CACHE 7 is launched with support from the @gatesfoundation.bsky.social and unpublished data from Damian Young at @bcmhouston.bsky.social, Tim Willson @thesgc.bsky.social and Neelagandan Kamaria InSTEM. Design selective PGK2 inhibitors. We'll test them experimentally. bit.ly/4lnVYOs

UCL, with @thesgc.bsky.social and scientists from 30 leading organisations, has published a landmark roadmap in @natrevchem.nature.com‬, outlining a global, open science strategy to scale up hit discovery efforts for every human protein. #Target2035 #DrugDiscovery www.nature.com/articles/s41...

Check how we are going to transform early-stage hit-finding into a data-driven, computational process driven by open science. www.nature.com/articles/s41...

CACHE4 results are out! All previously known CBLCB ligands shared the same scaffold. Congrats to Keunwan Park who successfully designed a chemically novel series, to the experimental team at @thesgc.bsky.social and thanks to @conscience-network.bsky.social for greasing the wheels! bit.ly/4mYNe3r

The last talk of the day at the 11th Novalix Conference “Biophysics in Drug Discovery” was the terrific keynote lecture by Stefan Knapp on "Comprehensive Characterization of Chemical Tools and New Modalities such as PROTACs". @thesgc.bsky.social

@thesgc.bsky.social is generating large/open screening data and inviting data scientists to train their ML models via DREAM challenges: 1- train your model on DEL data 2- retrospectively predict 138 ASMS true positives 3- predict new hits. We will test them and publish together. bit.ly/3YXVKoT

Advancing AI-driven drug discovery begins with open, high-quality data. A great editorial with the authors highlighting how openly accessible datasets have historically accelerated scientific breakthroughs and spotlighting our open data platform: aircheck.ai More: www.science.org/doi/10.1126/...

Advancing ML and drug discovery. @thesgc.bsky.social is now starting to generate protein-ligand data at scale. We’re partnering with CASP, CACHE and DREAM/Sage to run challenges on these data, and help critically assess computational hit-finding methods. Participate! www.synapse.org/Synapse:syn6...

Just out. Using the new @thesgc.bsky.social variation of ASMS, Diwen piloted the idea of identifying protein targets of environmental toxins. Lots of data on how old and new PFAS’s bind different members of the human fatty acid binding protein family. www.biorxiv.org/content/10.1...

A timely and thought-provoking publication proposes rethinking traditional patent-based drug development models. Regulatory exclusivities could better facilitate open science, and collaboration, and focus innovation on unmet medical needs. m4kpharma.com/newsandblogs...

In the past two decades, we've distributed over 5,200 plasmids through Addgene, supporting research at 1,084 organizations in 55 countries.

The CACHE #2 challenge focused on predicting ligands for the SARS-CoV-2 Nsp13 helicase, a key COVID-19 target. 23 teams applied diverse computational strategies, and SGC confirmed hits with inhibitory activity with biophysical assays. @conscience-network.bsky.social chemrxiv.org/engage/chemr...

🚀 100 scientists. 31 countries. And we’re just getting started. #MAINFRAME is uniting global experts to drive AI-powered hit finding. ML models trained on real experimental data. Predictive tools tested in the lab. 🔗 Now is the time to join: aircheck.ai/mainframe

Join us for the next ProteoCure Webinar on March 20th at 1PM (CET)! Nicola Burgess-Brown from @thesgc.bsky.social will discuss how you can contribute your proteins for screening and obtain protein ligands! Learn more here: proteocure.eu/proteocure-w.... Don't miss out!

The CACHE #2 preprint is now online: bit.ly/3DyCmHN Active learning and fragment growing delivered confirmed hits. A citizen scientist using the Fold-it gaming interface designed the top compound! Kudos to Sasha and Madhushika @thesgc.bsky.social at the bench. @conscience-network.bsky.social

"CACHE Challenge 2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13" is out now on ChemRxiv: dx.doi.org/10.26434/che... You can find a discussion of our workflow and designed compound in the preprint (WF1438), which was among 13 compounds confirmed to bind to Nsp13.

The Chemical Probes Portal now covers 601 protein targets, expanding resources for chemical biology & drug discovery! 🧪🔬 New high-quality probes target DCTPP1, MASTL, HCN1, plus E3 ligases & PROTACs for protein degradation. Learn more: www.chemicalprobes.org/news/600-tar... #ChemicalProbes

#RareDiseaseDay tomorrow, we are proud to announce the first three recipients of our Developing Medicines through Open Science (DMOS) program! These projects focus on three rare diseases that currently lack effective treatments. Read the press release here: conscience.ca/news/dmos-pr...

A new study revealed 4 distinct mechanisms through which small molecules can inhibit helicase activity. Through their analysis, they identified key binding pockets that could be targeted for drug discovery and development for cancer and infectious diseases. pubs.acs.org/doi/10.1021/...

The AIRCHECK Workshop isn't just another conference! It is an exclusive opportunity to learn, experiment, and get ahead of the curve in ML/AI-driven hit discovery. Register now: event.fourwaves.com/aircheckwork...

An inspiring story that we are extremely proud to be part of! Kudos to David Drewry and Opher Gileadi who worked along with Paul Workman to identify small molecules that target a historically undruggable transcription factor. Read their publication: www.nature.com/articles/s41...

Can you love computational work and experimental research at the same time? @mattschap.bsky.social and @rjharding.bsky.social have kicked off the first CrossTALK Bootcamp and they are ready to bring together the next generation of drug discovery experts! www.thesgc.org/blogs/bridgi...

A great article on Alison Axtman and her work on chemical tools for drug discovery targeting disease-related proteins. carolinapharmacy.org/2025/02/11/m... #OpenScience #MedicinalChemistry #DrugDiscovery

On the International Day of Women and Girls in Science, we take a moment to highlight the amazing work of @rjharding.bsky.social, who has been recognized by CIHR for her research on Huntington's Disease. www.thesgc.org/news/dr-rach...

🥳New paper from the lab!🍾 Excited to share our work with the Stefan Knapp lab (Goethe Uni, @thesgc.bsky.social & DKTK), published in J. Med. Chem. @pubs.acs.org. Here, we present the first degraders (PROTACs) targeting CK1 δ/ε—highly selective across the kinome & within the Casein kinase 1 family. 🧵

We are uniting experts in ML, computational chemistry, and drug discovery to get hands-on experience with AIRCHECK. Co-developed by SGC and @uhntoronto.bsky.social, AIRCHECK is an open data platform designed to enhance predictive models in drug discovery. event.fourwaves.com/aircheckwork...

>20 yrs ago, while at GW, now @thesgc.bsky.social UNC scientist Tim Willson and his team invented (and then shared) LXR agonist GW3965. And that GW3965 #chemicalprobe is still having an impact, including in a new study in which we played a small role. www.nature.com/articles/s41...

A lovely lunch of Arrowsmith lab and @thesgc.bsky.social friends celebrating Lunar New Year.

We identified 18 kinases with 19 cysteine sites, targeted for the first time! Our group developed a library of small molecules that can attach to kinases and systematically tested this library on 47 kinases with 60 cysteine sites near the ATP-binding pocket. onlinelibrary.wiley.com/doi/10.1002/...

Are you using the Chemical Probes Portal? If not, it’s time to explore this FREE resource which offers expert advice on >800 chemical probes, along with detailed guidelines on: ✅ How to choose the best probe for your protein of interest. ✅ How to use it appropriately to ensure reliable results.

A rigorous study of UPS tool compounds for #degrader evaluation is published by Stefan Knapp @thesgc.bsky.social in ACS Chemical Biology! They determine the optimal doses of UPS pathway inhibitors that rescue degradation without displaying off-target activity and toxicity. dx.doi.org/10.1021/acsc...

Researchers at @thesgc.bsky.social and The Neuro, along with scientists from 11 major antibody manufacturers, have developed and standardized an #OpenScience platform to characterize research antibodies. @ycharos.bsky.social aims to tackle a critical challenge in biomedical research reproducibility.

For over 20 years, our trainees have been the driving force behind our success stories in early drug discovery. www.thesgc.org/news/celebra...

Early registration is now open for the Conscience Symposium on Open Drug Discovery in Montreal on April 7-8! To ensure accessibility for all, we're offering significantly reduced registration fees for students and Early Bird discounts until Jan 31 - don't miss out! conscience.ca/event/consci...

Millions worldwide lack treatments for diseases that threaten their lives or quality of life. We believe #OpenScience is key to tackling these challenges and that we can transform #DrugDevelopment by fostering collaboration, sharing data, and prioritizing accessibility. conscience.ca/news/drug-de...

MAINFRAME membership offers: - Access to high-quality training datasets - Participation in benchmarking challenges with experimental validation - Collaborative research opportunities Join a community committed to open science: aircheck.ai/mainframe

The @ycharos.bsky.social antibody characterization protocol using knock-out cells as controls is now published, and endorsed. Remember though that it’s a generic protocol - you still need to do the proper controls for your own experiments! www.nature.com/articles/s41...

We co-hosted "Target 2035 – A Public-Private Partnership to Accelerate Hit-Finding" along with @uclofficial.bsky.social and Pfizer. 50 leaders from the pharmaceutical industry, academia, and funding organizations discussed how AI and ML can transform drug discovery. www.thesgc.org/news/structu...

You an ML researcher interested in drug discovery, but also want open source your methods to advance the public good? @thesgc.bsky.social is an open source data generation public-private partnership creating an affiliated network of open source ML researchers. It’s called MAINFRAME. Sign up!

We just launched #MAINFRAME! This international, #OpenScience Network brings #MachineLearning & #compchem scientists together to create open-source algorithms & benchmarks for tackling real-world challenges in #DrugDiscovery. Join us: aircheck.ai/mainframe

CACHE #3 data is out! As in other challenges, great diversity in computational workflows, many combining physics-based and ML methods and a recurring high performer. Shoutout to our target expert, @fraserlab.bsky.social, who's lab crystallized 44 CACHE compounds. bit.ly/3D8eABU @thesgc.bsky.social

Supported by U of T Data Sciences Institute, a program led by Matthieu Schapira will provide trainees with the skills necessary to interpret complex experimental data and drive breakthroughs in drug discovery. Registration for the first 9-week bootcamp is now open. www.thesgc.org/news/sgc-lau...

New episode for our Target 2035 Podcast Series 🎧 @milkakostic.bsky.social talks with @aledmedwards.bsky.social to unpack his journey from a traditional research scientist to a passionate open science advocate. Listen here: bit.ly/3AZQkBm

Often folks ask me what’s in it for pharma to fund us @thesgc.bsky.social when we put everything in the public domain. Well I submit it would be harder to do painstaking, non-hypothesis, benchmarking science like this paper from SGC-Frankfurt if we did not have a strong base of industry support.

A summary of the efforts of EUbOPEN, a public-private partnership dedicated to create, distribute and annotate the largest openly available set of high-quality chemical modulators for human proteins. pubs.rsc.org/en/content/a...

How does EZH2 inhibition make atypical teratoid rhabdoid tumor cells vulnerable to therapy? www.nature.com/articles/s41...

The Structural Genomics Consortium (SGC) is thrilled to join the BlueSky community! Follow us to stay updated on our latest research, collaborations, and efforts to shape the future of drug discovery. #OpenScience #DrugDiscovery #OpenData