Exploiting renal cell carcinoma dependency on SLC1A1 glutamate transporters: Structure-based mechanistic information guides Abhishek Chakraborty, Shaun Stauffer, @olgabiophys.bsky.social and collaborators in development of inhibitors with increased cytotoxicity link.springer.com/article/10.1...

‘Substrate allostery’: Cryo-EM structures by James Huntington and colleagues reveal a how #prothrombin substrate is repositioned to allow sequential and processive cleavage at distant sites without dissociation link.springer.com/article/10.1...

Eishi Aizawa, Tomoya Kitajima et al develop an ex-vivo culture system for long-term live imaging of mouse germ-cell development – revealing unexpected cellular dynamics but no signs of intercellular organelle transfer during oocyte formation link.springer.com/article/10.1...

Revised role for actin-rich protrusions in T-cell activation: @franbottanelli.bsky.social @probablycarmen.bsky.social et al reframe them as sites of enhanced receptor activation by exclusion & clustering dynamics, rather than pre-enrichment of signaling components link.springer.com/article/10.1...

Dozens of unexpected genes may play a key role in type 2 diabetes (T2D), according to new research from The Jackson Laboratory (JAX) published in @embojournal.org. 🧬 🧪 https://www.jax.org/news-and-insights/2026/april/diabetes-study-reveals-previously-overlooked-genes

CD20 tails interact with the 14-3-3/GEF-H1 complex and microtubule network upon PKCδ phosphorylation Kathrin Kläsener, Michael Reth and collaborators link.springer.com/article/10.1...

Interferon‑γ selectively promotes survival of alveolar progenitor cells in a human lung organoid model – @antonelladost.bsky.social et al @thecleverslab.bsky.social describe a reductionist platform for discovering strategies to enhance alveolar regeneration link.springer.com/article/10.1...

Extra-deep single-cell decoding of human pancreatic islets reveals T2D β-cell gene expression defects Michael Stitzel and colleagues link.springer.com/article/10.1...

ISSUE 8 Highlights: Feeder-free stem cell cultures Sperm age & RNA code Perspective: ensuring transcript fidelity in transgene expression Defining STI1 domain roles in ubiquilin Dual phage inhibition of bacterial virulence & defense Cover: Junichi Ikenouchi et al link.springer.com/journal/4431...

Research on CRISPR-Cas has largely focused on mechanisms & nucleases, with little attention to evolution & optimization. Together with @uni-freiburg.de, @unileipzig.bsky.social & @umich.edu, a HIRI team identified an optimization mechanism in CRISPR-Cas13: www.helmholtz-hiri.de/en/newsroom/... (1/3)

The metallopeptidase MATCAP1 preferentially binds microtubules with an expanded tubulin conformation to generate detyrosinated and ΔC2 α-tubulin @kjverhey1.bsky.social, Puck Ohi and collaborators link.springer.com/article/10.1...

New paper alert! In this study, we find that cells with chromosomal instability (CIN) secrete more extracellular vesicles (EVs). These CIN-induced EVs promote migration and invasion of EV-recipient cells an EFEMP1-dependent manner both in vitro and in vivo. link.springer.com/article/10.1...

So pleased to share that this project identifying convergent evolution of aerobic fermentation in a poorly characterized genus of yeasts (Saturnispora) is now out in @embojournal.org @hittingerlab.bsky.social @rokaslab.bsky.social @glbioenergy.bsky.social link.springer.com/article/10.1...

Breast cancer cells with chromosomal instability (CIN) promote cell migration and invasion of low-CIN cancer cells via secretion of extracellular vesicles transferring ECM components @foijer-lab.bsky.social and collaborators link.springer.com/article/10.1...

SenSet: Melanie Königshoff @eickelbergmd.bsky.social Ziv Bar-Joseph et al develop a learning/classification algorithm to define gene signatures distinguishing senescent cells in the aged human lung link.springer.com/article/10.1...

The H3K36me3 methyltransferase SETD2 contributes to PAF1C interactions with RNA Pol II and is required for neuronal differentiation Tuncay Baubec and coworkers link.springer.com/article/10.1...

Convergent evolution of aerobic fermentation through divergent mechanisms acting on key shared glycolytic genes @hittingerlab.bsky.social , @linder-surprise.bsky.social et al show how distinct genetic routes can converge on the same genetic outcome link.springer.com/article/10.1...

How come giant mimivirus virions retain icosahedral symmetry like smaller viruses? Chantal Abergel, Hugo Bisio @molbiolgv.bsky.social et al use bioinformatics, genetics & interactomics to elucidate spatial & functional organization of mimivirus virion morphogenesis link.springer.com/article/10.1...

Fantastic teamwork by Milica Mihailovic & Aleksandra Anisimova from the Karagöz lab @gekaragoz.bsky.social @maxperutzlabs.ac.at together with the @plantophagy.bsky.social lab — Another great collaboration 🙌 within our SFB program, published in @embojournal.org 🔗 link.springer.com/article/10.1...

How can cells maintain gene expression despite minimal transcription during prolonged mitotic arrest? @iaincheeseman.bsky.social @jimmy-ly.bsky.social et al reveal global transcriptome stabilization in mitotic cells, partly because of reduced mRNA deadenylation link.springer.com/article/10.1...

A conserved leader–repeat hairpin prevents processing of the first CRISPR repeat, suppressing extraneous crRNA production and preserving Cas13-mediated immunity Chase Beisel @helmholtz-hiri.bsky.social and coworkers link.springer.com/article/10.1...

A spontaneous termination mechanism of RNA polymerase V shapes the DNA methylation landscape in plants link.springer.com/article/10.1...

USP9X: understanding its cell-type-specific deubiquitination targets & mitotic arrest phenotypes in cancer cells Broad cancer cell-line screen by Philipp Schenk et al @komanderlab.bsky.social @wehi-research.bsky.social upon treatment with next-gen inhibitor WEHI-092 link.springer.com/article/10.1...

In ISSUE 7: Perspective: Molecular evolution of animal aging Review: eIF3 roles in cells and disease Sorting nexins & hybrid endosomal coats Purine metabolism supported by microcephaly protein WDR62 Cover: Biao Gong and colleagues link.springer.com/journal/4431...

Selective recognition of cyclic penta-adenylated stabilizes a Csm6 tetramer and triggers allosteric activation of its HEPN ribonuclease in a Type-III CRISPR-Cas system Zhonghui Lin, Haishan Gao and colleagues link.springer.com/article/10.1...

Association of orphan nuclear receptors and heterochromatin are involved in Alternative Lengthening of Telomeres – Liuh-Yow Chen and coworkers identify their link as the transcriptional corepressor TRIM28 Thanks to @reviewcommons.org for another #RefereedPreprint link.springer.com/article/10.1...

Cryo-EM structures of orphan GPCR Mas1 reveal distinctive, super-shallow hydrophobic binding pocket that accommodates diverse agonists, and a non-canonical activation mechanism distinguishing Mas1 from classical class A GPCRs Yumu Zhang, Dehua Yang, H Eric Xu et al link.springer.com/article/10.1...

💥Our latest @embojournal.org on membrane damage and repair. Di @dichen02.bsky.social @crick.ac.uk found that calcium is a conserved signal for ATG8/LC3 lipidation on membranes using novel probes to record calcium leakage. Congratulations Di et al! link.springer.com/article/10.1...

FADD is recruited to activated STING oligomers to initiate caspase-mediated NF-κB activation in Drosophila melanogaster Rune Hartmann, Jean-Luc Imler and coworkers link.springer.com/article/10.1...

GWAS have linked tRNA-modifying enzyme CDKAL1 to diabetes but why? Kazuhito Tomizawa and colleagues find it affects kidney function via impaired translation of lysine-rich podoycyte proteins link.springer.com/article/10.1...

Thermostable ancestors enabled evolutionary diversification of promiscuous chemical defence enzymes Elizabeth Gillam and coworkers link.springer.com/article/10.1...

What are the roles of UFMylation during ribosome-associated quality control? @gekaragoz.bsky.social @plantophagy.bsky.social and colleagues find it to cooperate with RQC factors in promoting clearance of arrested nascent polypeptides at the ER link.springer.com/article/10.1...

Proper chromosome segregation requires microtubule end capture by outer kinetochore @vladimirvolkov.bsky.social et al show that oligomerizing interactions of Ndc80 & Ska complexes underlie their ability to stabilize microtubule ends against detachment & shortening link.springer.com/article/10.1...

GTPase Rab11b and effector Rab11-FIP2 promote NLRP3 stability during inflammasome priming Harald Husebye and colleagues link.springer.com/article/10.1...

Congrats Milica @alessandrick.bsky.social & everyone @gekaragoz.bsky.social lab. Glad we could contribute to this awesome story on #UFMylation & #RQC crosstalk @embojournal.org link.springer.com/article/10.1...

Why do nucleoli adopt irregular shapes despite their liquid-like nature? Sara Cuylen-Häring and colleagues find that Ki-67 mediates this irregularity by tethering chromatin at the surface and creating internal chromatin invaginations link.springer.com/article/10.1...

FGF4 initiates X-chromosome inactivation via activating YY1 and prompting loss of pluripotency factors Jianhui Tian and coworkers link.springer.com/article/10.1...

🆕 publication! The @gekaragoz.bsky.social lab shows how cells clear stalled ribosomes at the ER, preventing harmful 'traffic jams' during protein synthesis🚦Their new @embojournal.org study reveals how quality control and UFMylation team up to keep translation moving ➡️ tinyurl.com/2czj8fvp

Huilun Helen Wang, Shengyi Sun, Ling Qi et al. serendipitously discover that mouse models expressing a fatal ERAD pathway mutation in SEL1L are rescued by alternative-splicing-mediated exclusion of the defective region link.springer.com/article/10.1...

Takumi Koshiba and collaborators identify membrane-anchored intermembrane space protein AIFM1 as a direct mitochondrial stress-responsive substrate of metalloprotease OMA1, whose cleavage helps define mitochondrial topology link.springer.com/article/10.1...

Enhanced P-TEFb activity compromises dentate gyrus neurogenesis in mice Yin Fang, Tong Qiu, Ping Wang et al. link.springer.com/article/10.1...

Crystal structure work by Matthew Wohlever and colleagues shows how ALS mutations disrupt self-association between the ubiquilin STI1 hydrophobic groove and internal placeholder sequences, modulating its phase separation link.springer.com/article/10.1...

Condensin loop extrusion properties, roadblocks, and role in homology search @aurelepiazza.bsky.social et al show yeast condensin unidirectionally extrudes long chromatin loops & contributes to biasing donor selection during recombinational DNA break repair link.springer.com/article/10.1...

Highly dynamic membrane-repair mechanisms are triggered upon lysosomal damage– @dichen02.bsky.social , @maxgg.bsky.social et al show that it is the leakage of calcium ions that initiates this process link.springer.com/article/10.1...

Happy to see the first paper from the lab published in the EMBO J today: link.springer.com/article/10.1... In it, we reconstitute self-assembling cooperative oligomers of human Ndc80 and Ska kinetochore complexes that stabilise microtubule ends, and study these samples using cryoET and TIRF

Which transcription factors control transposable element expression during zygotic genome activation? Gain-of-function screen by @metorrespadilla.bsky.social and coworkers identifies TBP as direct regulator of mouse endogenous retrovirus-like elements link.springer.com/article/10.1...

Happening soon - meet our immunology editor Ioannis Papaioannou at @keystonesymposia.bsky.social #InnateImmunity in beautiful Banff! #KSInnateImmune26 hubs.la/Q03TCrHw0

Loss of the ubiquitin ligase targeting factor KEAP1 induces NRF2-driven reductive stress, revealing KEAP1-dependent therapeutic vulnerabilities of KEAP1-mutant NSCLC, particularly under metabolic stress @idikic.bsky.social @diefenbacherlab.bsky.social and coworkers link.springer.com/article/10.1...

How do meiotic gene promoters become accessible prior to prophase I? Deniz Özata, @tianxiong-bear-yu.bsky.social and coworkers find that NFYA primes timely gene activation by establishing a poised chromatin state with paused RNA polymerase II link.springer.com/article/10.1...

Osmolarity as a new tissue-damage signal promoting regeneration: Bo Liu and collaborators implicate the osmosensing WNK-OXSR1 pathway in cytoskeletal remodeling and YAP activation during intestinal repair link.springer.com/article/10.1...