Vinith Kishore et al.: ICECREAM: high-fidelity equivariant cryo-electron tomography ##CryogenicElectronTomography##SelfSupervisedLearning##MachineLearning@insadelyon...##IUCrhttps://journals.iucr.org/paper?S2059798326001622

Proud to share the yeast telomerase structure, led by the talented @hongmiaohu.bsky.social in collaboration with the Wellinger and Chartrand labs. Discovered 37 years ago and took us nearly 7 years but totally worth the wait 😍. www.science.org/doi/10.1126/... www.youtube.com/watch?v=gFE4...

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“Compared with non-active travelers, the cyclists had a 19% lower risk of all-cause dementia, a 22% lower risk of Alzheimer's, a 40% lower risk of young-onset dementia (before the age of 65), and a 17% lower risk of late-onset dementia.” Getting around a bike more often could reduce dementia risk.

#TeamTomo if you want to use CTF-corrected 3D subtomos from AreTomo3 in RELION v.5.1 you can use this updated script: github.com/Phaips/aretomo3torelion5

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We're excited to announce the beta-release of #RELION-5.1! 🥳 This release has important updates on our #amyloid processing pipeline, as described in this preprint: doi.org/10.64898/202... There are also some tweaks for #teamtomo. #OpenSoftwareAcceleratesScience

#OpenSoftwareAcceleratesScience! 😍

Only a few days left for the below exciting opportunity at @mrclmb.bsky.social. Happy writing to the potential candidates! 🤗

We report the Pick fold and 2 variants thereof for tau filaments from individuals with MAPT mutations encoding for D252V, G272V, S320F and Delta_G389-I39, and we use these to reconstitute the Pick fold with recombinant tau in vitro. By @qcxy8886.bsky.social. 🥳 www.biorxiv.org/content/10.6...

PDB Reaches a New Milestone: more than 250,000 entries

Spring is in the air!

Because a booking with my local taxi company went wrong, yesterday night I had to take an Uber home. Cost to me £133; driver received £60 and had to pay £8 for the parking. #UsTechValueExtraction My suggestion: force all ride & taxi services to publish how much they pay the driver.

We are excited to be recruiting a new tenure track group leader in the Structural Studies Division at MRC LMB! It is an amazing place to start your own lab. @mrclmb.bsky.social Please get in touch if you have any questions. www.nature.com/naturecareer...

February Map of the Month: Aca2–RNA We reprocessed EMPIAR-11918 and achieved 2.76 Å in 50.5 compute hours. Sub-3 Å at ~40 kDa is a strong example of what modern cryo-EM workflows (and RELION with Blush) can deliver for small targets. 📧 [email protected] #CryoEM #CryoCloud

Are you a structural biologist pushing the boundaries of molecular science with an ambitious research programme? Join our Structural Studies Division as a tenure-track Group Leader, with core funding, world-leading facilities & enthusiastic colleagues. Apply by 16 MAR www.nature.com/naturecareer...

Since last year, I've been making a RELION GUI that supports viewing, navigating and running jobs in a way completely compatible with the original RELION pipeline. Now it's working nicely for both SPA and tomography! Please try it out - github.com/hanjinliu/hi...

The amyloid packing difference (APD) is a new metric to compare amyloid structures. Analysis of disease-specific structures provides context for the interpretation of APDs for new comparisons. I hope it will be useful! 🤗 www.biorxiv.org/content/10.6...

Congrats @olibclarke.bsky.social and co-authors! Happy to see this is out now. 🥳

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳 mrc.tal.net/vx/mobile-0/...

#BecomeRELION! 😜

How did life arise from simple chemical building blocks? New #LMBResearch led by @edogia.bsky.social in @philholliger.bsky.social group has identified a small self-replicating ribozyme that could be the answer. Read more: mrclmb.ac.uk/news-events/...

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📣 Applications are open for work experience 🧪🔬 Aimed at local Y12 students from underrepresented backgrounds interested in science 🗓️ 27/07 – 31/07 Eligibility and selection criteria apply Applications by 01/03 More info: mrclmb.ac.uk/careers-and-... #STEM #WorkExperience #BiologyCareers

As cryoEM becomes automated people forget Just Because (JB) it's picked Doesn't Mean (DM) it's a ptcl JB it's measured DM it's the CTF JB it's a class ave DM it looks like the ptcls JB it comes out of ab initio DM its the structure JB FSC=0.143 DM that's the res'n JB it's modeled DM it fits the map

This said, I felt it critical to note that many U.S. scientists are deeply unsettled by recent events and acting on this on a daily basis –

Join our division of Structural Studies at @mrclmb.bsky.social in the wonderful group of @suyangzhang.bsky.social!

Who first finds the picture that looks like a reenactment of the Last Supper? 🤔

This is bad by @theguardian.com: they could have a close look at themselves and instead of writing sensationalist click-bait pieces ("bombshell"), they could choose to help educating people about how science works: you change opinion when new evidence emerges. www.theguardian.com/environment/...

Oh wow: Cryo-EM structure of #TAF15 filaments from postmortem #FTLD brains by the group of Ben Ryskeldi-Falcon at the @mrclmb.bsky.social. What an amazing tour-de-force!! 🤯 www.biorxiv.org/content/10.6...

Looking to start your lab in generative biology / AI? Come join us at the @sangerinstitute.bsky.social Sanger is core-funded so you can generate data at scale to train the next generation of models and understanding. Design/Engineering/Chemistry/Proteins/Pathways! pls RT tinyurl.com/GenGenFaculty

A DVT after my trip to Berkeley early Oct wasn't great for the rest of the year, but happy to be back on the bike now. Still clocked 2.8 Mm in ~3 hrs/wk and with 25km height in 2025. Grateful to close the MTB year with my 76yo dad this afternoon. Looking forward to 2026! 🚴🚴🚴

If Martin Kettle would have read the great book Humankind by @rutgerbregman.com, this story would not have come as a surprise. Anyway, it is good he realises that journalists, including himself, are partially to blame for our skewed understanding of society. www.theguardian.com/commentisfre...

I much enjoyed reading this optimistic collection of data on how we deal with the climate crisis by data scientist @hannahritchie.bsky.social Get off social media and treat yourself to some positivity. 🤗

CryoEM folks, If you want to handle huge STAR file efficiently in Python, please try starfile-rs! github.com/hanjinliu/star… Reading a motion data of a particle from a 15 MB file is just like this ↓🤩

If 2025 feels overwhelming, I can highly recommend reading this insightful book by @rutgerbregman.com over the holidays. A radical view on humanity: most of us are pretty decent! 🤩

We have an opening for a research support officer. Come and join us! Please share.

Excellent opportunity for a #postdoc to join Michel Goedert’s group, investigating the mechanisms which cause the formation of amyloid filaments in neurodegenerative diseases, in collaboration with @sjorsscheres.bsky.social’s group. More details: www.nature.com/naturecareer... Closes 04 JAN

Fantastic news! Core funded institutes are often a highly efficient way of doing impactful science. Good to speak with one voice. 🥳

Postdoc opportunity with Michel Goedert and myself to work on #cryoEM/#cryoET structures of #amyloids. Feel free to email me with any questions you might have. mrc.tal.net/vx/mobile-0/...

Star student & postdoc Kiarash Jamali is setting up his own group at the Ellison institute in Oxford. Join him for the most exciting machine learning research in structural biology and beyond!! 🤩 #ProudPI

It seems many AI researchers live in a perpetual rush to submit their work to the next conference, on a 3-month cycle. When do they think or explore the unknown? Impactful work often takes years. www.theguardian.com/technology/2...

No lore for me. I thought I wanted to become a vet. In The Netherlands places to its only oversubscribed vet school were assigned in a lottery. Didn't get in and went to do chemistry instead. Had a lot of fun there and never looked back. 🤪

The role of @ebi.embl.org in the deployment of AI in biology has been and will continue to be essential. They do biological data like no one else in the world.

The LMB is deeply saddened to share that Martin Kyte, Senior Design Engineer in the Electronics Workshop, died suddenly on 3rd November 2025. A popular and trusted member of the LMB for over 30 years, Martin will be sorely missed. www2.mrc-lmb.cam.ac.uk/martin-kyte-... #LMBNews

I am delighted to share that our new manuscript is published as an online Pre-proof at the Journal of Biological Chemistry!! 🎉 www.jbc.org/article/S002...

Oh wow, this is 🤯 amazing: ~3-fold acceleration of running #relion on A100 GPUs for realistic single-particle refinement by the group of Guangwen Yang at @tsinghuauniversity.bsky.social . What a fantastic example of #OpenSoftwareAcceleratesScience, literally! 😍 dl.acm.org/doi/full/10....

I wonder how extremely busy people ever get any work done.

Want to join the LMB as a PhD student in October 2026? You’ve got two weeks left to apply! Visit our website for more details: www2.mrc-lmb.cam.ac.uk/students/int... Applications close on 2nd December 2025.

This study claims in vitro seeded assembly in brain homogenate is more disease-relevant than fibril extraction, without providing any evidence thereof. It also ignores ample data that in vitro seeding with aSyn may NOT template the structure of seeds. 😕 www.sciencedirect.com/science/arti...