📢We are delighted to share our latest themed collection on Induced-Proximity Pharmacology, guest edited by @lynjoneschembio.bsky.social, @hartungingo.bsky.social & Lindsey James! Explore the articles that make up this fantastic collection, here👇 pubs.rsc.org/en/journals/... #chemsky 🧪

Great visit to our longstanding collaboration partners at the ICR discussing how small molecules continue to generate clinical impact. Learned a lot about how Zoran and his team tackle glue degrader discovery to deliver on the promise of expanding the druggable space.

Hi all, our old #sciencetwitter party place is reopening. Just in case you didn‘t get the invite… bring your Popcorn!

This paper sounds interesting. Oh wait… @proxidrugs.bsky.social

Guess who is sitting in front of me…

I guess this means I made it through immigration… #AACR25

🚀 An inspiring milestone worth sharing! 🎥 Yesterday marked the official kick-off event for the 2nd phase of our BMBF-funded #Cluster4Future @proxidrugs.bsky.social. Thanks to all scientists, stakeholders, citizens & schools for actively participating and making it a very special day for us!

Una copa bien en alto por uno de mis autores favoritos. Gracias por las historias, las palabras, y la valentía. Buen viaje, Mario. 🥂📚 Farewell to the Last Writer of the Latin American Boom www.nytimes.com/2025/04/13/b...

Life could be worse… unfortunately, a pretty busy working week ahead.

First impressions of comparing #AACR25 coverage on Bluesky with the other place. I am used to check the conference handle regularly to build my conference schedule. Some interesting findings on Twitter, nothing here yet. I hope conference coverage will pick up here as well.

Still difficult for me to judge the reach of this platform. #AACR25 (5 weeks from now) will be the 1st real test for science posting here. The meeting program is packed w/ sessions about novel ADC approaches, degraders/proximity inducers, targeting intracktables, overcoming resistance, using AI.

Besonders die Einleitung des Artikels ist wichtig. Ich frage mich die ganze Zeit: warum sollte Putin warten, bis Europa sich besser verteidigen kann? ME ist das einzige, was ihn noch aufhält, der ukrainische Widerstand.

A bit more than one month til #AACR25 and two months til the ASCMEDI-EFMC symposium - both in Chicago. I never thought that traveling to the US may ever become an issue for political reasons. Let‘s see what the next weeks will bring…

More about rewiring transcription with bifunctional TCIP molecules: biological proof-of-concept in sarcoma cell lines www.biorxiv.org/content/10.1...

A small molecule USP7 activator from the Buhrlage Group! Important information in the SI not to be missed: significant activity differences between enantiomers & an inactive control compound. A very strong data package further enabling studies of USP7 biology.

📢Looking ahead to #AACR25 in Chicago — only 6 weeks away! Join the Meet-the-Expert session with Prof. Paul Workman, where he’ll emphasize the critical role of high-quality chemical probes in drug discovery. 📅 April 29, 2025 | ⏰ 5:00-5:45 PM Learn more👇 #CancerResearch

Summary: 1st Ph3 readout for a #PROTAC; likely path-to-approval in metastatic breast cancer patients w/ ESR1 mutations after having received endocrine therapy & CDK4/6 inhibitors; in line with previous clinical data; stock brokers don‘t understand Ph1/2 data. www.fiercebiotech.com/biotech/pfiz...

What a book! Very well deserved Booker Prize. Must-read recommendation. #ChemistsWhoRead

Tja, das ist mal ein Romanbeginn, der meine Aufmerksamkeit schon im ersten Satz gewonnen hat…

Small molecular weight drug molecules are products of design. Multiple characteristics are designed into one chemical structure. Read about how the combination of experimental data with calculated properties streamlines the discovery of oral designer PROTACs: pubs.rsc.org/en/content/a... @rsc.org

Visiting #Irsee2025 was again a true pleasure. Not only the great science in a unique environment. But also the truly Bavarian weather, food & beer! Already looking forward to 25th til 27th February 2026 for #Irsee2026! @dechema.bsky.social

More biocatalysis at #Irsee2025. It took us a few years to bring Uwe Bornscheuer all the way from the baltic sea to south-western Bavaria. But it was worth the wait… reengineering methyl transferases and monooxygenases. @dechema.bsky.social

The Hit to Lead process is an integral part of contemporary drug discovery. A perspective just published in #ChemMedChem (@chemistryeurope.bsky.social), highlight the new set of @euromedchem.bsky.social best practices focused on H2L. chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

The new perspective from the @euromedchem.bsky.social Best Practice Initiative is now online: chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1... Best practice recommendations for the optimization from a Hit to a Lead. Kudos to Bob Young & Jean Quancard for driving this initiative!

The power & coolness of biocatalysis at #Irsee2025: Rebecca Buller from Zurich University of Applied Sciences about strategies to evolve designer enzymes. Enabling the chlorination of the complex macrolide soraphen and the derivatization of terpenes.

„Was bei diesen Wahlen passiert, wird enorme Auswirkungen auf den Rest der Welt haben.“ Timothy Snyder #Bundestagswahl2025

It's finally out – actually out and in print! Many thanks to @jcornlab.bsky.social @matthiasmuhar.bsky.social @jakobfarnung.bsky.social and all the fantastic collaborators. What started as pure curiosity lead to an amazing find! www.nature.com/articles/s41...

Talking about VHL-based #PROTACs: Check out our newest publication from the @proxidrugs.bsky.social consortium in which we propose & exemplify a generalizable workflow for the validation of E3 ligands for developing PROTACs. pubs.acs.org/doi/10.1021/...

Still all fine on this side of the sea of greenland (formerly known as the atlantic ocean).

There are many reasons for drug discovery scientists to be interested in #PROTACs. VHL-based PROTACs should not be ignored, there are important use cases for them. @alessiociulli.bsky.social & colleagues now compiled the VHL ligand chemical space in this paper: www.tandfonline.com/doi/pdf/10.1...

I have to for upcoming conferences and speaker invitations. I always enjoyed visiting the US. But this is different now. My visa to enter the US ends in early 2026. So it will be fun with the immigration officers & even more fun with applying for a new one at the US embassy in Germany.

Yeah… #Commodore64 ftw www.shutterstock.com/image-photo/...

Commodore 64 with floppy disk generation over here 🤷‍♂️

RIP Amos Smith: www.chem.upenn.edu/news/2025/02... chemsky 🧪⚗️

I think some people hear “grants” and think that without them, scientists and government workers just have less stuff to play with at work. But grants fund salaries for students, academics, researchers, and people who work in all areas of public service. “Pausing” grants means people don’t eat.

Random chemist: Only biologists use pubmed, we still got google, scifinder… 😉

Welcoming the newest members of the #NatureReviews family @natrevbiodiv.bsky.social & @natrevcleantech.bsky.social on their launch week! You can follow them and more Reviews journals (and a few Editors) in this starter pack 🧪 go.bsky.app/KcxvQLp

Und noch eine Roman-Empfehlung mit aktuellem Bezug: Arnold Zweigs Roman “De Vriedt kehrt heim” über einen politischen Mord im britischen Mandatsgebiet Palästina (Erstveröffentlichung 1932!). Neuausgabe aus 2024 der Anderen Bibliothek. Über die Ursprünge des israelisch-palästinensischen Konflikts.

Nach längerer Pause gestern mal wieder im Theater: Faust 1&2 im Schauspiel Frankfurt, Regie Jan-Christoph Gockel, mit “Kommissar Brix” als Mephisto. 4h modernes, multimediales, sehr kurzweiliges Theater. Textkenntnis hilft, kann aber durch die Einführung ersetzt werden. Wieder im März & April.

Bluesky appears to be the official social media platform for science: In Jan 2025, a Nature survey of 6,000 scientists found: ▶️ 70% are now on Bluesky ▶️ 53% say they left X ▶️ 13.6% say they use X more than Bluesky www.nature.com/articles/d41...

Appropriate reading during these tumultuous days: „Twilight of Democracy“ by @anneapplebaum.bsky.social. A few teasers below for those interested in thinking about the historical perspective for the destructive centrifugal forces currently visible in all Western democracies. amzn.eu/d/1m8dE4G

Sunset are always spectacular when you are at the coast in the south.

Sehr guter Transfer meiner Roten. Jetzt gerne noch einen Stürmer…

In preparation for the inauguration on Monday I ask myself what has happened in the 16 years since this speech: youtu.be/HcOgwJ9uAMQ?... Since the days of cooperation across the aisle. Astonishing that we would look back at George W Bush this way.

Great news today: cKIT inhibitor M4205 aka IDRx-42 (discovered in our medicinal chemistry labs at @merckgroup.bsky.social) found a new home. Our fingers continue to be crossed that the compound will make a difference for GIST patients. New therapies are urgently needed! Congrats to the IDRx team!

Thanks to those who’ve reached out the last few days. I am grateful that my family and home are safe. Many of my friends and colleagues have lost homes. If you want to help Caltech/JPL faculty/students/staff, a relief fund has been established: giving.caltech.edu/areas-to-sup...

Es bleibt zu hoffen, dass sich der Bundestagswahlkampf um Inhalte drehen wird und weniger um „Was hat Söder gesagt und hat ihm Günther widersprochen?“. Im Moment findet die inhaltliche Auseinandersetzung um fundamentale politische Unterschiede nur in wenigen Printmedien statt. Hier z.B. im Cicero.

After having finished Angela Merkel‘s memoirs I am now moving further back in time. The relevance for today‘s situation in Europe is obvious. The author @anneapplebaum.bsky.social is an important voice in discussions about the future of Ukraine, Poland & the Baltic states. #ChemistsWhoRead

The main reason why I am using @duolingoesp.bsky.social is to be able - eventually - to read a book like this in its original version. Unfortunately, I am still a few years away from this goal… #ChemistsWhoRead