New paper in @natcomms.nature.com! We show how the Clostridia peptide CliM acts as a molecular handbrake to monitor YidC activity. Cryo-EM & MD show it stalls the ribosome using diverse mechanisms until membrane insertion releases it. Paper: www.nature.com/articles/s41...

The latest from the lab. Manikomycin, a new cyclic depsipeptide antibiotic from an 'old' source, the oxytetracycline producer Streptomyces rimosus. Still lots to be learned from this genus! Manikomycin blocks the E-site of the bacterial ribosome. A first. links.springernature.com/f/a/Q0JMeeZK...

🚨 New in @natureportfolio.nature.com! 🚨 Excited to share our discovery of Manikomycin—a novel antibiotic tackling the AMR crisis! 🦠 Using cryo-EM, we found it’s the first-in-class to target the ribosomal E-site, blocking tRNA entry and beating multi-drug resistance. Read: doi.org/10.1038/s415...

🚨 New in @natcomms.nature.com 🚨 Excited to share our paper on how proline-rich antimicrobial peptides interact with the bacterial ribosome. Using cryo-EM, we found that tiny sequence changes cause these peptides to "flip" orientation in the exit tunnel! 🔄🧫 Read: www.nature.com/articles/s41...

🔽 (the first) ribosomal E-site targeting antibacterial; producer avoids self-toxicity by rRNA methylation. #Ribosome #AMR

Diverse mechanisms of translation arrest by a Clostridia ribosome stalling peptide CliM pubmed.ncbi.nlm.nih.gov/42151144/ #cryoem

Diverse mechanisms of translation arrest by a Clostridia ribosome stalling peptide CliM - pubmed.ncbi.nlm.nih.gov/42151144/

2′-O-Methylation maintains ribosome structural and translation integrity: Molecular Cell www.cell.com/molecular-ce...

Ribosome heterogeneity in E. coli : ribosomal RNA (rRNA) sequence and modifications, r-protein stoichiometry and PTMs, and ribosome-associated proteins pubs.acs.org/doi/10.1021/... 🦠

Online Now: Mechanism of RACK1-dependent ZAKα activation at stalled and collided ribosomes Online now:

That celebration has waited for a long time... One year ago we uploaded the preprint and started the endeavor through the peer-reviewing. Lots of emotions on the way 🎭, lots of work, and quite some learning on "friend or foe"... Probably, deserves another post 🤫 But now - the paper is accepted!

🚨After 4 fantastic years in the Sorek lab @soreklab.bsky.social, I’ll be starting my own group at EMBL @embl.org bl.org Hamburg. www.embl.org/groups/oster... Metabolism-driven immunity: phages, metabolites, and discovery of new enzymes, molecules, and pathways 🦠🧬

Erweiterte Finanzierungsmöglichkeiten für Forschungsgroßgeräte! Gemeinsam mit dem BMFTR hat die DFG einen Fortschritt in der nachhaltigen Großgeräteforderung erzielt: Initiale Wartungs- und Servicekosten können nun im Forschungsgroßgeräte-Programm mitfinanziert werden. Alle Details: sohub.io/4j5h

How does a scanning ribosome decide where to start protein synthesis? In our new bioRxiv preprint, we identify an extended translation initiation sequence, the eTIS, an ~80-nt region around the start codon that shapes initiation efficiency: www.biorxiv.org/content/10.6... #Ribosome #CryoEM #mRNA

Excited to share our work uncovering SNOR, a ribosome-associated factor that promotes translation restart after dormancy published in Nature!! This was, as usual, a wonderful collaborative effort between our group and the Mattei Lab @simonemattei.bsky.social @embl.org www.nature.com/articles/s41...

New online: Membrane insertion of mitochondrial-encoded proteins regulates ribosome decoding speed

How do mitochondrial ribosomes keep pace with membrane insertion? Now out in NSMB: We show that mitoribosomes slow down at defined positions linked to membrane insertion and protein topology: rdcu.be/fhqIT #Mitochondria #Ribosome #CryoEM

The regulation, function and disease relevance of cytoplasmic tRNAs www.nature.com/articles/s41... Review: tRNAs: genomic organization, spatiotemporal expression, QC pathways, tissue-specific abundance, stress signalling, and emerging therapeutic strategies for translation defects #tRNA #RNAbiology

Ribosome collisions trigger tmRNA-mediated rescue through mRNA disengagement www.biorxiv.org/content/10.6... 🦠

Fascinating new @nature.com paper: a Pluto moment for biology. It introduces the concept of 'peptideins' - a new category for dark translated ORFs that produce detectable microprotein-like products with unknown biological roles.

Our story on RNA recognition by Egl-BicD is now published! Also delighted to share the accompanying News & Views article by Florence Besse and Andres Ramos, which beautifully highlights the work. Paper: www.nature.com/articles/s41... News & Views: www.nature.com/articles/s41...

Excited to share our latest work, now available on bioRxiv! doi.org/10.64898/202... Huge thanks to everyone involved: first authors Misha and Anneli; our collaborators Shirin, Daniel, and Maria (@selmerlab.bsky.social); and Caro, who started the project some eight years ago… Details in comments

The @biochemsoc.bsky.social Translation UK 2026 meeting will be at @universityofleeds.bsky.social from 30th June - 2nd July. Fantastic keynote speakers including @jbquerido.bsky.social, @nickywhiffin.bsky.social, Nicolas Locker Register and submit your abstract here: tinyurl.com/muy5kvax

Our latest contribution is out! In this highly collaborative paper, we show that tRNAs with a 4-base-pair anticodon stem are surprisingly frequent across organisms. Our atomistic MD simulations reveal the role of the 5th base pair. academic.oup.com/nar/article/...

How well can machine learning predict RNA secondary structure? This review surveys current approaches highlighting both impressive gains and key limitations in generalizability and interpretability #RNAbiology #MachineLearning #RNAstructure #ComputationalBiology #Genomics bit.ly/4spSj6s

Was just asked to spread the word about this position. Structural biology and Chemical Biology positions in Barcelona, one of the great cities of the world! www.irbbarcelona.org/sites/defaul...

Two weeks left for abstract submission - please do register; it's a great UK meeting, and lots of opportunities for ECRs to share their work 👇

Happy to share our new work on how phages escape bacterial immunity. We show that a phage homing endonuclease drives segmental amplification of anti-defense genes, pointing to a versatile and rapid mode of adaptation. www.nature.com/articles/s41... #PhageSky #MicroSky

CryoEM revealed 2MDa respiratory chain-ATP synthase supercomplex, organized around ATP synthase monomer together with complex II, dimer of complex IV A key organizing principle is a non-canonical subunit g′/g″ module repurposing ATP synthase dimerization interface to couple the respiratory chain 2/6

Ihre Forschung bildet die Grundlage für das nächste Jahrzehnt zellbiologischer Forschung und biomedizinischer Anwendungen. Herzlichen Glückwunsch zum #LeibnizPreis 2026, Julia Mahamid! 👏 (@embl.org) Ihre Arbeit im Video: youtu.be/mtmAQxZ33y0?...

Hello RNA Community! @rnasociety.bsky.social You are invited to join the next RNA Collaborative Seminar on Wednesday, April 8th at 10 am ET, 4PM CET. Seminar is hosted by Regensburg Center for Biochemistry (RCB) and University of Michigan. Registration link below us02web.zoom.us/webinar/regi...

New Online! Overcoming the challenge of preferred particle orientation in cryo-EM

The newly established NeCEN Utrecht is looking for a #cryoEM scientist! www.uu.nl/en/organisat... Work with a new Krios 5 + pFIB and support cutting-edge life science research. 📍 Utrecht | 🗓 Apply by 30 April Please share with your network!

Check out the final version of this work, out today! @natcomms.nature.com www.nature.com/articles/s41...

🚨 Preprint alert! We solved the structure of human NSUN2 bound to Asp tRNA, revealing how it installs m⁵C and recognizes RNAs #CryoEM #RNABiology A collab between Casañal & Gullerova labs, with @miclass.bsky.social and me working side by side as co-first authors 🔗 doi.org/10.64898/202... (0/7🧵)

Associate Senior Lecturer/Assistant Professor position in Molecular Microbiology available at Lund University, Sweden: lu.varbi.com/en/what:job/...

New online: Ribosome-associated quality control and related mechanisms

How can we tap into the enormous functional diversity of microbes on this planet? Join us at EMBL Heidelberg (8–10 Dec 2026) to learn about ongoing efforts to decode gene function and organisation in human gut microbes, and present your science.

We are looking for RNA enthusiasts to join us at the @uniregensburg.bsky.social as a junior group leader! Our university offer excellent infrastructure and collaboration opportunities for ground breaking RNA research. Please RT @jrrnascientists.bsky.social @rnasociety.bsky.social

PDB Reaches a New Milestone: more than 250,000 entries

New preprint from @novoalab.bsky.social ! Which tRNAs are used by ribosomes during translation? We introduce tRIBO-seq, a nanopore method to sequence ribosome-associated tRNAs and track how the active tRNA pool changes across stress conditions. www.biorxiv.org/content/10.6... Thread 👇