Are you attenting the @embo.org workshop on SUMOylation this week? So is our editor @hvodermaier.bsky.social - make sure to meet him and discuss your work with him #EMBOsumoylation

Nuclear rupture in confined cell migration triggers nuclear actin polymerization to limit chromatin leakage DDR sensor ATR protects against nuclear envelope rupture via formin phosphorylation inducing F-actin formation Christos Kamaras et al @grosselab.bsky.social www.embopress.org/doi/full/10....

Aging increases both #telomeric DNA damage and #Alzheimer’s disease risk. Fabrizio d'Adda di Fagagna and coworkers now find that these processes are linked, with Aβ42 oligomers triggering ROS-mediated telomeric damage that in turn increases neurotoxicity www.embopress.org/doi/full/10....

Commensal gut bacteria employ de-chelatase HmuS to harvest iron from heme Martin Lawrence, Jennifer DuBois and colleagues www.embopress.org/doi/full/10....

New Aurora A kinase role in maintaining proper nuclear shape organization at mitotic exit: NuMA inhibition causes its dynamic-to-solid material-state transition, leading to bending of segregated mitotic chromosomes Sachin Kotak @spindlebehavior.bsky.social et al www.embopress.org/doi/full/10....

Decoding #immunometabolism with next-generation tools: Ping-Chih Ho and colleagues review key challenges in exploring metabolic regulation of dendritic cells and T-cells, highlighting emerging methods and strategies for overcoming them www.embopress.org/doi/full/10....

Insights into how –and why– #polyubiquitin chain architecture on collided #ribosomes is maintained: Toshifumi Inada, Yoshitaka Matsuo et al find that distinct roles of yeast deubiquitinases Ubp2 and Ubp3 are essential for maintaining persistent #RQC activity www.embopress.org/doi/full/10....

In ISSUE 18: Actin sequestration & polymerization by synaptic vesicle condensates Brucella survival inside macrophages thanks to chimeric lipid transport system Neuronal tau uptake via LRP1 and LRRK2 Cover by @drawimpacts.bsky.social for Daisuke Kohno and colleagues www.embopress.org/toc/14602075...

Xingzhi Xu, Shunichi Takeda and collaborators show that UFL1-dependent #UFMylation of MCM5 promotes CMG replicative helicase formation and replication fork progression www.embopress.org/doi/full/10....

🚨 Happy to see this collaborative work out in @embojournal.org. How is spindle pole detachment at mitotic exit regulated and what happens to nuclear & chromosome organization when it goes wrong? Hint: chromosomes look like kidney beans! 🌮🌯 Tour-de-force by @spindlebehavior.bsky.social and team!

Bridge-like lipid transfer protein 3A (BLTP3A) participates in endomembrane repair as an effector of #ATG8 conjugation to single membranes (CASM) - helping repair or minimize #lysosome damage @mike-hanna.bsky.social et al, @pdc-lab.bsky.social www.embopress.org/doi/full/10....

...now also highlighted in this press release from University of Sydney: www.sydney.edu.au/news-opinion...

Eleni Petsalaki, George Zachos and colleagues identify a LINC-Rho-basedA mechanosensing mechanism that relays nuclear envelope stretching caused by late-mitotic chromatin bridges to formation of bridge-stabilizing actin patches www.embopress.org/doi/full/10....

Nuclear paxillin functions as a molecular switch for alternative splicing in neurons during a critical period of brain development Pei-Lin Cheng et al www.embopress.org/doi/full/10....

Delighted to share that our paper solving the age-old mystery of whether and how VH-replacement shapes the antibody repertoire is in @embojournal.org www.embopress.org/doi/full/10.... Fantastic work from Harry White, @peterch405.bsky.social @babraham-bioinf.bsky.social @babrahaminst.bsky.social

Shigella type-III secretion system effectors OspI, OspC1, and OspD3 counteract the induction of host inflammation and cell death, by suppressing NF-κB activation, caspase-8-mediated apoptosis, and necroptosis, respectively Hiroshi Ashida, Toshihiko Suzuki et al www.embopress.org/doi/full/10....

Genetic variance in the murine defensin locus modulates glucose homeostasis Mapping of outbred mice by Stewart Masson, David James et al uncovers genetic linkage of alpha-defensin 26 expression to insulin sensitivity www.embopress.org/doi/full/10....

Host cell and viral protease targets of human #SERPINs identified by in silico docking @dittmannlab.bsky.social, Ralf Dürr and collaborators find PAI-2 (SERPINB2) as a direct inhibitor of a viral protease, protecting against infection by human #adenovirus 5 www.embopress.org/doi/full/10....

Mammalian #mitohormesis: Amanda Gunawan, Irene Liparulo and Andreas Stahl review the winding path from mitochondrial stressors to organismal benefits www.embopress.org/doi/full/10....

Resistance to CDK7 inhibitors directed by acquired mutation of a conserved residue in cancer cells Laki Buluwela @simak.bsky.social @bjgreber.bsky.social et al find a single base change of #CDK7 conferring resistance to non-covalent CDK inhibition in prostate cancer www.embopress.org/doi/full/10....

NEWS | Work just published by the Corcoran lab has described a mechanism estimated to be responsible for shaping the generation of up to half of all antibodies. www.babraham.ac.uk/news/2025/09/institute-immunologists-new-process-antibody-diversity @annecorcoran.bsky.social

catching up with my old stomping ground molecular & preclinical cancer research. 2 wonderful @embo.org Global Investigator talks from EMBO associate Singapore by Dennis Kappei, CSI & Wee Wei Tee of IMCB. Spot the Singapore inspired @embojournal.org cover.

Congrats to Naz Şerifoğlu, @miguelgf.bsky.social et al for a really interesting paper — and a nice @embojournal.org cover image www.embopress.org/doi/full/10....

One more day until the start of #EMBODevMet @events.embl.org - don't miss your chance to meet @embojournal.org Senior Editor Ieva Gailite there and discuss your work with her!

VH-replacement shapes the antibody repertoire by removing the genes of non-functional heavy-chains Harry White et al @babrahaminst.bsky.social www.embopress.org/doi/full/10....

Bacterial cell widening alters periplasmic size and activates envelope stress responses Kerwyn Huang, @typaslab.bsky.social et al find that E. coli outer-membrane protein RcsF senses reduced periplasm thickness due to increased cell width, & activates Rcs signaling www.embopress.org/doi/full/10....

Congratulations to Hijiri Oshio of Gakushuin University, winner of the @embojournal.org poster prize at #OsakaMito2025!

Basal IFN-λ2/3 expression mediates tight junction formation in human epithelial cells Megan Stanifer, @boulantlab.bsky.social and colleagues www.embopress.org/doi/full/10....

Structural studies by Ahmad Jomaa and colleagues @jomaalab.bsky.social show how NAC on translating #ribosomes couples protein synthesis to N-myristoylation of nascent polypeptides by NMT2 www.embopress.org/doi/full/10....

Our RNA & translation editor Cornelius Schneider is excited to be at #EMBLProtein starting tomorrow – make sure to say Hi to him and drag him to your posters 😀 @events.embl.org ‬

Cancer encouraged to progress by immune cells in its microenvironment via Toll-JNK-Hippo signalling cascade & Pvf1 ligand/receptor interaction 📷 Sihua Zhao & Yifan Guo et al Westlake University, Hangzhou, China in @embojournal.org ➡️ bpod.org.uk/archive/2025...

Specific and redundant roles for Gli2 and Gli3 in establishing cell fate during murine hair follicle development Catherin Niemann and colleagues www.embopress.org/doi/full/10....

Do transcription and the synaptic steps of #recombination collide, or are they coordinated? Yasmina Djeghmoum and @aurelepiazza.bsky.social show that donor transcription suppresses D-loops in cis to promote genome stability and prevent rearrangements www.embopress.org/doi/full/10....

Comment in issue 17: Making sense of oxygen sensing Glutamine sensing by mTORC1 via GCN2 Androgen signaling control via Parp7 and an ADP-ribosyl degron Dendrite-like pseudopods let macrophages ingest bacteria Cover by @miguelgf.bsky.social et al www.embopress.org/toc/14602075...

GNAS/PKA signaling promotes aberrant osteochondral differentiation of Gli1+ tendon sheath progenitors www.embopress.org/doi/full/10....

The GTPase-activating protein RABGAP1 is a new interactor of amyloid precursor protein APP, facilitating its trafficking and proteolytic processing @dgershlick.bsky.social and coworkers @thecimr.bsky.social www.embopress.org/doi/full/10....

Crosstalk between gut microbiome and tumor microenvironment: Elisabeth Letellier and coworkers find that Fusobacterium nucleatum promotes invasiveness in colorectal cancer by increasing inflammatory cytokine secretion from cancer-associated fibroblasts www.embopress.org/doi/full/10....

Primary #cilia dysfunction as in Bardet-Biedl syndrome compromises normal adipogenic differentiation in favor of fibrogenic transition, predisposing to obesity @wachtenlab.bsky.social and collaborators www.embopress.org/doi/full/10....

Programmed cell revival from imminent cell death enhances tissue repair and regeneration Santosh Chauhan and coworkers www.embopress.org/doi/full/10....

Hemocytes facilitate interclonal cooperation-induced tumor malignancy by hijacking the innate immune system in Drosophila www.embopress.org/doi/full/10....

Cytosolic DNA crosstalk in #senescence Joao Passos, John Sedivy, Peter Adams et al comment on potential synergies and a new axis in inflammatory aging www.embopress.org/doi/full/10....

Pathogenic variants of RTN4IP1 cause mitochondrial disease by acting independently and directly on complex I assembly and coenzyme Q biosynthesis Monika Oláhová, Robert Taylor @taylorlabncl.bsky.social et al www.embopress.org/doi/full/10....

A general rather than site- & function-specific role for protein modification by ADP-ribosylation? @kfeijszaja.bsky.social , Roko Zaja and coworkers find that labeling by #PARP7 facilitates ubiquitin-dependent degradation of multiple targets upon proteotoxic stress www.embopress.org/doi/full/10....

NANOG is repurposed after implantation to repress Sox2 and begin pluripotency extinction Valerie Wilson, Ian Chambers and collaborators www.embopress.org/doi/full/10....

Really nice work by @fredwck.bsky.social and the groups of Val Wilson and Ian Chambers (including a small contribution from me from my Edinburgh postdoc years) showing how pluripotency factors can temporally orchestrate both pluripotency and it extinction: www.embopress.org/doi/full/10....

The two-component defense-associated reverse transcriptase system, DRT9, utilizes a protein-primed poly(dA) synthesis mechanism and an oligomerization transition essential for activation Heng Zhang and collaborators www.embopress.org/doi/full/10....

Epigenetics Update - Programmed cell revival from imminent cell death enhances tissue repair and regeneration bit.ly/4mtqiIU Santosh Chauhan (CSIR/BRIC/AcSIR) reporting in EMBO J #Epigenetics #RegenerativeMedicine #Chromatin --- Empower your research at epigenometech.com

Primary @embojournal.org article - "Dysfunctional mitochondria trap proteins in the intermembrane space" from Johannes Herrmann et al. Read it here 👉 www.embopress.org/doi/full/10....

Chromatin responses to transcription-blocking lesions: Maria Tresini, Wim Vermeulen and coworkers find that RNA polymerase II (RNAPII) stalling triggers histone acetylation, promoting ATM activation that in turn modifies chromatin in a regulatory feedback loop www.embopress.org/doi/full/10....

What’s the significance of X-Y chromosome non-homologous synapsis and desynapsis in #pachytene -stage #spermatocytes? Dongteng Liu, Louise Chow, Kui Liu et al find it to be driven by atypical CDK activator Speedy A, and essential for X-Y loop-axis organization www.embopress.org/doi/full/10....