Institute for Protein Innovation
@ipiproteins.bsky.social
📤 298
📥 271
📝 241
We advance protein science to accelerate research & improve human health | proteininnovation.org
pinned post!
We’re bringing our five-day yeast display course back for 2026! Last summer, 12 researchers from around the world joined IPI to learn the principles, applications and methods of
#yeastdisplaytechnology
— this year it could be you! Apply to join us this June:
buff.ly/IOLmxV2
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26 days ago
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Is it only March? It’s been a busy year so far! We kicked off the year hosting a lab automation course with HMS MEDscienceWorks at Emmanuel College.
about 23 hours ago
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One month left to apply to our hands-on
#yeastdisplay
course! Learn more ➡️
buff.ly/XpRYLOC
2 days ago
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New Neurexin and Neuroligin antibodies just joined our Synaptic Cleft Antibody Collection, available through
@addgene.bsky.social
: 🔹 IPI-NRXN1α 🔹 IPI-NRXN2α 🔹 IPI-NRXN3α 🔹 IPI-NLGN2 🔹 IPI-NLGN3 View more data ➡️
buff.ly/YYL1WWE
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Synaptic cleft antibody collection
Neuronal communication and neurological function rely on chemical signaling across a narrow extracellular space known as the synaptic cleft. Proteins posi
https://buff.ly/YYL1WWE
4 days ago
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A new
@pnas.org
study caught the eye of our bioinformatics team with its identification of ~4,500 targetable binding sites & binding seeds across human cell surface proteins—giving IPI and other labs a protein design launch point.
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Mapping targetable sites on the human surfaceome for the design of novel binders | PNAS
The human cell surfaceome, integral to cell communication and disease mechanisms, presents a prime target for therapeutic intervention. De novo pro...
https://buff.ly/graOPYC
5 days ago
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Applications for our 2026 Yeast Display Technology for Antibody Discovery course are due on March 30th. Here’s what you need to know! Apply now!
buff.ly/lag7LwW
7 days ago
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Attending
#SLAS2026
earlier this month was incredibly valuable for our Automation and Education teams as we think about how to build new resources for lab automation training. Here are a few of our biggest takeaways:
8 days ago
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New
#Neurexin
and
#Neuroligin
antibodies just joined our Synaptic Cleft Antibody Collection today, available through
@addgene.bsky.social
— 🔹 IPI-NRXN1α 🔹 IPI-NRXN2α 🔹 IPI-NRXN3α 🔹 IPI-NLGN2 🔹 IPI-NLGN3
buff.ly/YYL1WWE
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Synaptic cleft antibody collection
Neuronal communication and neurological function rely on chemical signaling across a narrow extracellular space known as the synaptic cleft. Proteins posi
https://buff.ly/YYL1WWE
11 days ago
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What does antibody discovery mean at IPI? It means using FACS and MACS to winnow a vast yeast synthetic library, with 10^10 unique sequences, down to just a few highly selective, tight-binding antibodies that hold potential as research reagents and therapeutics.
13 days ago
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Our director of automation, Curtis Walton, joined Opentrons on their Designing Open Science podcast last week. Listen to learn about IPI’s scalable, automated systems that support IPI scientists at the bench!
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Designing Open Science Podcast #2 - Curtis Walton - Opentrons
#2 - Curtis Walton
https://buff.ly/qxDZGwW
15 days ago
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Axon guidance shapes how
#neurons
connect—and proteins like
#Netrin-1
,
#DCC
and
#PUNC
sit at the center of this process đź§ IPI now offers
#recombinantantibodies
to all three targets, backed by solid validation data. Explore our reagents:
buff.ly/T1CktaD
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Axon Guidance Antibody Collection
For neurons to communicate, their axons must navigate precisely to their targets through a complex process known as axon guidance or neuronal migration. This pr
https://proteininnovation.org/axon-guidance-antibody-collection/?utm_source=linkedin&utm_medium=social&utm_campaign=distribution&utm_term=axonguidance&utm_content=post3
18 days ago
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IPI’s
#yeastdisplay
course is back by popular demand! Join us in June to learn the basics & hear directly from experts Dane Wittrup (
@mitkochinstitute.bsky.social
),
@surgebiswas.bsky.social
(Nabla Bio) & Justin Peruzzi (
@aiproteins.com
). Applications are due on March 30!
buff.ly/KmY7N86
19 days ago
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We kicked off
#SLAS2026
(
@slasorg.bsky.social
) by teaching a short course on automated liquid handling to some wonderful, engaged scientists and presenting our approaches to purification and integrated lab systems. Still time to find us to share strategies, approaches, hot-takes, etc!
21 days ago
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Hello from
#SLAS2026
(
@slasorg.bsky.social
)! We shared automation tips as part of a liquid handling short course today, and we're excited to connect all week. Come find us! 👉 Feb 9-11: Posters on characterization, purification, integrated systems & more 👉 Feb 11: IPI talks automation ed w/ Opentrons
24 days ago
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We’re bringing our five-day yeast display course back for 2026! Last summer, 12 researchers from around the world joined IPI to learn the principles, applications and methods of
#yeastdisplaytechnology
— this year it could be you! Apply to join us this June:
buff.ly/IOLmxV2
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26 days ago
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Applications for IPI’s 2026 Yeast Display Technology for Antibody Discovery course are now open! Join us for 5 days this June to learn everything from library preparation and antigen biotinylation to MACS and FACS cell sorting. Find out more:
buff.ly/AFAVmuP
29 days ago
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Did you know
@addgene.bsky.social
now offers antibodies? You can find 200+
#antibodies
in their catalog — including IPI recombinants targeting
#Netrin
,
#PUNC
,
#DCC
,
#Neurexin
,
#Neuroligin
,
#Glypican
,
#Integrin
and more. Browse here:
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Synaptic cleft antibody collection
Neuronal communication and neurological function rely on chemical signaling across a narrow extracellular space known as the synaptic cleft. Proteins positione
https://buff.ly/Qsj1gjI
about 1 month ago
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Good antibodies start with good data. Our new anti-DCC, anti-Netrin-1, and anti-IGDCC3 (PUNC)
#antibodies
come with full validation datasets—including demonstrated lack of
#crossreactivity
. Take a closer look:
buff.ly/LLL78N2
about 1 month ago
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IPI’s Haisun Zhu worked with the Chen Lab (
@harvardmed.bsky.social
@bostonchildrens.bsky.social
) to pinpoint the role of the S2’ cleavage in the SARS-CoV-2 spike protein. Their
@natcomms.nature.com
paper gives new details of pathogen entry that might guide future interventions ➡️
buff.ly/F9Xv2FJ
about 1 month ago
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Applications are due TOMORROW for IPI’s Springer-Lu Postdoctoral Fellowship program. Apply now!
buff.ly/BSjUH53
#proteinresearch
#PhDJobs
#postdocjobs
#proteomics
#proteinengineering
#antibodyresearch
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about 1 month ago
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Come work with us! Apply this week for the IPI Springer-Lu Postdoctoral Fellowship in cell-surface protein research and antibody engineering. Apply by Jan. 20!
buff.ly/w6AKPdd
about 1 month ago
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IPI teamed up with
@deboramarks.bsky.social
& Andrew Kruse
@harvardmed.bsky.social
to design optimized
#nanobody
binders using
#ML
on single-sort sequencing data. The approach could speed discovery by reducing the need for multi-sort
#affinitymaturation
. Read more:
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Machine learning enables efficient and effective affinity maturation of nanobodies
Antibodies can bind their targets with exquisite potency and selectivity due in part to large antibody-target protein-protein interaction surface areas. Despite the ...
https://buff.ly/BV4Retr
about 2 months ago
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IPI has new
#recombinant
antibodies available against DCC, anti-Netrin-1 and anti-IGDCC3 (PUNC), key players in axon guidance! Explore the datasheets and order here 👉
buff.ly/KYdEvur
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Axon Guidance Antibody Collection
For neurons to communicate, their axons must navigate precisely to their targets through a complex process known as axon guidance or neuronal migration. This pr
https://proteininnovation.org/axon-guidance-antibody-collection/?utm_source=bluesky&utm_medium=social&utm_campaign=distribution&utm_term=axonguidance&utm_content=post1
about 2 months ago
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Apply to the Springer-Lu Postdoctoral Fellowship to secure a place at IPI and 2+ years of funding to pursue ambitious research in
#proteinresearch
and
#antibodyengineering
. Applications close in one week on Jan. 20:
buff.ly/CCEOKjO
#PostDocJobs
#PostDocPosition
#PhDChat
#ScienceJobs
#STEMCareers
about 2 months ago
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IPI is recruiting a new commercial director! This senior leadership role is a wonderful opportunity to help translate world-class protein science and technology into real-world impact. Find out more:
buff.ly/4OvJUnF
#sciencejobs
#proteinscience
#proteomics
#commercialdirector
#antibodyreagents
đź§Ş
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Institute for Protein Innovation - Director of Commercialization
About IPI The Institute for Protein Innovation (IPI) is an independent nonprofit research institute dedicated to advancing protein science and accelerating biomedical discovery by developing and…
https://buff.ly/4OvJUnF
about 2 months ago
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HMS MEDscienceWorks program graduates joined IPI at Emmanuel College this week to learn lab automation, assays and
#Python-powered
liquid handling. Training the
#nextgen
of
#bioscientists
is a big responsibility—one we’re excited to take on as we roll out new courses this year. More soon!
about 2 months ago
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Applications to the IPI Springer-Lu Postdoctoral Fellowship are due on Jan. 20, 2026 — that’s two weeks away! Apply now:
buff.ly/Fp8rh51
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about 2 months ago
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Proteins positioned within the
#synapticcleft
govern
#synapse
formation, maintenance and
#neurotransmission
. But the exact architecture of this space is still a mystery. IPI’s new
#NRXN
and
#NLGN
antibodies could help reveal the blueprint. Order now:
buff.ly/AtBazlt
about 2 months ago
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As AI and machine learning capabilities expand, IPI is building nextgeneration Fab and VHH yeast display libraries to yield molecules with better developability. Our bioinformatics scientist Hoan Nguyen is central to this effort!
#bioinformatics
#proteinscience
#proteomics
#AI
2 months ago
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Lab coats off, holiday spirit on. 🎄✨ We’re wrapping up the year with the people who make our research possible. Cheers to a strong 2025 — and a bright year ahead!
2 months ago
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New from the Mizuno Lab, with help from IPI’s Nirakar Basnet: insights into how
#microtubule
shoots stabilize and repair
#axons
— and how epothilone B drives CNS regeneration. Read it in Nature:
buff.ly/lO9xwIX
2 months ago
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🗓️Mark your calendars 🗓️ Applications for the IPI Springer-Lu Postdoctoral Fellowship are due in ONE MONTH. Find out how to apply:
buff.ly/2b45pWI
#neurojobs
#sciencejobs
#postdocjobs
#proteinscience
#proteinengineering
2 months ago
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IPI’s glypican antibodies are used in labs around the world to study neurodegenerative diseases, brain development, cancer biology and more — and our collection with
@addgene.bsky.social
just expanded 🤯 Order reliable recombinant antibodies targeting GPCs 1-6 on our website:
buff.ly/QSwEnbQ
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Glypican antibody collection
Highly specific recombinant glypican (GPC) antibodies, validated for Flow cytometry and Immunofluorescence applications. Buy with Addgene!
https://buff.ly/QSwEnbQ
3 months ago
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We’re excited to announce our plans for a course on antibody validation and characterization — and we need your help! Fill out this survey to shape the course (it’s quick, we promise!) ➡️
buff.ly/KoyJfU9
3 months ago
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IPI has launched a postdoc for scientists working in cell-surface protein research/antibody engineering — and we’ve expanded eligibility to include recent MD/PhD/MD-PhD grads + early-career postdocs! Come work with us!
buff.ly/45QGcpW
#proteinscience
#postdocjobs
#neurojobs
3 months ago
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IPI collaborator Matthew Dalva (
@tulanebrain.bsky.social
) has a new paper out on the role of extracellular phosphorylation in regulating receptor interactions at synapses, with particular focus on
#EphrinB2-NMDAR
interaction. Take a look
@science.org
đź‘€
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The synaptic ectokinase VLK triggers the EphB2–NMDAR interaction to drive injury-induced pain
Phosphorylation of hundreds of protein extracellular domains is mediated by two kinase families but the functional role of these kinases is underexplored. We find that the presynaptic release of the…
https://buff.ly/CPX9k0f
3 months ago
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IPI is accepting applications to its FIRST postdoctoral fellowship program. Apply now for a 2+ year opportunity to push the boundaries of antibody science and cell-surface protein research!
#neurojobs
#phdjobs
#proteinscience
buff.ly/MPh7dR8
3 months ago
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Breakthrough work
@uwproteindesign.bsky.social
combines computation & yeast display to produce
#denovo
antibodies w/ “atomic accuracy.” We’re exploring how yeast display—key to IPI’s platform—can work in conjunction with AI. More
@nature.com
:
buff.ly/6CJDfzM
3 months ago
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What do autism, Alzheimer’s, schizophrenia, depression and obesity have in common? They’ve been linked to mutations in
#neurexin
genes—and IPI
#monoclonalantibodies
could help researchers learn more. Order IPI antibodies, including Neurexin 1/2/3:
buff.ly/ZUSDGZU
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Synaptic cleft antibody collection
Neuronal communication and neurological function rely on chemical signaling across a narrow extracellular space known as the synaptic cleft. Proteins positione
https://buff.ly/ZUSDGZU
3 months ago
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We brought the Antibodies Roadshow back to
#SfN2025
— this time on the USS Midway. Researchers shared new
#imagingtools
, community
#antibodydata
, and advances in
#synapticbiology
and
#braincircuitry
. Read the recap:
buff.ly/60ouG8A
3 months ago
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Are you a recent or soon-to-be PhD graduate who wants to work with
#yeastdisplay
, deep sequencing,
#proteinexpression
,
#biophysicalcharacterization
,
#antibodyvalidation
,
#confocalmicroscopy
,
#AI
,
#ML
or
#automation
? Apply to be an IPI
#postdoc
!
buff.ly/jvpT6MP
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Springer-Lu Postdoctoral Fellowship
Sorry, this product is unavailable. Please choose a different combination.
https://buff.ly/jvpT6MP
3 months ago
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Happy thanksgiving from IPI! We’re feeling especially grateful this week for our team and the many scientists, collaborators and partners who share our passion for advancing protein science. Your curiosity drives progress — and inspires us every day 🍂🧬
3 months ago
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Congrats to IPI postdoctoral fellow Nirakar Basnet for co-authoring a recent paper
@natcomms.nature.com
with former colleagues at the Mizuno Lab. They resolved the
#cryoEM
structure of
#SSNA-1
, providing a detailed look at its self-assembly and role in
#embryonicdevelopment
➡️
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Structural insights into SSNA1 self-assembly and its microtubule binding for centriole maintenance - Nature Communications
Cryo-EM shows SSNA-1 forms anti-parallel coiled-coils with a triple-helical junction for microtubule binding. Disrupting self-assembly or deleting SSNA-1 reduces C. elegans embryonic viability and…
https://buff.ly/JdVwNw1
3 months ago
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Scientists are drawn to their
#research
for all sorts of reasons, big and small. “What drives my science,” says IPI scientist Alex Morano, “is profound love of humanity and a desire to make the world better and safer for people.” Learn more about IPI’s story:
buff.ly/ifaeFo9
#whatdrivesmyscience
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3 months ago
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There’s some exciting work happening w/
#neuroscience
&
#antibodies—PRISM
barcoding,
#synaptome
mapping w/ ExA-SPIM,
#wholebraintissueclearing
and more. Huge thanks to the speakers who shared this work at a recent IPI meeting down the road (harbor? 🚢) from
#SfN2025
. Read more:
buff.ly/Utn94ct
3 months ago
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Come work with us! IPI is seeking a
#postdoctoralfellow
to join us and apply our
#antibodydiscovery
platforms to cutting-edge questions in
#cellsurface
#proteinresearch
and
#antibodyengineering
. It could be you! Learn how to apply today:
buff.ly/f2cLV4D
3 months ago
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🛑 Are you using glypican antibodies to study brain development, neurodegeneration, cancer biology or cell signaling? 🛑 IPI has recombinant antibodies to GPC1-6 and we want you to know about them! So, what’s amazing about our anti-glypicans?
4 months ago
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We had such a great time yesterday diving into cell-cell communication and the latest advances in molecular neuroscience on a rainy San Diego day!
#SfN2025
4 months ago
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reposted by
Institute for Protein Innovation
Addgene
4 months ago
New recombinant monoclonal antibodies from @ipiproteins.bsky.social at Addgene targeting Neurexin and Neuroligin — key mediators of synaptic adhesion and function. Explore the collection and advance your neuroscience research:
https://twp.ai/4itA72
#neuroscience
#neuroskyence
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🚨IPI just released new antibodies into the
@addgene.bsky.social
catalog targeting Neurexin 1/2/3 & Neuroligin 1. Order now!
buff.ly/CpP2b8x
#ProteinScience
#Neuroscience
#Antibodies
4 months ago
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IPI
#researchassociate
Minh Anh Kieu helps build and optimize our high-throughput antibody production pipeline — perfect for a problem-solver like her. Find out more about
#antibodyproduction
at IPI and stay tuned for what drives our science!
buff.ly/V4wps8X
#proteinscience
#proteomics
#bioscience
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4 months ago
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