Wonderful few days skiing in New Mexico. Every trip the boys get stronger, more controlled, and confident. It is fun to watch the progression in real time. Some fresh snow helped too!

So, to wrap up today's insanity: President Trump, who is deeply implicated in a pedophilia scandal involving his best friend, the sex trafficker, sent Attorney General Bondi -- who only has that job because Trump's first choice was also implicated in a separate pedophilia scandal -- to the House...

“What do you think the odds are that person is a goat fucker?!” Grade A trolling

Such a great conference for trainees and early career scientists. Going back for the first time last year (since leaving the Midwest) this conference felt like home. Such a wonderful supportive DNA repair community. Awesome science and even better people!!

This 👇is such a great opportunity for young scientists in the field. I “grew up” on this conference & still hold so many meaningful relationships to this day that I made at these conferences.

Great conference!!

📣 The 2026 Midwest DNA Repair Symposium is coming to Kansas City (registration is open) 🗓 May 30–31, 2026 ✨ Talks will be selected from abstracts, with a strong focus on trainees and new investigators. Please RT & share with your labs! 🔗 sites.google.com/view/kumc-mi...

🎉Kicking off 2026 with our first paper from the Freudenthal lab in NAR. Ribonucleotides reshape telomeric G4s and are resistant to RNase H2 repair. Congrats to the authors and huge thanks to our collaborator Hui-Ting Lee! academic.oup.com/nar/article/...

Fun filled weekend in San Diego and LA! Really nice to escape the cold and catch up with Mark and Amiel.

I tend to mostly post positive lab outcomes, but not every update is a win. Received my first not discussed grant score of the year. Part of the process and still plenty of year left. 🤞January has been a month. 😞

Minneapolis public schools canceled classes officials after Roosevelt High School said armed Border Patrol officers came on school property during dismissal Wednesday and began tackling people, handcuffed two staff members and released chemical weapons on bystanders www.mprnews.org/story/2026/0...

Is NHEJ truly a double-strand break repair pathway...repairing both strands, at the same time?

📢 Telomere community: Registration and abstract submission are now open for the EMBO Workshop “Telomere function and maintenance in health and disease”, May 25–30, 2026, in Lazise, Italy 🇮🇹. Looking forward to an exciting meeting! Please re-post. meetings.embo.org/event/26-tel...

Amazing to see the C-Trap in action! We’re proud that the C-Trap plays a part in supporting cancer research in @freudlab.bsky.social lab at @kucancercenter.bsky.social! 🙌

Grateful to host Sen. Moran and NIH Director Jay Bhattacharyya in the lab today. Proud of our trainees, who showcased their work using the @lumicks.bsky.social C-Trap and the KU Cryo-EM Facility. Their dedication shows how federal investment drives cancer research at @kucancercenter.bsky.social.

Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp

They’ve laid off so many people that the government is now getting its economic data from DoorDash.

Check out the perspective my lab wrote with @freudlab.bsky.social. We provide our perspective on recent work describing the structural basis of chromatin-based base excision repair!

🎉 Joint paper from the Freudenthal and @tmweaver.bsky.social Labs! Abbey Vito’s first publication discusses a tug-of-war between BER enzymes and chromatin for access to damaged DNA, a battle central to genome stability. Built on Tyler's foundational work! tinyurl.com/ywkt2bt5

It was wonderful hosting you for the seminar visit! Also appreciate you being a good sport for having an anglerfish introduce you.🤣

🎃 Happy Halloween from the Freudenthal Lab! 🐟🖤 Anglerfish PI + Emo Researchers = Bioluminescent Despair #Scienceunderpressure

One of my favorite activities of the year is our annual pumpkin carving competition with the Bose Lab. Everyone’s pumpkins were amazing!

I think people adjacent to science (but who now find themselves deciding the fate of US science somehow) undervalue humility, valuing braggadocios hubris instead. Yes it’s true that some scientific discoveries are complete paradigm changers, and we celebrate these. 1/

By far. Juvenile.

whoever did this little bit of magnificence, take a bow

Spread the word if you can. We have an unused stopped flow accessory from Applied Photophysics. We traded in our Chirascan CD instrument so we have no use for this anymore. Reach out if you are interested and can find a home for this setup. Will ofcourse only work with a Chirascan!

The Sangre de Cristo Mountains outside Santa Fe were beautiful today! Wonderful day for a hike.

Congratulations to our #EMGS2025 Best Oral Presentation Award Winners! Best Student Oral Presentation 1st Place (Tied): David Schuster and Abigayle Vito 2nd Place: Foster Jacobs Best Early Career Investigator Oral Presentation 1st Place: Elijah Newcomb 2nd Place: Lindsay Volk

The fiscal year is over. So how was the NIH appropriation committed? A long thread with institute by institute results about where the money went.

The fiscal year ends tomorrow. Here are results from NIH Reporter downloaded an hour ago. The total amount of funding committed for FY2025 at this point is 99.0% of that for FY2024. The same difference could be due to a variety of technical factors. 1/3

How it started: Assistant to the Professor 👨‍🔬✨ How it’s going: Professor mode unlocked 👨‍🏫 Also clear evidence that science doesn’t just build knowledge… it ages ya too. 😉 🙏Grateful to all the mentors, colleagues, trainees, friends & family who made this journey possible. I am here because you all!

Here is a plot in terms of PROJECTS rather than dollars. I am using projects rather than awards so that projects that received supplements do not get double-counted. While the FY25 curve is improving, it seems that the number of funded projects will drop by 3000-4000 compared with FY24.

i think regardless of who has authored a paper, we (the scientific community) can and should stop criticizing the work on lack of perceived novelty. we can do better than perpetuating harmful myths about individual scientific papers having to present a discovery no one has ever thought of before.

This one is a bit of a departure from the usual and definitely a work in progress! We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below. Read on for details... 1/x

Some (+)ve news to lighten another heavy weekend: our latest preprint (c/o Mattiroli + Ramani labs) is up! www.biorxiv.org/content/10.1... A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)

What an incredible @EMGSUS 2025 meeting last week! 🎉 Great science, community, and presentations. #EMGS2025 Special congrats to our lab members🏆 #proudPI: Abbey Vito – 1st, Student Oral Presentation Eli Newcomb – 1st, ECI Oral Presentation Spencer Thompson – 2nd, Student Poster

Are you a student, early career Investigator, or first time #EMGS meeting attendee? Take part in the #EMGS2025 Quest to make sure you don’t miss anything and earn prizes along the way! Start the Quest: form.jotform.com/251895711320...

Thrilled to share our lab’s latest work in JBC! 🎉 We uncovered a critical role for APE1 Asn174 in stabilizing AP-sites using mutagenesis, enzymology, crystallography, and MD-simulations. Congrats to Kaitlin Dehart and all the co-authors! Check it out: www.jbc.org/article/S002...

New from us in @natrevmcb.nature.com -- @szmyd-radoslaw.bsky.social & @radoncdocgee.bsky.social explore how DNA repair actively shapes cancer cell fate following DNA damage, reframing repair as both a protective process & a driver of treatment response and cell death. www.nature.com/articles/s41...

truly unreal. he's the guy who buys a lap dance and thinks the stripper and he had a deep connection

Great catching up with Matt during his visit with @barneslab.bsky.social!

Congratulations Dr. Sowa! Such a great defense and project. Sara has a great lab and is doing wonderful work.

The summer just flew by this year and today is the first day of 5th grade for these two. Go get em boys. 🥹

Spencer Thompson gave a great talk at the @kucancercenter.bsky.social Cancer Biology symposium this past week. He has really got this talk looking clean and sounding clear. #proudPI @lumicks.bsky.social

Great way to end two summer student internships with the KUcancercenter symposium. Fantastic work by Carson Gray (undergrad) and Esther Solange (high school student)! Kudos to Abbey Vito, Peyton Oden, and Justin Ling for being wonderful mentors.

In the past 24 hours, Trump’s threatened Elon Musk, Thomas Massie, Japan, a judge in Israel, the CEO of AT&T, Jerome Powell, Canada, Thom Tillis, a Forbes reporter, Harvard, & migrants with being eaten by Burmese pythons in the Everglades, while releasing a new line of colognes.

Congratulations Kaitlin Dehart on an outstanding PhD defense! I can’t believe another student has graduated from lab. #proudPI🥹

Who funds biomedical research? @nature.com www.nature.com/articles/d41...

I have had the privilege to train many chinese students over many years. They enriched our lives and did great science. Many are still here and contribute to the US scientific enterprise. The push to revoke student visas is cruel and unnecessary. We must push back. www.npr.org/2025/05/28/g...

Happy 10th birthday boys! It has been a busy few days celebrating your birthday with laser tag in KC and a trip to the Bahamas. Proud of the incredible boys you are becoming. 🎉🎂🎂🥳