Ribosomal allostery as a potential regulator of bacterial dormancy 🦠 www.nature.com/articles/s41...

When nature is messaging to finish up our structural study on ribosomes!

My PO said I had to fill out this form for 3 of my papers for the RPPR of my NIGMS MIRA grant in February, or I could not include them in my progress report. It looks like things have gotten even worse since then.

A dividing cell videoed through a microscope. Hot tip: Don't mess around with myosin II paralogs if you don't want your cells to freak out. #CellBiology www.cell.com/cell-reports...

Surprised to discover that Thermo Fisher appears to show a fake western blot for the validation of one of their p53 antibodies. I've added a diagram to show the very similar bands. This does not appear to be one of the "published figures" but their own internal data.

Excited to share our work uncovering SNOR, a ribosome-associated factor that promotes translation restart after dormancy published in Nature!! This was, as usual, a wonderful collaborative effort between our group and the Mattei Lab @simonemattei.bsky.social @embl.org www.nature.com/articles/s41...

Please share widely. The new (simpler) MIRA R35 for Early Stage Investigators (ESI) NOFO is published. First due date is 10/2/2026. files.simpler.grants.gov/opportunitie...

An in-press version of our latest paper in @natcomms.nature.com on phospho-activated protein-protein interactions with ssDNA-binding protein RPA during BIR. If your favorite pathway involves RPA, this may be for you! Thanks to the lab, collaborators & @ukri.org! www.nature.com/articles/s41...

This is a really important paper in an area that is hard to study. I would recommend any student read this preprint to see how confounding issues arise even in clever assays. Internal Ribosome Entry Sites (IRES) are very interesting because they bypass normal translation initiation mechanisms. 1/

Check out the final version of this work, out today! @natcomms.nature.com www.nature.com/articles/s41...

"Here, we discover that giant DNA viruses encode a distinct and functional IF4F translation-initiation complex to drive protein synthesis, thereby blurring the line between cellular and acellular biology" www.cell.com/cell/fulltex...

new data from NIH about funding trends through FY2025 also a flyby analysis from Claude lol grants.nih.gov/news-events/...

That thrill and excitement when a new idea formulates and can’t wait to test it out without knowing what really lies ahead (spoiler- it’s a dragon - it’s always a dragon!)

AlphaFold modeling & new assays for mitotic kinase activation in E. coli (#MITOKINAC) reveal molecular basis of specific Aurora A & PLK1 activation through Bora during mitotic entry Lionel Pintard @ccdlab.bsky.social et al #RefereedPreprint ℅ @reviewcommons.org link.springer.com/article/10.1...

Interested in direct tRNA-seq by Nanopore? We developed a new RNA-based barcoding aproach for seq parallelization; it is also cost-saving. Scripts available on github. #tRNA #Nanopore track.smtpsendmail.com/9032119/c?p=...

I think some folks might be happy to see this. NIGMS MIRA R35 for EI/NI has been published. PAR-26-121 files.simpler.grants.gov/opportunitie...

This was another fun collaboration with @professorantony.bsky.social and big thanks to lead authors (Poonam Roshan, Ayush Mistry and Vikas Kaushi) and to all the co-authors. www.nature.com/articles/s41...

Good news- they are continuing to do administrative supplements but the specific dates for NIGMS are unclear!

Updated guidance on NIH grant application due dates (10/1/2025-12/5/2025), along with some other Info. grants.nih.gov/grants/guide...

POSTDOCTORAL POSITION IN STRUCTURAL BIOLOGY We need a structural biologist to work on several CryoEM datasets. For more information, please visit: www.antonylab.org Expertise in structure refinement and model-building are required. Please share.

Science People: We at NSF are still recovering/catching up/getting our lives together. But the agency posted these FAQs about post-shutdown resumption of operations which might answer a lot of Qs for you: www.nsf.gov/resumption-o...

We have written two reviews providing a practical guide and fundamentals of cell migration: (1) How to select an optimal cell migration assay, (2) How to analyze cell migration data. We also added a perspective on AI methods of analysis. Coming out soon in Nature Methods.

Want to know how homologous recombination defects are caused upon loss of BRCA2? Check out our recent efforts in uncovering this phenomenon just out in Science! www.science.org/doi/10.1126/...

Among the anti-recombinases, FIGNL1 rules them all. So much that inactivating it brings BRCA2-deficient cells to life. Who is responsible for RAD51 loading without BRCA2/FIGNL1, check out the paper to find out! Great collaboration with @raychaudhurilab.bsky.social www.science.org/doi/10.1126/...

I love AlphaFold—but please include PAE (Predicted Aligned Error) plots for every “interaction.” Pretty PDBs ≠ proof. If the PAE doesn’t show an interface, it ain’t one. Show the plots. Structural biology's reputation is on the line.

See our paper “Mechanism of trinucleotide repeat expansion by MutSβ-MutLγ and contraction by FAN1”. Using biochemistry, we show how DNA incisions by the MutLγ nuclease can lead to expansions, and how expansion is prevented by FAN1. Well done Issam and Valentina! www.nature.com/articles/s41...

Beautiful reconstitution of amino acid stress-dependent ISR activation by my @harvardcellbio.bsky.social colleagues presenting a unifying mechanism for GCN2 activation, which requires ribosome collisions and is enhanced by cognate uncharged tRNA in the A site! www.science.org/doi/10.1126/...

Emmanuel Levy @elevylab.bsky.social has joined BlueSky 🌟 with a fantastic Cell paper with Shu-ou Shan, showing the interactome of the TOM complex and how cotranslational mito import prioritizes large globular domains. Beautiful science! Give him a warm welcome 🎉 link: www.cell.com/cell/fulltex...

The American Chemical Society announced that the ACS Board of Directors has approved $2.5 million to be granted to graduate students who have been impacted by the termination or cancellation of their adviser’s research grant(s) cen.acs.org/acs-news/acs... #chemsky

🧪BREAKING: NIH has laid out 5 options for funding publications costs on grants (yes, FIVE!). This is hugely impactful. Make your opinions known by September 15, fellow scientists. 🧪 grants.nih.gov/grants/guide...

Please register early and upload your abstracts. Looking forward to seeing many of you in Milwaukee in September!

So good that NIGMS is planning to renew call for EI (and ESI) MIRA. But really bad if this is just one deadline a year instead of the usual two (Jan and May) Anyone know anything else? Maybe time to panic.... simpler.grants.gov/opportunity/...

up to 4th percentile for NCI 😳

New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes? www.biorxiv.org/content/10.1...

How are Rad51 filaments formed during Homologous Recombination? Jaigeeth Deveryshetty and Ayush Mistry describe the mechanism through the lens of Rad52, the yeast homolog of human BRCA2. urldefense.com/v3/__https:/...

NIH BREAKING NEWS NIH BREAKING NEWS Hearing from multiple sources that an email went out late yesterday afternoon Effective immediately: Please do not terminate any additional grant projects. Please pull back all grant projects that are in the cue to be terminated.

What? Some good news on a Friday? Parent Fellowship Notices of Funding Opportunities are up! F30, F31, F32, F33 grants.nih.gov/grants/guide...

Registration now open for the Midwest Enzyme Chemistry Conference 2025. Registration Link: lnkd.in/ggHMWrF5 Event Date: September 27, 2025 Location: University of Wisconsin - Milwaukee It's free to register Kindly share as we want to grow this amazing community of mechanistic enzymologists.....

New NIH Notice rescinding the no DEI, no Israeli boycott term and condition added to NIH grants (covers the whole university) This is what Williams refused to sign and declined all federal funding. grants.nih.gov/grants/guide... 1/2

Wow, 7% depressing. In other news, please check your compiled grants in ERA Commons. 129 pages of our P50 missing going between the final preview of submitted Grant in ASSIST to the compiled grant in Commons. No errors. Put in ticket. Fixed. Still 2 pages missing. The NIH is not alright. 🙁

🚨 A new rule would let career scientists like NSF/NIH program officers be replaced by political appointees Already 14,000+ public comments, deadline is Friday 📣 Comments can be short. Courts consider them—and scientists with NSF/NIH experience are especially impactful Speak up! shorturl.at/WKuBj

poor nutrient-induced ribosomal frameshift promotes mRNA decay in eukaryotes and bacteria- from @pelechanolab.bsky.social #RNASky #ribosome 🧪

Our study highlights RNA as a direct template for DNA repair, revealing RT-DSBR as a previously unrecognized and potentially mutagenic pathway. Huge thanks to the incredible team who made this work possible! (5/5) 🔗 www.nature.com/articles/s41... #GenomeInstability #DNARepair #RNA #CRISPR #DSB

We are seeing multiple instances of reviewers doing manuscript reviews via use of AI/LLM. If you don't want to do a review the old-fashioned way, better to decline the request. Giving someone else's manuscript to AI is a violation of intellectual property rights/laws; the manuscript isn't yours...

RIOK3 mediates the degradation of 40S ribosomes: Molecular Cell www.cell.com/molecular-ce...

New paper from the lab! Want to know if there is a difference in ribosome collisions between your samples? We show that you can detect this in the rRNA reads in your ribosome profiling data. academic.oup.com/nargab/artic...

We have updated our database of funding opportunities for Early-Career Researchers (private foundations, federal, international) We have 456 entries, for which we provide $ amount, deadline, eligibility criteria, etc. Download this massive database here for free: research.jhu.edu/rdt/funding-...

The Spencer Foundation is offering rapid response bridge funding for those who lost NSF research grants. www.spencer.org/grant_types/...