Benoit Bruneau
@benoitbruneau.bsky.social
📤 5736
📥 2057
📝 2148
Cardiac developmental biologist. Oakland and San Francisco. Hi friends! 🇨🇦
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Benoit Bruneau
Nature Reviews Genetics
about 2 hours ago
FYI: New online! Gene regulatory networks: from correlative models to causal explanations
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Gene regulatory networks: from correlative models to causal explanations
Nature Reviews Genetics, Published online: 09 March 2026; doi:10.1038/s41576-026-00939-1In this Perspective, Maizels and Briscoe discuss the limitations of current models of gene regulatory networks and outline solutions to harness data abundance without compromising explanatory power.
http://dlvr.it/TRnXV9
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Gladstone Institutes
1 day ago
Gladstone President Deepak Srivastava was recognized as one of 15 innovators helping shape the future of medical technology.
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The Healthtech Playbook: 15 Innovators on How They Are Transforming Medical Care
By Dr. Sonya Reddy
https://bit.ly/40Ouo5k
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howdy
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Carl Quintanilla
1 day ago
Astrud Gilberto was a housewife in 1964 when saxophonist Stan Getz decided he wanted his hit “Girl From Ipanema” to be sung in English — something her husband, Joao, who sang the original track, couldn’t do. Sold 2 million copies. Born today in 1940. 💕
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#birdoftheday
Stellar's Jay, outside my house in Oakland.
1 day ago
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Dr. Dawn Wright
2 days ago
San Francisco Bay Area never disappoints!!
#NoKings
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Nice that one of our images is the featured Biomedical picture of the day! From our recent paper with
@irfankathiriya.bsky.social
@ucsfanesthesia.bsky.social
and our lab
@gladstoneinst.bsky.social
bpod.org.uk
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BPoD | Building Safe Walls
BPoD (Biomedical Picture of the Day) is a free educational resource showcasing biomedical imagery. Managed by the MRC Laboratory of Medical Sciences the website aims to engage the general public. Imag...
https://bpod.org.uk/
3 days ago
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Prasad Jallepalli, MD, PhD
3 days ago
the article gives me hope that we (and the American people) will win this fight a GOP-affiliated polling firm found that more than 90% of Americans think it’s important for the US to be the global leader in biomedical research & for the govt to fund it. 62% of Americans we need more $$$, not less
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RORY
3 days ago
IT’S SUSHI FRIDAY 🍣 There was some minor theory by Finley, but we will allow it
@goodboyfinley.bsky.social
#DogsOfBluesky
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BWJones
3 days ago
850 Tomahawk missiles could be $3,060,000,000... That is 3 billion sixty million US dollars. That is 1224 5 year biomedical research grants. Literally, over 6 millennia of biomedical research.
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It's The Weekend 😌
10 days ago
Ladies and gentlemen... the weekend. (also: you are important and are not alone 🧡)
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Jordan
5 days ago
Might be the greatest opening paragraph of anything ever.
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Only had my phone, but here’s an industrious hawk on UCSF campus
4 days ago
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Hiten Madhani
5 days ago
Congratulations to my @UCSF colleague Geeta Narlikar and my grad school classmate Abby Dernberg on this well-deserved honor (and everyone else too)! It’s good to have something to celebrate in these challenging times.
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Hiten Madhani
6 days ago
Another banger from my UCSF/Genentech Hall colleagues Yifan Cheng and David Julius!
www.nature.com/articles/s41...
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Structural energetics of cold sensitivity - Nature
Data from cryogenic electron microscopy combined with hydrogen–deuterium exchange mass spectrometry inform a mechanism for cold-evoked activation of the TRPM8 channel, providing a structural and ...
https://www.nature.com/articles/s41586-026-10276-2
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everyone is freaking out over Angine de Poitrine. I get that microtonal math rock is appealing, but there is no composition in their "songs". It's just one groove, with looping. The microtonal twist is cute, but that's it.
6 days ago
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Paul Francois
6 days ago
Wow, huge congratulations to
@jamesbriscoe.bsky.social
!!!
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Clinton Deploys Vowels on Bosnia is right up there.
www.ling.upenn.edu/~beatrice/hu...
also:
theonion.com/hey-you-got-...
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6 days ago
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Why do Parisians speak like this: “Mais voyons Sophie-aaah” “pourquoi-euuu”. They mock all other languages and yet…
7 days ago
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more macro goodness
7 days ago
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say hello to my little (slightly blurry) friend
7 days ago
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Miles Electric Band at SFJazz last night. So damn good!
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7 days ago
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Laura Martínez 🥑
8 days ago
Here's your moment of zen: A "holy" cat named Coco stands at the entrance of a church in Mexico, seemingly blessing everyone who walks in 🐱
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Gladstone Institutes
7 days ago
Gladstone scientists who develop new technologies—both
#AI
models on the computer and molecular tools in the lab—are coming together to solve one of the most challenging problems in science: what specific changes in the human genome cause disease?
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How AI Is Pinpointing the Genetic Cause of Disease
Scientists at Gladstone are combining AI models with cutting-edge lab tools to finally make sense of the human genome.
https://gladstone.org/news/how-ai-pinpointing-genetic-cause-disease
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Endless Screaming
8 days ago
AAAAAAAAAAAAAAAAHHHHHH
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why always "like no-one has seen before"? That could go either way buddy....
8 days ago
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alexis simpson
8 days ago
if i were an NHL player, i would simply put the puck in my opponent's net and not let my opponents score in my net
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Andi Zeisler
14 days ago
Portland pothole artists are seriously my favorite people. If you know one or are one and would be willing to talk about your craft, please DM
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Jeremy Reiter
8 days ago
An obit for Mike Bishop. Among his many accomplishments, pioneering work on Hedgehog signaling with Pascal Thérond. I asked him for his highlights once and he told me about throwing the first pitch at a Giants game. A true giant himself.
www.nytimes.com/2026/03/22/o...
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J. Michael Bishop, Nobel Prize Winner for Cancer Research, Dies at 90
https://www.nytimes.com/2026/03/22/obituaries/j-michael-bishop-dead.html
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Mir Lab
11 days ago
@mukherja.bsky.social
work on RNAPII clusters is in print today:
www.nature.com/articles/s41...
Congrats! TLDR: RNAPII clusters represent transcriptonally engaged molecules at single genes, not super-stochiometric assemblies. Please check it out and see the the thread below for a summary.
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down a rabbit hole of experimental cinema
play.hbomax.com/video/watch/...
play.hbomax.com/movie/759c97...
play.hbomax.com/movie/a14019...
play.hbomax.com/movie/b8bcd7...
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HBO Max | Stream Series and Movies
Stream must-see series, hit movies, exclusive originals, family favorites, and live sports.
https://play.hbomax.com/video/watch/4d7b7595-4ecc-46f3-9381-d30a8fe057d9/bd82dd5d-7e7a-4ab7-a2ef-40684c81ce02
9 days ago
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Zebrafish Rock!
9 days ago
Killifish community:
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Jeremy Berg
9 days ago
A very well produced story from NBC in San Diego about disruptions to can cancer research.
www.nbcsandiego.com/news/investi...
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San Diego cancer breakthroughs at risk from funding cuts and delays, experts say
Researchers say changes in how the National Institutes of Health approve and distribute grants are putting patients, cures and the entire biotech industry in peril.
https://www.nbcsandiego.com/news/investigations/san-diego-cancer-breakthroughs-at-risk-from-funding-cuts-and-delays-experts-say/3998054/
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Christophe 🔬 L
9 days ago
Tokyo and Mount Fuji on a Sunday morning 🗻
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Frog and Toad Bot
9 days ago
There was no answer.
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Hiten Madhani
10 days ago
Very sad to hear of the passing today of our UCSF colleague Mike Bishop at the age of 90. A legendary and inspiring figure. He also led UCSF as Chancellor. Have a listen to his Nobel lecture.
youtube.com/watch?v=CDv7...
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Michael Bishop, Nobel Prize in Physiology or Medicine 1989: Official Lecture
YouTube video by Nobel Prize
https://youtube.com/watch?v=CDv77rmzKR4
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this truly excellent. Having lost Tanya 3.5 years ago, my father a few weeks ago, and my dog last week (not kidding), this is timely
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9 days ago
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Dr Abolish ICE
12 days ago
i have a joke about ADHD
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Truly a first in 20 years here, especially in March.
10 days ago
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CJ Fogler
11 days ago
OH. MY. GAWD.
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Aaron Cohen
10 days ago
An update: we found the bride.
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Shawn Burgess
11 days ago
I'm not saying this study is relevant, but I'm also not saying it's not relevant:
www.nature.com/articles/d41...
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Knock knock, no one’s there. Study finds scientists’ jokes mostly fall flat
Survey examines how often academics attempt jokes during conference talks — and how these attempts at comedy land.
https://www.nature.com/articles/d41586-026-00854-9?utm_source=bluesky&utm_medium=social&utm_campaign=nature&linkId=60921839
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still laughing at the Oscars joke that the sequel to "F1" is going to be called "CapsLock", and that it fell flat
11 days ago
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Brad Takei
11 days ago
Imagine using that $80 billion to feed and house people instead of building a failed virtual world.
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Cc
@possumeveryhour.io
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12 days ago
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Matthew Gertz
12 days ago
You may think this is the most embarrassing thing a U.S. president has ever done to a Japanese prime minister, but George H.W. Bush barfed on one.
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Elzo de Wit lab @ NKI
13 days ago
🧵 CTCF is essential for embryonic development, but why has remained unclear. By combining gastruloids with a temporal degron system, we uncovered a surprising dual function — and it changes how we think about CTCF's role in development. 1/8
www.biorxiv.org/content/10.6...
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A dual role for CTCF in development
CTCF is an essential DNA binding protein whose absence leads to embryonic lethality. CTCF is primarily known for its role in 3D genome organization where its N-terminal domain interacts with cohesin to anchor chromatin loops. How CTCF facilitates proper embryonic development remains unclear, necessitating temporal control to resolve its stage-specific functions. By combining gastruloids, an in vitro model of embryonic development, with a degron system to rapidly deplete CTCF at defined timepoints, we show that early CTCF depletion impairs early gastruloid morphogenesis. Surprisingly, ATAC-seq and time-resolved RNA-seq revealed that differentiation was unaffected. CTCF binding is strongly enriched at promoters of downregulated genes. Re-expression of a CTCF variant with an N-terminal truncation, incapable of looping, was sufficient to rescue the expression of CTCF-promoter bound genes and the defects in morphogenesis. However, extended culture (up to 168 hours) of gastruloids reconstituted with N-terminal truncated CTCF led to their collapse. Our work shows that CTCF has a dual function in early mammalian development: at early stages CTCF regulates developmentally important genes through promoter binding, while at later stages its looping function is required for correct development. ### Competing Interest Statement The authors have declared no competing interest. European Research Council, https://ror.org/0472cxd90, 637587, 865459 Dutch Research Council, https://ror.org/04jsz6e67, 016.161.316, VI.C.222.049 Dutch Cancer Society, https://ror.org/0368jnd28, N/A
https://www.biorxiv.org/content/10.64898/2026.03.17.712290v1
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Mike Tremblay
13 days ago
My friend Laura died 10 years ago today. I'm sure there have been days I haven't thought about her, but not many. She was an amazing person and the world is a worse place without her. Fuck cancer
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MadScientist
14 days ago
It's out! Happy to present ITEC, a semi supervised algorithm with an extremely low error rate that can track cells in files of any size (think Terabytes!). We used it in many organisms, including zebrafish, to study how organs form and linked it to gene expression
www.biorxiv.org/content/10.6...
+🧪
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https://www.biorxiv.org/content/10.64898/2026.03.12.711203v1
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Nature
14 days ago
A simple celebratory post about completing my PhD went viral for all the wrong reasons. Here’s how I managed the backlash and used the attention to promote my research, says Juliet Turner
go.nature.com/4sQu3uX
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How I turned online misogyny about my PhD into momentum for my career
A simple celebratory post about completing my PhD went viral for all the wrong reasons. Here’s how I managed the backlash and used the attention to promote my research.
https://go.nature.com/4sQu3uX
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