Online Now: A dynamic RNA hub facilitates activation-induced cytidine deaminase recruitment to the immunoglobulin heavy-chain locus Online now:

Online Now: Translational activation: An unforeseen function of RNP biomolecular condensates Online now:

Online Now: Molecular mechanisms of naturally encoded signaling bias at the complement anaphylatoxin receptors Online now:

Online Now: Structure of E. Coli twin-arginine translocase (Tat) complex with bound cargo Online now:

Online Now: LRRC58 defines an E3 ubiquitin ligase complex sensitive to cysteine abundance Online now:

An aminoacyl-tRNA synthetase governs dsRNA-mediated trade-off between longevity and innate immunity

Stress granules go viral

Expanding the atlas of bacterial immunity with biological language models

Does gut oxygenation drive colorectal cancer?

Tracking mobilization uncovers an evolutionarily conserved mechanism in suppressing mobile genetic elements

PKCα-mediated nuclear translocation of cGAS stabilizes β-catenin and drives metastasis

Structure and engineering of the large serine recombinase Bxb1 for gene integration

TRIM21 induces selective autophagy of viruses and bacteria

Molecular mechanisms of the MLL4 complex in H3K4 methylation and p53-dependent transcription activation

H2O2 sulfenylates GRF8 to facilitate jasmonate signaling by relieving MYC2 inhibition in Arabidopsis

Mechanism of RACK1-dependent ZAKα activation at stalled and collided ribosomes

The DdmDE defense system eradicates plasmids by target-centered bidirectional ssDNA loop extrusion and site-specific cleavage

Mitochondria-lysosome coupling contributes to lysosome acidification and aging

Phenylalanyl-tRNA synthetase FARS-1/FARSA balances longevity and immunity by downregulating endogenous mitochondrial double-stranded RNAs

Nitric oxide drives proteomic diversity through alternative splicing

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Alphaviral non-structural protein-host RBP co-condensation as a mechanism to sustain virus replication

Cell Symposia is now Cell Press Symposia. Our meetings have always been shaped by Cell Press editors—this name simply makes that connection clearer. Read more: http://dlvr.it/TSr7FK

Online Now: Mtg16/Eto2 tumor suppressor maintains and establishes repression by distinct mechanisms Online now:

Online Now: FANCA-dependent FEN1 recruitment suppresses transcription-replication conflicts and PARPi sensitivity Online now:

Online Now: Gregory J. Hannon (1964–2026) Online now:

Online Now: RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription Online now:

🚨 Today we report cryo-EM structures of the Bxb1 integrase complexed with its attB/attP DNA substrates before, during and after recombination. Using these structures, we engineer Bxb1 mutants with improved recombination efficiencies and altered sequence recognition properties. Check it out! ⬇️

New research out in @cp-molcell.bsky.social from Rajan Jain & Ashley Karnay (@penncvi.bsky.social) finds that transcription & cohesin direct domain boundary spatial positioning & are linked to Friedreich’s ataxia @pennepigenetics.bsky.social tinyurl.com/yc4dcvmb

Online Now: Distinct associations of pioneer factor Ascl1-E12a with nucleosomes drive changes in cell fate Online now:

Online Now: SenCat: Cataloging human cell senescence through multi-omic profiling of multiple senescent primary cell types Online now:

Online Now: Structure and engineering of the large serine recombinase Bxb1 for gene integration Online now:

Everything you always wanted to know about plasmid chromatinization … but were afraid to ask

RNAP at the apex: Cryo-ET unveils the torsional tango between plasmid DNA and double-helix-melting proteins

Use it or lose it: A ubiquitin-mediated autophagy pathway for degradation of MHC-I in pancreatic cancer

Mitochondria across the globe: Diverse voices, shared energy

A multi-subunit autophagic capture complex facilitates degradation of ER-stalled MHC class I in pancreatic cancer

Structural basis for RISC assembly of human Argonaute2

Uncovering the initial response: Intra-mitochondrial surveillance activates the UPRmt

Design principles of a membrane-spanning ubiquitin ligase

Chromatin architectures underlying plasmid-based assays for regulatory variant effects

Hypoxia-driven lncRNA SHIELD promotes GPX4 translation and protects against ferroptosis in hepatocellular carcinoma

In vivo single-cell ribosome profiling reveals cell-type-specific translational programs during aging

Intrinsic bias of the genetic code shapes the folding and stability landscapes of microproteins

The E. coli DnaX clamp loader sharply bends DNA to load β-clamp at nicks and small gaps

S-acylation of TDP43 regulates its condensation in amyotrophic lateral sclerosis

Apical localization of RNA polymerases modulates transcription dynamics and supercoiling domains revealed by cryo-ET

5′-Triphosphate guanosine RNAs recruit GTP-binding proteins to suppress RIG-I/IFN type I signaling

✨ Excited to share our latest story, now online! 🧬 We investigated how ZAKα senses stalled and collided ribosomes in the ribotoxic stress response. Huge thanks to members of @cgen2025.bsky.social and all excellent collaborators who contributed to this work.👏 Congratulations to everyone involved!🎉

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