Oleg Dmytrenko
@olehdmy.bsky.social
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Microbiologist, CRISPR imposter
Russia is a terrorist state!
7 months ago
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Preprint alert: Putative phages with dsRNA genomes. Intriguing what bacteria they may infect. Natureās diversity continues to astonish!
www.biorxiv.org/content/10.1...
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āParaxenoviridaeā, a putative family of ubiquitous marine bacteriophages with double-stranded RNA genomes
Fragmented and primer Ligated DsRNA Sequencing (FLDS) was used to reconstruct five complete, bisegmented RNA genomes of paraxenoviruses, a group of viruses that was previously identified in the ocean ...
https://www.biorxiv.org/content/10.1101/2025.02.27.640542v1.full.pdf+html
8 months ago
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reposted by
Oleg Dmytrenko
The Kyiv Independent
8 months ago
The Russian spelling and pronunciation of Kyiv throughout the ages was no accident. While the name gets its origin from an empire that predates Russia, a series of policies by the Russian Empire and the Soviet Union that sought to Russify Ukraine and the Ukrainian language distorted its roots.
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Kyiv, not Kiev ā How Ukrainians reclaimed their capital
For decades, if not more, English speakers the world over referred to Ukraineās capital as Kiev, pronouncing it kee-yev. Few people knew they were using the Russian name for the city. The city is pro...
https://kyivindependent.com/kyiv-not-kiev-how-ukrainians-reclaimed-their-capital-and-their-future/
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9 months ago
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Iām very fortunate to be at the 2025 CRISPR Meeting in Christchurch to share our latest work on the quirky Cas12a diversity. What an amazing crowd and location!
@crisprmeeting.bsky.social
9 months ago
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The diversity of microbial defenses is amazing! Type IV Thoeris system shows an ancient innate immunity mechanism which uses a TIR protein to make N7-cADPR, activating a caspase-like protease to block phages. Learn more:
www.science.org/doi/10.1126/...
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TIR signaling activates caspase-like immunity in bacteria
Caspase family proteases and Toll/interleukin-1 receptor (TIR)-domain proteins have central roles in innate immunity and regulated cell death in humans. We describe a bacterial immune system comprisin...
https://www.science.org/doi/10.1126/science.adu2262
9 months ago
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reposted by
Oleg Dmytrenko
Sorek Lab
9 months ago
Our paper out @Nature: CARD domains mediate anti-phage defense in bacterial gasdermin systems CARDs are essential for caspase recruitment during human inflammasome activation. We now find them in bacterial immune systems Congrats Tana Wein! Thank you Kranzusch lab!
www.nature.com/articles/s41...
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Das Ende einer Ćra: Heute fand die allerletzte Klasse in meinem geliebten Yogastudio statt, das mir in den letzten sechs Jahren ein Zufluchtsort war. Danke, Clau, fĆ¼r all die Posen und erholsamen Savasanas.
10 months ago
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This is just wild: using AI-driven structural predictions, this study discovered how a phage-encoded āCas12 hackerā hijacks the bacterial hostās thioredoxin enzyme to supercharge its DNA-cleaving ability.
www.biorxiv.org/content/10.1...
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AI-driven discovery of host thioredoxin as a CRISPR enhancer of phage-encoded miniature Cas12 hacker nuclease
The evolutionary arms race between bacteriophages and their bacterial hosts has driven the evolution of sophisticated adaptive immune systems, such as CRISPR-Cas, as a crucial defense mechanism. While...
https://www.biorxiv.org/content/10.1101/2025.01.20.633832v1
10 months ago
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An excellent review on direct Nanopore sequencing of RNA for detecting epigenetic modifications. We are clearly just at the beginning of this journey, with many exciting discoveries to come.
www.sciencedirect.com/science/arti...
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Charting the epitranscriptomic landscape across RNA biotypes using native RNA nanopore sequencing
RNA modifications are conserved chemical features found in all domains of life and across diverse RNA biotypes, shaping gene expression profiles and eā¦
https://www.sciencedirect.com/science/article/pii/S1097276524010098?dgcid=author
10 months ago
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reposted by
Oleg Dmytrenko
Institut Pasteur | 130 years of biomedical research
10 months ago
š§¬ Save the date! The EMBO Workshop "The Immune System of Bacteria" will uncover groundbreaking insights into bacterial defense systems. Join us April 8-10, 2025, at Institut Pasteur, Paris. Submit your abstracts by Feb. 28 š
https://www.sisb2025.conferences-pasteur.org/home
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An excellent review on nucleic acid recognition in microbial immunity!
www.cell.com/molecular-ce...
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Nucleic acid recognition during prokaryotic immunity
Prokaryotes sense viral and plasmid nucleic acids to start defense pathways against these invaders. This review examines the different mechanisms of DNA and RNA recognition and how these distinguish s...
https://www.cell.com/molecular-cell/fulltext/S1097-2765(24)01002-5
10 months ago
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reposted by
Oleg Dmytrenko
Aude Bernheim
11 months ago
Registration now open for the EMBO Workshop: Immune System of Bacteria !!!!
www.sisb2025.conferences-pasteur.org/home
Joins us in Institut Pasteur, Paris, April 8-10th.
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Happy š¦ day, everyone!
12 months ago
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šÆļø
12 months ago
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