loading . . . Replicative gaps in DNA damage tolerance, genome instability, and cancer therapy Replicative single-stranded DNA gaps arise when DNA synthesis proceeds past lesions or difficult-to-replicate regions. This review delineates the pathways that generate, stabilize, and process these intermediates and discusses how their persistence drives fork degradation, genome instability, innate immune activation, and altered responses to DNA damage response-targeted therapies. http://dlvr.it/TRrT3v
