Sebastian Glatt
@sebastianglatt.bsky.social
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📥 286
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reposted by
Sebastian Glatt
Matt McFarland
24 days ago
Delighted that this is now out in its final form! 🥳 It's a fun story about an EF hand that doesn't bind Ca2+, but instead works as a ubiquitin-binding domain. Huge thanks to the rest of YK lab, the
@mrcppu.bsky.social
, and our collaborators (
@sebastianglatt.bsky.social
)!
add a skeleton here at some point
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Sebastian Glatt
Oleg Dmytrenko
6 months ago
Our paper is out! Hiding in plain sight among Cas12a nucleases, Cas12a3 cleaves not its RNA target but the 3′ ends of tRNA. Huge thanks to all who made this possible, especially the Beisel lab, Biao & Dirk for the structure, &
@sebastianglatt.bsky.social
for all things tRNA.
doi.org/10.1038/s415...
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RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity - Nature
Cas12a3 nucleases constitute a distinct clade of type V CRISPR–Cas bacterial immune systems that preferentially cleave the 3′ tails of tRNAs after recognition of target RNA to induce growth arres...
https://www.nature.com/articles/s41586-025-09852-9
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Sebastian Glatt
Svetlana Dodonova
8 months ago
Lab’s first paper is out!! We show the first structures of
#Asgard
#chromatin
by
#cryo-EM
🧬❄️ Asgard histones form closed and open hypernucleosomes. Closed are conserved across
#Archaea
, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here:
www.cell.com/molecular-ce...
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reposted by
Sebastian Glatt
Alicia Michael
9 months ago
We're hosting the 8th Austrian CryoEM symposium at ISTA Nov 11-12
@istaresearch.bsky.social
this year - you don't want to miss! We have a fantastic lineup of invited speakers + selected talks from abstracts
#cryoEM
Deadline for abstracts Oct 15 Final deadline Oct 31
cryoem-symposium.pages.ist.ac.at
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8th Austrian Cryo-EM Symposium
https://cryoem-symposium.pages.ist.ac.at/
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I'm excited to share that our latest review, “Mapping rRNA, tRNA, and mRNA Modifications in Ribosomes at High Resolution”, has just been published in
@cp-trendsbiochem.bsky.social
! Read the full review here 👉
www.sciencedirect.com/science/arti...
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Mapping rRNA, tRNA, and mRNA modifications in ribosomes at high resolution
Chemical modifications of rRNA, tRNA, and mRNA play key roles in protein synthesis by affecting the structure of these RNAs, by modulating decoding, a…
https://www.sciencedirect.com/science/article/pii/S0968000425001963
9 months ago
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Happy to share our latest review on PUS enzymes, which just got published in RNA Biology. Please have a look, if you want to know more about the enzymes that introduce Pseudouridine in RNA molecules.
www.tandfonline.com/doi/full/10....
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Mechanistic insight into the pseudouridylation of RNA
Pseudouridylation (Ψ) is a highly abundant and conserved RNA modification that is present in all three domains of life. The incorporation of Ψ can affect the stability of RNAs, modulate their inter...
https://www.tandfonline.com/doi/full/10.1080/15476286.2025.2541421
11 months ago
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We are excited to share our latest research on Q-modification in precursor-tRNAs, which just got published in
@natcomms.nature.com
. This was a very exciting and fruitful collaboration with
@francescatuorto.bsky.social
in Heidelberg.
www.nature.com/articles/s41...
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Queuosine is incorporated into precursor tRNA before splicing - Nature Communications
tRNA modifications are essential for function, yet their timing relative to processing is unclear. Here, the authors show that queuosine and derivative modifications occur before splicing of pre-tRNA^...
https://www.nature.com/articles/s41467-025-62220-z
11 months ago
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Sebastian Glatt
Jack Bravo
11 months ago
Thrilled to announce the nexy Austrian Cryo-EM Symposium, taking place 11th-12th November at
@istaresearch.bsky.social
, with speakers inc.
@grigoriefflab.bsky.social
,
@oliveiramann.bsky.social
,
@bjgreber.bsky.social
@svenklumpe.bsky.social
@sebastianglatt.bsky.social
‪‬https://tinyurl.com/cryo2025
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Austrian Cryo-EM Symposium
https://cryoem-symposium.pages.ist.ac.at/
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Dear all, We are starting an exciting new project in close collaboration with Clément Carré in Paris, France. A fully funded PhD position is available in my group at the vetmeduni Vienna! Please help us spreading the word - please forward it to interested students.
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https://www.vetmeduni.ac.at/fileadmin/v/z/mitteilungsblatt/stellen/2024_2025/20250730_0061_EN_Univ._Ass._Prae-Doc.pdf
11 months ago
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reposted by
Sebastian Glatt
The EMBO Journal
about 1 year ago
On the cover of issue 13:
@sebastianglatt.bsky.social
et al Highlights: circadian clock protein dynamics; inflammatory gut-kidney crosstalk Resource: EBV-host chromatin interactome Structural insights into mitochondrial translocation of folded Rieske protein ...
www.embopress.org/toc/14602075...
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reposted by
Sebastian Glatt
IMBB AMU Poznań
about 1 year ago
2nd Polish
#RNA
Biology Meeting in
#Poznan
co-organized by
@uam-ibmib.bsky.social
‬ has started yeaterday evening with talks of Ramesh Pillai & Sebastian Glatt
@sebastianglatt.bsky.social
‬ - many more great talks, posters & discussions ahead!
#PolishRNABiologyMeeting
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reposted by
Sebastian Glatt
EMBO
about 1 year ago
“EMBO is really a super-active community,” says Sebastian Glatt
@sebastianglatt.bsky.social
, EMBO Member, former EMBO Installation Grantee and Professor at the University of Veterinary Medicine Vienna
#Austria
. Read more here:
www.embo.org/people/the-b...
đź§Ş
#LifeSciences
#research
#opportunities
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The benefits of an unusual career path – People – EMBO
Meet Sebastian Glatt, Professor of Systems Genetics at the University of Veterinary Medicine in Vienna | EMBO Member and former EMBO Installation Grantee
https://www.embo.org/people/the-benefits-of-an-unusual-career-path/
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We are very excited about our latest work, which just came out
@embojournal.org
–
www.embopress.org/doi/full/10....
. The work @MCB_UJ was driven by Anna Biela and Ting-Yu Lin ćž—äşĺ¦¤ in collaboration with
@jmbujnicki.bsky.social
…a short🧵
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Determining the effects of pseudouridine incorporation on human tRNAs | The EMBO Journal
imageimagetRNAs harbour a complex set of modifications which are important for their function. Here, single particle cryo-EM, biophysics, and computational analyses of the effects of pseudouridine inc...
https://www.embopress.org/doi/full/10.1038/s44318-025-00443-y
about 1 year ago
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reposted by
Sebastian Glatt
The EMBO Journal
about 1 year ago
tRNAs are small and sport heterogeneous base modifications – yet
@sebastianglatt.bsky.social
@jmbujnicki.bsky.social
Ting-Yu Lin ćž—äşĺ¦¤ et al show
#cryoEM
combined with biophysical & computational approaches can give insights into how
#pseudouridine
affects human tRNA!
www.embopress.org/doi/full/10....
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reposted by
Sebastian Glatt
IMBB AMU Poznań
about 1 year ago
All Eurpean RNA Researchers: join us at the 2nd Polish RNA Biology Meeting
@uam-ibmib.bsky.social
,June 24-27 Poznan! Keynote speakers include Elena Conti, Andrzej Dziembowski
@sebastianglatt.bsky.social
, Reinhard Lührmann, Kai Papenfort, Ramesh Pillai & Bertrand Séraphin!
#RNA
2ndrna.web.amu.edu.pl
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Sebastian Glatt
Andreas Stadler
over 1 year ago
Austria 🇦🇹congratulates
@sebastianglatt.bsky.social
who receives the 🇵🇱 FNP Prize 2024 in Life and Earth Sciences – also known as the "Polish Nobel Prize". His findings open new pathways for research into genetic disorders and potential therapeutic developments.🔬
#FoundationForPolishScience
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