I’m thrilled to share that my PhD work has been just published in Cell. After a long and bumpy ride, we uncovered the core function of nuclear speckles -splicing of GC-levelled exons- and traced the evolution of this gene architecture and condensates themselves to amniotes.

Our most recent work on the “function and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social doi.org/10.1016/j.ce... Read the thread👇 for the highlights of our findings.

Three @biorxivpreprint.bsky.social preprints on acute depletion of FACT in ES cells. First, from my colleague at Pitt Sarah Hainer's lab 1/ www.biorxiv.org/content/10.6...

Bravo to our neighbours!

We are excited to be recruiting a new tenure track group leader in the Structural Studies Division at MRC LMB! It is an amazing place to start your own lab. @mrclmb.bsky.social Please get in touch if you have any questions. www.nature.com/naturecareer...

DNA replication globally disrupts the epigenome. But does this create a chromatin-access opportunity for TF binding to facilitate cell identity change? Now 𝐫𝐞𝐩𝐥𝐢-𝐀𝐓𝐀𝐂-𝐬𝐞𝐪 shows 𝘥𝘦 𝘯𝘰𝘷𝘰 chromatin opening & TF binding occurs specifically post-replication, in cellular differentiation & reprogramming!

1/New preprint just dropped! 🔥🔥 We investigate how the genome is destroyed in apoptotic cells in a way that prevents DNA fragments from spreading beyond the dying cell 🧬⚰ Done here at @imbavienna.bsky.social & in the super @rcollepardo.bsky.social & Rosen labs: www.biorxiv.org/content/10.6...

The most important #RNA conference of the year with lots of amazing science and a really friendly atmosphere. This year in beautiful Montreal 🇨🇦 ! www2.rnasociety.org

Come work with Ben Berks FRS in Oxford 2 x PDRA posts: Molecular Analysis of Bacterial Outer Membrane Protein Biogenesis 2 complementary projects investigating bacterial outer membrane protein biogenesis. Building on our recent work (Nature (2015) 647: 479-487) my.corehr.com/pls/uoxrecru...

Join us in Vienna for the biggest international 'FISH' meeting in 2026! No matter which fish is your favorite model - zebrafish, medaka, killifish, cavefish, Danionella, cichlids, stickleback, you name them...- this meeting is for you! www.ezm2026.org Abstract submission deadline is March 15th.

What I have been arguing is that without knowing the root position, one cannot conclude that Euglenozoa (or any group) are monophyletic. You make an assumption that the root is not within Euglenozoa when you say Euglenozoa are monophyletic.

This is my life

Happy to share our latest paper. Our findings uncover a unique chromatin architecture and spatial chromosome arrangement in gonadal germ cells and document that alongside global DNA demethylation, the germline epigenetic reprogramming involves reorganisation of the 3D genome.

🎉Proud to present our latest paper, out now in Nature Communications: www.nature.com/articles/s41... RNA Binding Proteins (RBPs) are often full of intrinsically disordered regions (IDRs), but what these regions do during RNA recognition is often unclear. 1/10 #RNA #IDR #RBP

Canada USA tomorrow morning! Too early for a beer? I don’t think so! Go Habs!

😂 ok but at least to dismiss the threat of a new alternative religion like the liquid-solid phase transition predicted by in vitro crystallization some arguments are required!

It’s a religion - logic isn’t required

If I claimed this liquid-to-solid phase transition assay on a pure protein in vitro predicts the same transition to happen in cells, what counterarguments would you raise? Would the same counterarguments apply to a liquid-to-liquid phase transition assay on the same pure protein in vitro?

the lab is 25 years old today! Feb 19 2001 my friend Jim and I rolled up to Sickkids and placed a bunch of freezer boxes up in my new lab space. I still have one of those boxes. A lab dinner from those times:

Started this project years ago, but now everything is deposited on @addgene.bsky.social and a short @protocolsio.bsky.social is online. Try it out to make your own (cheap) homemade nuclease/Benzonase! dx.doi.org/10.17504/protocols.io.261ged7xov47/v2 Thank you @jcoker10.bsky.social and Michael Lim!

Fellowship application dealdine for students from low income countries 🌐will be in 1️⃣ week. Dont miss out on this opportunity ! Hands on Summer School. Cut&Run, Cut@Tag, ChIP, ATACseq and analyse your own data ! ➡️Unique opportunity ! 15 exiting days ➕ Daily high profile lectures. 👉 bit.ly/4oGDR8f

New preprint from @anadopico.bsky.social (who I have had the great pleasure of supervising with Tom Milne) and our fantastic collaborators in the @davieslab.bsky.social www.biorxiv.org/content/10.6... #genomics #GeneRegulation #chromatin

🚨New preprint! We built a cell-free genomics platform (GATO-seq) to probe transcriptional regulation and discovered a “super pause” sequence that triggers a new Pol II active-site conformation. Huge shout-out to @robertovn.bsky.social for pulling off this monster of a project. tinyurl.com/superpause

I had a lot of fun putting this together with @suminkim.bsky.social and @andersshansen.bsky.social! Glad to have had the chance to work on it!

Excited to share @suminkim.bsky.social and @mileshuseyin.bsky.social 's new Current Opinion review on how Polycomb complexes mediate 3D genome interactions including mechanistic models and potential roles in gene regulation: www.sciencedirect.com/science/arti...

@nbcsportsbayarea.com It’s called “hockey”. Not “ice hockey”. That’s like saying “snow skiing”. Come on Amurricans you can do better

To kickstart this new Bluesky account: We're hiring! The Bertolin Lab @dundee.ac.uk is looking for a postdoc to work on DNA-end homeostasis & genome stability, funded by Wellcome Trust Award. Exciting science, fantastic environment, founding role in the lab. Details in the flyer — get in touch! 👇

Equity, Diversity and Inclusion: Four women whose pioneering contributions to science have been largely overlooked @elife.bsky.social #womeninSTEM elifesciences.org/articles/110...

Aim 1: Revolutionize science publishing @qedscience.bsky.social

Because all the data in the Protein Databank was fully available to anyone who wanted to analyse it, AlphaFold and Rosetta were possible. The biggest public funded cancer genetics resource - COSMIC - is locked down in a commercial straitjacket. It’s as though they don’t want to cure cancer.

Wow, big time preprint drop from @jacobsenucla.bsky.social lab! One of the holy grails of DNA methylation research. Also, the 2-figure paper reminds me of the classic Science Brevia from Simon Chan and Steve showing RNA-directed DNA methylation drives de novo DNAme www.biorxiv.org/content/10.6...

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳 mrc.tal.net/vx/mobile-0/...

The demystification of piRNA clusters if you wonder how cells generate piRNAs specifically against transposons & you are looking for a weekend read check out @86dominik.bsky.social's opus magna (or Dominik's great thread) a shared project with the one and only Rippei Hayashi, lab alumnus & friend

New paper from my group in @science.org : "A small polymerase ribozyme that can synthesise itself and its complementary strand" www.science.org/doi/10.1126/... Outstanding work by @edogia.bsky.social

I appreciate the comments by Max Raas, Eelco Tromer and others on my paper published last year "Hypothesis that ancestral eukaryotes sexually proliferated without kinetochores or mitosis". However, I do not think their critiques can reject my hypothesis. For details, please read the paper. 1/n

Are you a DNMT3 enthusiast wondering how they achieve specificity at CpG islands during development? And why is DNMT3B specifically required for methylation on the inactive X? We set out to dissect the mechanism, now published in Genes & Development genesdev.cshlp.org/content/earl... [1/12]

Interested in transcriptional regulation, enhancers and 3D genome folding? In this new study we wondered about the role of cohesin loading at enhancers for long-range transcriptional control www.biorxiv.org/content/10.6... detailed 🧵👇

Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now? www.nature.com/articles/s41... More functional data, many thousands of words removed, and a few other updates from last year's preprint.

Please join Andreas Ladurner and me for the GRC Chromatin Structure and Function conference to be held near Barcelona Spain from May 31-June 5! We accepting abstracts for posters and talks. The meeting is preceded by an awesome GRS. Learn more in our video below and apply www.grc.org/chromatin-st...

Every time I upload a paper to #bioRxiv, I wonder why it can't be this easy at every journal 🧪

New Preprint www.biorxiv.org/content/10.6... from our lab - work by (now) Dr. Feyza Polat Haas with fabulous contributions from many. We show that mammals have a 💪 POWER-Spliceoeome in the 🧠 optimized for metabolic functions. This happens because SNRPB (SmB) is replaced by its paralogue SNRPN (SmN).

Come join us for a great week of science in Dublin this summer! @brianstrahl.bsky.social @vanrechemlab.bsky.social @bonalditiziana.bsky.social @garcialabms.bsky.social @metorrespadilla.bsky.social

Particularly excited to announce "In Formation" 👉Vernissage 17h00 Munich *5th of July* @Muffatwerk 1st exhibition of Art&Science work from 4 artists, including annadumitriu.co.uk + @replifate.bsky.social Helen Pynor,Solveig Lill & Pei-Ying Lin replifate.eu/event/in-for... 😇STAY TUNED 4more info

I’ll be there 😃! Can’t wait, should be an outstanding conference!

We are in EMBO J. See DNA and non-octameric nucleosome-like particles in situ link.springer.com/article/10.1...

Fascinating cryo-ET study! 🔬🧬 We can now trace strings of nucleosomes directly in cells. Congratulations to the @eltsovmikhail.bsky.social‬ team! 🎉

Let’s celebrate women and girls in scientific research! Often underestimated, women drive research in biomedical sciences both intellectually and at the bench. Research should be a “gender-blind” endeavor, but rarely is. Stop bigotry ! Stop unconscious bias ! Go women & girls!

Happy International Day of Women and Girls in Science! 🧪 Don't forget to send in your nominations for the FEBS | EMBO #WomenInScience Award. Deadline: 15 May Read more: https://www.embo.org/the-embo-communities/febsembo-women-in-science-awardees/nominate-for-the-women-in-science-award/#WomenInScience#award

Honored to be a finalist for the 2026 Blavanik Awards in the UK in Life Sciences. I’m grateful to past and present lab members, collaborators, colleagues and mentors, who made it possible. It’s even better to share this from Vietnam while celebrating the Tet holidays with family.

View of the @britishlibrary.bsky.social from my hotel. A long day again, but a good day