Hong Cheng and collaborators show how alternative polyadenylation can facilitate muscle differentiation and regeneration: 3’UTR shortening of differentiation-gene mRNAs alleviates their repression by myomiR muscle-specific miRNAs link.springer.com/article/10.1...

Basonuclin-2 promotes fracture repair through NuRD-dependent chromatin remodeling in periosteal stem cells Weiguo Zou, Lijun Wang and colleagues link.springer.com/article/10.1...

The Dana-Farber Cancer Institute’s multimillion-dollar settlement has been applauded by science integrity sleuths. https://scim.ag/4j3S65W

link.springer.com/article/10.1... The transaminase-ω-amidase pathway senses oxidative stress to control glutamine metabolism and α-ketoglutarate levels in endothelial cells

Tumor-secreted clusterin promotes cachectic fat wasting via disrupting circadian gene expression and adipogenesis Yan Liu, Liming Chen et al link.springer.com/article/10.1...

The transaminase-ω-amidase pathway senses oxidative stress to control glutamine metabolism and α-ketoglutarate levels in endothelial cells Ralf Brandes, Flavia Rezende and coworkers link.springer.com/article/10.1...

Widespread mono- and oligoadenylation direct small noncoding RNA maturation versus degradation fates Jens Lykke-Andersen and colleagues link.springer.com/article/10.1...

Thanks, Chris! And yep, all going brilliantly - 270 delegates and fantastic talks and posters. Great to see so much support for fundamental discovery science and membrane biology here! Thanks @jcellsci.bsky.social, @embojournal.org and @bscb-official.bsky.social for support!

A mechanism for controlling mRNA localization to neuronal projections: Daniel Dominguez, Matthew Taliaferro @jmtali.bsky.social and collaborators implicated ALS-linked TDP-43 as inhibitor of mRNA accumulation in neurites, possibly by promoting their decay link.springer.com/article/10.1...

Final issue 24/25! Comment: Measuring mitochondrial membrane potential Highlights: Tau/TDP-43 double-trouble; immunoactive complement C3 fragment Review: antifungal immunity signaling … Cover: liver capture of bacteria by CRP; Chen et al link.springer.com/journal/4431...

Weekend reading needed? Aygul Subkhangulova & Marina Mikhaylova review Golgi apparatus adaptations to neuronal shape and functions link.springer.com/article/10.1...

New methods article: David Fay et al integrate endogenous TurboID labeling and data-independent acquisition mass-spectrometry for in vivo proximity labeling link.springer.com/article/10.1...

Somatic hypermutation patterns are shaped by both motif position and sequence grammar Rushad Pavri and coworkers link.springer.com/article/10.1...

Sign up now for the EMBO | The Company of Biologists Workshop "Interfacing biophysical and molecular mechanisms of animal #homeostasis and repair" in #Haining, China, 6–10 April 2026. Deadline: 20 December 2025 https://meetings.embo.org/event/26-homeostasis#homeostasis#Haining#EMBOBiophysicalRepair #EMBOevents 🧪

Evolutionary adaptation of bacterial proteomes: Keigo Fujiwara, Shinobu Chiba et al show that RAPP-like sequences are widely selected against in microbial proteins, while somtimes employed as a ribosome-stalling mechanism in arrest peptides with diverse functions link.springer.com/article/10.1...

The m6A reader IGF2BP3 cooperates with YBX2 to regulate histone-to-protamine replacement during mouse spermiogenesis Mei Wang and coworkers link.springer.com/article/10.1...

ERAD without N-glycosylation? Yeast screen by Leticia Lemus, Veit Goder et al reveals a novel O-mannosyltransferase complex acting on misfolded secretory substrates that lack N-glycans link.springer.com/article/10.1...

New paper out! How can we force HIV genomes out of their capsid shells and what can we learn about HIV biology doing so? Hint: capsid inhibitors actively re-route nuclear HIV complexes, and expose genomes via intriguing structural effects! open access: link.springer.com/article/10.1... read below

In ISSUE 23 Highligh: IL-26 - no guts, no glory Review: initiating autophagy by selective receptors Method: 3D-SPARK for spatial mapping of DNA synthesis Resource: senotypes across aging human and mouse tissues Cover: Sachin Kotak et al @spindlebehavior.bsky.social link.springer.com/journal/4431...

Come join us in beautiful Roscoff for this Conference Jacques Monod on Developmental regulation: from molecular to ecological niches May 18-22, 2026 Roscoff, France Abstract deadline: January 31, 2026 Apply here: cjm.sb-roscoff.fr/en

and here's the link to the article: www.embopress.org/doi/full/10....

Wow, researchers from our #SFB1129 are implicated in the Science 2024 Breakthrough of the Year, because they showed that HIV-capsids are flexible and go through nuclear pores. The latest paper on Lenacapavir-induced capsid damage just came out in @embojournal.org link.springer.com/article/10.1...

Lysosomal localization impacts their function in neurons: Jie Luo and coworkers identify ER-linked AREL1 ubiquitin ligase as regulator of lysosome positioning and acidification via V-ATPase ubiquitination www.embopress.org/doi/full/10....

Lenacapavir-induced capsid damage uncovers HIV-1 genomes emanating from nuclear speckles By exposing integration-competent genomes, Müller, Kräusslich et al find that reverse transcription can be completed in closed viral capsids without directly inducing uncoating www.embopress.org/doi/full/10....

ALYREF condensation stabilizes m5C-modified PARP10 mRNA and promotes PI3K-AKT signaling in ovarian cancer www.embopress.org/doi/full/10....

Heterochromatin epimutations impose mitochondrial dysfunction to confer antifungal resistance @andreasfellas.bsky.social, Alison Pidoux et al @allshire-lab.bsky.social www.embopress.org/doi/full/10....

Mono-ADP-ribosylation as a degradation mark? @andriigorelik.bsky.social, Ivan Ahel et al observe increased ADP-ribosylation of aryl hydrocarbon receptor (AHR) & PARP7 upon ubiquitin-proteasome blockage, crosstalk with DTX2 E3, as rapid AHR-transcription off-switch www.embopress.org/doi/full/10....

Dynein-2 prefers to bind the retrograde-targeted A-tubule in intraflagellar transport - likely because of its tyrosination, suggest cryo-ET data and MD simulations by @ichikawa-lab.bsky.social and coworkers www.embopress.org/doi/full/10....

MCM loading onto replication origins: when does it need ORC6 and when not? AlphaFold-guided structural phylogenetic analyses by @okhay97.bsky.social & @bleichertlab.bsky.social suggests surprising heterogeneity of origin licensing mechanisms across Metazoa www.embopress.org/doi/full/10....

Weekend reading: Judy Lieberman and colleagues reflect on the roles of innate immunity in cancer #immunotherapy, with a focus on how tumors evade immune surveillance and on strategies for enhancing tumor responsiveness www.embopress.org/doi/full/10....

New insights into post-translational regulation of maternal-to-zygotic transition in vertebrate development: Zebrafish screen by @crisprscan.bsky.social , @bazzinilab.bsky.social et al identifies Bckdk role in controlling H3K27 acetylation via Phf10 phosphorylation www.embopress.org/doi/full/10....

Dual interference with host #neuropeptide signaling allows #parasitoid wasp to hijack sugar metabolism of its moth host - involving the help of parasitoid’s symbiotic virus! Xue-Xin Chen and coworkers www.embopress.org/doi/full/10....

Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens Omer Dushek @tcell.bsky.social and colleagues show that 3D solution affinities of the OT-I TCR for foreign and self-antigens predict functional T-cell responses www.embopress.org/doi/full/10....

Our paper on dynein-2's track recognition mechanism is now published in The EMBO Journal @embojournal.org!! Cryo-ET and MD simulations reveal that dynein-2 is tuned for binding to the A-tubule of the ciliary doublet | The EMBO Journal www.embopress.org/doi/full/10....

✨ Happy to share that our work is now published in @embojournal.org ! ✨ Our fantastic collaboration between @crisprscan.bsky.social @bazzinilab.bsky.social Here is the updated thread (1/13): www.embopress.org/doi/full/10....

Thanks to authors of the News&Views for highlighting the role of NLRP6 in sensing homeostatic disruption @alexandraboegli.bsky.social @embojournal.org link.springer.com/article/10.1...

Early registration and abstract deadlines are 15 December for @fusionconf.bsky.social "Mitochondria & Cell Fate Transitions: From Stemness to Senescence Conference". @embojournal.org Senior Editor Daniel Klimmeck is looking forward to this meeting in Malta! For info & registration: bit.ly/43AaInH

The NLRP6 #inflammasome is activated by sterile or pathogen-induced endolysosomal damage Petr Broz @brozlab.bsky.social and colleagues www.embopress.org/doi/full/10....

Direct and indirect neurogenesis from radial glial progenitor cell clones in the mouse neocortex Dan Shen et al www.embopress.org/doi/full/10....

Is there a convergent mechanism for triggering PINK1-Parkin-dependent mitophagy? Derek Narendra and coworkers find that diverse forms of mitochondrial damage are all sensed by a loss of mitochondrial membrane potential (MMP) www.embopress.org/doi/full/10....

Now published in peer-reviewed version: Systematic analysis of immune cell motility leveraging the open intravital microscopy database #Immunemap www.embopress.org/doi/full/10....

Christoph Ringli and collaborators identify a new regulator of the Arabidopsis extensin-mediated cell wall integrity sensing: phosphatase PP2C12 inhibiting receptor kinase FERONIA www.embopress.org/doi/full/10....

Cytosolic receptors and signaling in antifungal immunity Benoit Briard and colleagues review current understanding of the diverse cytosolic sensing systems and signaling pathways involved in antifungal immunity www.embopress.org/doi/full/10....

Chromatin recruitment and cohesion establishment of human Sororin requires not just SMC3 acetylation, but also S-phase PARylation of the Sororin-binding microprotein RSMC Wenya Hou, Huiqiang Lou and collaborators www.embopress.org/doi/full/10....

Homeostatic control of energy metabolism by monocyte-derived macrophages @elmiguelche.bsky.social and colleagues show that macrophages sense dysregulated iron metabolism in parenchymal cells and respond by sustaining mitochondrial function in affected cells www.embopress.org/doi/full/10....

We are pleased to once again partner with @fusionconf.bsky.social for the 2026 conference season! Looking forward to "Fibroblast Growth Factor Signalling in Development, Health & Disease Conference" in March when @embomolmed.org editor Lise Roth will attend. Registration until 5 Feb: bit.ly/49nSmKj

Our new paper is officially published today in @embojournal.org ! We show that protein phosphorylation plays a key regulatory role during early embryogenesis. An amazing collaboration with @crisprscan.bsky.social 🔗 www.embopress.org/doi/full/10.... .

NEW #research: A new @embojournal.org paper from @bazzinilab.bsky.social reveals how chemical tags on proteins regulate the embryo’s earliest decisions. A major leap in understanding early development. #ResearchSky 🔗 Read more: bit.ly/4i6Hdjl

Starting today: @events.embl.org #EESNucleus Make sure to say Hi to our editor @hvodermaier.bsky.social and discuss your latest work with him!

Microglial colonization of the developing mouse brain is controlled by both microglial and neural CSF-1 Sonia Garel, @morganethion.bsky.social and collaborators www.embopress.org/doi/full/10....