Thank you so much for all of your happy birthday wishes. Honestly, I don’t really feel 100. I feel pretty good. I feel like I’m only 98!

An enormous inspiration

NIH All of Us has just released a massive multi-omics dataset, including: • 535K WGS (120K+ added; now larger than UKB) • ~10K proteomics + RNAseq + long-read • ML-curated clinical notes • 68K with Fitbit data Kudos to this great initiative and to the participants for advancing science

I’ve had students lose their jobs because of Depression with catastrophic consequences. It would be real decent if Kean spoke about the privilege he had to disappear for a fifth of his term and suffer no consequences, and maybe he might work to help others.

the future of tech is 500 distinct apps offering to take notes for you

Frog and Toad were sad for a while.

Excited to see James' Genome-wide Absolute Quantification of Looping paper out in @natsmb.nature.com : www.nature.com/articles/s41... This has been in collaboration with @lucagiorgetti.bsky.social @leonidmirny.bsky.social @zechnerlab.bsky.social labs. Brief thread below on some key updates

Wow this Netherlands goal was something else, but even better to watch on Telemundo and get 20 seconds of Gooooooooooooooooooooool!

holy shit Paraguay!

really makes my blood boil

Game over. It will NEVER get better than this. #WorldBollardAssociation

🇨🇦🇨🇦🇨🇦

“You are Canadian heroes!”

During my postdoc I was trying to move to a new area, my supervisor said: you have to go to a conference, it's the only way to learn what they are thinking and what the key questions are. He was completely right. Science is a collective and social human pursuit, not a bunch of pdfs online

My son upon seeing that USA is playing Bosnia & Herzegovina exclaims “they have to play against two teams at the same time!” Funny guy

to disconnect service from Xfinity it took me 45 minutes, three confirmations of my ID, a 400 Bad request that needed their It to solve, and nobody to respect that my only goal was to cancel. Good riddance

Less than 24 hours after RFK Jr. became health secretary, his press secretary delivered an order from him to the CDC: Take down your ad campaign promoting flu vaccines. That same day, the CDC reported flu-related ailments that season had killed 68 children — 11 that week alone — and 16,000 overall.

Many years ago a Kookaburra ate part of my pancake on Hamilton Island. Rude.

(Nelson voice: “Ha-ha!”)

This week someone targeted my family for harm with a false report. We’re physically OK, but that doesn’t mean we weren’t harmed. I am beyond furious. Whatever your politics, this is awful, wrong, and can never become normal.

my kind of Jubilee, the Japanese national team vs. 100 kids

‘The Bear’ Ends With Continuous 45-Minute Shot Of Carmy Screaming While Stirring Tomato Sauce https://theonion.com/the-bear-ends-with-continuous-45-minute-shot-of-carmy-screaming-while-stirring-tomato-sauce/

So zen

Fulfilling the purpose for which it was built almost 2000 years ago, football fans packed the Roman Theatre of Amman to watch the Jordan v Algeria World Cup match. What a sight. [kottke.org]

sums it up. #heatwave in Europe.

A study published in Nature identifies an electrocardiogram marker by using an AI model trained on electrocardiograms of individuals that experienced sudden cardiac death. www.nature.com/articles/s41...

Thi Nguyen's paper on ciliary PKA activity is now published at @plosbiology.org: journals.plos.org/plosbiology/... She developed a ciliary PKA activity sensor, then, inspired by recent work from @benmyerslab.bsky.social and Susan Taylor's labs, showed that SMO inhibits PKA within cilia. 1/6

ICYMI

Really nice interactive here. Also, tax these killing machines into obscurity. www.nytimes.com/interactive/...

this is so important. DOGE had real impact on lives, here and across the globe

When reality surpasses fiction! Top: fictional forecast for August 2050, broadcast by French TV in 2014 to warn about the consequences of global warming. Bottom: Real French forecast for yesterday, June 22, 2026.

Apart from the fact this is on substack (💩) this is quite brilliant. Coming to a qualifying exam near you…

In a 2 min video, the inspirational @angierasmussen.bsky.social, Science Chair for @saveamericamvmt.bsky.social, lays out the horrors of Vought’s proposed OMB Rule It’ll end scientific research AND apply MAGA autocracy to ALL federal grants (schools, roads, hospitals, etc) youtu.be/gfAqCT1u97Y?...

AAAAHHHHHHHHHHHH

"I don't play a lot of fancy guitar. I don't want to play it. The kind of guitar I want to play is mean, mean licks." - John Lee Hooker The legendary blues singer, songwriter, and guitarist, John Lee Hooker, passed on this day, 2001. One of the greatest blues vocalists & guitarists of all time.

Why Politicians Fail To Understand The Elaborate Mythical Realm I’ve Made Up In My Head

oops the Xmas music ice cream truck is back, please avoid that portal to Hell if you can

I wish I could disagree with @brainmist.bsky.social about MAGA/MAHA. I cannot. In the eyes of MAGA/MAHA, people who dedicate their lives to improving the health of people worldwide are simply “woke liberal losers” And apparently withdrawing the US from the WHO “puts America first, cuz USA USA!!”

46C in Confolens. That's 114F.

(1/n) Very excited to share tri-lab collab (Mirny & Zechner) led by Harvey, Henrik & Jack: Q: How do enhancers & promoters interact in space (contact vs. action-at-a-distance) and time (stable vs. transient)? A: Transient E-P contact (~25-42 nm lasting ~10-20 sec): www.biorxiv.org/content/10.6...

My friend's NSF CAREER received the highest possible score (Excellent, Excellent, Excellent: High Priority) and it was rejected today. This would have been my friend's first extramural award, 5 years after starting their lab, exactly when grant $ is make or break for an Assistant Professor's career.

"Men who prioritize fatherhood may lose some sleep, gain some extra weight and enjoy less free time, but they can also discover a richer life with greater meaning, purpose and connection." Excellent! (free gift article) www.nytimes.com/2026/06/06/o...

this Belgium-Iran game....

Happy Father's Day to all of you!

Alexi Lalas's broadcast career is case-in-point evidence that a White man in the US can be leagues below his competitors and still end up getting the job. www.theguardian.com/football/202...

The Gracie’s Ice Cream Father’s Day commercial was conceived by a 10 year-old.