegari
10 months ago
Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science
www.science.org/doi/10.1126/...
@wehi-research.bsky.social
@komanderlab.bsky.social
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Sherry Pagoto, PhD
10 months ago
New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024. That's not to mention the countless lives that biomedical research has saved. Show me a better investment than that.
www.forbes.com/sites/michae...
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NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report
National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.
https://www.forbes.com/sites/michaeltnietzel/2025/03/12/nih-grants-fueled-95-billion-in-economic-activity-finds-new-report/
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Ryan Potts - real
Cell Chemical Biology
10 months ago
Online now! @pottslab.bsky.social @amgen.bsky.social demonstrate proof-of-concept of disease-specific targeted degradation by redirecting virally encoded E3 ubiquitin ligases with VIPER-TACs.
http://dlvr.it/TJLmvh
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🚨Hiring Alert🚨 Recruiting an accomplished leader to serve as Director and Head of Discovery
#Proteomics
at Amgen. Find out more and apply here:
careers.amgen.com/en/job/south...
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Director of Discovery Proteomics Jobs at Amgen in United States of America
Explore the details of a Director of Discovery Proteomics career in South San Francisco. Live. Win. Thrive. Search and apply for a rewarding new career at Amgen.
https://careers.amgen.com/en/job/south-san-francisco/director-of-discovery-proteomics/87/78217960112
10 months ago
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New
@biorxivpreprint.bsky.social
preprint from Amgen induced proximity group and
@dannomura.bsky.social
lab just posted that describes Covalent Destabilizing Degrader of AR and AR-V7 in Androgen-Independent Prostate Cancer Cells. Read on for an overview 1/7
www.biorxiv.org/content/10.1...
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Covalent Destabilizing Degrader of AR and AR-V7 in Androgen-Independent Prostate Cancer Cells
Androgen-independent prostate cancers, correlated with heightened aggressiveness and poor prognosis, are caused by mutations or deletions in the androgen receptor (AR) or expression of truncated varia...
https://www.biorxiv.org/content/10.1101/2025.02.12.637117v1
10 months ago
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Happy to share a
@nature.com
News and Views on the amazing discoveries by
@brianliau.bsky.social
& Ning Zheng labs on how a molecular glue unexpectedly mimics the effect of cancer mutations. Such cool science and with implications to drug discovery. Check it out.
www.nature.com/articles/d41...
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Molecular glue unexpectedly mimics the effect of cancer mutations
Protein structures could guide the design of molecular glue degraders.
https://www.nature.com/articles/d41586-025-00090-7
10 months ago
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reposted by
Ryan Potts - real
Dan Nomura
10 months ago
Our latest BioRxiv by
@cmzammit.bsky.social
, Cory Nadel,
@pottslab.bsky.social
on a covalent destabilizing degrader against AR & AR-V7 in prostate cancer that targets an IDR C125 to destabilize, inhibit, and degrade TF! Thanks to
@amgen.bsky.social
, MTI, Berkeley MCB/Chemistry, NCI, TMFCR, and NSF!
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Covalent Destabilizing Degrader of AR and AR-V7 in Androgen-Independent Prostate Cancer Cells
Androgen-independent prostate cancers, correlated with heightened aggressiveness and poor prognosis, are caused by mutations or deletions in the androgen receptor (AR) or expression of truncated varia...
https://www.biorxiv.org/content/10.1101/2025.02.12.637117v1
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Ryan Potts - real
Sri Kosuri
11 months ago
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
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Ryan Potts - real
Citizen.Coping
over 1 year ago
Harvard and Google AI mapped one cubic millimeter of a human brain. It took up 1.4 petabytes of storage just in pictures of the specimen. So the entire brain would take ~ 1.6 zettabytes of storage, cost $50 billion, and require 140 acres. It would be the largest data center on the planet— one brain.
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Full scan of 1 cubic millimeter of brain tissue took 1.4 petabytes of data, equivalent to 14,000 4K movies — Google's AI experts assist researchers
Mind-boggling mind research.
https://www.tomshardware.com/tech-industry/full-scan-of-1-cubic-millimeter-of-brain-tissue-took-14-petabytes-of-data-equivalent-to-14000-full-length-4k-movies
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Somatic FBXW7-R465C mutant shows promise in targeted protein degradation in cancer cells. This approach enhances protein degradation specificity in diseased cells. Congrats Xiaoyu Zhang and colleagues. 🧪
#chembio
#TPD
#CancerResearch
www.biorxiv.org/content/10.1...
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Harnessing the FBXW7 somatic mutant R465C for targeted protein degradation
Targeted protein degradation (TPD) is a pharmacological strategy that eliminates specific proteins from cells by harnessing cellular proteolytic degradation machinery. In proteasome-dependent TPD, exp...
https://www.biorxiv.org/content/10.1101/2024.12.03.626601v1.full.pdf+html
about 1 year ago
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Ryan Potts - real
Bluesky
about 1 year ago
Scientists, academics, researchers: We’re excited to share that
@altmetric.com
is now tracking mentions of your research on Bluesky! 🧪
add a skeleton here at some point
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reposted by
Ryan Potts - real
Abhishek Chatterjee
about 1 year ago
Got the chance to put together the "Click of Chemical Biologists" starter pack v1 and v2 over the Thanksgiving Break. Feel free to ping me on who else I might be missing! V1:
go.bsky.app/3P5i7nJ
V2:
go.bsky.app/Cr4ej7
add a skeleton here at some point
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Ryan Potts - real
John Ngo
about 1 year ago
We designed MS2 and PP7 binding coat proteins that are degraded in cells except when bound by their hairpin RNAs. You can check out our pre-print here:
tinyurl.com/27p7hyt9
, and listen to a Google AI-generated podcast on it here:
notebooklm.google.com/notebook/d71...
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Ryan Potts - real
Zunlong Ke
about 1 year ago
A fun journey of full-length EGFR with Dan Leahy and
@edwardmarcotte.bsky.social
at UT Austin
@utaustin.bsky.social
. See below: Structure and organization of full-length Epidermal Growth Factor Receptor in extracellular vesicles by cryo-electron tomography
www.biorxiv.org/content/10.1...
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Nifty, innovative approach
add a skeleton here at some point
about 1 year ago
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Ryan Potts - real
Xiuzhen Chen
about 1 year ago
Came to a new understanding of 'colocalization' since starting STED microcopy: there is no colocalizaiton, objects cannot occupy the same physical space!
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reposted by
Ryan Potts - real
Ingo Hartung
about 1 year ago
If you are not yet sure how to best spend your time in May next year, come to Chicago & hear about small molecule drug discovery. It‘s where all the cool stuff is currently happening (I may be slightly biased in my opinion).
www.medchemfrontiers.org/@acsmedi.bsk...
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Ryan Potts - real
Witold Szymański
about 1 year ago
Just got my TimsTof Ultra cookie form 😏 a nice touch from
#bruker
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Ryan Potts - real
bioRxiv Biochemistry
about 1 year ago
Dynamic regulation of the oxidative stress response by the E3 ligase TRIP12 https://www.biorxiv.org/content/10.1101/2024.11.25.625235v1
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Dynamic regulation of the oxidative stress response by the E3 ligase TRIP12 https://www.biorxiv.org/content/10.1101/2024.11.25.625235v1
The oxidative stress response is centered on the transcription factor NRF2 and protects cells from r
https://www.biorxiv.org/content/10.1101/2024.11.25.625235v1
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Ryan Potts - real
Ingo Hartung
about 1 year ago
There are no shortcuts in drug discovery. And it takes incredible efforts to make sense of what you can find in the scientific literature. This is an excellent piece of work to quality check what has been claimed as a new avenue in targeted protein degradation (TPD).
www.nature.com/articles/s41...
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Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets - Nature Communications
Autophagosome tethering compounds (ATTECs) are small molecule degraders hijacking the autophagy system. Here, the authors show that current ATTEC ligands did not bind to their designated targets but e...
https://www.nature.com/articles/s41467-024-54409-5
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Ryan Potts - real
ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ
about 1 year ago
in-frame deletion
#genetics
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reposted by
Ryan Potts - real
Greg Medlock
about 1 year ago
I’m creating a drug development starter pack, reach out to join or suggest additions:
go.bsky.app/B2pzQm2
add a skeleton here at some point
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reposted by
Ryan Potts - real
Razvan Borza
about 1 year ago
⚠️THREAD OF ALL SCIENCE-RELATED STARTER PACKS! ⚠️ 🔄Share to help people finding its topic/field - STRUCTURAL BIOLOGY Structural Biology 1:
bsky.app/starter-pack...
Structural Biology 2:
bsky.app/starter-pack...
Crystallography:
bsky.app/starter-pack...
Synchrotron&CryoEM:
bsky.app/starter-pack...
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Interesting study from Genentech showing previously thought to be TEAD-YAP PPI inhibitors actually work through promoting TEAD interaction with the VGLL4 transcriptional repressor. Shows importance of deep mechanistic understanding of cmpd MOA. 🧪
www.biorxiv.org/content/10.1...
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TEAD-targeting small molecules induce a cofactor switch to regulate the Hippo pathway
TEAD proteins are the main transcriptional effectors of the Hippo signaling pathway and a pharmacological target in oncology. Most TEAD-targeting small molecules act by disrupting interaction with the...
https://www.biorxiv.org/content/10.1101/2024.11.15.623512v1
about 1 year ago
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Using a PAL-based Chem-CLIP approach, NVS researchers identified RNA targets binding directly with splice modulating compounds, revealing novel RNA interactions. Key findings include TERC as a new target and GATA3 as a novel target with decreased exon inclusion. 🧪
www.biorxiv.org/content/10.1...
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Photoaffinity enabled transcriptome-wide identification of splice modulating small molecule-RNA binding events in native cells
Splice modulating small molecules have been developed to promote the U1 snRNP to engage with pre-mRNAs with strong and altered sequence preference. Transcriptomic profiling of bulk RNA from compound t...
https://www.biorxiv.org/content/10.1101/2024.11.14.623654v1
about 1 year ago
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Ryan Potts - real
Dr Neil Stone
about 1 year ago
I can't figure out if vaccines work or not. Tough one. I can see why RFK Jr is so concerned. Need Sherlock Holmes on this one.
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Wow is this cool! Discovery in penguins: Over 10,000 daily naps, each lasting just 4 seconds, accumulate to over 11 hours of restorative sleep. This adaptation to their vigilant lifestyle in Antarctica reveals how sleep benefits can accrue incrementally. 🧪
www.science.org/doi/10.1126/...
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Nesting chinstrap penguins accrue large quantities of sleep through seconds-long microsleeps
Nesting chinstrap penguins accrue large quantities of sleep through seconds-long microsleeps
https://www.science.org/doi/10.1126/science.adh0771
about 2 years ago
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Stress granules, what are they good for? Cellular repair! They act as plugs to stabilize damaged endolysosomal membranes, facilitating efficient repair. Blocking their formation in macrophages creates a conducive environment for M. tuberculosis. 🧪
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Stress granules plug and stabilize damaged endolysosomal membranes - Nature
Stress granules function at sites of intracellular membrane damage by forming on and stabilizing the ruptured membrane and promoting membrane repair.
https://www.nature.com/articles/s41586-023-06726-w
about 2 years ago
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Molecular glues that promote PPIs are an exciting drug modality. It has been unclear whether endogenous MGs exist in humans. New work reports endogenous MGs (pAGs) that induce proximity of butyrophilins to promote antigen recognition by γδ-T cells. Very cool! 👏🧪
www.nature.com/articles/s41...
about 2 years ago
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c&en: Why small-molecule drug discovery is having a moment. Induced proximity / multi-specifics are ushering in new age for small molecule drug discovery. 🧪
cen.acs.org/pharmaceutic...
about 2 years ago
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New here, joining this feed? 🧪
@danirabaiotti.bsky.social
over 2 years ago
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