How can we study the function of nucleotide-based #SecondMessengers? @oliveiramann.bsky.social presented her group's exciting findings in this field at #Biochemistry2026. She e.g. presented the #cryoEM structure of OAS2, which has key #antiviral functions. linkinghub.elsevier.com/retrieve/pii...

"Nucleotidyltransferases and nucleotide-based second messengers" Carina Baer de Oliveira Mann (@oliveiramann.bsky.social) gave an insightful talk on this topic at #Biochemistry2026. febs.onlinelibrary.wiley.com/doi/full/10.... #Biochemistry #SecondMessenger #CyclicNucleotide CC: @gdch.de

We are very excited to be hosting #Biochemistry2026 in Würzburg in the coming 3 days. We have a great program of speakers waiting for you! If you are on the way to Würzburg, share your excitement with #Biochemistry2026! (1/3) www.gdch.de/biochemistry... #ChemSky #ChemBio #Biochemistry @gdch.de

You are interested in immunology and how nucleic acid structures contribute to their function and how this impacts disease development - Rayk Behrendt and myself have open PhD positions for a joint PhD program between Bonn and Osaka.

It’s out! Using cryo-ET in Dicty cells, we take a fresh in situ look at vaults. Surprisingly, we uncover vaults associated with ER and NE membranes, and find that many vaults enclose ribosomes in defined orientations, opening new avenues to their cellular function! www.biorxiv.org/lookup/conte...

Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.

The mechanistic basis of cargo selection during Golgi maturation. From Rebecca Taylor, @katciazynska.bsky.social, @jggkaufman.bsky.social & @grigorytagiltsev.bsky.social at @mpibiochem.bsky.social with David Owen and Sean Munro's group @cellbiol-mrclmb.bsky.social | www.science.org/doi/10.1126/...

Kicking off the 2nd Symposium on the Immunobiology of Pattern Recognition Receptors organized by our department in Lausanne! @brozlab.bsky.social @martinon.bsky.social @rebsamenlab.bsky.social @fbm-unil.bsky.social

We're hosting the 8th Austrian CryoEM symposium at ISTA Nov 11-12 @istaresearch.bsky.social this year - you don't want to miss! We have a fantastic lineup of invited speakers + selected talks from abstracts #cryoEM Deadline for abstracts Oct 15 Final deadline Oct 31 cryoem-symposium.pages.ist.ac.at

🚀 Check out our new preprint on extending the scope of single-particle cryo-EM with 2D template matching! Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching is now available on bioRxiv! www.biorxiv.org/content/10.1...

Myeloperoxidase transforms chromatin into neutrophil extracellular traps @nature.com @intein.bsky.social @mpiib-berlin.mpg.de www.nature.com/articles/s41...

What is cell death? Honored to participate in this article where the question was posed to a dozen experts. Thanks to the fantastic team at Nature Structural & Molecular Biology for organizing this discussion. rdcu.be/eG1Nm

📢 New preprint alert! We designed synthetic proteins that can block bacterial immune systems, allowing phages + plasmids to overcome natural defenses. This could transform phage therapy + genetic engineering. Here’s what we found 🧵 Preprint🔗: www.biorxiv.org/content/10.1...

Laser flash melting cryo-EM samples to overcome preferred orientation pubmed.ncbi.nlm.nih.gov/40877464/ #cryoem

Feeling recharged after our lab retreat in Obergurgl 🌞⛰️ Great hikes, perfect weather, motivating talks from @oliveiramann.bsky.social, Liudmila Andreeva and lots of inspiring discussions. Big thanks for the warm hospitality!

Thrilled to announce the nexy Austrian Cryo-EM Symposium, taking place 11th-12th November at @istaresearch.bsky.social, with speakers inc. @grigoriefflab.bsky.social, @oliveiramann.bsky.social, @bjgreber.bsky.social @svenklumpe.bsky.social @sebastianglatt.bsky.social ‪‬https://tinyurl.com/cryo2025

I am very excited to share the second paper of my PhD published in @cp-cell.bsky.social. Many thanks to all co-authors, especially from Thomas Carell's group, and my supervisor @v-hornung.bsky.social for their great support and collaboration! www.cell.com/cell/fulltex...

Proud to present a cover inspired by the structural and functional analysis of OAS2 by @oliveiramann.bsky.social, @indrabekere.bsky.social, and Veronika Merold, live at @cp-molcell.bsky.social. Big news on RNA sensing and antiviral defenses! #sciart ⌬ #research ⌬ #chemistry ⌬ #immunology

Excited to share our latest update on @cp-cell.bsky.social! We introduce VICAR (VIral-induced Centromeric DNA Amplification and Recognition) : a newly identified nuclear cGAS defense system to detect viruses. www.cell.com/cell/abstrac...

Our manuscript on dsRNA sensor OAS2 from the lab of @oliveiramann.bsky.social is now out in @cp-molcell.bsky.social ! Thanks again to the whole team for their effort putting this story together!

Wow, so cool!🌟 Excellence in Nucleic Acid Sciences and Technologies: NUCLEATE Cluster selected for national recognition Led by spokesperson Veit Hornung, the NUCLEATE Cluster secures funding in Germany’s Excellence Strategy 🥂🥳🤩 www.lmu.de/en/newsroom/... @v-hornung.bsky.social

Together with the Roers Lab from @uniheidelberg.bsky.social and @bms-us.bsky.social we propose that controlled low level systemic activation of #cGAS by endogenous nucleic acids is a safe and effective way to boost #cancer #immunotherapy. aacrjournals.org/cancerres/ar...

Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6

Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/... @wehi-research.bsky.social @komanderlab.bsky.social

Meet Carina Baer de Oliveira Mann, our newly appointed professor of #Biomolecular Cryo-Electron Microscopy, in the latest NewIn episode. She aims to identify #molecularswitches in the human #immunesystem that activate the immune defenses: go.tum.de/157504 @oliveiramann.bsky.social 🎥ProLehre

Structural Basis for OAS2 Regulation and its Antiviral Function https://www.biorxiv.org/content/10.1101/2025.01.28.635220v1

🎉Super excited to share our story on how the substrate receptor FBXO31 functions as a quality control factor by recognizing amides. This has been an amazing collaboration between Bode lab and @jcornlab.bsky.social. Special shutout goes to @matthiasmuhar.bsky.social www.nature.com/articles/s41...

Confirmed speakers: A. Ablasser L. Andreeva @audeber.bsky.social @jelenalab.bsky.social V. Dixit @v-hornung.bsky.social B. Lemaitre O. Majer @manellab.bsky.social E. Miao @oliveiramann.bsky.social M. Pasparakis @inflammasomelab.bsky.social @sparrerlab.bsky.social R. Vance @lozanzi.bsky.social

Happy to share the first preprint from my lab by @indrabekere.bsky.social and Veronika Merold! We solved the cryo-EM structure of the RNA immune sensor OAS2 and revealed how dimerization and subcellular localization regulate its activity! Check out Indra’s thread for a summary:

We have an exciting opportunity for a new independent group leader with an interest in structural/molecular biology and machine learning to join our Division of Structural Studies at the @mrclmb.bsky.social! 🥳 Re-posts appreciated. www.nature.com/naturecareer...

Try out our integration of the amazing protein structure search tool #Foldseek on #SubtiWiki (subtiwiki.uni-goettingen.de/foldseek)! Just upload a structure or use PDB/AlphaFoldDB entries to find similar structures. #IMPRS-GS #UniGoettingen #alphafold #bacillus #subtilis