Heading to Discovery & Development Europe 2026 in Berlin 🇩🇪 Proud that our Portal Director, Paul Workman, will deliver a keynote, and Susanne Müller-Knapp will co-organise the Target Identification & Validation Track (with ELRIG). 📅 15–16 June #DrugDiscovery #ChemicalBiology #ELRIG Link 👇

Breakthrough Aurora A PROTAC on the Chemical Probes Portal ⭐⭐⭐⭐ CCT400028 @icr.ac.uk London overcomes the hook effect, delivers >120h stability, is highly selective, and includes a matched inactive control. Powering paediatric cancer research. #ChemicalProbes #PROTAC Read more 👇

A successful PROTAC Hackathon hosted at [email protected]: • 34 participants • 24 reviews generated • 100% reported improved understanding Organised by the Chemical Probes Portal with academic & industry collaboration. Next Hackathon: EUFEPS–SITELF 2026 in Naples 🇮🇹 #ChemicalProbes #PROTACs #EUFEPS

Excited about tomorrow! A full house at @crick.ac.uk for the 9th Chemical Probe Hackathon, with experts from GSK, @icr.ac.uk & TheCrick working with PhDs & postdocs to review chemical probes and improve research quality. #ChemicalProbes #ChemBio #OpenScience #Hackathon

Warm congratulations to Professor Paul Workman on receiving an OBE in the 2026 New Year Honours for services to cancer research. A leader in precision medicine and co-founder of the Chemical Probes Portal, his work has had a lasting impact on chemical biology, drug discovery, and patient benefit. 🎉

Season's Greetings from The Chemical Probes Portal mailchi.mp/cd05056fa93f...

We brought together 22 researchers & 6 experts for a full day of evaluating GPCR and ion channel probes — and completed 26 reviews! Lots of learning, laughter, and deep discussions about what makes a great chemical probe. #ChemicalProbes #OpenScience #DrugDiscovery #GPCR #IonChannels

We’re in Oxford today for the 1st UK Chemical Probes Hackathon! 🎯 Postdocs & PhD students join experts to assess GPCR probes and improve research quality. Hosted by @ChemProbes + @UniofOxford #ChemicalProbes #GPCRs #DrugDiscovery

Happening today and tomorrow (7 October)! Join Müge Sarper, Scientific Coordinator of the Chemical Probes Portal at the @icr.ac.uk, at the poster sessions of the 5th Crick International Cancer Conference. Stop by to learn how the Portal supports cancer and biomedical research. #CrickCancerConf

Excited to share that Müge Sarper, Scientific Coordinator of the Chemical Probes Portal at the Institute of Cancer Research, London (ICR), will present a poster at the 5th Crick International Cancer Conference (5–7 October 2025, London). www.crick.ac.uk/whats-on/5th...

🎉 The Chemical Probes Portal turns 10! We’re honoured to be featured in Dr Dan Erlanson’s latest Practical Fragments blog, reflecting on a decade of advancing chemical biology and open science. 🔗 Read the blog: practicalfragments.blogspot.com/2025/08/the-... #ChemicalProbes #Target2035

After 5 years of planning and pilot projects, Target2035, which aims to develop and share pharmacological probes for all human proteins by 2035, is coming out of stealth mode. Our Roadmap for accelerating small molecule hit discovery is now published. rdcu.be/exxi7

🚀 On July 21, the Chemical Probes Portal celebrates 10 years! Launched after the landmark 2015 @NatChemBio paper by Arrowsmith et al., it now features >1150 compounds, >600 targets, and 1600+ expert reviews—powering better biomedical research. 🧪🔬 👉 chemicalprobes.org #ChemicalBiology @icr.ac.uk

New @ACSChemBio study provides strong evidence that the effects of CDK8/19 inhibitors CCT251545 and CCT251921 are on-target. Using CRISPR knockouts + phosphoproteomics, authors show transcriptional & antitumor effects depend on CDK8/19. 🔗 pubs.acs.org/doi/10.1021/... #ChemicalProbes #CDK8 #OnTarget

📣 Happening today! Join the Babraham Distinguished Lecture with Prof Paul Workman | 1–2pm, 12 June 🧬 “Probing and drugging stress pathways: Chemical Biology and therapeutic discovery” #Cancer#StressResponse#DrugDiscovery#ChemicalBiology #TargetValidation#MolecularPharmacology #TranslationalResearch

Julio et al. reveal that covalent fragments, often used in screens, can trigger stress/proteostasis responses, complicating target validation. Key takeaway: Rigorous controls are crucial to distinguish genuine on-target effects. #ChemBio #DrugDiscovery #Proteostasis www.nature.com/articles/s41...

Reminder: Tomorrow, Professor Paul Workman will give his Meet the Expert Lecture at #AACR: Personalized Molecular Medicine Enabled by Multidisciplinary Approaches to Cancer Drug Discovery and Clinical Development. Details: www.abstractsonline.com/pp8/#!/20273... #AACR2025 #CancerResearch

Have you caught Episode 6 of the #Target2035 Podcast? 🎙️ Danette Daniels (@ FoghornTx) joins Milka Kostic, to dive into the power of #ProteinDegradation – what sets degraders apart, why #TPD is surging, and how we speed discovery. Plus: championing #WomenInSTEM 💪

Capivasertib – the first-in-class AKT inhibitor – is now approved by NICE for NHS use in England & Wales, following FDA and EMA approvals for cancer treatment. #Oncology #CancerResearch #AKT #TargetedTherapy #NICE @icr.ac.uk www.icr.ac.uk/about-us/icr...

🎧 New Target 2035 Podcast! Rachel Harding & Matthieu Schapira dive into #CACHEChallenges — a global effort to refine small-molecule discovery algorithms with real-world validation. 🔬 How does CACHE boost #DrugDiscovery? Find out: lnkd.in/gcwkUXup #AIinDrugDiscovery #OpenScience #MachineLearning

This excellent commentary is a must-read for cancer biologists (and all biologists, really). Probing cancer with small-molecule tools—Progress and challenges: Cancer Cell www.cell.com/cancer-cell/...

📢Looking ahead to #AACR25 in Chicago — only 6 weeks away! Join the Meet-the-Expert session with Prof. Paul Workman, where he’ll emphasize the critical role of high-quality chemical probes in drug discovery. 📅 April 29, 2025 | ⏰ 5:00-5:45 PM Learn more👇 #CancerResearch

Congratulations to our Chemical Probes Portal Executive Director, Professor Paul Workman, on his election as a Fellow of the AACR Academy Class of 2025! 🎉 An incredible recognition of his lasting impact on cancer research. #AACR #CancerResearch #DrugDiscovery

The Chemical Probes Portal now covers 601 protein targets, expanding resources for chemical biology & drug discovery! 🧪🔬 New high-quality probes target DCTPP1, MASTL, HCN1, plus E3 ligases & PROTACs for protein degradation. Learn more: www.chemicalprobes.org/news/600-tar... #ChemicalProbes

We provide a new checklist for selecting & using chemical probes—valuable for researchers, journal editors, reviewers, and vendors. Ensure best practices in chemical biology! 🧪✅ 🔗 Supplementary material: ars.els-cdn.com/content/imag... #ChemicalProbes #DrugDiscovery #ChemicalBiology

Our Cancer Cell Commentary reviews progress on chemical probes since Arrowsmith et al. (Nat Chem Biol 2015) and the launch of the Chemical Probes Portal. We highlight key issues, propose solutions, and outline a path to a quality probe for every human protein. #ChemicalProbes

The brachyury structure, along with crystallographic fragment-based screening and enhanced compounds, may enable the development of chemical probes and future drugs. This approach could also be applied to other hard-to-drug transcription factors and proteins.

ICR's Professor Paul Workman, and researchers at @ox.ac.uk and @uncchapelhill.bsky.social have made a breakthrough that could lead to drugs for the 'undruggable' chordoma - the rare #BoneCancer that killed Paul's mother. Read more from Professor Workman here ⬇️ www.icr.ac.uk/research-and...

🔬 The Chemical Probes Hackathon is underway in Vienna! Experts from academia & industry, along with international students, are reviewing kinase inhibitors & PROTACs—advancing biomedical research through collaboration. Excited to see today’s findings! 🚀 #EUFEPS #chemicalprobes

🔬 Calling all PhD students & postdocs in chemistry/biology! Join us at the Chemical Probes Hackathon 🧪: 🗓️ Feb 20, 2025 | 10:00–14:30 📍 Vienna, Austria 💡 Evaluate chemical probes w/ experts & improve global science 🌍. 🎓 Earn a Certificate of Attendance! Learn more & register 👇

🎙️ New podcast episode alert! Professor Paul Workman joins Opher Gileadi on the #Target2035 podcast to dive into the science of chemical probes. 🧪 🔍 What makes a great probe? 🛑 Common lab mistakes. 🌐 Learn about the Chemical Probes Portal. 🎧 Listen now 👇

NXP800 is an analogue of CCT251236, also used in the paper, which is listed on the Portal as inhibitor of the HSF1 pathway. The new findings show therapeutic potential in prostate cancer no longer responsive to hormone therapy.

Chemical probes are vital for studying proteins & developing treatments, but misuse can mislead research. The Chemical Probes Portal offers free expert advice on selecting high-quality, potent, selective probes. Latest updates aim to boost research reliability. #DrugDiscovery

Season’s Greetings and Best Wishes for 2025 from the Chemical Probes Portal! ✨🔬

🌟 Exciting news! Introducing #MAINFRAME, a global #OpenScience network uniting #MachineLearning & #CompChem experts to drive innovation in #DrugDiscovery. 🚀 Their mission? Open-source algorithms, real-world benchmarking, and faster, affordable medicine development. Learn more👇

Paul Workman, Sharad Verma, Timothy A. Yap, and Jerome Mettetal discussed "Developing Efficacious Drugs with Better Combinability" in a plenary session at the AACR Conference on Optimizing Therapeutic Efficacy and Tolerability through Cancer Chemistry. #AACRchem24 #AACRCICR

Paul Workman highlighted the importance of selectivity towards the protein target of interest – both for modern, molecularly-targeted drugs and also for high-quality chemical probes for use in laboratory exploration of protein function. #AACRchem24 @icrlondon.bsky.social @mdanderson.bsky.social

🧪 How can we develop efficacious drugs with better combinability? Join Paul Workman, Timothy A. Yap & Jerome Mettetal at @AACR’s #AACRchem24 conference (Dec 9–11) as they tackle this critical topic. Learn more: bit.ly/4gLZMYO

🚨 Just Launched! Episode 1 of the Target 2035 Podcast Series 🎧 Join @LabScribbles as they chat with @CherylArrowsmi1, a trailblazer in chemical biology and co-founder of #Target2035. Discover the story behind this ambitious initiative for #OpenScience and #DrugDiscovery. 🎙️ Listen now: Link below 👇

🚨 New publication alert! 🚨 Our latest update on the Chemical Probes Portal is live! 🎉 📜 Read the paper: doi.org/10.1093/nar/... 🔍 Learn about our expanded content + improved functionality in the 2024 Nucleic Acids Research Database Issue. #ChemicalProbes #BiomedicalResearch #OpenScience