Structural basis for multi-subunit DNA-dependent RNA polymerase catalytic activity

Sub-2 Å cryo-EM structures of transcribing RNA polymerase II reveal critical roles of water molecules in catalysis

Proteotoxic stress response is governed by ER-associated sorting of proteasome transcriptional activators

Acyltransferase ZDHHC22 promotes N-Myc transcriptional activation to drive neuroblastoma progression and chemoresistance

Deciphering the dual effects of transcription on DNA replication elongation by replication-associated Micro-C

Rapid customization of base editors via machine learning-powered combinatorial mutagenesis

MRE11 proximal polyadenylation site-mediated looping impacts transcription and genomic stability

Online Now: Nitric oxide drives proteomic diversity through alternative splicing Online now:

Online Now: Ribo-Tweezer: Rapid removal of ribosomal proteins reveals additional layers of post-transcriptional gene regulation Online now:

Read the latest issue www.cell.com/molecular-ce...

Online Now: Alphaviral non-structural protein-host RBP co-condensation as a mechanism to sustain virus replication Online now:

Online Now: Intrinsic bias of the genetic code shapes the folding and stability landscapes of microproteins Online now:

Online Now: The E. coli DnaX clamp loader sharply bends DNA to load β-clamp at nicks and small gaps Online now:

Online Now: Transcription and cohesin direct domain boundary spatial positioning and are linked to Friedreich’s ataxia Online now:

Online Now: S-acylation of TDP43 regulates its condensation in amyotrophic lateral sclerosis Online now:

Online Now: High-throughput screening approach identifies substrate-selective Hsp104 variants that counter amyloid seeding with diminished off-target effects Online now:

Online Now: 5′-Triphosphate guanosine RNAs recruit GTP-binding proteins to suppress RIG-I/IFN type I signaling Online now:

Online Now: Apical localization of RNA polymerases modulates transcription dynamics and supercoiling domains revealed by cryo-ET Online now:

Online Now: Salmonella effector SteE reprograms the macrophage regulatory network to drive specific hyperactivation of STAT3 target genes Online now:

Microbial signals meet regulatory DNA: Gut microbiota control liver gene expression through cis-regulatory elements

Enzyme agglomerates change cytoplasmic fluidity

Extracellular alkalinization boosts plant immunity

Aconitase 2 the rescue: A safeguard against excess mitochondrial citrate

PARP1 suppression drives ROS resistance in aneuploid cancer cells

Mutual antagonism between PRC1 condensates and SWI/SNF in chromatin regulation

PDS5 proteins control genome architecture by limiting the lifetime of cohesin-NIPBL complexes

Cohesin cofactor dosage sets the rate of loop extrusion, rendering genome folding tunable yet vulnerable to genetic disruption

A time-resolved atlas of histone modifications during mitotic entry

Gut microbiota modulation of regulatory DNA elements revealed by massively parallel functional characterization

Alu repeat-containing RNAs spatially organize actively transcribed genomic regions around nuclear speckles

A phosphorelay circuit drives extracellular alkalinization in receptor kinase-mediated immune and cell-wall damage signaling

Multi-site DMS probing reveals higher-order structure of RNA-protein complexes in living cells

The discovery of 5mC-selective deaminases and their application to ultra-sensitive direct sequencing of methylated sites at base resolution

Cytoplasmic RNase III Drosha controls lipogenesis by noncanonical regulation of SREBP1

H2AK119ub1-MLL2 counteraction underlies heritable H3K27me3 formation in oocytes

Here you can find the press release by @ruhr-uni-bochum.de of on latest paper: „Proteotoxic stress response is governed by ER-associated sorting of proteasome transcriptional activators“ published in @cp-molcell.bsky.social www.cell.com/molecular-ce... #proteostasis

Our latest issue is now online www.cell.com/molecular-ce...

Condition-dependent amorphous protein agglomerates control cytoplasmic rheology

Online Now: CRL2FEM1B uses heme to recruit BACH1 for degradation and regulate ferroptosis in lung cancer Online now:

Online Now: Sub-2 Å cryo-EM structures of transcribing RNA polymerase II reveal critical roles of water molecules in catalysis Online now:

Online Now: PARP1 suppression drives ROS resistance in aneuploid cancer cells Online now:

Online Now: Proteotoxic stress response is governed by ER-associated sorting of proteasome transcriptional activators Online now:

Online Now: Damage-induced i-loops generate eccDNA from repetitive elements Online now:

Online Now: Structural basis for multi-subunit DNA-dependent RNA polymerase catalytic activity Online now:

Online Now: Acyltransferase ZDHHC22 promotes N-Myc transcriptional activation to drive neuroblastoma progression and chemoresistance Online now:

Online Now: Mutual antagonism between PRC1 condensates and SWI/SNF in chromatin regulation Online now:

Online Now: Cohesin cofactor dosage sets the rate of loop extrusion, rendering genome folding tunable yet vulnerable to genetic disruption Online now:

Online Now: PDS5 proteins control genome architecture by limiting the lifetime of cohesin-NIPBL complexes Online now:

Online Now: A time-resolved atlas of histone modifications during mitotic entry Online now:

Online Now: Gut microbiota modulation of regulatory DNA elements revealed by massively parallel functional characterization Online now: