Folks with Christmas around the corner can I suggest a meaningful present real quick? 🎄

...and here is the show and tell video for those of you who have a minute to spare

STRUCTURE OF A NITROGENASE-PII SUPERCOMPLEX New work from the oxidoreductase half of the group. www.biorxiv.org/content/10.1...

We were one of the lucky ones to receive our NCI award. We have an open postdoctoral fellow or research tech position in the group. If you (or anyone you know) has strong expertise in structural biology or cell biology (genomic instability mechanisms) please reach out. www.antonylab.org

Also, check the accompanying article: Principles of cotranslational mitochondrial protein import: Cell www.cell.com/cell/fulltex...

It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it". During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication. Read our review and find out why and how: doi.org/10.1016/j.ti...

My lab at BU is looking to hire a post-doc with experience in biophysics, protein engineering, and chemical (or synthetic) biology. The anticipated start date is Jan 2026. Please send a resume, cover letter, and names/emails for 3 references. We are looking to interview people during Sept/Oct 2025.

Please help promote the meeting by reposting: @loizoulab.bsky.social @hopfnerlab.bsky.social @lapassmore.bsky.social @raychaudhurilab.bsky.social @hw1o9.bsky.social @westlabcrick.bsky.social @gwuite.bsky.social @dijiang319.bsky.social

One more week for abstract deadlines for MECC-2025. Looking forward to seeing many of you in Milwaukee! mecc2025.midwestenzyme.org

Just published: Our paper on high-throughput analysis of cyclin docking interactions, led by the group of Norman Davey @icr.ac.uk and with some small-complex-plus-peptide #cryoEM by @natalia-mg.bsky.social from my lab. Congratulations, everyone! www.nature.com/articles/s41...

Are you an undergrad thinking about grad school? Check out the St. Jude @stjuderesearch.bsky.social Symposium for Predoctoral Research! 🧪 *Reposts appreciated! 🤓

Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before. www.biorxiv.org/content/10.1...

BIOCHEMISTS! We are looking for a new post-doctoral colleague at BU who will be devoted to a combination of teaching Biochemistry and engaging in Research. Ask me anything! The deadline is short, but the job is awesome. #ChemJobs You can apply here: academicjobsonline.org/ajo/BU/CH/PA...

Check out our new preprint on the discovery of a molecular switch in NAC that mediates nascent chain sorting on the ribosome and prevents mitochondrial protein mistargeting by SRP. A great collaboration with the Shan Lab @Caltech and the Qi Lab @UVA: www.biorxiv.org/content/10.1...

our paper is online! rdcu.be/exXBX . Who would have thought that some #giantviruses not only have #histones, but even histone variants that make weird #nucleosomes (pdb 9CVT). Fantastic work from Ale Villalta and Chelsea Toner, with Hugo Bisio @molbiolgv.bsky.social and Chantal Abergel

Please register early and upload your abstracts. Looking forward to seeing many of you in Milwaukee in September!

Funding policy for 2025 from NCI. Was just released: 4 percentile…maybe! www.cancer.gov/grants-train...

New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes? www.biorxiv.org/content/10.1...

Just 300 NoA's issued for new NCI R01 grants in 2025. Am I reading this right?

How are Rad51 filaments formed during Homologous Recombination? Jaigeeth Deveryshetty and Ayush Mistry describe the mechanism through the lens of Rad52, the yeast homolog of human BRCA2. urldefense.com/v3/__https:/...

📢NEW YORK STUDENTS: The #EMGS is offering a Free Student Day for local students at the #EMGS2025 Annual Meeting in #Rochester! Come attend sessions, connect with peers, and explore career opportunities - FREE! #NewYork Just use the code STUDENT25DAY when you register! emgs-us.org/page/2025-re...

Anyone know where to source some 55FeCl3? Perkinelmer appears to have split and dont seem to carry it anymore

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms. Please get in touch with your CV if you are interested; closing date: 27th June 2025. More details here: candidate.hr-manager.net/ApplicationI...

So many folks reaching out as they are losing their jobs due the funding environment. Science is not doing well, in case anyone still wonders.

MEET THE SPEAKERS! Our invited speakers for Symposium 9 of #EMGS2025 will include Drs. Ina Dobrinski and Brandon Pearson.🧬 Two more speakers will be selected from submitted abstracts for this session! 🔊 Submit an Abstract by May 31st: app.oxfordabstracts.com/stages/76738...

One more appointment with great science in a few days, one click away 👇

Registration now open for the Midwest Enzyme Chemistry Conference 2025. Registration Link: lnkd.in/ggHMWrF5 Event Date: September 27, 2025 Location: University of Wisconsin - Milwaukee It's free to register Kindly share as we want to grow this amazing community of mechanistic enzymologists.....

Hundreds of National Science Foundation staffers turned out for a group photograph to celebrate the besieged agency’s 75th anniversary—despite efforts by NSF officials to prevent the picture from being taken. scim.ag/4jcGpIt

Hello Bluesky! 🌤️ We're on the Molecular Cell cover! How are ribosome levels adjusted? Stm1 not only protects ribosomes from degradation, it also promotes their biogenesis in nutrient-rich conditions. Two roles, one protein - tuned by nutrient availability. 🔗 www.cell.com/molecular-ce...

RIOK3 mediates the degradation of 40S ribosomes: Molecular Cell www.cell.com/molecular-ce...

Parts from GE-Cytiva for AKTAs were always ridiculous to begin with….Now look, no time wasted!!!!

Our story detailing how asymmetry in nitrogenase-like proteins regulate electron transfer reactions is finally out! rdcu.be/ejaeK Congratulations to postdoc @rajnandani.bsky.social and fantastic collaborators. Thanks to funding from the Department of Energy and the NIH.

I am incredibly excited to share my first-ever research paper that has just been published in Nature! I thank my fellow co-first authors @fidelormz.bsky.social and @rnfr2d2.bsky.social and @schullerjm.bsky.social for leading this project. www.nature.com/articles/s41...

🧬 Don't miss the fourth and final session of NAR Cancer's 5th Anniversary Virtual Symposium! 🕛 Thursday 17 April at 12pm US Eastern time 👥 Speakers include Dr Elise Fouquerel and Dr Robert W. Sobol Register here: lnkd.in/eRxxSxeu #NARCancer #PARPInhibitors #DNARepair #GenomicStability

Gorgeous!

Excited to share our new pre-print. Direct, ensemble FRET assays developed by our lab reveal that assembly of Rad51 filaments at stalled replication sites via RPA/Rad51 exchange causes complete & irreversible PCNA unloading. Big implications for interplay between human DNA damage tolerance pathways

Two new CLIP-based technologies enable the characterization of multiprotein assemblies on RNA in living cells www.nature.com/articles/s41... #NBThighlight

Countdown to an epic new pre-print. Mitochondria are cells within our cells. They need the same core activities - replication, transcription, translation. How do cells enable these diverse activities in both compartments? We uncover an unexpected + broad strategy with ancient origins. Stay tuned!

Beyond core cellular function, this is critical for understanding rare human disease. Alternate protein isoforms are selectively mutated in genetic disorders. You can't interpret these mutations without understanding the isoforms and they are central to the unique clinical symptoms.

This is an important preprint from the Pelligrini group for the HR field with some super clever experimental design! Bravo! www.biorxiv.org/content/10.1...

Check out our review on DNA end resection! With Raphael Ceccaldi, www.nature.com/articles/s41...

Combining bacterial end joining with programmable nucleases, we induced mtDNA deletions in human cells at varying heteroplasmy and examined their metabolic and cellular effects. Simple tool to apply across any cell type and engineer pathogenic mtDNA deletions. www.sciencedirect.com/science/arti...

Cytoplasmic #ribosomes on #mitochondria alter the local membrane environment for protein import, say Ya-Ting Chang, Danielle Grotjahn (@nanigrotjahn.bsky.social) @scripps.edu and colleagues: rupress.org/jcb/article/... #ProteinHomeostasis #Organelles #StructuralBiology #CryoET

Our review on machine learning methods to study sequence–ensemble–function relationships in disordered proteins is now out in COSB authors.elsevier.com/sd/article/S... Led by @sobuelow.bsky.social and Giulio Tesei

Dr. Matt Memoli... He appointed himself but then delegated much of the work to three experienced NIH hands. Interestingly, they are all biophysicist/biochemists.

How do replisomes walk on DNA? And what happens when they run into a G-quadruplex? @sahilbatra.bsky.social and @benallwein.bsky.social provide unexpected insight in our latest paper with Richard Hite @mskcancercenter.bsky.social @science.org www.science.org/doi/10.1126/.... Congrats to all authors!

On Tuesday I received the NOA (notice of award) for an #NHLBI R01 grant submitted back in Feb 2024 and marked pending after the Oct 2024 Council meeting. Let me tell you the story of the 15 years it took to get here:

I received a new RO1 award from the NCI. Starting date Feb. 24. Full IDC (55% for Hopkins).