Institute for Protein Innovation
@ipiproteins.bsky.social
š¤ 306
š„ 272
š 275
We advance protein science to accelerate research & improve human health | proteininnovation.org
IPI is building new antibodies to label
#glialcellstates
at the
#protein
level. Our Friday workshop brought researchers together to discuss: How can protein markers assist in glia state identifications? Which
#antibodies
would be most impactful for the community? Which targets are most critical?
about 5 hours ago
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We had a great two days with Just A Start Biotechnology Careers Program alumni! Thanks to all who joined us for a hands-on course on lab automation, liquid handling and assay design basics š„¼ š§Ŗ
3 days ago
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Congratulations to our 2026 Alloy Scholars, Shelby Harris & Lorenzo Agostini! Sponsored by our partner, Alloy Therapeutics, these exceptional scientists will have the opportunity to gain hands-on training in our June Yeast Display course & bring this knowledge back to their labs.
5 days ago
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IPI is excited to announce that weāve opened our course in laboratory automation to the scientific community! Register to learn the basics of liquid handling, method development and automation for antibody discovery ā”ļø
buff.ly/vs162WJ
š July 23ā24, 2026 š Boston, MA š„ Only 8 spots available
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2026 Introduction to Automated Liquid Handling
A two-day course on automated liquid handling techniques for the life sciences.
https://buff.ly/oEOdhXD
5 days ago
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More than 50 researchers joined us yesterday for our
#adhesionGPCR
targets workshop! Thanks to all who participated to help us prioritize targets & design purpose-built
#Abs
. Interested in joining future workshops on
#glialcellphenotyping
&
#synapticcleftsignaling
? Get updates ā”ļø
buff.ly/9uAso7K
6 days ago
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New integrin antibodies targeting integrin beta 1 and beta 2 just joined the IPI collections š§Ŗ These recombinant monoclonals recognize human targets, do not cross-react with other protein family members and are recommended for flow cytometry. Order now:
buff.ly/VpcxzlC
7 days ago
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Weāre excited to welcome alumni from Just A Startās Biotechnology Careers Program to a 2-day automation course next week, made possible through support from the Mass Life Sciences Center Pathmaker program! More soon š¬ Sign up for updates on future courses ā¬ļø
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IPI Events & Programs Newsletter
Sign up to receive news and updates on IPI educational events and programs.
https://buff.ly/kVjWSYe
10 days ago
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Stanford researcher Stephen Quake imagines IPI as a modern-day Library of Alexandria, preserving and activating protein knowledge to influence how a whole new generation of therapies will be made. Thatās why heās joined forces as part of our Board of Directors. Learn more:
buff.ly/PmIpnht
13 days ago
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#Robo3
antibodies are crucial for detecting the Roundabout Guidance Receptor 3 protein & studying neuraldevelopment &
#axonnavigationābut
reliable
#antibodies
are in short supply. IPI just released two anti-ROBO3s that might help. Dive into the data on our product pages ā”ļø
buff.ly/kk4fLJJ
19 days ago
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In a recent study, the IPI team tested 5 codon optimization schemes (including
#NativeCodons
) in the construction/expression of 18 neurologically relevant human & murine
#glycoproteins
. See which yielded the most proteins ā”ļø
buff.ly/TaFaWkY
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Codon optimization ābake-offā suggests native constructs are best tool for mammalian protein expression
In the world of protein production, codon optimization is generally considered the go-to method to enhance expression and increase yields. Swapping native
https://buff.ly/TaFaWkY
20 days ago
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Thereās a lot of hype around
#AI
&
#proteindesign
, but there are some important considerationsāincluding how these molecules perform in laboratory conditions, says IPI's platform director AndrĆ© Teixeira. Read more from Teixeira in this Science Arena article ā”ļø
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Design de proteĆnas: como cientistas estĆ£o criando molĆ©culas sob medida para enfrentar grandes desafios | Science Arena
A partir de modelos computacionais e IA, cientistas desenvolvem proteĆnas para enfrentar desafios cientĆficos e tecnológicos
https://buff.ly/nNQmSqb
21 days ago
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This former HHMI investigator and CZI leader was determined to keep exploring lifeās smallest pieces in pursuit of large-scale scientific impact. So heās returned to his Stanford lab and joined an effort to advance protein science. Read his story:
buff.ly/ciTChrs
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His next big idea might emerge from something small: Stephen Quake joins IPI Board
Biophysicist Stephen Quake has held many titles. Heās invented devices, developed diagnostics and launched companies. Heās won dozens of prizes and been
https://buff.ly/ciTChrs
27 days ago
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New
#Robo
#Slit
antibodies just joined the IPI collections š§Ŗ Recommended for flow, ICC and IHC, these chimeric
#recombinantproteins
are specific to human and mouse targets and do not cross-react with other family members.
#axonguidance
#neuronalmigration
buff.ly/mtViWPa
28 days ago
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š£LAST CHANCE! Applications for our 2026 yeast display course are due TODAY š£ Come learn the basics of
#yeastdisplaylibrary
prep, MACS & FACS sorts, and
#AI-enabled
discovery in just 5 days ā directly from yeast display leaders and working scientists. Apply now!
buff.ly/4Y5YvwK
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2026 Yeast Display Technology for Antibody Discovery
A five-day course in June 2026 combining lectures and hands-on laboratory sections to train participants in the core principles of yeast display technology.
https://buff.ly/4Y5YvwK
29 days ago
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Don't have a favorite part of
#antibodydiscovery
? Maybe you'll find it in our 5 day
#yeastdisplay
course this summer! Apply now ā applications close March 30th ā²ļø
buff.ly/oBlGknl
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about 1 month ago
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reposted by
Institute for Protein Innovation
Addgene
about 1 month ago
New antibody release! We've expanded our catalog of synaptic cleft antibodies with
@ipiproteins.bsky.social
's new antibodies targeting neurexins and neuroligins. Find these and more in our IPI Collection page:
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Addgene: IPI Antibody Collection
Find unique recombinant antibodies targeting families of cell surface and secreted proteins from a collaboration between Addgene and IPI.
https://twp.ai/4ixUFw
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Exciting update: Alloy Therapeutics will be funding two scholarships to attend IPI's 5 day course on yeast display technology for antibody discovery! The course is open to postdocs, students, faculty & industry scientists. Scholarships will go to top candidates who apply by 3/30 ā°
buff.ly/av8zOGo
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2026 Yeast Display Technology for Antibody Discovery
A five-day course in June 2026 combining lectures and hands-on laboratory sections to train participants in the core principles of yeast display technology.
https://buff.ly/2VaieOG
about 1 month ago
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Our automation team is running a
#PEGSBoston
short course on May 12 for scientists looking to gain skills in automated liquid handling and see integrated systems for protein & antibody engineering in action. Early bird registration ends March 27th & spots are limited. Check it out!
buff.ly/MHgLfXV
about 1 month ago
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š«Preprint alert š« A new IPI study suggests scientists may be overestimating the value of
#codonoptimization
when producing
#mammalianproteins
in mammalian cell lines, throwing the value of these strategies into question. Read more:
buff.ly/1vUqbTj
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Codon optimization ābake-offā suggests native constructs are best tool for mammalian protein expression
New work from IPI suggests scientists may have overestimated the value of codon optimization ...
https://buff.ly/1vUqbTj
about 1 month ago
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ā ļø ONE WEEK to apply for our yeast display course ā ļø Join us in June to get experience designing yeast display libraries, running
#MACS/#FACS
sorts & discovering top antibody candidates. Apply now:
buff.ly/7rqgQWz
Thanks to our sponsors Alloy Therapeutics,
@twistbioscience.com
& Sony Biotechnology!
about 1 month ago
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Learn the ins and outs of yeast display discovery, from antigen biotinylation to antibody identification, in our 5 day summer course. Apply by March 30th!
buff.ly/1pWSBdO
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about 1 month ago
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Our course on automated liquid handling for protein/antibody engineering is coming to
#PEGSBoston
on May 12, 2026. Participants will develop methods on the Opentrons Protocol Designer, operate an OT-2 & Biomek i3 and tour the IPI lab. Spots are limited ā find out more & register:
buff.ly/MHgLfXV
about 1 month ago
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Interested in learning the basics of
#yeastdisplaytechnology
and
#antibodydiscovery
from leaders in the field? Join us in June for our hands-on 5-day course. Spots are limited ā apply now:
buff.ly/zrnlPN7
about 1 month ago
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This article
@thetransmitter.bsky.social
shows just how vital labeling tools (like IPIās epitope tag antibodies) can be in determining the functional identity of brain cells. Read the piece:
buff.ly/Vcsim6J
Check out our protein tools:
buff.ly/SzcrTp1
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From genes to dynamics: Examining brain cell types in action may reveal the logic of brain function
Defining brain cell types is no longer a matter of classification alone, but of embedding their genetic identities within the dynamical organization of population activity.
https://buff.ly/Vcsim6J
about 1 month ago
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Find new IPI ROBO/Slit antibodies in the
@addgene.bsky.social
catalog!
add a skeleton here at some point
about 1 month ago
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New antibody release! š§Ŗ Anti-ROBO1 [IPI-ROBO1.81] š§Ŗ Anti-ROBO3 [IPI-ROBO3.119] š§Ŗ Anti-ROBO3 [IPI-ROBO3.124] š§Ŗ Anti-Slit-2 [IPI-Slit2.37] Use our recombinant monoclonals to study
#axonguidance
#cellmigration
#tissueformation
#cytoskelatalorganization
,
#neuronalwiring
& more
buff.ly/oNye2Ky
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Axon Guidance Antibody Collection
For neurons to communicate, their axons must navigate precisely to their targets through a complex process known as axon guidance or neuronal migration. This pr
https://buff.ly/oNye2Ky
about 1 month ago
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"Antibody discovery is like a race," says IPI research associate Swethika Balasankar. Learn how to run your own discovery campaigns using
#yeastdisplaytechnology
at our hands-on course this June. Apply by March 30th!
buff.ly/92wAFCo
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about 1 month ago
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"AI isn't smart enough to provide the ultimate solution to a problem, but it's very good at finding alternative solutions," says AndrƩ Teixeira, senior director of the IPI
#antibody
platform. Read more from Teixeira and others in this Science Arena rundown on
#AI
and
#proteindesign
.
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Protein design: how scientists are creating tailor-made molecules to tackle major challenges | Science Arena
Using computational models and AI, scientists are developing proteins to address scientific and technological challenges.
https://buff.ly/nNQmSqb
about 2 months ago
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Apply now for our 2026 Yeast Display Technology for Antibody Discovery course!
buff.ly/KuyAKw3
Highlights include: āŖļø Lab sessions on library prep, biotinylation, MACS & FACS āŖļø Lectures on principles, applications and methods of yeast display āŖļø Seminars from invited experts on display technology
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about 2 months ago
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IPI welcomes Stanford biophysicist Stephen Quake to our Board of Directors! He brings a wealth of experience with HHMI, CZI and more, and his unique perspective will be instrumental in launching the next era of protein science. Read more:
buff.ly/9coNPo2
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His next big idea might emerge from something small: Stephen Quake joins IPI Board
Biophysicist Stephen Quake has held many titles. Heās invented devices, developed diagnostics and launched companies. Heās won dozens of prizes and been
https://buff.ly/9coNPo2
about 2 months ago
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A team at Seoul National University (
@martinsteinegger.bsky.social
) recently introduced FoldMason
@science.org
āan open-source tool to compare MSTA of 1000s of proteins. We see big potential to analyze proteins w/ conserved structure & limited sequence conservation
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Multiple protein structure alignment at scale with FoldMason
Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extendedā¦
https://buff.ly/vME7lOs
about 2 months ago
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Scientific progress is built on shared knowledge, accessible learning, and hands-on training. So this June weāre teaching a 5 day immersive course on the
#yeastdisplay
principles, applications and practical workflows that drive our
#antibodydiscovery
campaigns. Apply by March 30 ā¬ļø
buff.ly/n8crLD0
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2026 Yeast Display Technology for Antibody Discovery
A five-day course in June 2026 combining lectures and hands-on laboratory sections to train participants in the core principles of yeast display technology.
https://buff.ly/AL83sLT
about 2 months ago
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Is it only March? Itās been a busy year so far! We kicked off the year hosting a lab automation course with HMS MEDscienceWorks at Emmanuel College.
about 2 months ago
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One month left to apply to our hands-on
#yeastdisplay
course! Learn more ā”ļø
buff.ly/XpRYLOC
about 2 months ago
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New Neurexin and Neuroligin antibodies just joined our Synaptic Cleft Antibody Collection, available through
@addgene.bsky.social
: š¹ IPI-NRXN1α š¹ IPI-NRXN2α š¹ IPI-NRXN3α š¹ IPI-NLGN2 š¹ IPI-NLGN3 View more data ā”ļø
buff.ly/YYL1WWE
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Synaptic cleft antibody collection
Neuronal communication and neurological function rely on chemical signaling across a narrow extracellular space known as the synaptic cleft.Ā Proteins posi
https://buff.ly/YYL1WWE
about 2 months ago
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A new
@pnas.org
study caught the eye of our bioinformatics team with its identification of ~4,500 targetable binding sites & binding seeds across human cell surface proteinsāgiving IPI and other labs a protein design launch point.
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Mapping targetable sites on the human surfaceome for the design of novel binders | PNAS
The human cell surfaceome, integral to cell communication and disease mechanisms, presents a prime target for therapeutic intervention. De novo pro...
https://buff.ly/graOPYC
2 months ago
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Applications for our 2026 Yeast Display Technology for Antibody Discovery course are due on March 30th. Hereās what you need to know! Apply now!
buff.ly/lag7LwW
2 months ago
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Attending
#SLAS2026
earlier this month was incredibly valuable for our Automation and Education teams as we think about how to build new resources for lab automation training. Here are a few of our biggest takeaways:
2 months ago
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New
#Neurexin
and
#Neuroligin
antibodies just joined our Synaptic Cleft Antibody Collection today, available through
@addgene.bsky.social
ā š¹ IPI-NRXN1α š¹ IPI-NRXN2α š¹ IPI-NRXN3α š¹ IPI-NLGN2 š¹ IPI-NLGN3
buff.ly/YYL1WWE
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Synaptic cleft antibody collection
Neuronal communication and neurological function rely on chemical signaling across a narrow extracellular space known as the synaptic cleft.Ā Proteins posi
https://buff.ly/YYL1WWE
2 months ago
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2
What does antibody discovery mean at IPI? It means using FACS and MACS to winnow a vast yeast synthetic library, with 10^10 unique sequences, down to just a few highly selective, tight-binding antibodies that hold potential as research reagents and therapeutics.
2 months ago
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Our director of automation, Curtis Walton, joined Opentrons on their Designing Open Science podcast last week. Listen to learn about IPIās scalable, automated systems that support IPI scientists at the bench!
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Designing Open Science Podcast #2 - Curtis Walton - Opentrons
#2 - Curtis Walton
https://buff.ly/qxDZGwW
2 months ago
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Axon guidance shapes how
#neurons
connectāand proteins like
#Netrin-1
,
#DCC
and
#PUNC
sit at the center of this process š§ IPI now offers
#recombinantantibodies
to all three targets, backed by solid validation data. Explore our reagents:
buff.ly/T1CktaD
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Axon Guidance Antibody Collection
For neurons to communicate, their axons must navigate precisely to their targets through a complex process known as axon guidance or neuronal migration. This pr
https://proteininnovation.org/axon-guidance-antibody-collection/?utm_source=linkedin&utm_medium=social&utm_campaign=distribution&utm_term=axonguidance&utm_content=post3
2 months ago
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IPIās
#yeastdisplay
course is back by popular demand! Join us in June to learn the basics & hear directly from experts Dane Wittrup (
@mitkochinstitute.bsky.social
),
@surgebiswas.bsky.social
(Nabla Bio) & Justin Peruzzi (
@aiproteins.com
). Applications are due on March 30!
buff.ly/KmY7N86
2 months ago
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We kicked off
#SLAS2026
(
@slasorg.bsky.social
) by teaching a short course on automated liquid handling to some wonderful, engaged scientists and presenting our approaches to purification and integrated lab systems. Still time to find us to share strategies, approaches, hot-takes, etc!
3 months ago
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Hello from
#SLAS2026
(
@slasorg.bsky.social
)! We shared automation tips as part of a liquid handling short course today, and we're excited to connect all week. Come find us! š Feb 9-11: Posters on characterization, purification, integrated systems & more š Feb 11: IPI talks automation ed w/ Opentrons
3 months ago
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Weāre bringing our five-day yeast display course back for 2026! Last summer, 12 researchers from around the world joined IPI to learn the principles, applications and methods of
#yeastdisplaytechnology
ā this year it could be you! Apply to join us this June:
buff.ly/IOLmxV2
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3 months ago
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Applications for IPIās 2026 Yeast Display Technology for Antibody Discovery course are now open! Join us for 5 days this June to learn everything from library preparation and antigen biotinylation to MACS and FACS cell sorting. Find out more:
buff.ly/AFAVmuP
3 months ago
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Did you know
@addgene.bsky.social
now offers antibodies? You can find 200+
#antibodies
in their catalog ā including IPI recombinants targeting
#Netrin
,
#PUNC
,
#DCC
,
#Neurexin
,
#Neuroligin
,
#Glypican
,
#Integrin
and more. Browse here:
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Synaptic cleft antibody collection
Neuronal communication and neurological function rely on chemical signaling across a narrow extracellular space known as the synaptic cleft.Ā Proteins positione
https://buff.ly/Qsj1gjI
3 months ago
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1
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Good antibodies start with good data. Our new anti-DCC, anti-Netrin-1, and anti-IGDCC3 (PUNC)
#antibodies
come with full validation datasetsāincluding demonstrated lack of
#crossreactivity
. Take a closer look:
buff.ly/LLL78N2
3 months ago
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IPIās Haisun Zhu worked with the Chen Lab (
@harvardmed.bsky.social
@bostonchildrens.bsky.social
) to pinpoint the role of the S2ā cleavage in the SARS-CoV-2 spike protein. Their
@natcomms.nature.com
paper gives new details of pathogen entry that might guide future interventions ā”ļø
buff.ly/F9Xv2FJ
3 months ago
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