Trends in Microbiology
@cp-trendsmicrobiol.bsky.social
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Posts by Shankar Iyer, editor of Trends in Microbiology.
pinned post!
The September issue is live now! With the cover image depicting diet-pathobiont interplay in health and inflammatory bowel disease. We also kickstart our series on 'Scientific mobility in microbiology'. Read the full issue here:
www.cell.com/issue/S0966-...
6 months ago
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Unraveling posttranscriptional regulatory networks in phage infection
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Unraveling posttranscriptional regulatory networks in phage infection
Phages employ sophisticated transcriptional regulatory networks to optimize replication. Recently, Silverman et al. used RIL-seq (RNA interaction by ligation and sequencing) to reveal an additional layer of regulation and uncovered the Hfq-mediated posttranscriptional regulon of the model phage lambda.
http://dlvr.it/TRBHWP
2 days ago
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Addressing gaps: Brazilâs approach to microbial biobanks
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Addressing gaps: Brazilâs approach to microbial biobanks
This commentary examines the strategic significance of microbial biobanks and their crucial role in preserving microbial genetic resources and their associated data, laying the groundwork for advancing research and innovation. However, this essential link must be sufficiently robust to unlock the full potential of microbial diversity, generating both scientific knowledge and economic growth.
http://dlvr.it/TRB7DR
2 days ago
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Ecological battle of gut microbiota under drug intervention
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Ecological battle of gut microbiota under drug intervention
Ecological consequences of drug exposure in the gut microbiota remain difficult to predict. In a recent Cell study, Shi et al. have demonstrated that nutrient competition and interspecies antagonism drive drug-induced microbiome restructuring. Their predictive framework advances mechanistic understanding of drugâmicrobiome interactions and fecal microbiota transplantation.
http://dlvr.it/TR6xqQ
5 days ago
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reposted by
Trends in Microbiology
Ăkos T KovĂĄcs
11 days ago
Our review has been published online first a year ago, and later with a cover in the July issue of
@cp-trendsmicrobiol.bsky.social
... now above 60 citations! with
@xinmingxu.bsky.social
and
@neftalyl.bsky.social
#MicrobiomeEcology
at
#LeidenBiology
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Orsay virus
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Orsay virus
Orsay virus (OrV) was discovered in 2011 in Orsay, France and is currently the only known natural virus of the free-living bacterivorous nematode Caenorhabditis elegans. Although it has yet to be formally classified by the International Committee on Taxonomy of Viruses (ICTV), OrV is most closely related to nodaviruses, which mostly infect fish and insect hosts. It has a single-stranded, positive-sense RNA genome with two genomic segments, measuring around 6 kb in total length. Although several OrV strains have been independently identified, there are no major differences between them.
http://dlvr.it/TR0CJ4
12 days ago
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Early registration discount deadline March 13. Register for the Cell Press Symposia #CSMicrobiome2026 (10â12 May 2026, Bruges). Join leading experts exploring hostâmicrobiome interactions and therapeutic innovation. @cellpressevents.bsky.social
http://dlvr.it/TQzzqr
12 days ago
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Ochrobactrum intermedium
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Ochrobactrum intermedium
Ochrobactrum intermedium is a Gram-negative, rod-shaped, nonspore-forming bacterium that shows rapid colony growth on MacConkey agar (>0.5 mm after 24 h) with mucoid colony morphology and positive motility [1]. It is oxidase, urease, and catalase-positive and capable of growing at 37°C on Blood agar, Chocolate agar, and MacConkey agar [2]. Ochrobactrum species have been widely distributed in various environments, such as animals, plants and their rhizosphere, soil, (waste) water, and humans [3].
http://dlvr.it/TQxkkv
15 days ago
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Ehrlichia chaffeensis
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Ehrlichia chaffeensis
Ehrlichia chaffeensis is an obligatory intracellular Gram-negative bacterium that causes human monocytic ehrlichiosis (HME), a tick-borne infection with a spectrum of severity from mild to severe and increasing public health relevance. While initially identified as a human pathogen, E. chaffeensis infections have been confirmed naturally in humans and dogs. The pathogen is primarily transmitted by the three-host lone star tick, Amblyomma americanum, and persists in white-tailed deer (Odocoileus virginianus) as its principal reservoir.
http://dlvr.it/TQm8hM
24 days ago
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(This is coming in a bit late but...) Happy new year, everyone! As I continue planning 2026 travels, please give a shout if you are organizing a microbiology conference this year (or attending one).
#microsky
about 1 month ago
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Role of bile acid metabolites in regulating viral infections
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Role of bile acid metabolites in regulating viral infections
Gut microbiota-derived bile acids are emerging as pivotal regulators of viral pathogenesis. They exhibit dual roles by directly blocking or promoting viral entry, while also systemically tuning immune responses. This forum discusses how spatiotemporal mapping of these interactions can address unresolved questions and inspire novel microbiome-based antiviral strategies.
http://dlvr.it/TQbjCd
about 1 month ago
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CS: Host-microbiome dynamics abstract deadline extended to Feb 6. Share your research with leading scientists exploring the ecology of the human microbiome, its influence on host physiology & its complex interactions with the immune system.
http://dlvr.it/TQVndz
about 1 month ago
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Emerging advances in prokaryotic transposition: TnPedia as a promising tool
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Emerging advances in prokaryotic transposition: TnPedia as a promising tool
TnPedia provides a curated framework for understanding prokaryotic transposable elements (TEs), including general and historical information and basic concepts, while integrating mechanistic insights, family-level classification, and representative examples. It summarizes key developments reshaping the field, including RNA-guided transposition, and provides information on TE acquisition and transmission of antimicrobial resistance-associated transposons.
http://dlvr.it/TQSjLc
about 1 month ago
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Host-centric approach toward increased recombinant protein solubility
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Host-centric approach toward increased recombinant protein solubility
The recently published paper by Mital et al. elegantly employs a simple yet extremely powerful and effective approach to increase the solubility of Escherichia coli-produced proteins usually destined for aggregation.
http://dlvr.it/TQPqlm
about 1 month ago
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A tunable microbial factory for rare sugar coproduction
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A tunable microbial factory for rare sugar coproduction
Palur et al. developed a tunable microbial platform that converts d-glucose into d-sedoheptulose and d-mannose at food-relevant levels. Their platform may be a starting point for exploring the metabolism of additional rare C7 sugars while unlocking a wide array of natural products derived from d-sedoheptulose-7-phosphate.
http://dlvr.it/TQP0hW
about 1 month ago
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Emergence of traits in human fungal pathogens
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Emergence of traits in human fungal pathogens
Invasive human fungal pathogens cause significant morbidity and mortality. Both environmental and host factors have driven the evolution of key traits, such as pathogenicity and drug resistance. This has led to the emergence and spread of novel pathogens and drug-resistant variants, posing a substantial threat to public health. Unlike well-reviewed bacterial or viral pathogens, fungal pathogens can utilize eukaryote-specific mechanisms to rapidly acquire adaptive traits. Understanding the drivers and molecular mechanisms behind these traits is essential. This review systematically elucidates these processes in common and emerging fungal pathogens. We highlight the urgent need for next-generation antifungal strategies with high resistance barriers, discussing their necessity and feasibility to limit the emergence of drug resistance.
http://dlvr.it/TQMw1T
about 1 month ago
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Scientific mobility in microbiology â 12
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Scientific mobility in microbiology â 12
Alwar Ramanujam Padmavathi
http://dlvr.it/TQLyVM
about 2 months ago
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Scientific mobility in microbiology â 11
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Scientific mobility in microbiology â 11
Duhita Sant
http://dlvr.it/TQLnGR
about 2 months ago
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Emerging roles of lipids in the flavivirus life cycle
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Emerging roles of lipids in the flavivirus life cycle
Flaviviruses, such as Dengue, Zika, and West Nile virus, cause a significant global health burden and have earned attention as high-pandemic risk pathogens. Flaviviruses interact closely with cell membranes at every stage of their life cycle, and mounting evidence demonstrates that flaviviruses rely on specific lipids and lipid-remodeling proteins, presenting potential therapeutic opportunities for targeting the hostâs lipid metabolism. Our understanding of lipid function in infection has expanded considerably in recent years, partly thanks to advances in lipidomics, cryo-electron tomography, lipid-based chemical tools, and biophysical characterization techniques. In this review, we highlight recent breakthroughs that have clarified flavivirus lipid requirements and functions, as well as ongoing technological advances in the virusâlipid interaction field, which are poised to enable the next wave of discoveries.
http://dlvr.it/TQGmxq
about 2 months ago
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Deep-learning dive into the antimicrobial potential of Archaea
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Deep-learning dive into the antimicrobial potential of Archaea
The global burden of antimicrobial resistance demands the urgent development of new antibiotics. To face this threat, Torres et al. leveraged deep-learning models to identify archaeal encrypted peptides (termed âarchaeasinsâ) with potential antimicrobial activity. This work highlights Archaea as an underexplored but potentially rich source of antibiotics.
http://dlvr.it/TQCwFW
about 2 months ago
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Multiscale imaging of RNA virus: bridging structural mapping and functional insights
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Multiscale imaging of RNA virus: bridging structural mapping and functional insights
RNA viruses, exemplified by the COVID-19 pandemic, pose a significant threat to global health. Their rapid mutation and host adaptability highlight the need for advanced tools for efficient viral studies and timely countermeasure development. Imaging technologies, such as cryo-electron microscopy and super-resolution microscopy, have been pivotal in advancing our understanding of viral structures, infection mechanisms, and virusâhost interactions. However, each technique has limitations in the field of view or resolution. Recent advancements have focused on developing integrated multiscale imaging to better understand RNA virus pathogenesis. In this review, we examine recent progress in RNA virus imaging across molecular, cellular, and tissue scales, including cryo-electron tomography and correlative multiscale imaging, which link structural mapping with functional insights.
http://dlvr.it/TQClgv
about 2 months ago
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Uncovering the hidden risks of microplastics in the food chain
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Uncovering the hidden risks of microplastics in the food chain
Microplastics pose hidden risks to the food chain by acting as vehicles for microbial colonization. The plastisphere may facilitate pathogen transfer through seafood, agricultural products, and food processing, raising major concerns for food safety. Standardized methodologies, stronger regulations, and further research are urgently needed to address these emerging risks.
http://dlvr.it/TQBdBg
about 2 months ago
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More than just membranes: membrane contact sites as crossroads for infections
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More than just membranes: membrane contact sites as crossroads for infections
Membrane contact sites (MCSs), tethering zones between organelles, have emerged as critical hubs for regulating cellular metabolism, homeostasis, and immune responses. Recent discoveries reveal that a wide range of intracellular pathogens, including bacteria, viruses, parasites, and fungi, exploit MCSs to establish and maintain their replicative niches within host cells. By co-opting the host MCS machinery, these pathogens create specialized interfaces between their vacuoles, replication complexes, or cytosolic domains and host organelles, enabling nutrient acquisition, immune evasion, and spatial signaling. This review highlights how intracellular pathogens, such as Salmonella and others, subvert MCS architecture and function. Furthermore, emerging concepts and tools in the study of pathogenâMCS interactions are discussed, along with how these insights influence the development of host-directed therapies against infectious diseases.
http://dlvr.it/TPzbsZ
2 months ago
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Studying low-dose antibiotic effects on the gut microbiome
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Studying low-dose antibiotic effects on the gut microbiome
Antibiotics at sub-minimal inhibitory concentrations (sub-MICs), which are commonly present in food and the environment, can reach the human gut microbiome and silently disrupt the balance of microbes, contributing to the emergence and persistence of antimicrobial resistance (AMR). The gastrointestinal (GI) tract presents spatially heterogeneous antibiotic exposures, making it challenging to assess their full impact with conventional experimental approaches. Although in vitro and in vivo models provide some insight, they often lack physiological relevance or scalability. This highlights the need to reconsider the criteria used to determine âsafeâ upper concentration limits in food, as current standards may underestimate the risks of sub-MIC exposures. Therefore, better integrative modeling approaches are essential to uncover hidden drivers of resistance and guide effective interventions.
http://dlvr.it/TPv8k3
2 months ago
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Paradigms for microbiome analysis in infectious and non-communicable diseases
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Paradigms for microbiome analysis in infectious and non-communicable diseases
Next-generation sequencing and bioinformatics paved the way in deciphering the human gut microbiome and challenged fundamental postulates on the causal role of the microbiota for health and pathogenesis of infectious and noncommunicable diseases. To exploit the clinical relevance and potential of microbiome diagnostics and therapy, deep metagenomic sequencing with standardized, validated laboratory procedures, aiming at deciphering the microbiome at strain level and applying index-scores to allow classification of individual microbiomes as dysbiotic (associated with disease) or eubiotic (associated with health) should be implemented. By this means, metagenomically informed therapies with live biotherapeutic products, fecal microbiota transfer, pro-, pre-, or postbiotics might become a standard in personalized prevention and treatment of infectious and non-communicable diseases.
http://dlvr.it/TPt49S
2 months ago
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Powassan virus
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Powassan virus
Powassan virus (POWV) was first isolated in 1958 from a child with a fatal case of encephalitis in Powassan, Ontario, Canada. POWV is an enveloped Orthoflavivirus with a single-stranded, positive-sense RNA of 11kb. Its genome encodes a single polyprotein that is cleaved into three structural (Capsid, pre-Membrane, and Envelope) and seven nonstructural proteins (NS1, NS2a, NS2b, NS3, NS4a, NS4b, and NS5). Although not as well studied, extrapolations from closely related Orthoflaviviruses, including West Nile and dengue, have contributed to our understanding of POWV replication.
http://dlvr.it/TPpKwK
3 months ago
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Producing Trojans: hijacking of monocyte differentiation by pathogens
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Producing Trojans: hijacking of monocyte differentiation by pathogens
Pathogens can exploit the plasticity of host immune cells, such as the pathway of monocyte differentiation into macrophages and dendritic cells. This review discusses how microbial pathogens hijack the monocyte fate and reprogram macrophages to establish infection, evade immune surveillance, and persist within the host. Viruses such as HIV and cytomegalovirus (CMV) rewire host sentinel cells through modulation of transcriptional networks, cytokine signaling cascades, and autophagic pathways. Bacterial pathogens such as Mycobacterium tuberculosis, Salmonella enterica, or Bordetella pertussis create safe replication niches by disrupting monocyte differentiation. Fungal pathogens expand this repertoire by leveraging cytokine modulation and phenotypic reprogramming to subvert host innate and pathogen-specific immune responses. We highlight here the newly emerging molecular mechanisms of monocyte reprogramming towards pathogen survival and transmission.
http://dlvr.it/TPnZMb
3 months ago
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Alteromonas macleodii
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Alteromonas macleodii
The heterotrophic bacterium Alteromonas macleodii is a gram-negative, rod-shaped bacterium with a single flagellum. This aerobic species was originally described in 1972 after being isolated from the coastal waters of Hawaii, USA. Since then, it has been found throughout temperate and tropical oceans and can be free-living or attached to substrates, including other organisms. All A. macleodii strains are copiotrophs with diverse metabolic and sensory capabilities. Furthermore, A. macleodii is a common and persistent âweedâ in laboratory phytoplankton cultures and has been suggested as a model system for studying phytoplanktonâheterotroph interactions.
http://dlvr.it/TPlSDp
3 months ago
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From global to local: rethinking the design of probiotic intervention strategies
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From global to local: rethinking the design of probiotic intervention strategies
The human microbiome plays a crucial role in maintaining homeostasis and influencing disease development, yet its composition varies across geography, age, and lifestyle. These differences challenge the efficacy of universal probiotic treatments and call for more personalized or regionally adapted approaches. In this review we examine the limitations of universal probiotics, emphasizing the importance of considering hostâmicrobe co-adaptation, local dietary practices, and ecological context. We argue that probiotic design must account for microbial diversity, strain-level adaptation, and functional redundancy, and we explore how these factors affect colonization success and therapeutic potential. Finally, we discuss ways to re-center microbiome knowledge within diverse ecological, cultural, and epistemic traditions for a global, inclusive approach allowing for microbiome-targeted therapies that are both effective and accessible.
http://dlvr.it/TPdqB4
3 months ago
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Cellular and viral RNA polymerases: evolutionary insights into eukaryotic origins
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Cellular and viral RNA polymerases: evolutionary insights into eukaryotic origins
Nucleocytoplasmic large DNA viruses (NCLDVs) encode multi-subunit RNA polymerases (msRNAPs) that challenge conventional views of viral evolution. Phylogenetic and structural studies reveal that NCLDV RNAP catalytic cores share deep evolutionary roots with eukaryotic counterparts, implicating ancient gene transfers that shaped the last eukaryotic common ancestor (LECA), underscoring NCLDVsâ pivotal role in eukaryotic origins. NCLDV RNAP retains the fundamental architecture of cellular RNAPs while evolving and adapting for viral gene regulation. This review summarizes structural and functional divergences between viral and cellular RNAPs, synthesizes evidence for virus-driven RNAP evolution, and evaluates emerging hypotheses of viral eukaryogenesis. Viewing viruses as evolutionary collaborators offers new insights into RNAP adaptability and bridges virology, evolutionary biology, and synthetic biology across diverse biological contexts.
http://dlvr.it/TPdfhL
3 months ago
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Opportunities and challenges in applying microbiota to clinical cancer immunotherapy
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Opportunities and challenges in applying microbiota to clinical cancer immunotherapy
Fundamental research has elucidated the indispensable role of gut microbiota in modulating cancer immunotherapy efficacy. Despite promising preclinical findings, few related approaches have reached clinical trials. In this opinion, we provide insights based on current clinical trials using fecal microbiota transplant or specific bacterial strains as adjuvants to enhance immune checkpoint blockade therapy. We also systematically analyze the challenges in trial design, with a focus on donor selection, patient enrollment, implantation procedures, antibiotic use, safety assessment, and endpoint evaluation. Moving forward, we offer a comprehensive â4Dâ framework (diversity, diffusion, depth, and delicacy) for accelerating the bench-to-bedside translation. It is hoped that this opinion will help researchers and clinicians aiming to harness microbiome-based strategies to improve cancer immunotherapy outcomes.
http://dlvr.it/TPcgFh
3 months ago
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Collateral sensitivity and genetic vulnerability of antibiotic resistance
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Collateral sensitivity and genetic vulnerability of antibiotic resistance
Antibiotic combination therapy has a critical role in limiting emergent antibiotic resistance in bacterial pathogens. Collateral sensitivity (CS), resistance to one antibiotic that is inextricable from sensitivity to another antibiotic, presents an opportunity for combinations explicitly selecting against resistance. Complementing efforts to select against resistance, differential genetic vulnerability mapping unravels dependencies unique for resistant strains. In this review, we discuss the potential implications of CS and genetic vulnerability data for the design of bespoke antibiotic combinations, drug discovery, and tracking evolution of resistant strains.
http://dlvr.it/TPbKqR
3 months ago
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From feedbacks to functional teams in the rhizosphere
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From feedbacks to functional teams in the rhizosphere
Johnson and MarĂnâs paper presents functional team selection (FTS) as a major conceptual advance in plantâmicrobiome ecology. FTS explains how limiting resources and/or stress selects cooperative microbial teams that promote plant adaptation, integrating ecological feedback and evolutionary selection to predict when and where resilient plantâmicrobiome partnerships will arise.
http://dlvr.it/TPXPVj
3 months ago
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Friend or foe? Contextualizing Bacteroides through the lens of niche remodeling
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Friend or foe? Contextualizing Bacteroides through the lens of niche remodeling
The genus Bacteroides comprises canonical commensals of the gastrointestinal microbiota that maintain intestinal homeostasis and contribute to host health. Yet, emergent evidence has revealed that these same bacteria can also increase host susceptibility to infectious and noninfectious diseases, as well as directly drive intestinal inflammatory pathology. In this review we reconcile this duality with the paradigm that Bacteroidesâ pathogenic potential scales with the degree to which it remodels its intestinal niches. Understanding the molecular and ecological mechanisms underlying this niche remodeling is essential to defining when Bacteroides acts as friend or foe. This review highlights recent advances that illuminate these context-dependent behaviors and their implications for gut health and disease.
http://dlvr.it/TPWpZn
3 months ago
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Type I interferons in tuberculosis pathogenesis and prevention
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Type I interferons in tuberculosis pathogenesis and prevention
Mycobacterium tuberculosis (Mtb) remains an epidemiological concern due to heterogeneous outcomes in tuberculosis (TB) pathology and the lack of mechanistic understanding of early immune events. Type I interferons (IFNs) in TB are generally described as pathological. However, evidence also suggests a protective role in vaccination and adjunctive to chemotherapy. Understanding Type I IFN signaling in Mtbâhost interactions is therefore critical as it is among the earliest signatures of progressive infection. Crosstalk between Type I and II IFN signaling during TB may also be key to disease outcome. This review explores our current understanding of the role of Type I IFNs in Mtb infection and vaccination and offers the IFN type switching model, among others, to explain the duality of IFNs' function in TB.
http://dlvr.it/TPWhDK
3 months ago
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Engagement and justice considerations in mitigation of antimicrobial resistance
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Engagement and justice considerations in mitigation of antimicrobial resistance
We are delighted by the response by Dobreva et al. to our original article, and by the detail they provide about the methods used to try and ensure epistemic justice in the WHO antimicrobial resistance (AMR) research priority setting process [1]. That regardless of the efforts made, the process still led to over-representation from the global North, as the authors themselves concluded, is evidence of the complexity of ensuring epistemic justice in relation to AMR [2].
http://dlvr.it/TPVt7x
3 months ago
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Vibrio natriegens
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Vibrio natriegens
Vibrio natriegens is a Gram-negative, halophilic member of the Harveyi clade and Vibrio core group that inhabits marine and estuarine coastal waters and sediments. While generally considered nonpathogenic, this species shares this clade with serious human pathogens (e.g., Vibrio parahaemolyticus) and aquatic animal pathogens (e.g., Vibrio harveyi, Vibrio campbelllii, and Vibrio alginolyticus). Although it was discovered more than 65 years ago, most of our knowledge regarding this bacterium has been generated in the past decade.
http://dlvr.it/TPVlYS
3 months ago
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PilY proteins: bimodular drivers of type IV pilus versatility
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PilY proteins: bimodular drivers of type IV pilus versatility
Type IV pili (T4P) are dynamic surface fibers that mediate diverse bacterial activities, including adhesion, twitching motility, horizontal gene transfer, biofilm formation, and virulence. The PilY family of T4P-associated proteins are found across a wide range of bacterial species and are critical for key T4P functions. PilY proteins are characterized by a shared domain architecture which consists of a variable N-terminal region that mediates adhesion and a conserved C-terminal beta-propeller domain that facilitates pilus biogenesis. Given their surface exposure and roles in virulence, PilY family proteins represent an attractive target for novel therapeutic interventions, including small-molecule antivirulence therapies against pathogenic bacteria and potential as vaccine antigens. This review synthesizes our current understanding of PilY structure, localization, function, and evolutionary relationships across T4P systems.
http://dlvr.it/TPTw17
3 months ago
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Microbial rhythms â a new target to promote health?
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Microbial rhythms â a new target to promote health?
Daily dynamics in the composition and function of the human gut microbiota have been recognized since 2014, yet the molecular mechanisms underlying these rhythms and their impact on human health remain unclear. Disrupted microbial oscillations are increasingly linked to metabolic diseases such as obesity and type 2 diabetes, and to inflammatory conditions in the gut and beyond. We propose advancing from observational studies to experimentally targeting microbial rhythms and clocks to uncover causal relationships. In vivo and in vitro models offer opportunities to uncover how signaling cues and dietary patterns influence microbial oscillations and, in turn, host metabolic and immune functions. Manipulating microbial rhythmicity independent of host physiology represents a new frontier for microbiota-based strategies to promote health and prevent diseases.
http://dlvr.it/TPTmRM
3 months ago
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Advancing equity in antimicrobial resistance research and policy
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Advancing equity in antimicrobial resistance research and policy
The recent article 'Tracing epistemic injustice in global antimicrobial resistance research' reasons that injustices in setting global research priorities â that is, who produces and uses antimicrobial resistance (AMR) knowledge, and valuing certain types of knowledge â have created âblind spotsâ in research and policy on AMR [1]. Research and interventions relevant to low- and middle-income countries (LMICs) have been underprioritised, even though more than half of the 92 million people whose lives could be saved by 2050 through improved access to antibiotics and health care are in sub-Saharan Africa and South Asia [2].
http://dlvr.it/TPK8CS
3 months ago
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Localized glutamine leakage shapes root microbiome
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Localized glutamine leakage shapes root microbiome
Root exudates are vital for guiding microbial dynamics in the rhizosphere. Nevertheless, the key component in root exudates responsible for defining the root microbiome has remained obscure. Tsai et al. recently offered insights into how Casparian strips prevent glutamine leakage from the vasculature, thereby shaping the root microbiome.
http://dlvr.it/TPDdSK
4 months ago
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Mycorrhizal networks transfer jasmonic acid to recruit pathogen-suppressors
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Mycorrhizal networks transfer jasmonic acid to recruit pathogen-suppressors
Common mycorrhizal networks (CMNs) formed by arbuscular mycorrhizal fungi interconnect neighbouring plants. New evidence from Zhang et al. demonstrates that CMNs transfer jasmonic acid from necrotrophic pathogen-infected to uninfected tomato plants, priming defence responses and recruiting disease-suppressive bacteria. These findings establish a key mechanistic link underlying CMN-mediated plant defence communication.
http://dlvr.it/TPChZL
4 months ago
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The pig that could save us: swine models in respiratory infections
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The pig that could save us: swine models in respiratory infections
Respiratory infections kill millions and overwhelm the healthcare systems worldwide. Swine are powerful allies in this fight. They provide practical, human-like platforms to study pathogens, test vaccines/therapies, and strengthen pandemic readiness. Pig models, with the advent of genetic engineering tools, are closing translational gaps and revealing mechanisms that guide interventions effectively.
http://dlvr.it/TPCXZ6
4 months ago
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The hitchhikerâs guide to cross-species DNA delivery
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The hitchhikerâs guide to cross-species DNA delivery
Microbial hitchhikers are rewriting the rules of horizontal gene transfer. He, Patkowski, et al. reveal how phage satellites assemble chimeric infective particles that deliver DNA across species boundaries through âtail piracyâ. This discovery reframes microbial innovation and provides a blueprint for next-generation biotechnologies, achieving what phage engineering has long pursued.
http://dlvr.it/TP8l5z
4 months ago
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Toward a Yanomami framework for ethical microbiome research
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Toward a Yanomami framework for ethical microbiome research
This paper proposes an ethical framework for microbiome research with the Yanomami, an Indigenous Amazonian people, grounded in collaboration, reciprocity, and relational accountability. Key elements include dedicated funding for community-identified initiatives, sustained community-led ethical oversight, and meaningful benefit-sharing. This approach fosters trust and supports equitable, culturally aligned, and sustainable research collaboration.
http://dlvr.it/TP7vjt
4 months ago
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PurFect timing: revisiting purine metabolism for tuberculosis treatment
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PurFect timing: revisiting purine metabolism for tuberculosis treatment
Eradication of tuberculosis requires new drugs targeting novel pathways. Although purine metabolism represents an essential antitubercular target, concerns about host nucleobase rescue limited its exploration. New data demonstrate that nucleobase levels in human lung tissue are insufficient to confer rescue, renewing interest in this pathway for tuberculosis drug discovery.
http://dlvr.it/TP6wq5
4 months ago
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Tackling the active antibiotic-resistant bacteria in soils
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Tackling the active antibiotic-resistant bacteria in soils
Soils are critical reservoirs of antibiotic-resistance genes (ARGs) and antibiotic-resistant bacteria (ARB), serving as interfaces among human, animal, plant, and environmental microbiomes. While many studies have profiled soil ARGs, most rely on DNA-based methods that cannot distinguish total from metabolically active ARB, limiting risk assessment and mitigation. This review outlines soil ARG sources, their mobility, and potential transmission to plants and the food chain. We highlight advances in community- and single-cell-level approaches for characterizing active ARB and explore emerging mitigation strategies such as advanced waste treatment and bioremediation. This review aims to bridge the gap between ARG pollution and its risk mitigation, contributing to a comprehensive framework for tackling active ARB in soils.
http://dlvr.it/TP6lzG
4 months ago
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Methanobrevibacter smithii
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Methanobrevibacter smithii
Methanobrevibacter smithii is one of the most prevalent and worldwide distributed archaea in the human gut. M. smithii is a strict anaerobe that obtains its energy through methanogenesis. In culture, it reduces CO2 to methane (CH4) using H2 as electron donor (i.e., CO2-reducing hydrogenotrophic methanogenesis) and to a lower extent, formate. Other potential methanogenic substrates, methanol and ethanol, are not used in culture, but genes involved in their utilization are upregulated when colonizing the mouse intestine.
http://dlvr.it/TP0ZZk
4 months ago
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Argentine microbiology: between scientific legacy and systemic fragility
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Argentine microbiology: between scientific legacy and systemic fragility
Argentinaâs microbiology, born from 19th-century public health challenges, built enduring institutions and contributed globally to the fight against infectious diseases, to agriculture, and to biotechnology. Yet chronic underfunding, political instability, and policy discontinuity have undermined progress. Revitalization requires a sustained strategy that fosters investment and collaboration, transforming historical strengths into lasting scientific and societal development.
http://dlvr.it/TP0Qg6
4 months ago
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Revisiting the order Nitrospirales: phylogeny, habitat range, metabolism
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Revisiting the order Nitrospirales: phylogeny, habitat range, metabolism
Nitrification is a key process in the nitrogen cycle performed by several functional groups of chemolithoautotrophic microorganisms. The order Nitrospirales plays a central role in this process. Comprehensive genomic analysis conducted by Kop et al. revealed unexplored phylogenetic diversity, habitat range, and metabolic versatility within the order Nitrospirales.
http://dlvr.it/TNzYGF
4 months ago
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Cellulose biosynthesis and function in Streptomyces
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Cellulose biosynthesis and function in Streptomyces
Cellulose, a ubiquitous polysaccharide with critical roles in life, provides structural integrity to cells in plants and aids biofilm formation in many bacteria. Although bacterial cellulose biosynthesis is well studied in certain groups, its diversity in other lineages remains underexplored. Recent insights from filamentous streptomycetes reveal that cellulose is directly incorporated into the cell wall at growing tips, likely protecting hyphae during growth. This review examines cellulose biosynthesis, regulation, and secretion mechanisms in Streptomyces, and highlights how its structural organization supports distinct cellular functions. We also discuss the evolutionary context of this system. Together, these insights broaden our understanding of bacterial cellulose diversity and suggest that cellulose biosynthesis has evolved convergently to support different lifestyles, growth modes, and morphogenetic strategies.
http://dlvr.it/TNzN3V
4 months ago
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