Deep-mining the archaeal proteome for antibiotics www.nature.com/articles/s41...

Our article on human multidomain protein biogenesis is now published in @natsmb.nature.com www.nature.com/articles/s41...

The team of Prof. Dr Niels Gehring @volkerboehm.bsky.social records a comprehensive database that records systematically which genes and gene variants are directly affected by "Nonsense-mediated mRNA Decay" which opens up new avenues for RNA and genome research. The database ➡️ nmdrht.uni-koeln.de

Join us for the Austrian Cryo-EM Symposium Nov 11–12 at @istaresearch.bsky.social! Top speakers, cutting-edge cryo-EM, and a chance to explore Vienna & the ISTA campus. Register now 👉 cryoem-symposium.pages.ist.ac.at #cryoEM #teamtomo

Confidence-guided cryo-EM map optimisation with LocScale-2.0 www.biorxiv.org/content/10.1101/2025.09.11.674726v1 #cryoem

Evolution of drug-binding residues in eukaryotic ribosomes…. pubmed.ncbi.nlm.nih.gov/40944914/

Congratulations to Dirk Görlich and Steven L. McKnight, 2025 #LaskerAward winners! - “for discoveries that exposed the structures and functions of low-complexity domains within protein sequences” 🧪 @mpi-nat.bsky.social #Lasker2025 #LaskerLaureate #structuralbiology #phaseseparation

Just a reminder to check for your name in this list of books that OpenAI trained from. If your name is there, they probably owe you several thousand dollars. OpenAI cried that if everyone eligible author files, the company will go bankrupt, so I'm alerting every author I have ever spoken to.

🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬 Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...

Julian Davies was a renowned scientist who made crucial strides in the study of antibiotics & antibiotic resistance. Honor his legacy at the Julian Davies Memorial Symposium on Oct. 10, hosted by the University of British Columbia. Register by Sept. 15 to attend via Zoom or in person! asm.social/2Af

Thrilled to announce our #preprint on a new factor in the last line of defense in #translation quality control out on #bioRXiv! Spearheaded by fantastic PhD student @kaushikiyer.bsky.social, supported by Chloé Walter, Alina Kraft, Max Müller and Lena Tittel.

Mechanism of 30S subunit recognition and modification by the conserved bacterial ribosomal RNA methyltransferase RsmI #microsky #rnasky 🦠 www.biorxiv.org/content/10.1...

OMG this is it?! The final piece in the puzzle?!😲 tRNAs are the key, because archaic tRNAs sit at the core of all ribosomes. If aminoacyl-tRNAs could form on early Earth, you have a plausible route for the first self-replicators, the bridge from chemistry to biology www.nature.com/articles/d41...

I am delighted to share that I have started my lab in the Dept. of Biochemistry @uofubiochem.bsky.social at the University of Utah @utah.edu. My laboratory will study key aspects of protein synthesis and translational control in healthy and diseased states. #RNAsky sinha.biochem.utah.edu

📄 New paper: 3DEM Structure Map Validation Recommendations Two new metrics assess model-to-map fitness in cryo-EM: 🔹 Q_relative_all → compares avg Q-score across PDB/EMDB 🔹 Q_relative_resolution → compares within similar resolution #3DEM #CryoEM #wwPDB

Latest from the lab! Analysis of everyone’s favorite regulatory mechanism in bacteria — the RF2 programmed frameshift! Likely present in the ancestor of bacteria, use of this mechanism is influenced by stop codon usage! Big congrats to @cassidyprints.bsky.social journals.asm.org/doi/10.1128/...

Our #CryoET story on how a top antimalarial drug candidate perturbs the native malarial translation machinery is out @natsmb.nature.com🥳 rdcu.be/eBbrH A massive team effort led by @leonieanton.bsky.social Meseret Haile & Wenjing Cheng in collaboration with Jerzy Dziekan & the Alan Cowman! #TeamTomo

Research has found that, though open offices often foster a symbolic sense of organizational mission, they are damaging to workers’ attention spans, productivity, and creative thinking. So why does the open-office plan persist? nyer.cm/voWmBqs

AI designs antibiotics for gonorrhoea and MRSA superbugs. 🧪 www.bbc.co.uk/news/article...

Our significantly expanded preprint is out. In it we show that pancreatic cancer cells can transfer ribosomes via tunnelling nanotubes and rescue protein synthesis when co-cultured with cells with impaired ribosomal biogenesis. 🧪 (Includes some #bayesian #rstats inspired by @rmcelreath.bsky.social)

Ever wondered why some antibiotics are made by Streptomyces on agar plates but not in liquid cultures? Read this work on redox control of antibiotic biosynthesis. Led by katienoble241.bsky.social and Rebecca Devine, and in collaboration with @barriewilks.bsky.social journals.asm.org/doi/10.1128/...

“What a [sunburned] cell is trying to do is make decisions about whether to live or die based on how damaged the DNA is… but amazingly, it’s the RNA that signals that. That’s the remarkable observation.” — Rachel Green, biologist at Johns Hopkins University. www.quantamagazine.org/rna-is-the-c...

Our RAPPL purification of ribosomes and associated material is out. I am really proud of this study in collaboration primary with Pavlovic-Djuranovic lab, as well as Jovanovic and Hashem Labs. This method aims to replace 60 years old purification of ribosomes by sucrose cushions rdcu.be/ezlhg

Escherichia coli with a 57-codon genetic code | Science. Syn57, uses 55 codons to encode the 20 canonical amino acids. #rnasky #microsky 🦠 www.science.org/doi/10.1126/...

@acs.org is recognizing Jennifer A. Doudna with the Priestley Medal for her discoveries on ribozyme function, the Dicer RNase enzyme, double-stranded RNA processing, and CRISPR gene editing, along with her impactful international science leadership. cen.acs.org/people/award... #chemsky 🧪

Check out our new preprint on the discovery of a molecular switch in NAC that mediates nascent chain sorting on the ribosome and prevents mitochondrial protein mistargeting by SRP. A great collaboration with the Shan Lab @Caltech and the Qi Lab @UVA: www.biorxiv.org/content/10.1...

A complex between IF2 and NusA suggests early coupling of transcription-translation… pubmed.ncbi.nlm.nih.gov/40715203/

Nice review on RNase R and RNA degradation… www.tandfonline.com/doi/full/10....

Get hands-on training on #cryofreezing, #DataAcquisition and more at EMBO Practical Course "Cryo electron microscopy and 3D image processing" in New Delhi, IN, 21 Feb–3 Mar 2026 Registration by 15 Sep Abstract submission by 30 Sep meetings.embo.org/event/26-cem... #cryoEM #EMBOCryo3D #EMBOevents 🧪

Now out in Structure: Paper on high-resolution #cryoEM using the 100 kV Tundra cryo-TEM by Dimple Karia, Adrian Koh, @abhaykot.bsky.social, @lingboyu.bsky.social, @landerlab.bsky.social and many others. Happy to have contributed to this effort. Check it out: www.sciencedirect.com/science/arti...

Free tRNALeu shows flexible variable arm and CCA end, reshaped by LeuRS and ribosome binding #tRNA #StructuralBiology bit.ly/45PxJF5

New from our lab in @narjournal.bsky.social: We dissect the folding dynamics of a fundamental element of RNA secondary structure—a stem-loop—at single-molecule and microsecond resolution. doi.org/10.1093/nar/... 1/5

Just finished this wonderful book by @jacindaardern.bsky.social. If only more politicians would be like this brave woman, the world would be so different! Read this book and be inspired for a kinder future.

Editor's Pick: Shen, Ye et al. review recent literature on the role of bacterial ribosome heterogeneity on facilitating rapid response to stress. journals.asm.org/doi/10.1128/... @asm.org #JBacteriology

New preprint alert! 🚨👇 I'm delighted to share the latest research from @jemmabetts.bsky.social in our group: ‘A new protein-dependent riboswitch activates ribosomal frameshifting’. Huge congratulations to Jemma for the first manuscript of her PhD! ✨ www.biorxiv.org/content/10.1...

Finally out! I’m thrilled to share our new paper (Wolin et al., Cell 2025). This paper describes SPIDR, a high-throughput method for mapping RBP binding sites. By combining #SPIDR with #cryoEM, we identified the exact binding site of LARP1 within the #mRNA channel of the 40S ribosomal subunit.

How many (distinguishable) classes can we identify in Single Particle Analysis? www.biorxiv.org/content/10.1101/2025.07.14.664719v1 #cryoem

“What a [sunburned] cell is trying to do is make decisions about whether to live or die based on how damaged the DNA is… but amazingly, it’s the RNA that signals that. That’s the remarkable observation.” — Rachel Green, biologist at Johns Hopkins University. www.quantamagazine.org/rna-is-the-c...

Out now: Structure of an archaeal ribosome reveals a divergent active site and hibernation factor @jhdcate.bsky.social @banfieldlab.bsky.social @diptinayak.bsky.social & co #microsky www.nature.com/articles/s41...

Structure of an archaeal ribosome reveals a divergent active site and hibernation factor | Nature Microbiology https://www.nature.com/articles/s41564-025-02065-w

Preprint from our collaboration with the labs of Gerry Wright and Shura Mankin identifying the first translation inhibitor binding to the E-site of the bacterial ribosome… www.researchsquare.com/article/rs-6...

New paper out in Mol Cell, where we show how N-myristolytransferases lipidate proteins on the translating ribosome! Continuing our successful collaboration with DeuerlingLab @uni-konstanz.de & Shu-ou Chan @caltech.edu @snsf.ch @ethz.ch www.cell.com/molecular-ce...

New review from our lab! Compartmentalization during bacterial spore formation. Focusing on latest discoveries in Bacillus subtilis #subtiwiki www.sciencedirect.com/science/arti...

New Independent Fellowship position in Microbiology to launch your lab in our department @johninnescentre.bsky.social (UK). We are conducting a broad search in the area of plant-associated microbial interactions. Message me if you have any questions. Apply here: www.jic.ac.uk/vacancies/in...

Distant ribose 2'-O-methylation of 23S rRNA helix 69 pre-orders the capreomycin drug binding pocket at the ribosome subunit interface pubmed.ncbi.nlm.nih.gov/40626557/ #cryoem

🐦 For the early birds and #ribosome #MD and #ML enthusiasts #EBSA2025: Don't miss 📌 Lars' @larsvbock.bsky.social oral presentation (O-16.1) tomorrow at 8:30 during session 16 in hall 1: "Combining #Simulations and Machine Learning with Experiments to Explore Ribosomal #Translation" 🔗 t1p.de/ccmwk

Congrats Haaris!!