Structural insights into the atypical filament assembly of pyrin domain-containing IFI16 Jungsan Sohn and colleagues www.embopress.org/doi/full/10....

What signaling dependencies underlie cancer transmissability in Tasmanian devils? Phosphoproteomics & xenograft assays by Richard Moriggl, @andreasbergthaler.bsky.social et al delineate distinct adaptations & sensitivities to tyrosine kinase inhibition strategies www.embopress.org/doi/full/10....

Notch signaling is a driver of glandular stem cell activity and regenerative migration after damage @davidecinat.bsky.social, Lara Barazzuol, Rob Coppes et al www.embopress.org/doi/full/10....

Stationary-phase E. coli cells exhibit asymmetric division and macromolecule localization due to uneven accumulation of glycogen between the cell poles over divisions Christine Jacobs-Wagner and coworkers www.embopress.org/doi/full/10....

Mechanism of #autophagy initiation by transmembrane selective autophagy receptors @elias-adriaenssens.bsky.social & @martenslab.bsky.social review emerging mechanistic differences between soluble and transmembrane autophagy receptors www.embopress.org/doi/full/10....

DNGR-1 signalling limits dendritic cell activation for optimal antigen cross-presentation @reisesousalab.bsky.social et al implicate recruitment of phosphatase SHIP1 by receptor DNGR-1/CLEC9A in uncoupling of cross-presentation from inflammatory induction www.embopress.org/doi/full/10....

Concurrence of FGFR1 mutations modulates oncogenesis in glioneuronal tumors Barbara Rivera and coworkers www.embopress.org/doi/full/10....

Distinct senotypes in p16+ & p21+ cells across aging human & mouse tissues: large meta-analysis by Joao Passos, @skhos78.bsky.social et al suggests that senolytic targeting of cells driven into senescence by different CDK inhibitors may require bespoke approaches www.embopress.org/doi/full/10....

Cell cycle-driven transcriptome maturation confers multilineage competence to cardiopharyngeal progenitors Wei Wang, @lionlchristiaen.bsky.social and colleagues www.embopress.org/doi/full/10....

Annexin A7 enhances TIA1 axonal trafficking to counteract pathological aggregation in neurons Tong Wang and coworkers www.embopress.org/doi/full/10....

Two alternative isoforms of PRC2 accessory subunit AEBP2 modulate developmental Polycomb functions in opposite ways - with broadly-expressed AEBP2L acting as an intrinsic inhibitor in somatic cells @adrianbracken.bsky.social @davidovichlab.bsky.social and colleagues www.embopress.org/doi/full/10....

Non-cell-autonomous control of mouse gastruloid development by the ultra-conserved lncRNA T-UCstem1 Gabriella Minchiotti, @annalisafico.bsky.social and collaborators www.embopress.org/doi/full/10....

Gut-brain-gut circuitry in C. elegans: intestinal iron depletion upon altered gut microbe metabolism is sensed by the central nervous system and countered by neurotransmitter-induced ferritin expression Hongyun Tang and coworkers www.embopress.org/doi/full/10....

Now in @embojournal.org: Researchers in @labgrosshans.bsky.social & UCSC found that similar molecular machineries control daily circadian rhythms & developmental timing—showing that evolution can repurpose core timing systems to coordinate both daily cycles & growth. www.fmi.ch/news-events/...

We’re on the cover of @embojournal.org Odin, from Norse mythology, emerges from the Odinarchaeota yellowstonii genome, holding FtsZ1 and FtsZ2 the ancestral twins of tubulin highlighting their evolutionary divergence in Asgard archaea. 👉 shorturl.at/n7iZE #archaea #evolution #tubulin #cytoskeleton

...and here is the link to this paper! www.embopress.org/doi/full/10....

Delighted that this study is finally out @embojournal.org. A detailed analysis of how DNGR-1/CLEC9A signals to promote cross-presentation of dead cell-associated antigens yet does not activate dendritic cells. www.embopress.org/doi/full/10....

Issue 21 highlights: Paxilin’s nuclear switch in the brain RING E3s reading & extending ADPr-ubiquitin Review: Decoding immunometabolism Nuclear actin limits chromatin leakage upon migratory squeeze Cover by @syncellbiolab.bsky.social: unlike Odin-archael FtsZ twins www.embopress.org/toc/14602075...

Our latest review is now online! 👇 @martenslab.bsky.social Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal www.embopress.org/doi/full/10....

Structural insights into selective and dual antagonism of EP2 and EP4 #prostaglandin receptors #CryoEM structures by H Eric Xu and colleagues reveal interactions of the dual antagonist TG6-129 with EP2 and EP4 via different pharmacophores www.embopress.org/doi/full/10....

Happy to have contributed to this interesting study from penengolab.bsky.social! another interesting example of how chromatin modifications and their readers orchestrate replication fork plasticity and protection 👏👇

Excited to share the peer-reviewed version of our work, now online in @embojournal.org! Big thanks to our reviewers and @hvodermaier.bsky.social for facilitating this process. Looking forward to continuing this fun collaboration with @michaelnadbio.bsky.social! www.embopress.org/doi/full/10....

1/5 Glad to share our latest work with Ian Chambers’ lab published @embojournal.org in which we investigated the role of TET DNA de-methylases during cell fate transitions. Great team effort, many thanks to Sara Gonzalez Brito @ebarbieri.bsky.social @edinuni-irr.bsky.social doi.org/10.1038/s443...

End of the @events.embl.org Symposium on Organoids #eesorgan last week - our @embojournal.org editor Ieva Gailite had the pleasure to hand one of the poster prizes to Sagarika Dawka from @merihuchlab.bsky.social

Optimization of a workflow for protease activity profiling reveals a highly abundant, stable C-terminal fragment of complement component 3 (C3) with an immunomodulatory effect Fatih Demir, Markus Rinschen et al www.embopress.org/doi/full/10....

Interactions with the nucleosome’s acidic patch and DNA entry/exit site give the chromosomal passenger complex CPC a non-catalytic role in stabilizing #centromeric chromatin #cryoEM and biochemical, cellular data by AA Jeyaprakash and coworkers www.embopress.org/doi/full/10....

H2B ubiquitination by RNF20/40 safeguards replication fork dynamics in human cells, by facilitating fork reversal and recruiting RNF169 that protects from excessive degradation of nascent DNA @penengolab.bsky.social and collaborators www.embopress.org/doi/full/10....

TET knockout cells transit between pluripotent states and exhibit precocious germline entry Ian Chambers and collaborators www.embopress.org/doi/full/10....

What specific targets & roles are there for all distinct polyubiquitin chain types? Niels Mailand, Robert Shearer et al profile a panel of #ubiquitin replacement cell lines, implicating K29 chains in chromatin regulation via SUV39H1 destabilization www.embopress.org/doi/full/10....

How do cells curb nutrient uptake during quiescence & does it matter? @teislab.bsky.social & Co. show TXNIP-dependent endocytosis of amino acid transporter LAT1/SLC7A5 is essential to prevent cell death and human disease #RefereedPreprint c/o @reviewcommons.org www.embopress.org/doi/full/10....

ER-phagy receptor FAM134C moonlights in selective autophagy of BMP receptors at the plasma membrane, affecting intestinal crypt regeneration Xin-Hua Feng and coworkers www.embopress.org/doi/full/10....

How is lineage specification coordinated with cell cycle progression? Hongtao Yu & coworkers find that post-replicative initial expression of master transcription factor PAX6 is essential for ensuring initiation & faithful inheritance of neural cell fate in mammals www.embopress.org/doi/full/10....

📃Read a #ResearchHighlight on a study led by Shuhei Yoshida & Tomoya Kitajima (Lab for Chromosome Segregation) in which they find MPS1 proteins play a key role to ensure spindle bipolarization occurs before #kinetochores attach to microtubles in #oocytes during #meiosis. www.riken.jp/en/news_pubs...

What role does gut-inflammation-associated, bactericidal IL-26 play in vivo? Pedro Hernandez @zebragut.bsky.social and coworkers use zebrafish to show that it regulates gut microbiota composition and gut epithelial homeostasis during early life www.embopress.org/doi/full/10....

Why do many Argonaute proteins localize to germ granules? Stela Jelenic et al show that for C. elegans WAGO-4, it seems to ensure accurate small RNA loading, in particular for targets not shared with cytoplasmic CSR-1 www.embopress.org/doi/full/10....

Inter-bacterial competition: Sarah Coulthurst and colleagues describe a widely-occurring family of T6SS-dependent pore-forming effectors, exemplified by S. marcescens Ssp4 www.embopress.org/doi/full/10....

Shared mechanisms across distinct biological clocks: Jordan Ward @gotworms.bsky.social , Helge Grosshans @labgrosshans.bsky.social & collaborators find the nematode homologs of mammalian circadian clock proteins PERIOD & CK1 to control developmental timing in worms www.embopress.org/doi/full/10....

E. coli bacteriophage N15 suppresses Mre11-Rad50-mediated end degradation of its linear genome via a telomere-resolution-independent function of its telomere resolvase TelN #RefereedPreprint c/o @reviewcommons.org by @gruberlab.bsky.social www.embopress.org/doi/full/10....

Direct interaction between TDP-43 and Tau promotes their co-condensation, while suppressing Tau fibril formation and seeding @dormannlab.bsky.social www.embopress.org/doi/full/10....

The twist-and-squeeze activation of CARF-fused adenosine deaminase by cyclic oligoadenylates CryoEM by Hong Li and collaborators reveals basis of allosteric activation of CRISPR adenosine deaminase TaqCad1 www.embopress.org/doi/full/10....

T-cell smFISH: @anilevetu.bsky.social, @monikawolkers.bsky.social et al present an optimized workflow for simultaneously quantifying nascent and mature mRNA, and its localization with single-cell resolution in human T-cells #RefereedPreprint c/o @reviewcommons.org www.embopress.org/doi/full/10....

And also the bacterial telomere protection paper by Maya, Nicolas, & Ania is out: doi.org/10.1038/s443... Great experience with @reviewcommons.org & @embojournal.org Feels just right to have the manuscript reviewed without having to target a specific journal from the start.

And it's out! Our paper on the optimization of smFISH to quantify cytokine mRNAs in T cells is published in EMBO Journal. Using this protocol, we gathered interesting insights on cytokine mRNAs co-expression and localization in these teeny tiny human cells. www.embopress.org/doi/full/10....

A novel INO80 chromatin remodeler function in genome maintenance independent of its role in double-strand break repair: Helle Ulrich and coworkers show it facilitates bypass of DNA lesions during replication by promoting repair of damage-induced daughter-strand gaps www.embopress.org/doi/full/10....

Issue 20 cover & highlight: Controlling synaptic autophagy from the neuronal soma @verstrekenlab.bsky.social Comment: Need for unified definition of cellular identity in enteric nervous system Review: Mammalian mitohormesis ...and many more articles… www.embopress.org/toc/14602075...

Maternal antibodies protect during pregnancy and lactation but interfere with with neonatal B-cell responses - due to clearance of attenuated vaccine in the case of rotavirus immunization, find @drsarahcaddy.bsky.social and coworkers www.embopress.org/doi/full/10....

Fibril formation of α-synuclein, central to Parkinson’s disease, is catalyzed by ubiquilin-2 droplets and can be suppressed by small-molecule targeting of UBQLN2 #RefereedPreprint c/o @reviewcommons.org by Masaya Imoto, Nobutaka Hattori and coworkers www.embopress.org/doi/full/10....

Control of flagellar gene expression by Tls chemotaxis receptor-like regulator in pathogenic Escherichia coli Victor Sourjik and coworkers www.embopress.org/doi/full/10....

Type IV secretion systems: from structures to mechanisms Kévin Macé and colleagues summarize recent structural insights into the assembly and function of bacterial type IV secretion systems www.embopress.org/doi/full/10....

Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.