Ana Tufegdzic Vidakovic
@anatv.bsky.social
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Group Leader at MRC Laboratory of Molecular Biology. Transcription, RNA Polymerase II, Ubiquitin
reposted by
Ana Tufegdzic Vidakovic
Kelly Nguyen
19 days ago
We have an opening for a research support officer. Come and join us! Please share.
add a skeleton here at some point
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reposted by
Ana Tufegdzic Vidakovic
Patrycja Kozik
about 1 month ago
Time for a new pre-print! How do dendritic cells control pore formation in their own endocytic compartments? Our work shows that the unique transmembrane anchor of perforin-2 does not protect DC membranes, but instead it enables antigen escape during cross-presentation
doi.org/10.64898/202...
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reposted by
Ana Tufegdzic Vidakovic
Rob Klose
about 1 month ago
An early Christmas present for those interested in chromatin and transcription! Fantastic work from
@au-ho-yu.bsky.social
and
@aleksszczurek.bsky.social
. Thanks to Inge and Michiel for their help. Please repost!
www.biorxiv.org/content/10.6...
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SET1/MLL complexes control transcription independently of H3K4me3
Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...
https://www.biorxiv.org/content/10.64898/2025.12.08.692985v1
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Happy to share a new preprint from our lab, uncovering "spooky action at a distance" - for RNA Polymerase II:
www.biorxiv.org/content/10.6...
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Stalling of elongating Pol II triggers Ser7 phosphorylation in trans to drive transcription recovery
DNA is scattered with obstacles that stall RNA polymerase II (Pol II) and block the production of full-length transcripts. Two mechanisms are known to resolve stalled Pol II: transcription-coupled nuc...
https://www.biorxiv.org/content/10.64898/2025.12.04.692291v1
about 1 month ago
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It is a privilege to join the international EMBO community and I look forward to meeting and exchanging ideas with fellow EMBO investigators! I am most grateful to my fantastic lab members who made this possible. 🧪🧫 🧬
add a skeleton here at some point
about 1 month ago
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Our dxChIP-seq protocol is now online! If you have a difficult chromatin target, you may want to give it a try (it also works for "easy" targets such as Pol II and histones).
www.sciencedirect.com/science/arti...
about 2 months ago
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@mrclmb.bsky.social
MRC LMB is looking for a new group leader in Chemical/Synthetic Biology. Come and join us in this fantastic institute! Core funding, amazing science all around you and great collaborative colleagues are just some of the highlights. Please share the news!
add a skeleton here at some point
5 months ago
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Looking forward to presenting at the Cambridge RNA club again! If you are interested in gene regulation and around Cambridge, stop by!
add a skeleton here at some point
7 months ago
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reposted by
Ana Tufegdzic Vidakovic
Susan Shao
10 months ago
~1 week left to register for the EMBO workshop on RNA meets protein decay!
#EMBOrnaDecay
Come join us for a fun time and invigorating scientific discussions in Vienna!
meetings.embo.org/event/25-rna...
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RNA meets protein decay
Establishing the composition of RNAs and proteins that defines the identities and functions of cells relies not only on the regulated biosynthesis of these molecules, but also equally importantly, on…
https://meetings.embo.org/event/25-rna-decay
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The first PhD student of our lab, 5'-Ivan Shlamovitz, has passed his viva with flying colours! What a special moment! The whole lab (and many friends at the LMB) are proud! 👏😁
11 months ago
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The first paper from our lab is online! A wonderful collaboration with
@scottbscience.bsky.social
lab. We discover that Pol II is extensively regulated by Ubiquitin at the beginning of the transcription cycle!
www.cell.com/molecular-ce...
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CRL3ARMC5 ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcription
Cacioppo, Gillis, Shlamovitz, Zeller, et al. show that CRL3ARMC5 ubiquitylates RNA Pol II at early stages of transcription as part of a major homeostatic RNA Pol II turnover mechanism. CRL3ARMC5 and the Integrator phosphatase act as complementary pathways, monitoring the quantity and quality of RNA Pol II complexes before they are licensed into elongation.
https://www.cell.com/molecular-cell/fulltext/S1097-2765(24)00949-3
about 1 year ago
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