Join @youngscinet.bsky.social for "Under Pressure: A Mental Health Conversation for the Academic Community," a virtual workshop aimed at building resilience, support and creating a healthier future for yourself and academia. October 10 - 1PM 🔗 us06web.zoom.us/webinar/regi...

👩‍🔬 Have you read our latest #MedChemBioConversation ? Get to know Maria Letizia Barreca from University of Perugia, Italy.🔍 Dive into our monthly talks with specialists to explore the latest breakthroughs in drug discovery and pick up some valuable advice. 🔗https://buff.ly/63Jy5As

The report of the FiMC, co-organized by the Med Chem Division of the @gdch.de, the #DPhG and the @scs-dmccb.bsky.social, has been just published in #ChemMedChem (@chemistryeurope.bsky.social) chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

A new #ChemMedChem (@chemistryeurope.bsky.social) article explores the effect of modified bifunctional antisense oligonucleotides (BASOs) on the phenotype of cancer cells, evaluated by real-time measurement of cell proliferation and motility. chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out (chemistry-europe.onlinelibrary.wiley.com/toc/18607187...) with a Front Cover illustrating the crystal structure of the N-terminal domain of clathrin with the known binding sites colored and a selection of Pitstop 2 analogues.

An Highlight article just accepted in #ChemMedChem (@chemistryeurope.bsky.social) spotlights #balinatunfib, an orally available small molecule jointly developed by Sanofi and UCB preventing TNFα from effectively binding to its receptors. chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out (chemistry-europe.onlinelibrary.wiley.com/toc/18607187...)!

I have poked the @rsc.org on X/Twitter a bit over the years (sorry folks...), but huge kudos to them for leaving what has become even more of a toxic and hateful platform www.rsc.org/news-events/... 👏 #chemsky

Only two weeks left to apply for a Flash Talk at the 5th Virtual @chembiotalks.bsky.social! If you are a PhD or postdoc and want a chance to present to a global #ChemBio audience, make sure to check out our abstract challenge: chemistry-europe.onlinelibrary.wiley.com/hub/journal/...

Another great edition of @youngscinet.bsky.social #MedChemBioOnline is going to start in 1 hour and a half. Do not miss the opportunity to learn about "Best Practices in Discovering PROTACs" with experts in the field!

The last talk of the day at the 11th Novalix Conference “Biophysics in Drug Discovery” was the terrific keynote lecture by Stefan Knapp on "Comprehensive Characterization of Chemical Tools and New Modalities such as PROTACs". @thesgc.bsky.social

Amazing keynote lecture by Amanda Garner at the 11th Novalix Conference—Biophysics in Drug Discovery in Strasbourg. Amanda delivered a brilliant talk on "Enabling Technologies for Revealing Druggable Paths in RNA Biology". @acsmedi.bsky.social

Great talk by @mariaduca-cnrs.bsky.social at the 11th Novalix Conference about Biophysics in Drug Discovery. Maria presented a few of her group projects, talking on how to target RNA using synthetic small molecules and how to discover an characterize RNA binders. Brilliant!

The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out! chemistry-europe.onlinelibrary.wiley.com/toc/18607187...

No orders for supplies/reagents/equipment (already a huge bottleneck after earlier cuts). No travel or conference registrations. And certainly no hiring. So this could be a total freeze, in everything but name. Is that the new workaround the administration is trying? Isn't that illegal? (2/2)

I'm getting word that the latest attempt to strangle what's left of the NIH is that purchasing agents have been mostly/completely cut, with the purchasing to be done by centralized GSA staff. Who either don't exist or aren't assigned. That means in practice no spending at all! (1/2)

If you love drug candidates but weren't able to attend the #FirstTimeDisclosures symposium at #ACSSpring2025, check out my story about the session for @cenmag.bsky.social - with lots of cool-looking molecules. cen.acs.org/acs-news/acs...

An amazing, totally inspirational and emotional journey! The @acs.org Priestley Medal talk by @francesarnold.bsky.social at #ACSSpring2025

The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out! chemistry-europe.onlinelibrary.wiley.com/toc/18607187...

New on @science.org's daily Trump Tracker: A key influenza vaccine meeting gets abruptly canceled, and more than 90% of all USAID grants are terminated. www.science.org/content/arti...

A new White House freeze on using government-issued credit cards is the latest shock for federal scientists, potentially affecting everything from conference travel to needed purchases for clinical care or lab work. scim.ag/4hV9oRb

A Career doing STUFF, a Guest Editorial by Mike Hann for the #ChemMedChem (@chemistryeurope.bsky.social) MedChem Musings series, summarises the many things he did during his 45 year-career in drug discovery. Practical advices and inspiration for future generations of researchers. lnkd.in/dNNy7FaE

The Hit to Lead process is an integral part of contemporary drug discovery. A perspective just published in #ChemMedChem (@chemistryeurope.bsky.social), highlight the new set of @euromedchem.bsky.social best practices focused on H2L. chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out! chemistry-europe.onlinelibrary.wiley.com/toc/18607187...

This is the most relevant article to NIH and research cuts I’ve seen. Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !” globalnews.ca/news/9793403...

Understanding of how structural elements impact #atropisomer stability enables the more efficient optimization of this important feature. A new manuscript just accepted in #ChemMedChem (@chemistryeurope.bsky.social) chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

If you work in drug discovery and you read one thing this weekend, make it this exceptional J Med Chem editorial. Hits on almost every blessed thing I’ve tweetorialized over the last several years. Quantitation and Error Measurements in Dose–Response Curves

Concluding remarks by Claudia Höbartner at #EFMCISCB25. Thanks to sponsors, exhibitors, committees, secretariat and, above all, participants that made this event a very successful one. See you again in 2027! @euromedchem.bsky.social @youngscinet.bsky.social

🌟Poster prize winners - ISCB 🌟 Congratulations to : - Barbara HERRMANN, TU Wien, 🇦🇹 - Zeyneb Vildan CAKIL, Max-Planck-Institut für Molekulare Physiologie, 🇩🇪 -Christine MARTY, EPFL,🇨🇭 - Luka RAGUZ, University of Basel, 🇨🇭 - Alfred DOHERTY, GSK, 🇬🇧 @chemistryeurope.bsky.social @gsbardella.bsky.social

An amazing KL by Akane Kawamura (@kawamuragroup.bsky.social) opened the session on “Chemical Biology of Chromatin and the Epitranscriptome” at #EFMCISCB25, chaired by Paola Arimondo. Akane thrilled the audience with her work on 2OG Oxygenases in Epigenetic Regulation. @euromedchem.bsky.social

Chaired by Claudia Höbartner, the last day at #EFMCISCB25 starts with the PL by Cynthia Burrows (@uofupress.bsky.social) thrilling the audience with her nanopore studies on chemically modified RNA. @euromedchem.bsky.social

The 2nd day at #EFMCISCB25 starts early with a Career Panel Discussion, featuring @stephanhacker2.bsky.social, @kawamuragroup.bsky.social, Cristoph Dumelin, and Thais Gazzi, chaired by Laia Josa Culleré. @euromedchem.bsky.social @youngscinet.bsky.social

And now is the turn of @euromedchem.bsky.social President, @luvah.bsky.social, introducing EFMC and its many activities in the Medicinal Chemistry and Chemical Biology field and to cheer the attendees of #EFMCISCB25

And finally the #EFMCISCB25 is starting, opened by Uwe Grether, co-chair of the event together with Claudia Hobartner. @euromedchem.bsky.social

A β-glucuronidase-responsive albumin-binding prodrug programmed to release a potent Isocombretastatin A-4 analog within the tumor microenvironment. Just accepted in #ChemMedChem @chemistryeurope.bsky.social chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Just arrived in Basel, ready for the @euromedchem.bsky.social #EFMCISCB25 starting tomorrow!

A new methodology to derive biomolecular structure ensembles from distance distribution measurements via a library of tagged proteins bound to an unlabeled and otherwise unmodified target biologic. Just accepted in #ChemMedChem (@chemistryeurope.bsky.social) lnkd.in/eAiqfVWa

The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out! chemistry-europe.onlinelibrary.wiley.com/toc/18607187...

LAST CHANCE TO JOIN @euromedchem.bsky.social EFMC-ISCB 2025! Do not miss this key event in chemical biology, already attracting over 225 participants! (www.efmc-iscb.org/speakers) Day pass available. Register Now! (www.efmc-iscb.org/registration) #EFMCISCB25 @youngscinet.bsky.social

Assessing protonation states for two separate systems (protein and ligand) might result in the incorrect assignment of protonation states and hence incorrect calculation of binding energy. Just accepted in #ChemMedChem (@chemistryeurope.bsky.social). lnkd.in/ePCrpt8S

Nicely written by Kurt Ritter with a finishing touch by Jean Quancard, a short article highlighting the recent set on #PROTACs of the @euromedchem.bsky.social Best Practices in Medicinal Chemistry series. Thank you, @drughunter.com, for hosting it! drughunter.com/articles/emf...

Such a sad news and a huge loss for the whole scientific community. I had the chance to know Fraser during my period at @uclacb.bsky.social. He will be so much missed. @sebvidalchem.bsky.social @stuartcantrill.bsky.social @nobelprize.bsky.social #Chemsky chemistry.northwestern.edu/people/in-me...

A review just accepted in #ChemMedChem (@chemistryeurope.bsky.social) highlights the application of deuteration strategy in drug design and summarize the progress in the field of deuterated drugs. chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

In a manuscript just accepted in #ChemMedChem (@chemistryeurope.bsky.social), the authors (@novartis.bsky.social) present thiazole-based IL-17 inhibitors discovered through a scaffold-morphing strategy. chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Happy Holidays from the EFMC @euromedchem.bsky.social! The Executive Committee (www.efmc.info/cust_committ...) wishes you and your loved ones a joyful festive season filled with good health, relaxation, and happiness and a successful, prosperous and happy 2025!

Happy Holiday Season from #ChemMedChem (@chemistryeurope.bsky.social). We want to thank all the authors and reviewers for all the contributions to CMC in this 2024. We hope you will have a great break, and wish you a fantastic 2025! And we also hope to receive a lot of manuscripts from you in 2025!

The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out (chemistry-europe.onlinelibrary.wiley.com/toc/18607187...), with a cover showing the encapsulation of Aβ peptides within reverse micelles, symbolizing the controlled aggregation of Aβ oligomers within these nano-sized environments.

Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪

The EFMC is now officially on BlueSky! #Chemsky @euromedchem.bsky.social