Ana Tufegdzic Vidakovic
@anatv.bsky.social
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📥 316
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Group Leader at MRC Laboratory of Molecular Biology. Transcription, RNA Polymerase II, Ubiquitin
reposted by
Ana Tufegdzic Vidakovic
Lori Passmore
10 days ago
We are excited to be recruiting a new tenure track group leader in the Structural Studies Division at MRC LMB! It is an amazing place to start your own lab.
@mrclmb.bsky.social
Please get in touch if you have any questions.
www.nature.com/naturecareer...
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reposted by
Ana Tufegdzic Vidakovic
MRC Laboratory of Molecular Biology
22 days ago
How did life arise from simple chemical building blocks? New
#LMBResearch
led by
@edogia.bsky.social
in
@philholliger.bsky.social
group has identified a small self-replicating ribozyme that could be the answer. Read more:
mrclmb.ac.uk/news-events/...
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It was great fun collaborating with Scott Berry's lab, as always!
@scottbscience.bsky.social
@cftbla.bsky.social
Wonderful to see this work online 🧪 🔬 🧫! How cells respond to changes in RNA Pol II abundance 👇
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about 2 months ago
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reposted by
Ana Tufegdzic Vidakovic
Kelly Nguyen
3 months ago
We have an opening for a research support officer. Come and join us! Please share.
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reposted by
Ana Tufegdzic Vidakovic
Patrycja Kozik
3 months ago
Time for a new pre-print! How do dendritic cells control pore formation in their own endocytic compartments? Our work shows that the unique transmembrane anchor of perforin-2 does not protect DC membranes, but instead it enables antigen escape during cross-presentation
doi.org/10.64898/202...
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Rob Klose
3 months ago
An early Christmas present for those interested in chromatin and transcription! Fantastic work from
@au-ho-yu.bsky.social
and
@aleksszczurek.bsky.social
. Thanks to Inge and Michiel for their help. Please repost!
www.biorxiv.org/content/10.6...
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SET1/MLL complexes control transcription independently of H3K4me3
Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...
https://www.biorxiv.org/content/10.64898/2025.12.08.692985v1
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Happy to share a new preprint from our lab, uncovering "spooky action at a distance" - for RNA Polymerase II:
www.biorxiv.org/content/10.6...
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Stalling of elongating Pol II triggers Ser7 phosphorylation in trans to drive transcription recovery
DNA is scattered with obstacles that stall RNA polymerase II (Pol II) and block the production of full-length transcripts. Two mechanisms are known to resolve stalled Pol II: transcription-coupled nuc...
https://www.biorxiv.org/content/10.64898/2025.12.04.692291v1
3 months ago
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It is a privilege to join the international EMBO community and I look forward to meeting and exchanging ideas with fellow EMBO investigators! I am most grateful to my fantastic lab members who made this possible. 🧪🧫 🧬
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3 months ago
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Our dxChIP-seq protocol is now online! If you have a difficult chromatin target, you may want to give it a try (it also works for "easy" targets such as Pol II and histones).
www.sciencedirect.com/science/arti...
4 months ago
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@mrclmb.bsky.social
MRC LMB is looking for a new group leader in Chemical/Synthetic Biology. Come and join us in this fantastic institute! Core funding, amazing science all around you and great collaborative colleagues are just some of the highlights. Please share the news!
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7 months ago
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Looking forward to presenting at the Cambridge RNA club again! If you are interested in gene regulation and around Cambridge, stop by!
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9 months ago
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reposted by
Ana Tufegdzic Vidakovic
Susan Shao
12 months ago
~1 week left to register for the EMBO workshop on RNA meets protein decay!
#EMBOrnaDecay
Come join us for a fun time and invigorating scientific discussions in Vienna!
meetings.embo.org/event/25-rna...
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RNA meets protein decay
Establishing the composition of RNAs and proteins that defines the identities and functions of cells relies not only on the regulated biosynthesis of these molecules, but also equally importantly, on…
https://meetings.embo.org/event/25-rna-decay
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The first PhD student of our lab, 5'-Ivan Shlamovitz, has passed his viva with flying colours! What a special moment! The whole lab (and many friends at the LMB) are proud! 👏😁
about 1 year ago
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The first paper from our lab is online! A wonderful collaboration with
@scottbscience.bsky.social
lab. We discover that Pol II is extensively regulated by Ubiquitin at the beginning of the transcription cycle!
www.cell.com/molecular-ce...
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CRL3ARMC5 ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcription
Cacioppo, Gillis, Shlamovitz, Zeller, et al. show that CRL3ARMC5 ubiquitylates RNA Pol II at early stages of transcription as part of a major homeostatic RNA Pol II turnover mechanism. CRL3ARMC5 and the Integrator phosphatase act as complementary pathways, monitoring the quantity and quality of RNA Pol II complexes before they are licensed into elongation.
https://www.cell.com/molecular-cell/fulltext/S1097-2765(24)00949-3
about 1 year ago
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