New preprint from the lab, looking at how multiple different adaptors interact with dynein! Work led by @amicoennio.bsky.social. Available now on BioRxiv: doi.org/10.64898/202...

Congratulations to @lapassmore.bsky.social, Joint Head of the LMB’s Structural Studies Division, who has been elected an international member of @nationalacademies.org Congratulations to #LMBalumni Andrea Brand who has also been elected. Read more: mrclmb.ac.uk/news-events/... #LMBNews

Thrilled with this result, tune in for more soon!

The early release version of our #cryoEM work on CDK11-cyclin L-SAP30BP has now been published at Nature Communications: www.nature.com/articles/s41... We got very helpful comments from the reviewers and added more structural analysis and biochemistry to support our conclusions. Please have a look!

Congratulations to Manu Hegde, Group Leader & Joint Head of @cellbiol-mrclmb.bsky.social, who has been elected a member of the American Academy of Arts & Sciences. Congratulations also to the #LMBalumni joining him, Julie Ahringer & Edward Egelman. Read more: mrclmb.ac.uk/news-events/... #LMBNews

Very pleased that after a rigorous (and lengthy) review process, our paper visualizing how myosin generated forces modulate actin filament structure for mechanosensitive recogntion by α-catenin has appeared in @nature.com : www.nature.com/articles/s41...

The LMB is proud to launch the Career Returner Fellowship, a three-year, fully funded postdoc placement for scientists who have had a career break of over 1 year. Applications are open now! More details: mrclmb.ac.uk/careers-and-... Please share this post with anyone who may be interested!

I am excited to share our most recent work collaborating with @centriolelab.bsky.social and @stearnslab.bsky.social to look at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM www.biorxiv.org/content/10.6...

2nd call for postdoc positions in the lab. Get in touch for more information or simply apply here: mbg.au.dk/en/news-and-...

Sad news on the passing of Prof. Andreas Engel, a pioneer in the field of cryo-EM (shared with the 3DEM community by Henning Stahlberg). Andreas' kindness, warmth, and enthusiasm for science and his colleagues will be missed.

Our latest @biorxivpreprint.bsky.social: "Prion-like transmission of human tau strains in the mouse brain" 🥳 With Michel Goedert and Masato Hasegawa. www.biorxiv.org/content/10.6...

We are looking for a postdoc to join us on the quest for understanding RNA Pol II destruction machines! If you are curious why more than 80% of Pol II are removed from genes, check out the post below: www.nature.com/naturecareer...

New preprint! We identified many components that localize to the structure involved in "eating" in a marine organism. #ProtistOnSky #diplonemid www.biorxiv.org/content/10.6...

Inaugural paper from the Lau lab. Beautiful work. Congratulations Clinton and teams!

Check out the final version of this work, out today! @natcomms.nature.com www.nature.com/articles/s41...

Congratulations Verena, now in our neighboring Carter lab!

Have a look at our latest results on #CDK regulation, just posted as a pre-print! This study was spearheaded by PhD student Amy McGeoch. Amy has determined the #cryoEM structure of the CDK11-cyclin L-SAP30B complex, an important regulator of #spliceosome activation. www.biorxiv.org/content/10.6...

Excited to share my postdoc work on the cryo‑EM structure of the budding yeast telomerase holoenzyme! 🧫🧬 It’s been a real privilege to be part of the awesome Kelly Lab @kellythd-nguyen.bsky.social. Grateful as well to the incredible facilities @mrclmb.ac.uk.

Proud to share the yeast telomerase structure, led by the talented @hongmiaohu.bsky.social in collaboration with the Wellinger and Chartrand labs. Discovered 37 years ago and took us nearly 7 years but totally worth the wait 😍. www.science.org/doi/10.1126/... www.youtube.com/watch?v=gFE4...

Excited to decode the intricate language of ubiquitin chains and unravel their role in protein degradation? 🧬🔬 👉 APPLY NOW to join the lab of Dr. Leo Kiss @leokiss.bsky.social @imprs-lm.bsky.social. #CellularBiochemistry #Ubiquitin #Proteostasis #ProteinDegradation

Happy to share my first adventure in #TeamTomo in collaboration with the talented @inaharasimov.bsky.social. It was a fun experience experience with a lot of learning along the way.

Our paper is now live🎉! Huge thanks to all co-authors for your support @yiliangding.bsky.social @johninnescentre.bsky.social @thesainsburylab.bsky.social Our journey of AI in plant science starts here, built for plant scientists, aimed at accelerating discovery. www.cell.com/molecular-pl...

🔍 Want to uncover how proteolytic enzymes in the ubiquitin system work—and exploit those insights for novel therapeutic approaches? Apply to the Gersch Lab @maltegersch.bsky.social at @imprs-lm.bsky.social. #proteolysis #ubiquitin #biochemistry #proteinchemistry

📣 Physicists and engineers: apply your experimental skills to biology! Join the group of Katerina Naydenova @imprs-lm.bsky.social for a #PhD to develop new technologies that enable answering fundamental biological questions. Apply NOW!

Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with @niakanlab.bsky.social and work led by @kashishsingh.bsky.social and @inaharasimov.bsky.social . It is now out on BioRxiv: www.biorxiv.org/content/10.6...

Happy to share our latest work on the previously uncharacterized splicing factor Cwc15! Importantly, all of the people who did this work are/were undergrads! S. cerevisiae Cwc15p Tunes the Spliceosome Active Site for 5' Splice Site Cleavage www.biorxiv.org/content/10.6...

Three years ago Thalia was diagnosed with a brain tumour. She had multiple surgeries, chemotherapy and radiotherapy. This year we are walking the Nine Edges Challenge to raise awareness and money for OSCAR's Paediatric Brain Tumour Charity. Please donate: www.justgiving.com/team/thaliaf...

Always excited when Relion changes its color 😍.

Check out our pre-print, where we train a protein and small molecule force field from scratch with a graph neural network. We show comparable performance to existing, manually-tuned force fields on a range of tasks including binding free energy prediction. (1/4) arxiv.org/abs/2603.16770

Join #EMBOCryoEM to get a comprehensive foundation in advanced single-particle and cellular tomography techniques – we'll cover the entire workflow from sample preparation to data collection and image processing. https://s.embl.org/cry26-01-bl Apply by: 11 May 2026 @embo.org

Postdoc positions available in my lab in Aarhus, Denmark on 'Mammalian Nuclear RNA Production and Turnover Systems'. Please get in touch for further information or simply apply here: mbg.au.dk/en/news-and-...

We have an open position for a #PhD student (last week to apply!) & a lab technician/TA. For more information see: www.beuschlab.org/join-us Interested in understanding post-transcriptional regulation and how #RNA #splicing decisions are made? Then take a look or share with people who might be! 🧪🧫

Fantastic news! 🙌 The Perutz is excited to welcome Danny Nedialkova as a new group leader starting this April! 🎉 She will strengthen the institute's research on the fundamental mechanisms that shape cellular physiology and disease ➡️ www.maxperutzlabs.ac.at/research/res...

Exciting opportunity to work with an amazing scientist at the cutting edge of DNA repair and telomere biology.

VACANCY - We’re looking for a Laboratory Technician to join the @yiliangding.bsky.social group, investigating the role of #RNA structure in the post-transcriptional regulation of gene expression. www.jic.ac.uk/vacancies/la... Closing date - 17 March Contract - 36 months, Full-time

I am so grateful to the Blavatnik Family Foundation and the New York Academy of Sciences for this honor. Can’t wait to be back to the lab and celebrate with lab members on this special recognition of their hard work.

Are you a structural biologist pushing the boundaries of molecular science with an ambitious research programme? Join our Structural Studies Division as a tenure-track Group Leader, with core funding, world-leading facilities & enthusiastic colleagues. Apply by 16 MAR www.nature.com/naturecareer...

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳 mrc.tal.net/vx/mobile-0/...

How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller? Excited to share our latest work in @science.org on a new small polymerase. 1/n

Congratulations Brenda! You are yourself an RNA hero for me and many others.

Open Postdoc position in our lab! #actin #Huntingtin #cryoET #cellbio If you enjoy working at the interface of cell biology, structural biology, and quantitative imaging, this could be an excellent fit. ista.ac.at/en/job/postd... Please share and feel free to reach out if there are questions!

A. baumannii is one of the most notorious multidrug-resistant pathogens, capable of forming drug-tolerant biofilms that make infections exceptionally difficult to treat. But how are these complex microbial fortresses built? Just published in Nat Comms. pubmed.ncbi.nlm.nih.gov/41654547/

Stories from #WomenInScience who changed how we visualize #proteins: Ahead of her 85th birthday, Jane Richardson (Duke Univ, @biophysicalsoc.bsky.social president 2012-13) discussed her life from making a telescope to developing ribbon diagrams for 3D protein structure www.nature.com/articles/s41...

Honored to be a finalist for the 2026 Blavanik Awards in the UK in Life Sciences. I’m grateful to past and present lab members, collaborators, colleagues and mentors, who made it possible. It’s even better to share this from Vietnam while celebrating the Tet holidays with family.

Very happy to say that our work on how axonemes are generated is now available on bioRxiv: www.biorxiv.org/content/10.6... - if you’ve ever wondered how the incredibly beautiful, complex structures within motile #cilia are constructed then this is for you!

🧬🌉Online @science.org Programmable genome editing in human cells using RNA-guided bridge recombinases | Science www.science.org/doi/10.1126/...

Here is the official announcement. Now more than ever, acknowledging the contributions of immigrants is so important. Thank you @vilcekfoundation.bsky.social, and congrats to my fellow awardees. Can't wait to meet you all.

Now online! Hallmarks of cancer—Then and now, and beyond

Second PhDone from our lab. Congrats Seb! What a start to 2026, a paper out, a successful PhD defense, two new members and two visits from our collaborators Michael Stone and @janovictom.bsky.social! Can’t be more grateful but time for a short break with family in Vietnam 🇻🇳.

New pre-print from the lab! Lead by Mariia Mikhova and in collaboration with Kefei Yu’s lab @msumgi.bsky.social we dug into the molecular mechanism of class switch recombination in B cells using simultaneous RNA and protein single-molecule imaging. 1/n www.biorxiv.org/content/10.6...