📣 Applications are open for work experience 🧪🔬 Aimed at local Y12 students from underrepresented backgrounds interested in science 🗓️ 27/07 – 31/07 Eligibility and selection criteria apply Applications by 01/03 More info: mrclmb.ac.uk/careers-and-... #STEM #WorkExperience #BiologyCareers

As cryoEM becomes automated people forget Just Because (JB) it's picked Doesn't Mean (DM) it's a ptcl JB it's measured DM it's the CTF JB it's a class ave DM it looks like the ptcls JB it comes out of ab initio DM its the structure JB FSC=0.143 DM that's the res'n JB it's modeled DM it fits the map

This said, I felt it critical to note that many U.S. scientists are deeply unsettled by recent events and acting on this on a daily basis –

Join our division of Structural Studies at @mrclmb.bsky.social in the wonderful group of @suyangzhang.bsky.social!

Who first finds the picture that looks like a reenactment of the Last Supper? 🤔

This is bad by @theguardian.com: they could have a close look at themselves and instead of writing sensationalist click-bait pieces ("bombshell"), they could choose to help educating people about how science works: you change opinion when new evidence emerges. www.theguardian.com/environment/...

Oh wow: Cryo-EM structure of #TAF15 filaments from postmortem #FTLD brains by the group of Ben Ryskeldi-Falcon at the @mrclmb.bsky.social. What an amazing tour-de-force!! 🤯 www.biorxiv.org/content/10.6...

Looking to start your lab in generative biology / AI? Come join us at the @sangerinstitute.bsky.social Sanger is core-funded so you can generate data at scale to train the next generation of models and understanding. Design/Engineering/Chemistry/Proteins/Pathways! pls RT tinyurl.com/GenGenFaculty

A DVT after my trip to Berkeley early Oct wasn't great for the rest of the year, but happy to be back on the bike now. Still clocked 2.8 Mm in ~3 hrs/wk and with 25km height in 2025. Grateful to close the MTB year with my 76yo dad this afternoon. Looking forward to 2026! 🚴🚴🚴

If Martin Kettle would have read the great book Humankind by @rutgerbregman.com, this story would not have come as a surprise. Anyway, it is good he realises that journalists, including himself, are partially to blame for our skewed understanding of society. www.theguardian.com/commentisfre...

I much enjoyed reading this optimistic collection of data on how we deal with the climate crisis by data scientist @hannahritchie.bsky.social Get off social media and treat yourself to some positivity. 🤗

CryoEM folks, If you want to handle huge STAR file efficiently in Python, please try starfile-rs! github.com/hanjinliu/star… Reading a motion data of a particle from a 15 MB file is just like this ↓🤩

If 2025 feels overwhelming, I can highly recommend reading this insightful book by @rutgerbregman.com over the holidays. A radical view on humanity: most of us are pretty decent! 🤩

We have an opening for a research support officer. Come and join us! Please share.

Excellent opportunity for a #postdoc to join Michel Goedert’s group, investigating the mechanisms which cause the formation of amyloid filaments in neurodegenerative diseases, in collaboration with @sjorsscheres.bsky.social’s group. More details: www.nature.com/naturecareer... Closes 04 JAN

Fantastic news! Core funded institutes are often a highly efficient way of doing impactful science. Good to speak with one voice. 🥳

Postdoc opportunity with Michel Goedert and myself to work on #cryoEM/#cryoET structures of #amyloids. Feel free to email me with any questions you might have. mrc.tal.net/vx/mobile-0/...

Star student & postdoc Kiarash Jamali is setting up his own group at the Ellison institute in Oxford. Join him for the most exciting machine learning research in structural biology and beyond!! 🤩 #ProudPI

It seems many AI researchers live in a perpetual rush to submit their work to the next conference, on a 3-month cycle. When do they think or explore the unknown? Impactful work often takes years. www.theguardian.com/technology/2...

No lore for me. I thought I wanted to become a vet. In The Netherlands places to its only oversubscribed vet school were assigned in a lottery. Didn't get in and went to do chemistry instead. Had a lot of fun there and never looked back. 🤪

The role of @ebi.embl.org in the deployment of AI in biology has been and will continue to be essential. They do biological data like no one else in the world.

The LMB is deeply saddened to share that Martin Kyte, Senior Design Engineer in the Electronics Workshop, died suddenly on 3rd November 2025. A popular and trusted member of the LMB for over 30 years, Martin will be sorely missed. www2.mrc-lmb.cam.ac.uk/martin-kyte-... #LMBNews

I am delighted to share that our new manuscript is published as an online Pre-proof at the Journal of Biological Chemistry!! 🎉 www.jbc.org/article/S002...

Oh wow, this is 🤯 amazing: ~3-fold acceleration of running #relion on A100 GPUs for realistic single-particle refinement by the group of Guangwen Yang at @tsinghuauniversity.bsky.social . What a fantastic example of #OpenSoftwareAcceleratesScience, literally! 😍 dl.acm.org/doi/full/10....

I wonder how extremely busy people ever get any work done.

Want to join the LMB as a PhD student in October 2026? You’ve got two weeks left to apply! Visit our website for more details: www2.mrc-lmb.cam.ac.uk/students/int... Applications close on 2nd December 2025.

This study claims in vitro seeded assembly in brain homogenate is more disease-relevant than fibril extraction, without providing any evidence thereof. It also ignores ample data that in vitro seeding with aSyn may NOT template the structure of seeds. 😕 www.sciencedirect.com/science/arti...

Excellent #postdoc opportunity available in @sjorsscheres.bsky.social’ group, working on new image processing algorithms for #cryoEM structure determination in their #RELION open-source software. www.nature.com/naturecareer... Apply by 25 NOV #PostdocJobs #ScienceJobs

Very happy that NWO supports this major upgrade of our national EM infrastructure. It is great that this initiative got broad support all over NL, and it will EMPower fantastic science - looking forward to that! www.uu.nl/en/news/33-m...

At some point, Doppio will replace relion's gui. Already you can do more in Doppio than in relion! 🤩

Doppio is a great tool (more of a toolbelt actually) to go all the way from micrographs to deposition!! (and the more people using it, the greater it gets)

🥳🥳🥳

Max is a fantastic scientist!! 🤩

We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated. mrc.tal.net/vx/appcentre...

Our amazing Sofia did it again! She previously won the Perutz Prize for best PhD thesis at the LMB; this year she has won the Joan Steitz Prize for best postdoctoral work. She is on the job market for an independent position. Any institute would be lucky to have her. 🥳

We are looking to hire a postdoc to take this and other TDP-43 assay development forward! Please re-post!

We are excited to share our latest work on GLIC published in @pnas.org, where we developed a #cryoEM data processing strategy that allowed us to isolate and reconstruct multiple asymmetric states, revealing detailed insights into the channel’s activation mechanism. tinyurl.com/mwtb4rpj

Chris Russo and Anastasiia Gusach have developed a new method to prepare #cryoEM samples that avoids protein damage during freezing Read more: www2.mrc-lmb.cam.ac.uk/a-new-method... #LMBResearch

What do apple trees, Nobel Prizes, cows, and world-changing innovation all have in common? Well, they're all part of a new animated journey across one of Europe’s most extraordinary places, the Cambridge Biomedical Campus. youtu.be/2K7Txdwb_k4

You might like our lego @johninnescentre.bsky.social

I’m pleased to announce that my Lego lab will officially be moving to this building should it be funded

I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗 beta.ideas.lego.com/product-idea...

the GNE headcrab went for its latest victim today, a wild @sjorsscheres.bsky.social… Thankfully @przemekdut.bsky.social was there to save the day!

John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died. Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology. More: www2.mrc-lmb.cam.ac.uk/john-gurdon-... #LMBNews

Below (by @landerlab.bsky.social) is the 2nd #cryosparc recipe on @biorxivpreprint.bsky.social in a month. I remain worried about closed-source software affecting progress in #cryoEM. We should develop new algorithms instead! #OpenSoftwareAcceleratesScience www.biorxiv.org/content/10.1...

184 years earlier than predicted, London has met the legal limits for toxic NO2 for the first time. This historic milestone proves that bold action like expanding ULEZ works, protecting children’s health and giving millions cleaner air to breathe.

Finally someone speaking up! "Targeting refugees will do nothing to tackle [the UK's] structural issues or improve people’s lives". If you agree, why not send a signal and donate to Refugee Action today (donate.refugee-action.org.uk/page/99385/d...)? www.theguardian.com/politics/202...

We have an open post-doc position in my group to study mRNA cleavage and polyadenylation using biochemical reconstitution and cryoEM. Please get in touch if you are interested in joining this amazing team! 🔬🧬🤩 #RNA #cryoEM

Initial attempt at replicating in relion (parameters in next post). This is for Aca2-RNA, using a 100k subset of the 2D-classified particles (no prior 3D cleanup). A 1-class ab initio in relion, then local refinement in relion (1.8deg searches+blush) gives a nominally 3.3Å map; 3.5 Å w/out blush.

I can raise the issue to higher ups!