Good morning, Bay! I’m up early to head out to University of Florida and Daniel Kopinke. I hope to see you at the Dept of Pharmacology seminar Wednesday!

Good news. Faculty expressing their concerns seems to be having effects. If you are in academia, make sure your administration knows your views on the compact.

I am excited to share our preprint on the use of machine learning to identify abnormal cilia function. I am proud of Nicholas Hadas, a talented PhD candidate, for his hard work in compiling the code and preparing this manuscript. www.biorxiv.org/content/10.1...

Looking forward to a day with the developmental biologists at WashU in St Louis. Honoured to be giving the 44th Annual Oliver H. Lowry Lecture 4pm Jeffrey T. Fort NRB Building, Auditorium happenings.wustl.edu/event/44th-a...

An obituary for the venerable Dr. Marthe Gautier: www.nytimes.com/2025/10/30/h...

Today is the #BBSGlobalDay — an opportunity to raise awareness of this rare condition and offer support to everyone living with BBS and their loved ones 🌍 🌎 🌏 www.img.cas.cz/2025/10/8758...

Karl’s putting on a good performance this morning.

Meet the 2025 cohort of @dev-journal.bsky.social Pathway to Independence fellows Read about the scientific visions of eight dev bio post-docs entering the academic job market journals.biologists.com/dev/article/...

Congrats CD on your well-earned achievement! (This is _actually_ on the "journal" website) ＼(〇_ｏ)／

New cures feel sudden, but the seeds were planted decades ago by basic scientists. Which seeds will turn into cures? Unpredictable looking forward, a straight line looking back. 🧪🧬 🧵

Yifan Cheng to Receive 2026 Anatrace Membrane Protein Award buff.ly/ooI1UDy

I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪

🎉 Congratulations to Needhi Bhalla, UC Santa Cruz (www.bhallalab.com ), named a 2025 #ASCB Fellow! This honor celebrates her outstanding contributions to cell biology, leadership, & service. Fellows will be recognized at #CellBio2025 in Philadelphia this December. #CellBiology

Apply by Oct 15 - please spread the word!

Side hustle level-up! My book, IN THE BEGINNING, will be published by @harperonebooks.bsky.social in 2027! It's about the human embryo, how it gets built, and what it means for where we come from and where we're going. @harpercollins.bsky.social (1/2) @socdevbio.bsky.social #devbiol #scicomm

Whoa - neuronal ciliary proteome! Tons to dig into here - different from kidney cilia proteome (perhaps unsurprising) and enriched for many postsynaptic proteins, strengthening previous suggestions of cilia as postsynaptic signaling structures. @nachury.bsky.social www.biorxiv.org/content/10.1...

Congrats to Lucy Shapiro, a pioneering microbiologist, for winning the 2025 Lasker-Koshland Award. So deserving! laskerfoundation.org/winners/pion...

Redox-driven mineral and organic associations in Jezero Crater, Mars: "...conclude that the Bright Angel formation contains textures, chemical and mineral characteristics, and organic signatures that warrant consideration as ‘potential biosignatures’." www.nature.com/articles/s41...

Co-discoverer of reverse transcriptase at 32, Nobel Prize at 37, played a key role at the 1975 Asilomar comference.

Congratulations to Thi Nguyen for an excellent, insightful, rollicking defense!

Ahh! The classic Bay Area fall triad: fog, soccer and geese coexisting.

I'm loving the @idlesband.bsky.social-fueled soundtrack for Caught Stealing. The album cover is a chest X-ray most notable for the six foreign objects in the lung fields. Also notable is the right-sided cardiac apex. Does this individual also have heterotaxia?

New preprint with @gfudenberg.bsky.social We find the rate of cohesin loop extrusion in cells is set by NIPBL dosage and tunes many aspects of chromosome folding. This provides a molecular basis for NIPBL haploinsufficiency in humans. 🧵👇 www.biorxiv.org/content/10.1...

I know there is A LOT going on but just a heads up: TOMORROW, 9/3, is the last day to apply for a talk (or early poster) at #CellBio2025 in December! There will be a #Meiosis4Eva: The Cell Biology of Reproduction minisymposium on 12/7 at 10am. Please apply if you are interested in giving a talk! 🧪

Gordon Ramsay had a basal cell carcinoma (BCC). Protect yourself and your loved ones from too much sun, and avoid misactivating ciliary Hedgehog signal transduction! www.nbcnews.com/pop-culture/...

Research team @nadlerlab.bsky.social, A. Honigmann @biotec-tud.bsky.social, B.Drobot @hzdr.bsky.social, M. Hof @heyrovskeho-ustav.bsky.social develops approach to visualize lipids in cells & uncovers the main transport mechanism for lipids within the cell. @nature.com www.mpi-cbg.de/news-outreac...

⏳ Last days to apply to the International Course in Developmental Biology "From #stemcells to #morphogenesis" organized by Institut Curie and @sorbonne-universite.fr 📅 Application deadline: September 5 🔗 Program & registration: training.institut-curie.org/courses/deve... #devbio

From the Strahov monastery library in Prague, Galileo looking cheery. I guess he didn’t know what was coming…

Remebering Paul Kulesa (1962–2025) We honor Dr. Paul Kulesa, whose pioneering work on neural crest cell development has profoundly impacted neuroscience and pediatric cancer research. His loss has deeply impacted the Developmental Biology community and everyone he graced with his presence in life.

Have you saved the date for #Cilia2027? It is going to be in March 2027 at this lake near #Milan. 👇

In our ongoing saga of description of new protists, we are happy to introduce Multisulcus malaysiensis, a deep-branching heterolobosean that forms highly unusual multiflagellated cells with multiple ventral grooves. Great work by @kristina-prokina.bsky.social onlinelibrary.wiley.com/doi/epdf/10....

A Summer reading recommendation: new primer in @dev-journal.bsky.social explains how dynamical systems theory unlocks the logic of developmental patterning Everything from bistable switches & oscillators to phase portraits & more with Python code to explore journals.biologists.com/dev/article/...

Peak #SummerFun- our amazing line-up for our 52nd @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposium 19/08/2025 15:00-17:45 is now live! Join us for all things #cilia & #centrosomes- free & open to all. Register for here- www.eventbrite.co.uk/e/1220921258...

Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before. www.biorxiv.org/content/10.1...

This working paper looks really cool. "The Education-Innovation Gap" 🧵🧵🧵

The Pfeffer lab has been publishing a string of interesting papers mapping links between Parkinson's disease and cilia. The latest: www.sciencedirect.com/science/arti...

New STAT story about multi-year funding. www.statnews.com/2025/07/29/n...

New, from an anonymous NIH insider: Trump is being pushed to spend more NIH money. The White House is ordering NIH to do multi-year budgets for awards. This budget trick means fewer awards, fewer labs funded, and lower paylines for researchers. 🧵 donmoynihan.substack.com/p/alert-the-...

Straight talk from Dr. Francis Collins on the devastating - and politically motivated - cuts to science and public health in the United States. Anybody who cares about their health or the future or science, technology, and innovation in this country should watch this. www.cnn.com/2025/07/25/T...

Resolution from Reps. Diana DeGette (CO-01), Jamie Raskin (MD-08), and Jake Auchincloss (MA-04) recognizing the importance of U.S. leadership in biomedical research and the federal government’s responsibility to protect and expand that leadership. #SaveNIH degette.house.gov/media-center...

Tenure-track faculty search of the UCSF Biochemistry & Biophysics Department is open for applications! We are looking for creative, innovative scientists asking fundamental questions in any area of biology. Join our vibrant, collaborative, and supportive community! aprecruit.ucsf.edu/JPF05702

A red algal polysaccharide influences the multicellular development of the choanoflagellate Salpingoeca rosetta in @currentbiology.bsky.social www.cell.com/current-biol...

Bayfront Park brings the drama today…

Some personal news…

The NIH is asking scientists and the public to comment on plans to drastically limit animal model research. If you think animal models remain important tools for basic and clinical research tell them! Click the link below and scroll down to send your comments! www.fda.gov/news-events/...

Frank Stahl died today at 95. He and his colleague Matt Meselson found a way to demonstrate how DNA replicated. Their lab experiment has been called the "most beautiful experiment". Here's a video of them describing how they did it. Video h/t NYT. #science www.youtube.com/watch?v=7-tn...

Cilia Alert! So excited to finally have this paper on the CPLANE complex out in @natcomms.nature.com! We show that RSG1 is a human ciliopathy protein and links CPLANE to the transition zone. 1/n www.nature.com/articles/s41...

So much great science here! Congratulations all! And a special hooray to Hanna Martens and Isha Jain! www.hhmi.org/programs/fre...

🚨 New preprint! Using U-ExM + in situ cryo-ET, we show how C2CD3 builds an in-to-out radial architecture connecting the distal centriole lumen to its appendages. Great collab with @cellarchlab.com @chgenoud.bsky.social @stearnslab.bsky.social 🙌. #TeamTomo #UExM www.biorxiv.org/content/10.1...

Hey there, Our latest paper is out in Cell. We made a knockout collection in a human fungal pathogen, performed over 140 screens, and developed 6 follow up stories. Phenotypic landscape of an invasive fungal pathogen reveals its unique biology Share link: authors.elsevier.com/c/1lFMiL7PXu...