Structure of the Pre-Initiation Complex Explains CMGE Biogenesis www.biorxiv.org/content/10.64898/2026.05.15.725318v1 #cryoem

TorchRef: An open-source PyTorch Framework for Crystallographic Refinement www.biorxiv.org/content/10.64898/2026.05.13.724821v1 #cryoem

Optimizing somatic embryogenesis in Indonesian cassava genotypes: Effects of 2,4-D or Picloram supplementation and explant type pubmed.ncbi.nlm.nih.gov/42137030/ #cryoem

Immune shielding of viral vectors via capsid engineering with genetically encoded zwitterionic peptides pubmed.ncbi.nlm.nih.gov/42137280/ #cryoem

A novel fusion tool to enable G protein-coupled receptor structure determination pubmed.ncbi.nlm.nih.gov/42138221/ #cryoem

Structural and Dynamics Insights into Melatonin Binding to MT1 Receptor pubmed.ncbi.nlm.nih.gov/42138317/ #cryoem

Architecture of clathrin-independent AP3:ARF1-coated carriers pubmed.ncbi.nlm.nih.gov/42139345/ #cryoem

An engineered insulin analog with dual insulin and IGF-1 receptor agonism and distinct signaling pubmed.ncbi.nlm.nih.gov/42139356/ #cryoem

Structural basis for the subtype-selective activation of KCa3.1 channels pubmed.ncbi.nlm.nih.gov/42140186/ #cryoem

The E. coli DnaX clamp loader sharply bends DNA to load β-clamp at nicks and small gaps pubmed.ncbi.nlm.nih.gov/42140189/ #cryoem

Evolutionarily conserved spliceosome-exosome pathway in nuclear mRNA surveillance pubmed.ncbi.nlm.nih.gov/42140674/ #cryoem

Structural basis for RNA synthesis and inhibition of the orthobunyavirus polymerase pubmed.ncbi.nlm.nih.gov/42140913/ #cryoem

EMReady2: improvement of cryo-EM and cryo-ET maps by local quality-aware deep learning with Mamba pubmed.ncbi.nlm.nih.gov/42140917/ #cryoem

Catalytic and regulatory basis of tRNA t6A modification by the KEOPS complex pubmed.ncbi.nlm.nih.gov/42140986/ #cryoem

Ice-free vitrification of embryos and its impact on post-warming outcomes pubmed.ncbi.nlm.nih.gov/42141048/ #cryoem

Structure and inhibition of the sperm TMEM95-FIMP complex in mammalian fertilization www.biorxiv.org/content/10.64898/2026.05.14.724122v1 #cryoem

De novo design of transmembrane accessory subunits for fold stabilization and expansion www.biorxiv.org/content/10.64898/2026.05.14.725059v1 #cryoem

Applications and prospects of cryo-electron tomography in drug discovery and understanding disease pubmed.ncbi.nlm.nih.gov/42134002/ #cryoem

TEM analysis of dicarboxylic acid-induced transition from unilamellar to multilamellar MEL-A vesicles pubmed.ncbi.nlm.nih.gov/42132688/ #cryoem

Improving Protein Structure Prediction Using Integrative Cryo-EM and Ion Mobility Mass Spectrometry Modeling pubmed.ncbi.nlm.nih.gov/42130166/ #cryoem

Mutation-Driven Remodeling of the LRRK2 Kinase Free-Energy Landscape and Its Consequences for Conformational Transitions and Inhibitor Binding Affinity pubmed.ncbi.nlm.nih.gov/42130234/ #cryoem

New profile pic! Courtesy of the talented @lenka11.bsky.social in the Zhou lab at UCLA.

A Structural Context for the Mechanisms of Uncoupling Protein 1 in Brown Fat Thermogenesis pubmed.ncbi.nlm.nih.gov/42130299/ #cryoem

Structural Basis of Lipopolysaccharide O-Antigen Chain Length Modality pubmed.ncbi.nlm.nih.gov/42131584/ #cryoem

Exploring Passive Permeability Profiles of Cyclic Heptapeptide Chemical Space Uncovers Bioactivity of Mortiamide Scaffold Driven by Colloidal Aggregation pubmed.ncbi.nlm.nih.gov/42131907/ #cryoem

Mapping the Conformational Landscape of DNA Minicircles Through Atomic Force Microscopy and Shape Space Analysis pubmed.ncbi.nlm.nih.gov/42132089/ #cryoem

A Dynamic NMR Lineshape Simulation Framework for Lipid Diffusion and Membrane Thinning in Bicelles and Nanodiscs pubmed.ncbi.nlm.nih.gov/42133034/ #cryoem

Design and validation of a ribosome display library for synthetic nanobody selection pubmed.ncbi.nlm.nih.gov/42133239/ #cryoem

Structural basis for hemoglobin scavenging by CD163 reveals mechanism of ligand promiscuity pubmed.ncbi.nlm.nih.gov/42133656/ #cryoem

In situ single-particle Cryo-EM methods: Principle and applications pubmed.ncbi.nlm.nih.gov/42134001/ #cryoem

Recent advances in integrative cryoEM/ET toward visualizing the molecular sociology of cellular organelles pubmed.ncbi.nlm.nih.gov/42134003/ #cryoem

Protein Engineering-Enabled Cryo-EM Investigation of Small GTPases pubmed.ncbi.nlm.nih.gov/42134495/ #cryoem

Structure and function of IWS1 in transcription elongation pubmed.ncbi.nlm.nih.gov/42134803/ #cryoem

In situ architecture of plasmodesmata in Physcomitrium patens resolved by cryo-electron tomography pubmed.ncbi.nlm.nih.gov/42135498/ #cryoem

ppGpp regulates transcription elongation via direct and indirect inputs to RNA polymerase pausing and nucleotide addition www.biorxiv.org/content/10.64898/2026.05.13.724835v1 #cryoem

Transthyretin amyloid fibrils adopt distinct folds in the brain www.biorxiv.org/content/10.64898/2026.05.12.724695v1 #cryoem

Structural basis for the intestinal protocadherin-based intermicrovillar adhesion complex www.biorxiv.org/content/10.64898/2026.05.11.724279v1 #cryoem

Cryo-EM structure and biochemical characterization of a BRAF/CRAF heterodimer: Negative charge in the NtA motif is not required for RAF activation www.biorxiv.org/content/10.64898/2026.05.11.724350v1 #cryoem

Benchmarking Boltz-2 for Screening of Therapeutic Antibody-Antigen Interactions www.biorxiv.org/content/10.64898/2026.05.13.724924v1 #cryoem

Hsp10: From Single to Double Rings-Structural Basis of Protein Homeostasis www.biorxiv.org/content/10.64898/2026.05.12.724654v1 #cryoem

The pod components of the Shigella T3SS sorting platform accommodate multiple copies of Spa33 (SctQ) pubmed.ncbi.nlm.nih.gov/42124646/ #cryoem

Envelope-Limited Chromatin Sheets (ELCS) Formation in The Nuclear Envelope of HL-60/S4 Cells pubmed.ncbi.nlm.nih.gov/42124592/ #cryoem

Structural basis of the lobster carapace blue colour mediated by an HPR protein pubmed.ncbi.nlm.nih.gov/42124608/ #cryoem

A Dynamic NMR Lineshape Simulation Framework for Lipid Diffusion and Membrane Thinning in Bicelles and Nanodiscs pubmed.ncbi.nlm.nih.gov/42124613/ #cryoem

Broad Neutralizing Activity of Monoclonal Antibodies Against the Omicron Variants Isolated From Patients With Early Severe Acute Respiratory Syndrome Coronavirus-2 pubmed.ncbi.nlm.nih.gov/42126192/ #cryoem

Isolation and characterization of Avs-1, a bacteriophage effective against the aquaculture pathogen Aeromonas veronii pubmed.ncbi.nlm.nih.gov/42126281/ #cryoem

Open and closed forms of assembled henipavirus nucleoprotein suggest structural basis of genome access pubmed.ncbi.nlm.nih.gov/42127178/ #cryoem

In situ structure of the human gap junction pubmed.ncbi.nlm.nih.gov/42127184/ #cryoem

Comprehensive Chemoproteomics Unveils Selective HMG-CoA Synthase 1 Inhibitors for Targeting Mevalonate Metabolism in Cancer pubmed.ncbi.nlm.nih.gov/42127206/ #cryoem

Cryo-EM structure of RubisCO from Nitrosospira multiformis pubmed.ncbi.nlm.nih.gov/42127514/ #cryoem