Benoit Bruneau
@benoitbruneau.bsky.social
📤 5728
📥 2056
📝 2133
Cardiac developmental biologist. Oakland and San Francisco. Hi friends! 🇨🇦
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Benoit Bruneau
Hiten Madhani
about 6 hours ago
Another banger from my UCSF/Genentech Hall colleagues Yifan Cheng and David Julius!
www.nature.com/articles/s41...
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Structural energetics of cold sensitivity - Nature
Data from cryogenic electron microscopy combined with hydrogen–deuterium exchange mass spectrometry inform a mechanism for cold-evoked activation of the TRPM8 channel, providing a structural and ...
https://www.nature.com/articles/s41586-026-10276-2
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everyone is freaking out over Angine de Poitrine. I get that microtonal math rock is appealing, but there is no composition in their "songs". It's just one groove, with looping. The microtonal twist is cute, but that's it.
about 21 hours ago
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Paul Francois
1 day ago
Wow, huge congratulations to
@jamesbriscoe.bsky.social
!!!
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Clinton Deploys Vowels on Bosnia is right up there.
www.ling.upenn.edu/~beatrice/hu...
also:
theonion.com/hey-you-got-...
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1 day ago
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Why do Parisians speak like this: “Mais voyons Sophie-aaah” “pourquoi-euuu”. They mock all other languages and yet…
2 days ago
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more macro goodness
2 days ago
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say hello to my little (slightly blurry) friend
2 days ago
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Miles Electric Band at SFJazz last night. So damn good!
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2 days ago
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Benoit Bruneau
Laura Martínez 🥑
2 days ago
Here's your moment of zen: A "holy" cat named Coco stands at the entrance of a church in Mexico, seemingly blessing everyone who walks in 🐱
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Gladstone Institutes
2 days ago
Gladstone scientists who develop new technologies—both
#AI
models on the computer and molecular tools in the lab—are coming together to solve one of the most challenging problems in science: what specific changes in the human genome cause disease?
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How AI Is Pinpointing the Genetic Cause of Disease
Scientists at Gladstone are combining AI models with cutting-edge lab tools to finally make sense of the human genome.
https://gladstone.org/news/how-ai-pinpointing-genetic-cause-disease
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Endless Screaming
3 days ago
AAAAAAAAAAAAAAAAHHHHHH
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why always "like no-one has seen before"? That could go either way buddy....
3 days ago
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alexis simpson
3 days ago
if i were an NHL player, i would simply put the puck in my opponent's net and not let my opponents score in my net
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Andi Zeisler
9 days ago
Portland pothole artists are seriously my favorite people. If you know one or are one and would be willing to talk about your craft, please DM
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Jeremy Reiter
3 days ago
An obit for Mike Bishop. Among his many accomplishments, pioneering work on Hedgehog signaling with Pascal Thérond. I asked him for his highlights once and he told me about throwing the first pitch at a Giants game. A true giant himself.
www.nytimes.com/2026/03/22/o...
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J. Michael Bishop, Nobel Prize Winner for Cancer Research, Dies at 90
https://www.nytimes.com/2026/03/22/obituaries/j-michael-bishop-dead.html
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Benoit Bruneau
Mir Lab
6 days ago
@mukherja.bsky.social
work on RNAPII clusters is in print today:
www.nature.com/articles/s41...
Congrats! TLDR: RNAPII clusters represent transcriptonally engaged molecules at single genes, not super-stochiometric assemblies. Please check it out and see the the thread below for a summary.
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down a rabbit hole of experimental cinema
play.hbomax.com/video/watch/...
play.hbomax.com/movie/759c97...
play.hbomax.com/movie/a14019...
play.hbomax.com/movie/b8bcd7...
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HBO Max | Stream Series and Movies
Stream must-see series, hit movies, exclusive originals, family favorites, and live sports.
https://play.hbomax.com/video/watch/4d7b7595-4ecc-46f3-9381-d30a8fe057d9/bd82dd5d-7e7a-4ab7-a2ef-40684c81ce02
3 days ago
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Zebrafish Rock!
4 days ago
Killifish community:
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Jeremy Berg
3 days ago
A very well produced story from NBC in San Diego about disruptions to can cancer research.
www.nbcsandiego.com/news/investi...
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San Diego cancer breakthroughs at risk from funding cuts and delays, experts say
Researchers say changes in how the National Institutes of Health approve and distribute grants are putting patients, cures and the entire biotech industry in peril.
https://www.nbcsandiego.com/news/investigations/san-diego-cancer-breakthroughs-at-risk-from-funding-cuts-and-delays-experts-say/3998054/
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Christophe 🔬 L
4 days ago
Tokyo and Mount Fuji on a Sunday morning 🗻
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Frog and Toad Bot
4 days ago
There was no answer.
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Hiten Madhani
5 days ago
Very sad to hear of the passing today of our UCSF colleague Mike Bishop at the age of 90. A legendary and inspiring figure. He also led UCSF as Chancellor. Have a listen to his Nobel lecture.
youtube.com/watch?v=CDv7...
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Michael Bishop, Nobel Prize in Physiology or Medicine 1989: Official Lecture
YouTube video by Nobel Prize
https://youtube.com/watch?v=CDv77rmzKR4
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this truly excellent. Having lost Tanya 3.5 years ago, my father a few weeks ago, and my dog last week (not kidding), this is timely
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4 days ago
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Benoit Bruneau
Dr Abolish ICE
6 days ago
i have a joke about ADHD
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Truly a first in 20 years here, especially in March.
5 days ago
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Benoit Bruneau
CJ Fogler
5 days ago
OH. MY. GAWD.
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Aaron Cohen
5 days ago
An update: we found the bride.
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Shawn Burgess
5 days ago
I'm not saying this study is relevant, but I'm also not saying it's not relevant:
www.nature.com/articles/d41...
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Knock knock, no one’s there. Study finds scientists’ jokes mostly fall flat
Survey examines how often academics attempt jokes during conference talks — and how these attempts at comedy land.
https://www.nature.com/articles/d41586-026-00854-9?utm_source=bluesky&utm_medium=social&utm_campaign=nature&linkId=60921839
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still laughing at the Oscars joke that the sequel to "F1" is going to be called "CapsLock", and that it fell flat
5 days ago
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Brad Takei
5 days ago
Imagine using that $80 billion to feed and house people instead of building a failed virtual world.
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Cc
@possumeveryhour.io
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6 days ago
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Benoit Bruneau
Matthew Gertz
6 days ago
You may think this is the most embarrassing thing a U.S. president has ever done to a Japanese prime minister, but George H.W. Bush barfed on one.
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Elzo de Wit lab @ NKI
7 days ago
🧵 CTCF is essential for embryonic development, but why has remained unclear. By combining gastruloids with a temporal degron system, we uncovered a surprising dual function — and it changes how we think about CTCF's role in development. 1/8
www.biorxiv.org/content/10.6...
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A dual role for CTCF in development
CTCF is an essential DNA binding protein whose absence leads to embryonic lethality. CTCF is primarily known for its role in 3D genome organization where its N-terminal domain interacts with cohesin to anchor chromatin loops. How CTCF facilitates proper embryonic development remains unclear, necessitating temporal control to resolve its stage-specific functions. By combining gastruloids, an in vitro model of embryonic development, with a degron system to rapidly deplete CTCF at defined timepoints, we show that early CTCF depletion impairs early gastruloid morphogenesis. Surprisingly, ATAC-seq and time-resolved RNA-seq revealed that differentiation was unaffected. CTCF binding is strongly enriched at promoters of downregulated genes. Re-expression of a CTCF variant with an N-terminal truncation, incapable of looping, was sufficient to rescue the expression of CTCF-promoter bound genes and the defects in morphogenesis. However, extended culture (up to 168 hours) of gastruloids reconstituted with N-terminal truncated CTCF led to their collapse. Our work shows that CTCF has a dual function in early mammalian development: at early stages CTCF regulates developmentally important genes through promoter binding, while at later stages its looping function is required for correct development. ### Competing Interest Statement The authors have declared no competing interest. European Research Council, https://ror.org/0472cxd90, 637587, 865459 Dutch Research Council, https://ror.org/04jsz6e67, 016.161.316, VI.C.222.049 Dutch Cancer Society, https://ror.org/0368jnd28, N/A
https://www.biorxiv.org/content/10.64898/2026.03.17.712290v1
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Benoit Bruneau
Mike Tremblay
8 days ago
My friend Laura died 10 years ago today. I'm sure there have been days I haven't thought about her, but not many. She was an amazing person and the world is a worse place without her. Fuck cancer
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MadScientist
9 days ago
It's out! Happy to present ITEC, a semi supervised algorithm with an extremely low error rate that can track cells in files of any size (think Terabytes!). We used it in many organisms, including zebrafish, to study how organs form and linked it to gene expression
www.biorxiv.org/content/10.6...
+🧪
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https://www.biorxiv.org/content/10.64898/2026.03.12.711203v1
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Nature
8 days ago
A simple celebratory post about completing my PhD went viral for all the wrong reasons. Here’s how I managed the backlash and used the attention to promote my research, says Juliet Turner
go.nature.com/4sQu3uX
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How I turned online misogyny about my PhD into momentum for my career
A simple celebratory post about completing my PhD went viral for all the wrong reasons. Here’s how I managed the backlash and used the attention to promote my research.
https://go.nature.com/4sQu3uX
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Michael Baym
8 days ago
Annual reminder: if you’ve been accepted to multiple graduate programs and are still deciding, please let the ones you’re definitely not going to know as soon as possible! -Someone who got into his PhD off the waitlist the day after the deadline
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Annie Andrews, MD
9 days ago
Do the big thing. 🇺🇸
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Jenna Norton
9 days ago
This Russell Vought, trying to usurp the power of the purse. Congress and the people have made it abundantly clear that they want to fund science. But Vought keeps trying to steal those funds.
www.science.org/content/arti...
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Analysis: Why the research money isn’t flowing from NSF and NIH
White House review of agency spending plans for this year is causing delays
https://www.science.org/content/article/analysis-why-research-money-isn-t-flowing-nsf-and-nih
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Peter Sagal
9 days ago
From the ruling: “This argument [by the Government] can only be countenanced if one completely abandons the idea of objective fact…” That really is the issue at the heart of many of the legal cases against the Administration.
www.nytimes.com/interactive/...
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U.S. Court Rules Against RFK Jr.’s Vaccine Policies
The decision by Judge Brian Murphy immediately halted implementation of a series of measures imposed by the Trump administration that were aimed at upending decades of immunization standards.
https://www.nytimes.com/interactive/2026/03/16/us/pi-opinion.html?smid=nytcore-ios-share
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a large boulder the size of a small boulder
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9 days ago
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Benoit Bruneau
Lara Williams
9 days ago
If we're all talking about Colossal and direwolves again: As I wrote almost exactly a year ago: Wouldn’t the enthusiasm and resources be better devoted to protecting the animals and planet we already have?
www.bloomberg.com/opinion/arti...
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Woolly Mammoths? Mars? Let's Take Care of What We've Got
Better to safeguard our existing animals and the Earth than resurrect extinct species or flee to another planet.
https://www.bloomberg.com/opinion/articles/2025-03-11/woolly-mice-and-mammoths-mars-let-s-take-care-of-what-we-ve-got?accessToken=eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJzb3VyY2UiOiJTdWJzY3JpYmVyR2lmdGVkQXJ0aWNsZSIsImlhdCI6MTc3MzY3MTY1NCwiZXhwIjoxNzc0Mjc2NDU0LCJhcnRpY2xlSWQiOiJTU1kwSzREV1gyUFMwMCIsImJjb25uZWN0SWQiOiJFQUM5MEQ5ODAzNTU0ODdEQjQ2NDFDMjdGRDVBMzUxNiJ9.oou4Az-TINrM3kaIeMQxb8mdT4gvF56d17snz_EbXAc
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read this in full. Fascinating
www.nytimes.com/interactive/...
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U.S. Court Rules Against RFK Jr.’s Vaccine Policies
The decision by Judge Brian Murphy immediately halted implementation of a series of measures imposed by the Trump administration that were aimed at upending decades of immunization standards.
https://www.nytimes.com/interactive/2026/03/16/us/pi-opinion.html
9 days ago
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Jared Pechaček
9 days ago
add a skeleton here at some point
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Max Kozlov
9 days ago
"...a nihilist endeavor this Court does not find appropriately read into Congress’s public health statutes." He added that "the newly appointed members appear distinctly unqualified" on vaccines.
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Same and yes
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9 days ago
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Alex Merz 🇺🇸🇨🇦🇺🇦
9 days ago
Great news for science and public health.
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Having been in Canada and now here in US and A, I sympathize but also understand the strategy
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9 days ago
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David Ho
9 days ago
Wtaf
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U.S. Considers Withholding H.I.V. Aid Unless Zambia Expands Minerals Access
https://www.nytimes.com/2026/03/16/health/zambia-hiv-aid-minerals-trump.html?unlocked_article_code=1.TlA.aGZs.CEA9NkxSA10k&smid=url-share
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Heterotypic transplantation! It is what made me love developmental biology as an undergrad, with axolotl embryos
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9 days ago
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