New methods article: David Fay et al integrate endogenous TurboID labeling and data-independent acquisition mass-spectrometry for in vivo proximity labeling link.springer.com/article/10.1...

“This should be straightforward“ The sentence that really worries my team when I utter it during meetings with collaborators 🤣

I think some folks might be happy to see this. NIGMS MIRA R35 for EI/NI has been published. PAR-26-121 files.simpler.grants.gov/opportunitie...

What does phosphorylation do to RPA? This has been a long-standing question in the field of genome integrity. In our newest publication in Nature Communications rdcu.be/eT4z3 with @proforiganti.bsky.social , we reveal the answer. Thanks to funding from NIGMS to our groups.

CryoET exploration today - come on Santa!!!!!!!

Good news- they are continuing to do administrative supplements but the specific dates for NIGMS are unclear!

2025 has been quite a successful year in terms of scientific discoveries, publications, grants, etc. But, boy-o-boy, the one word to describe my year and all the uncertainties ........... EXHAUSTED!

POSTDOCTORAL POSITION IN STRUCTURAL BIOLOGY We need a structural biologist to work on several CryoEM datasets. For more information, please visit: www.antonylab.org Expertise in structure refinement and model-building are required. Please share.

From your friendly neighborhood SRO: thanks to everyone for their patience while we work to make these rescheduled meetings happen.

Please repost - Multiple PhDs available www.findaphd.com/phds/project... www.findaphd.com/phds/project... www.findaphd.com/phds/project...

See our paper “Mechanism of trinucleotide repeat expansion by MutSβ-MutLγ and contraction by FAN1”. Using biochemistry, we show how DNA incisions by the MutLγ nuclease can lead to expansions, and how expansion is prevented by FAN1. Well done Issam and Valentina! www.nature.com/articles/s41...

This is super cool! Congratulations on a fantastic study. Looking forward to trying out these tricks in our ncAA incorporation setup.

🚨Our paper is out! 🥳 Hijacking a bacterial ABC transporter for efficient genetic code expansion. Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social www.nature.com/articles/s41... it all started years ago with a failed experiment 🧵👇 1/9

Have you ever looked at the night sky and wondered if there’s a chlorophyll f in the reaction centre of Photosystem I from far-red light adapted cyanobacteria? 🦠 Well, we did (don’t judge) and the work that followed is now out as a First Release in @science.org www.science.org/doi/10.1126/...

Delighted to announce our latest work on how Wadjet loads onto and establishes topological entrapment of plasmid DNA prior to initiating loop extrusion. At @gruberlab.bsky.social, Dubochet Center for Imaging and BSI @igbmc.bsky.social www.cell.com/molecular-ce...

Spread the word if you can. We have an unused stopped flow accessory from Applied Photophysics. We traded in our Chirascan CD instrument so we have no use for this anymore. Reach out if you are interested and can find a home for this setup. Will ofcourse only work with a Chirascan!

MECC 2025 was a success at UW-Milwaukee! 153 attendees. 76 poster presenters. Talks by 4 faculty, 1 post-doc, 4 grad students, and 1 keynote. Check out our poster prize winners on the website: mecc2025.midwestenzyme.org/photographs See you next year in Chicago at Loyola University for MECC 2026!

@midwestenzyme.bsky.social MECC 2025 was a very cool meeting this year. 160 attendees, 80 posters, and great science all around. Thanks to our sponsors @slu-biochemistry.bsky.social @uwmilwaukee.bsky.social Refeyn @ei-science.bsky.social Abbott Inc, Hampton Research, CoAla BioSci, NEB

Folks with Christmas around the corner can I suggest a meaningful present real quick? 🎄

...and here is the show and tell video for those of you who have a minute to spare

STRUCTURE OF A NITROGENASE-PII SUPERCOMPLEX New work from the oxidoreductase half of the group. www.biorxiv.org/content/10.1...

We were one of the lucky ones to receive our NCI award. We have an open postdoctoral fellow or research tech position in the group. If you (or anyone you know) has strong expertise in structural biology or cell biology (genomic instability mechanisms) please reach out. www.antonylab.org

Also, check the accompanying article: Principles of cotranslational mitochondrial protein import: Cell www.cell.com/cell/fulltex...

It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it". During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication. Read our review and find out why and how: doi.org/10.1016/j.ti...

My lab at BU is looking to hire a post-doc with experience in biophysics, protein engineering, and chemical (or synthetic) biology. The anticipated start date is Jan 2026. Please send a resume, cover letter, and names/emails for 3 references. We are looking to interview people during Sept/Oct 2025.

Please help promote the meeting by reposting: @loizoulab.bsky.social @hopfnerlab.bsky.social @lapassmore.bsky.social @raychaudhurilab.bsky.social @hw1o9.bsky.social @westlabcrick.bsky.social @gwuite.bsky.social @dijiang319.bsky.social

One more week for abstract deadlines for MECC-2025. Looking forward to seeing many of you in Milwaukee! mecc2025.midwestenzyme.org

Just published: Our paper on high-throughput analysis of cyclin docking interactions, led by the group of Norman Davey @icr.ac.uk and with some small-complex-plus-peptide #cryoEM by @natalia-mg.bsky.social from my lab. Congratulations, everyone! www.nature.com/articles/s41...

Are you an undergrad thinking about grad school? Check out the St. Jude @stjuderesearch.bsky.social Symposium for Predoctoral Research! 🧪 *Reposts appreciated! 🤓

Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before. www.biorxiv.org/content/10.1...

BIOCHEMISTS! We are looking for a new post-doctoral colleague at BU who will be devoted to a combination of teaching Biochemistry and engaging in Research. Ask me anything! The deadline is short, but the job is awesome. #ChemJobs You can apply here: academicjobsonline.org/ajo/BU/CH/PA...

Check out our new preprint on the discovery of a molecular switch in NAC that mediates nascent chain sorting on the ribosome and prevents mitochondrial protein mistargeting by SRP. A great collaboration with the Shan Lab @Caltech and the Qi Lab @UVA: www.biorxiv.org/content/10.1...

our paper is online! rdcu.be/exXBX . Who would have thought that some #giantviruses not only have #histones, but even histone variants that make weird #nucleosomes (pdb 9CVT). Fantastic work from Ale Villalta and Chelsea Toner, with Hugo Bisio @molbiolgv.bsky.social and Chantal Abergel

Please register early and upload your abstracts. Looking forward to seeing many of you in Milwaukee in September!

Funding policy for 2025 from NCI. Was just released: 4 percentile…maybe! www.cancer.gov/grants-train...

New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes? www.biorxiv.org/content/10.1...

Just 300 NoA's issued for new NCI R01 grants in 2025. Am I reading this right?

How are Rad51 filaments formed during Homologous Recombination? Jaigeeth Deveryshetty and Ayush Mistry describe the mechanism through the lens of Rad52, the yeast homolog of human BRCA2. urldefense.com/v3/__https:/...

📢NEW YORK STUDENTS: The #EMGS is offering a Free Student Day for local students at the #EMGS2025 Annual Meeting in #Rochester! Come attend sessions, connect with peers, and explore career opportunities - FREE! #NewYork Just use the code STUDENT25DAY when you register! emgs-us.org/page/2025-re...

Anyone know where to source some 55FeCl3? Perkinelmer appears to have split and dont seem to carry it anymore

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms. Please get in touch with your CV if you are interested; closing date: 27th June 2025. More details here: candidate.hr-manager.net/ApplicationI...

So many folks reaching out as they are losing their jobs due the funding environment. Science is not doing well, in case anyone still wonders.

MEET THE SPEAKERS! Our invited speakers for Symposium 9 of #EMGS2025 will include Drs. Ina Dobrinski and Brandon Pearson.🧬 Two more speakers will be selected from submitted abstracts for this session! 🔊 Submit an Abstract by May 31st: app.oxfordabstracts.com/stages/76738...

One more appointment with great science in a few days, one click away 👇

Registration now open for the Midwest Enzyme Chemistry Conference 2025. Registration Link: lnkd.in/ggHMWrF5 Event Date: September 27, 2025 Location: University of Wisconsin - Milwaukee It's free to register Kindly share as we want to grow this amazing community of mechanistic enzymologists.....

Hundreds of National Science Foundation staffers turned out for a group photograph to celebrate the besieged agency’s 75th anniversary—despite efforts by NSF officials to prevent the picture from being taken. scim.ag/4jcGpIt

Hello Bluesky! 🌤️ We're on the Molecular Cell cover! How are ribosome levels adjusted? Stm1 not only protects ribosomes from degradation, it also promotes their biogenesis in nutrient-rich conditions. Two roles, one protein - tuned by nutrient availability. 🔗 www.cell.com/molecular-ce...

RIOK3 mediates the degradation of 40S ribosomes: Molecular Cell www.cell.com/molecular-ce...

Parts from GE-Cytiva for AKTAs were always ridiculous to begin with….Now look, no time wasted!!!!

Our story detailing how asymmetry in nitrogenase-like proteins regulate electron transfer reactions is finally out! rdcu.be/ejaeK Congratulations to postdoc @rajnandani.bsky.social and fantastic collaborators. Thanks to funding from the Department of Energy and the NIH.