In a new study published in @natmethods.nature.com, @danafarber.bsky.social’s @nickpolizzi.bsky.social uses features from a pretrained neural network to train a logistic regression model, AF2BIND, which could be used for drug discovery and uncovering functional sites in proteins. ➡️ rdcu.be/e7SnX

Congratulations to @nickpolizzi.bsky.social and colleagues! They combine protein structure prediction with prediction of small molecule binding to map a wide range of functional sites on proteins. Way to boost the hunt for targetable (ligandable) sites!

I’m looking to hire a research technician for my lab at Harvard & DFCI, who would primarily work in the wet lab expressing and characterizing designed proteins, starting this summer. A great role for a recent college grad looking for an immersive research experience before grad school.

New paper from Will Gibson's lab showcases how induced proximity can be used to induce targeted protein mislocalization as a strategy to trigger cancer cell death. Interesting, very interesting!!!!! www.nature.com/articles/s41...

We are looking to hire an Assistant/Associate Professor interested in creating an innovative (and exciting) program of research in chemical biology, medicinal chemistry, ML/AI, drug discovery - all in the context of cancer biology! careers.dana-farber.org/job/11813/as...

New paper from @nickpolizzi.bsky.social, Bill Degrado and Bobo Dang showing that de novo designed small molecule binding proteins can bind to the drug and clear it from the circulation in vivo. Read in Nature Biomedical Engineering! www.nature.com/articles/s41...

⏳ Only 4 days left to submit your abstract and secure the #ChemBioParis2025 early bird rate! Deadline: June 10 🗓️ Don’t miss keynotes, awards & the trainee symposium in Paris 🇫🇷 🔗 chembioparis2025.com #ChemBioEvent #ICBS2025 #ECBS2025

#ChemRxiv would love your help! Give us your thoughts on preprints in a brief survey (americanchemical.co1.qualtrics.com/jfe/form/SV_...), whether or not you've ever posted a #preprint before. Your feedback will help us focus on the best possible ways to support open science in chemistry.

🌍 Be part of the global spotlight at #ChemBioParis2025 — the premier Chemical Biology event of 2025 at Sorbonne Université, Paris. 💼 Sponsorship starts at just €300. Showcase your brand to world-leading scientists! 📩 Get our partnership kit: chembioparis2025.com #ICBS2025 #ECBS2025 #ChemBio

Characterization of PROTAC specificity and endogenous protein interactomes using ProtacID

BIG NEWS - for the first time ever, we're running a Bioimage Analysis Beginnings Bootcamp. Learn #bioimageanalysis from awesome folks, and gain familiarity with some new tools as well as how to pick the right tool in the first place. Aug 4th-8th - apply here (soon!) forms.gle/d2fCXsrWHVP8...

The cryo-em core at kumc is looking for a lab manager. This is an exciting opportunity to join a growing facility. kumc.wd5.myworkdayjobs.com/en-US/kumc-j...

NEW PREPRINT ALERT: Buhrlage lab in collaboration with @irinabezsonova.bsky.social has developed a new class of USP7 activators! www.biorxiv.org/content/10.1...

Super excited to share a new preprint from our lab on design of small-molecule binding proteins using neural networks! The paper has a bit of everything. A new graph neural network, new design algorithms, and experimental validation. www.biorxiv.org/content/10.1... 🧵🧪

We provide a new checklist for selecting & using chemical probes—valuable for researchers, journal editors, reviewers, and vendors. Ensure best practices in chemical biology! 🧪✅ 🔗 Supplementary material: ars.els-cdn.com/content/imag... #ChemicalProbes #DrugDiscovery #ChemicalBiology

Review @cp-cellchembiol.bsky.social @volkerhaucke-lab.bsky.social Mechanisms and functions of lysosomal lipid homeostasis www.cell.com/cell-chemica...

Make use of our public database of Postdoc fellowships (private foundations, federal agencies). It's downloadable and free. We list 290 different fellowships and funding opportunities, along with description, deadline, amount, and eligibility criteria Download here: research.jhu.edu/rdt/funding-...

Potential explanation for the results of the most recent elections? Seems like H. sapiens can't fight biology? "Both male and female mice exhibit female preference (under normal conditions) but shift to male preference when confronted with survival threats." www.science.org/doi/10.1126/...

Go ahead - I know you want to! Just scratch that itch!!! www.science.org/doi/10.1126/...

What do you get when you put @aledmedwards.bsky.social and me in front of a microphone? You get a great conversation about #openscience, #ChemicalProbes, and a crazy goal about creating tool compounds and probes for every protein in the human proteome by 2035. creators.spotify.com/pod/show/tar...

Our upcoming #TPD webinar features an intriguing talk "Ub or Not Ub: Decoding Ubiquitin-Dependent and Independent Degradation Pathways" by Itay Koren (Bar-Ilan University). Tomorrow at noon EST - www.danafarbertargetedproteindegradation.org

An in-cell approach to evaluate E3 ligases for use in targeted protein degradation. https://www.biorxiv.org/content/10.1101/2024.12.19.629291v1

In a study published today in @jclinical-invest.bsky.social, @behnamnabet.bsky.social and collaborators describe how they used targeted protein degradation in mice to rapidly destroy lung and pancreas tumors caused by a variant of a commonly mutated, cancer-driving gene.

Ever wonder where Nobel Prize-winning AlphaFold got its training data? Read how pioneering crystallographer Helen Berman helped build the Protein Data Bank as a home for more than 200,000 protein structures that would come to shape AI and protein prediction ➡️

Excited to share this beast of a review on the potential of protein-based degraders from trainees who are all not on the Sky! Herein we cover choice of binders, selection strategies, E3 ligases, and DELIVERY! pubs.acs.org/doi/10.1021/...

We've a postdoc opening for our lab at the Broad: Cambridge MA! Must have experience in toxicology + data science Work on the wonderful OASIS dataset we are producing... Cell Painting, transcriptomics, proteomics in various liver cell and tissue models! broad.io/mlcbpostdoc

The Young Scientist Award of @gdchbiochem.bsky.social of @gdch.bsky.social is open for nominations. If you know an excellent candidate, who defended their PhD or had a publication in 2024 in the field of biochemistry (or related), strongly consider nominating them. en.gdch.de/network-stru...

Excited to share our work investigating how ligand residence time influences targeted protein degradation outcomes at scale, and how we can combine kinetic scout degrader approaches with mathematical modeling to accelerate hit finding and optimization! onlinelibrary.wiley.com/doi/abs/10.1...

New episode for our Target 2035 Podcast Series 🎧 @milkakostic.bsky.social talks with @aledmedwards.bsky.social to unpack his journey from a traditional research scientist to a passionate open science advocate. Listen here: bit.ly/3AZQkBm

New episode of Target 2035 podcast dropped today - in it, I talk with Al Edwards about #openscience. Al is an open science trailblazer, and we had a great conversation about being open. #chemsky #chembio #chemicalbiology #drugdiscovery creators.spotify.com/pod/show/tar...

Through a series of cryo-EM structures, this study shows how an E2 and ubiquitin itself can play a "structural" role to specify ubiquitin linkage. 🧪 Lovely work by Katrina Warner, @moritzhunkeler.bsky.social @kheewoongbaek.bsky.social, @katherinedonovan.bsky.social and others in the Fischer Lab!

New #preprint - a amazing study of HECT ligase Tom1. This paper is a treat for those of you who LOVE #cryoEM and for those who love #ubiquitin! Congrats to the Fischer lab, including @moritzhunkeler.bsky.social and @ssroyburman.bsky.social who are on #bluesky. www.biorxiv.org/content/10.1...

Amazing new story from Michael Rape’s lab @ucberkeleyofficial.bsky.social on dynamic regulation of the oxidative stress response by the E3 ligase TRIP12!

The dark side of fluorescent protein tagging: the impact of protein tags on biomolecular condensation www.biorxiv.org/content/10.1...

Let's degrade GPCRs! Nice review on all the possible ways proposed by Bogusalwa Korona and Laura Itzhaki at University of Cambridge. www.jbc.org/article/S002...

We’re excited to celebrate the FDA approval of revumenib, a menin inhibitor, for relapsed or refractory acute leukemia with a KMT2A translocation. We’re proud of the dedication and innovation that have led to a new therapy now available to patients who need it most. Learn more: bit.ly/3UYY90B

Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️ So how can we ever achieve #gender #equality? We discuss various strategies in this #Cell Commentary #WomeninSTEM www.cell.com/cell/fulltex... 🧵 1/

It seems no starter pack exists yet for the migrated #TPD community - here is an attempt at one: go.bsky.app/FreGFDW

If you are looking for an exciting PhD in the fields of #ChemicalBiology, #ChemBio, #Proteomics and #Immunology, in a dynamic group with an inspiring PI, Madeline Kavanagh has an open position for a PhD project involving synthesis, chemical proteomics and immunology. drive.google.com/file/d/11Mhm...

If you are interested in #ChemicalBiology #ChemBio, check out the Virtual @chembiotalks.bsky.social and already block your agenda for September 20th, 2025. If you have ideas for speakers for next year or for general changes to the format, please reply to the below post.

📯Chemical Biology Starter Pack ＃2: Probes Aficionadas👩‍🔬 go.bsky.app/DEjVGEn as generalist ChemBio Pack ＃1 go.bsky.app/KLrTWoj is full 🚩Feed reposting #ChemBio: bsky.app/profile/trac... 🚩 #Photoswitch: bsky.app/profile/trac... 🚩 #FluorescenceFriday: bsky.app/profile/trac... #chemsky #realtimechem