Microcephaly-associated protein WDR62 supports purine metabolism by interacting with co-chaperone BAG2 Dominic Ng and coworkers link.springer.com/article/10.1...

Asgard #archaea: have we found our microbial ancestors? New review (also for newcomers to the field!) by Christa Schleper and Thiago Rodrigues-Oliveira link.springer.com/article/10.1...

Featured in issue 5: Mitotic entry—Bora takes Polo to Aurora Tyrosine kinase targeting in Tasmanian devil cancer—cover by Morrigl and colleagues Proteome/transcriptome uncoupling in cellular quiescence Unique compartmentalization of holocentric silkworm chromosomes link.springer.com/journal/4431...

TASK two-pore domain channels are inhibited by GPCR signaling – Marcus Schewe, @profkalium.bsky.social and collaborators show how diacylglycerol generated downstream of Gq protein activation interacts with channels and alters their open-probability link.springer.com/article/10.1...

Molecular #evolution of animal #aging: A field perspective explores the impact of evolution on aging and offers a multi-angle view on longevity variation across model organisms and environments link.springer.com/article/10.1...

It’s finally out! Together with @embopress.org and @reviewcommons.org, we conducted a structured side-by-side comparison of human peer review and our AI scientific review (see thread 👇👇👇🔥).

The cholesterol transfer protein STARD3 regulates late-endosome positioning via a GSK3-controlled phosphorylation switch Catherine Tomasetto, @fabienalpy.bsky.social link.springer.com/article/10.1...

Our latest work on the structural determinants for GPCR-mediated inhibition of TASK K2P channels by diacylglycerol is now finally published open access @embojournal.org link.springer.com/article/10.1...

Arthropod exosomal glycine-rich protein as a potential vaccine candidate effectively reduces tick blood-feeding and pathogen transmission Hameeda Sultana and coworkers link.springer.com/article/10.1...

Excited to announce the upcoming Jacques Monod Conference on the mechanistic and evolutionary basis of programmed DNA elimination (Sept 21–25, 2026): cjm.sb-roscoff.fr/en/conferenc... Organized by @laurarossevo.bsky.social and myself.

New paper out in EMBO Reports! We show that Cdc42 regulation is oligomerization-dependent and that a GEF and a GAP act synergistically: Cdc24 relieves self-inhibition of oligomeric Rga2, enabling robust Cdc42 cycling. doi.org/10.1038/s44319-026-00695-7 #cellpolarity #Cdc42 #synergy #syntheticbiology

Explore how genetics, evolution and ecology intertwine at EMBO Workshop "Evolving together: From genomics to biological interactions" in #Taipei, TW, 24–27 Apr 2026. Abstract submission/Registration by 20 Jan/28 Feb https://meetings.embo.org/event/26-bio-interactions#Taipei#EMBOEvoGenBio #EMBOevents 🧪

TRPML1 suppresses pulmonary fibrosis by limiting collagen and elastin deposition link.springer.com/article/10.1...

Eukaryotic translation initiation factor 3: Reza Mohammadinejad, Dieter Wolf and collaborators review the various roles of #eIF3 in mRNA translation and beyond, and its involvement and potential therapeutic targeting in disease link.springer.com/article/10.1...

Read how @embopress.org is expanding its focus on molecular ecology and evolution as central underpinnings of functions/interactions/diversification of biological systems – by @yehumoran.bsky.social, @berndpulverer.bsky.social, and our new team of Editorial Advisors link.springer.com/article/10.1...

Editor perspective: finding 2–3 reviewers often means sending >20 invites. The peer-review system doesn’t run on magic. Worth remembering before clicking “decline” and later complaining about extremely slow reviews.

How is lipopolysaccharide mobility restricted in the outer membrane of Gram-negative bacteria? Christoph Baumann, Martin Fascione et al @york.ac.uk define the roles of intermolecular LPS interactions, membrane asymmetry, & divalent cations in LPS lateral confinement link.springer.com/article/10.1...

Registration now open for the EMBO Workshop "Quantitative tissue morphogenesis - models, manipulations and mechanisms" in #Alibaug, India, 28 September–1 October 2026. Deadline: 30 April 2026 https://meetings.embo.org/event/26-tissue-morphogenesis#Alibaug#EMBOTissueMorphogenesis #EMBOevents 🧪

Elmar Schiebel, Azqa Khan and colleagues identify two roles for yeast Brl1 and Brr6 in nuclear envelope fusion during nuclear pore complex biogenesis: an early role in Nic96 recruitment & a later role in nuclear envelope fusion through spanning the perinuclear space link.springer.com/article/10.1...

Retromer recruits distinct sorting nexins SNX3 and SNX-BAR into hybrid endosomal coats to allow for flexible cargo sorting Navin Gopaldass, Andreas Mayer et al link.springer.com/article/10.1...

In issue #4: Perspective: Cancer as the parasite within Proteolysis in the cell cycle of an archaeon Client recruitment to the cytosolic Fe-S cluster assembly targeting complex Rhizosphere ROS recruit beneficial bacteria Cover: Weiguo Zou, Lijun Wang and colleagues link.springer.com/journal/4431...

🎉 𝐄𝐱𝐜𝐢𝐭𝐞𝐝 𝐭𝐨 𝐬𝐡𝐚𝐫𝐞 𝐨𝐮𝐫 𝐧𝐞𝐰 𝐩𝐮𝐛𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐢𝐧 𝐓𝐡𝐞 𝐄𝐌𝐁𝐎 𝐉𝐨𝐮𝐫𝐧𝐚𝐥! After 8 months of revision, our work is now online: shorturl.at/WHmFq We uncover a previously unrecognized way that 𝑀𝑦𝑐𝑜𝑏𝑎𝑐𝑡𝑒𝑟𝑖𝑢𝑚 𝑡𝑢𝑏𝑒𝑟𝑐𝑢𝑙𝑜𝑠𝑖𝑠 survives toxic metal stress during infection. ...

In this review we map the journey to animal multicellularity and define three extinct ancestral stages: 🔹 LUAA: Last Unicellular Animal Ancestor. 🔹 FACA: First Animal Common Ancestor. 🔹 LACA: Last Animal Common Ancestor. Check it out: bit.ly/4azuLVY @embojournal.org

Mycobacterium tuberculosis is so evolved at surviving environmental stresses! By @oneyrolles.bsky.social & team #TBSky #MicroSky @embojournal.org link.springer.com/article/10.1...

How can bacterial pathogens weather metal ion stress during infection? @pierredupuy.bsky.social, @oneyrolles.bsky.social et al implicate ‘effluxosomes’, membrane clusters of metal-binding chaperones & exporters coordinating M. tuberculosis resistance to toxic metals link.springer.com/article/10.1...

Still a chance to register for @keystonesymposia.bsky.social #InnateImmunity : Diversity in #HostDefense & Disease, this March in Banff! Our @embojournal.org subject editor Ioannis Papaioannou is looking forward to joining you there! #KSInnateImmune26 hubs.la/Q03TCrHw0

Yeast ubiquilin Dsk2 scaffolds proteasome-containing condensates under stress via multivalent interactions – @castanedalab.bsky.social et al show how dynamic interactions among its STI1 domain & transient helices in its disordered region promote its phase-separation link.springer.com/article/10.1...

Calcium sensor STIM1 affects mitochondrial calcium content not only indirectly via store-operated calcium entry into the cytoplasm, but also by promoting direct ER-to-mitochondria ion flow at contact sites @fjvrmrtn.bsky.social , @jorgms.bsky.social and coworkers link.springer.com/article/10.1...

Cryo-electron tomography by eltsovmikhail.bsky.social, Fadwa Fatmaoui et al allows the direct observation of linker DNA geometry and nucleosome conformational variability in a near-native cellular context in the Drosophila embryo link.springer.com/article/10.1...

Very last chance to join us (Deadline tomorrow Feb 10!) at this Developmental Biology meeting! Have a nice story? Come and discuss it with editors from @embojournal.org @plosbiology.org and @dev-journal.bsky.social ! A one hour info session from @erc.europa.eu will also be presented!

New insight into dimethylsulfoniopropionate catabolism by marine bacteria, important for global organosulfur cycling: how DmdR regulator controls DMSP levels in ubiquitous Roseobacter link.springer.com/article/10.1...

Gene drive biasing inheritance of specific alleles in populations as a potential strategy for population suppression: Xuejiao Xu, @jackson-champer.bsky.social et al test 9 female fertility genes as targets for CRISPR-based homing suppression drives in Drosophila link.springer.com/article/10.1...

The CNRS is breaking free from the Web of Science | CNRS https://www.cnrs.fr/en/update/cnrs-breaking-free-web-science

Cellular quiescence uncouples the proteome from the transcriptome in neural stem cells Rita Sousa-Nunes and colleagues link.springer.com/article/10.1...

Is cortical actin the sole driver of cellular membrane bleb expansion? Junichi Ikenouchi and colleagues implicate also calcium-dependent CaMKII supercomplex reorganization, generating local osmotic pressure to cause water influx for bleb growth link.springer.com/article/10.1...

RBM15B recognizes H3K79me2 to guide selective m6A-modification of mRNA and enhance oncoprotein translation in MLL-r leukemia Tian-Qi Chen, Yu-Meng Sun, Shun-Xin Zhu et al link.springer.com/article/10.1...

What determines cell-cycle-dependent loading of human CENP-A? Bypassing the MIS18α/β scaffold via artificial M18BP1 dimerization allows @andrea-musacchio.bsky.social and coworkers to identify determinants, including structure of the M18BP1 SANTA domain link.springer.com/article/10.1...

Yuan Zheng and coworkers identify receptor competition as a mechanism underlying stabilization of the #Arabidopis master germination repressor RGL2, integrating abscisic acid and #gibberellin signaling during seed germination link.springer.com/article/10.1...

Cardiologist Dr. Helen Taussig founded the field of pediatric cardiology. Co-developed the Blalock-Thomas-Taussig shunt in 1944. This groundbreaking surgical procedure treated "blue baby syndrome" saving thousands of infants who previously had no treatment option. #WomensPhysiciansDay #WomenInSTEM

“Favorable conditions bring yield, stress enhances quality”: Biao Gong and colleagues explain how mild salt stress leads to tomato sweetening via root-derived abscisic acid signaling towards the ZHD8 transcription factor link.springer.com/article/10.1...

How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms? Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment link.springer.com/article/10.1...

In issue 3: Cover: Jie Luo and colleagues Review: roles of homologous recombination proteins in genome stability Method: bacterial ubiquitin ligase engineered for target identification and: ATG8 ligases in membrane repair Shaping somatic hypermutation patterns … link.springer.com/journal/4431...

Our @embojournal.org editor Daniel Klimmeck is looking forward to the #MitoCellFate conference in May. Submit poster abstracts and registration until February 9th => bit.ly/43AaInH @fusionconf.bsky.social

✍️ The Pintard Lab ( @ccdlab.bsky.social ) published a new article 📖 @embojournal.org 📃 Molecular basis for the activation of Aurora A and Plk1 kinases during mitotic entry 🔗 link.springer.com/article/10.1...

Excited to share a new piece of work in @embojournal.org Parasitoid wasps hijack a bacterial gene that governs venoms against host. Coauthors include @rokaslab.bsky.social and others. Read more from: link.springer.com/article/10.1...

Coming soon –with poster submission deadline Feb 2nd– #KSUbiquitin26 Our editor hvodermaier.bsky.social is looking forward to being there! hubs.la/Q03TCqzV0

AlphaFold modeling & new assays for mitotic kinase activation in E. coli (#MITOKINAC) reveal molecular basis of specific Aurora A & PLK1 activation through Bora during mitotic entry Lionel Pintard @ccdlab.bsky.social et al #RefereedPreprint ℅ @reviewcommons.org link.springer.com/article/10.1...

Arianna Esposito Verza, @andrea-musacchio.bsky.social et al describe the long-sought-after mechanism of Bora dependency of PLK1 activation by Aurora A kinase during mitotic entry Another #RefereedPreprint ℅ @reviewcommons.org link.springer.com/article/10.1...

TORC1-dependent translation remodels chromatin to repress the undifferentiated germ cell program and initiate the maternal program, thereby promoting oocyte fate in Drosophila @n-kotb.bsky.social, Prashanth Rangan et al link.springer.com/article/10.1...

Biochemist/molecular biologist Joan Steitz was born #OTD in 1941. She (& team) figured out how our cells read/use genetic instructions to make proteins. A key person who helped crack the code on RNA—the molecule that acts like a messenger between DNA & and the proteins our bodies need. #WomenInSTEM