Recent study in @natbiotech.nature.com: A team led by #HIRI’s Beisel lab introduced a new way to fine-tune genetic material. They describe an innovative technique where chemical tags are attached directly to DNA, opening new possibilities in medicine, agriculture, and biotechnology. ➡️ rdcu.be/eG4fk

2/2 @jorg-vogel-lab.bsky.social, @gerovac.bsky.social & team @helmholtz-hiri.bsky.social developed a non-genetic antisense oligomer approach to silence phage genes and probe their function—a powerful tool for functional genomics & phage therapy. Now out @nature.com go.nature.com/46b1XAQ

1/2 Bacteriophages are among Earth’s most diverse biological entities, but many resist genetic manipulation. This leaves much of their diversity unexplored and constrains efforts to discover new proteins and exploit their potential for biotechnology and therapeutic applications.

Der HZI-Standort @helmholtz-hioh.bsky.social erforscht die Gesundheit von Menschen, Tieren und Umwelt als ein untrennbares Ganzes. In Greifswald wurde heute mit Gästen aus Wissenschaft und Politik der #Grundstein für das HIOH-Forschungsgebäude gelegt. #OneHealth www.helmholtz-hzi.de/media-center...

Der Grundstein ist gelegt! Wir freuen uns darauf, dass unser neues #OneHealth-Gebäude in #Greifswald Gestalt annimmt, wo bald neue Ideen und #Teamwork zusammenkommen werden. www.helmholtz-hioh.de/de/newsroom/... @unigreifswald.bsky.social

No Genetics? Try ASOs – A non-genetic approach to silence genes at the phage-host interface. We use it to study jumbo phage biology and anti-phage defence. @jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social @uni-wuerzburg.de @helmholtzhzi.bsky.social published now in @nature.com

Programmable #antibiotics: Using innovative #RNA technology, Würzburg researchers succeeded in specifically interfering with #phage reproduction in #bacteria. New publication @nature.com @helmholtz-hiri.bsky.social @jorg-vogel-lab.bsky.social #asobiotics

Looking for a new approach to studying or eliminating phages? Check out our study introducing anti-phage ASOs (antisense oligos) out in @Nature today. nature.com/articles/s4158…

Um das molekulare Wechselspiel zwischen #Bakteriophagen & Bakterien zu untersuchen, haben Forschende um @jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social & @gerovac.bsky.social mithilfe von Antisense Oligomeren gezielt die Phagen-Entwicklung "gehacked". www.helmholtz-hzi.de/media-center...

Phages, viruses that infect bacteria, could help fight antibiotic resistance, but phage–host interactions are not yet sufficiently understood. Researchers from #HIRI, JMU & HZI now successfully interfered with phage reproduction using ASOs. Just out in @nature.com: www.nature.com/articles/s41...

New study published at Nature Structural & Molecular Biology: Pox viruses have developed a unique strategy to rapidly multiply after infecting a host cell. The findings may serve as a starting point for the development of new antiviral agents. go.uniwue.de/smallpox

We are very proud of our researchers Beatrice Baragli, Jerome Beetz, Jacqueline Degen, Mona Garvert, Jake Greenfield, and Jens Hör: They have been awarded prestigious ERC Starting Grants worth €1.5 million. Congratulations! @erc.europa.eu #ERCStG ➡️ www.uni-wuerzburg.de/en/news-and-...

Im Kampf gegen multiresistente Keime können #Bakteriophagen eine weitere Waffe sein. Für sein Projekt "RIBO-PHAGE" erhält @jenshoer.bsky.social, Nachwuchsgruppenleiter @helmholtz-hiri.bsky.social, nun einen #ERCStG des @erc.europa.eu!🎉 Herzlichen Glückwunsch! www.helmholtz-hzi.de/media-center...

Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes - @helmholtz-hiri.bsky.social go.nature.com/4n7zDpG

Congratulations to our #HIRI group leader and JMU junior professor @jenshoer.bsky.social on receiving a 1.5 million euro #ERCStG from @erc.europa.eu! In his RIBO-PHAGE project, he will study phages—viruses that infect bacteria—with RNA genomes. 🥳👏 @helmholtzhzi.bsky.social @uni-wuerzburg.de

How can the outdoor area of the new #HIRI building be designed sustainably? At the last Sustainable Thursday, Tobias Kerrinnes, Head of Scientific Infrastructure, presented a greening concept with robust plants and locally inspired flora & materials.🌱🏗️🪨 More at: www.helmholtz-hiri.de/en/newsroom/...

Congratulations to @westermannlab.bsky.social, who has been recognized as one of the “Supervisors of the Year” by the @gslsuniwue.bsky.social at @uni-wuerzburg.de! 🎉🥈 Read more: www.helmholtz-hiri.de/en/newsroom/...

AI can optimize processes & automate everyday work tasks. As part of #HIRI’s Sustainable Thursday series, Head of Administration Britta Grigull discussed how administration and communication could benefit from AI, highlighting both its potential and challenges: www.helmholtz-hiri.de/en/newsroom/...

Check out this feature on HIRI-associated scientist @lbarquist.bsky.social, in which he talks about his career journey, his research interests, and one of his latest publications. 👇

The Friends of the @helmholtzhzi.bsky.social have awarded Gianluca Prezza the HZI PhD Award for his outstanding doctoral thesis. In #HIRI's @westermannlab.bsky.social, he investigated #sRNAs in the gut bacterium B. theta. 🦠👨🎓 Congrats, @gprezza.bsky.social! www.helmholtz-hiri.de/en/newsroom/...

Congratulations! 🧬🏆

what a day! 🎓🌞 huge thanks to everyone who came out for grad schools day – great career session, inspiring talk, sizzling bbq, and smooth live music to close it off. so good to see our community connect, share, and just enjoy the summer together. 🔥🎶💬 #phdlife #GSLS @uni-wuerzburg.de

Beim gestrigen Festakt wurden zudem die HZI-Promotionspreise an Wenchao Li @ciim-hannover.bsky.social und @gprezza.bsky.social aus der Gruppe von @westermannlab.bsky.social @helmholtz-hiri.bsky.social verliehen. Wir gratulieren den beiden zu ihren ausgezeichneten Doktorarbeiten!

📢ONLINE @natgenet.nature.com 📰A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen. By @mldm.bsky.social, @lbarquist.bsky.social, Mikael E. Sellin and colleagues. ⬇️ www.nature.com/articles/s41...

Our latest: www.cell.com/cell-reports/fulltext/S2211-1247(25)00615-1. Links Bacteroides cell size w/ gene expression. Protocol works even for single cells. 🦠 Shoutout to @elisebor.bsky.social, @emmanuel-saliba.bsky.social, @lbarquist.bsky.social, @jorg-vogel-lab.bsky.social, Till Strowig & KC Huang.

Marco Antonio Olguín Nava from Redmond Smyth’s lab has successfully defended his doctoral dissertation, becoming the second graduate of the “RNA & Infection” program at #HIRI. Congratulations, Marco! 🎓🎉 Read more: www.helmholtz-hiri.de/en/newsroom/...

Despite being genetically identical, bacteria can vary considerably in shape & size. 🦠 Whether these variations affect bacterial function has remained an open question. #HIRI’s @westermannlab.bsky.social‬ has characterized the functional differences between various forms of gut bacterium B. theta.

Very excited about our latest combining advanced cell culture, transposon-insertion sequencing, and statistical modeling to map Shigella virulence determinants in organoid models. Great collaboration w/ @mldm.bsky.social @sellinlab.bsky.social in @natgenet.nature.com www.nature.com/articles/s41...

How do we foster a sustainable work environment at the #HIRI?🌱👥 That was the central question during our third Sustainable Thursday. Britta Grigull, Head of Administration, invited participants to share ideas on how to make everyday work life more sustainable. www.helmholtz-hiri.de/en/newsroom/...

Our latest work combines human gut epithelial #organoid culture with experimental #Shigella #infections, transposon mutagenesis, and statistical modeling. This has led to the mapping of the comprehensive geneset that drives Shigella epithelial colonization. Out @natgenet.nature.com: rdcu.be/eqGgf

Thanks to lab-grown miniature intestines, researchers at #HIRI & Uppsala University have mapped how Shigella bacteria infect the human gut. This @natgenet.nature.com study opens the door to using cultured mini-organs to investigate a wide range of infections. 📍🦠 www.nature.com/articles/s41...

It was a pleasure having you, @delafuentelab.bsky.social! Thank you for the insightful talk as part of the Würzburg Life Science Seminar series. 🙌

Check out this new @narjournal.bsky.social paper on the novel spatial transcriptomics technique mudRapp-seq! Congratulations to @shazebahmad.bsky.social and fellow authors! 👏

Let’s give a big round of applause to Jakob Jung, who has successfully defended his dissertation! 👏 Congratulations, @jabster93.bsky.social‬! The #HIRI family is celebrating with you! 🥳 Read more: www.helmholtz-hiri.de/en/newsroom/...

Through our Sustainable Thursday series, we aim to further develop the sustainability of our institute. Last week, #HIRI Lab & Infrastructure Manager Christiane Albert-Weißenberger shared practical tips on how to reduce electricity consumption in labs. 🌱💡 ➡️ www.helmholtz-hiri.de/en/newsroom/...

Exzellente Forschungsaussichten! Das HZI ist zukünftig an zwei Exzellenzclustern beteiligt: @resist-cluster.bsky.social wird für weitere sieben Jahre gefördert und #NUCLEATE @uni-wuerzburg.de kommt neu dazu! Herzlichen Glückwunsch an alle Beteiligten! 📷MHH/JMU www.helmholtz-hzi.de/media-center...

Excellent news! 👏🧬🥳

In wenigen Stunden ist es so weit: Die zukünftig geförderten #Exzellenzcluster werden bekannt gegeben! 🔴 Livestream ab ca. 17 Uhr auf YouTube. Alle Informationen veröffentlichen @wissenschaftsrat.de u. die #DFG auf ihren Websites – und natürlich hier. Zum Stream:▶️ www.youtube.com/c/DFGbewegt_...

👏🔥

MATQ-seq allows the detection of a large number of genes per single bacterium and is characterized by a high cell retention rate. 🦠 A #HIRI & @uni-wuerzburg.de research team recently published a step-by-step protocol in @natprot.nature.com. Learn more ⬇

Eine Negativ-Kontrolle überraschte @jorg-vogel-lab.bsky.social et al. vom @helmholtz-hiri.bsky.social beim Test eines Wirkstoffs gegen Fusobakterien: Genau die lieferte letzlich einen unverhofften #Bakterien -Killer. @mariorembold.bsky.social erzählt die Story: www.laborjournal.de/editorials/3...

#Fusobakterien gehören zur normalen Mundflora, stehen aber auch im Verdacht, das Wachstum von Krebs zu fördern. Forscher:innen @helmholtz-hiri.bsky.social zeigen nun, dass eine Peptidnukleinsäure-Verbindung das Wachstum versch. Fusobakterien-Stämme stoppen kann. www.helmholtz-hzi.de/media-center...

An unexpected bacterial blocker 🦠🛑 Fusobacteria are suspected of playing a role in cancer progression. #HIRI researchers have now identified a novel compound that effectively halts the growth of five Fusobacterium species. Just out in @asm.org journal mBio: www.helmholtz-hiri.de/en/newsroom/...

T-cell activation involves not just one phase, but two. T-cell priming first activates many T-cells, then selects and expands the most effective ones. This finding was published today in @science.org. doi.org/10.1126/scie... GIF: © Deeksha Seetharama / Max Planck Research Group

Last week's @embo.org Sectoral Meeting on #RNA and Structural Biology, organized by #HIRI's @emmanuel-saliba.bsky.social, was a huge success. A heartfelt thank you to everyone who contributed and participated! 👏🧬 Read more: www.helmholtz-hiri.de/en/newsroom/...

Microbial single-cell MATQ-seq developed by @emmanuel-saliba.bsky.social & @jorg-vogel-lab.bsky.social allows detection of a large number of genes per single bacterium & stands out for its high rate of cell retention. For a detailed protocol, see rdcu.be/eg0Xc, now available @natprot.bsky.social.

RNA-basierte Medizin hat das Potenzial viele Krankheiten zu heilen. Am @helmholtz-hiri.bsky.social arbeiten Forscher:innen unter anderem an programmierbaren #Antibiotika und diagnostischen Werkzeugen auf RNA-Basis. Mehr dazu findet ihr in unserem Wissensportal. www.helmholtz-hzi.de/wissen/wisse...

Looking to do single-cell #RNA-seq in bacteria? 🦠🧬 Check out this step-by-step MATQ-seq protocol by #HIRI's @jorg-vogel-lab.bsky.social – a robust & reliable method, even for small sample sizes! Just out in @natprot.bsky.social! 🔥

New Article! Transcriptomic profiling of individual bacteria by MATQ-seq

New preprint from @westermannlab.bsky.social about a pair of antagonistic #Salmonella sRNAs. Check it out 👇🏻