Cheng Lab
@chenglabfudan.bsky.social
📤 36
📥 67
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We are ribosome lovers from Fudan university in Shanghai.
https://chengjdlab.fudan.edu.cn
Together with the Hurt lab and
@beckmannlab.bsky.social
, we uncovered that Rrp12 coordinates ordered decoding center assembly. Wrongly assembled DC triggers premature recruitment of Rio1 in the nucleoplasm most likely for quality control.
#ribosome
#cryo-EM
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Nucleoplasmic checkpoint of the 40S ribosomal decoding center maturation
Lau et al. report that Rrp12 coordinates ordered decoding center assembly during 40S biogenesis by promoting timely assembly factor release and preventing premature rRNA folding. Rrp12 C-terminal trun...
https://www.cell.com/cell-reports/fulltext/S2211-1247%2826%2900623-6
14 days ago
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reposted by
Cheng Lab
Beckmann Lab
3 months ago
Proud to share our latest preprint! 🥳 Using a multidisciplinary approach, we uncover a dual function of the snR37 H/ACA snoRNP - combining pseudouridylation with ribosome chaperone activity within a single RNP.🔬🧬 Challenging the traditional view of snoRNP function. 👇
#cryoEM
#ribosome
#RNA
#snoRNA
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https://www.biorxiv.org/content/10.64898/2026.03.20.713187v1
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