Thiago Carvalho
@cyrilpedia.bsky.social
đ€ 5135
đ„ 6060
đ 10759
I've worked on all of science, from T cells to B cells.
https://fellowsherpa.com
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Thiago Carvalho
IDIBAPS
6 days ago
đŁ
#JOBOFFER
Lâ
#IDIBAPS
ofereix 5ïžâŁ beques de doctorat a travĂ©s del programa doctoral
#DYNAMIS,
cofinançat per la UniĂł Europea Prepara la teva solicitud dâentre les 27 lĂnies de recerca que ofertem đ
https://f.mtr.cool/tpsnufflrf
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Thiago Carvalho
Grant Stewart
about 17 hours ago
Interested in inherited chromosomal instability syndromes and DNA repair? We are looking for an enthusiastic person to join the Stewart lab at the University of Birmingham as a senior technician. Please checkout the job advert:
www.jobs.ac.uk/job/DPH515/senior-research-technician
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Senior Research Technician at University of Birmingham
An academic position as a Senior Research Technician is being advertised on jobs.ac.uk. Click now to find more details and explore additional academic job opportunities.
https://www.jobs.ac.uk/job/DPH515/senior-research-technician
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Mohamed-Ali HAKIMI
1 day ago
Nature Com. now live! đ Silviaâs amazing PhD supervised by Alex âthe Greatestâ & Christopherâs big-bang contribution. Huge thanks to our stellar team & collaborators. We went fishing in the FDA pond and hooked LY2090314 đŁ Blocks GSK3 đŻin
#Toxoplasma
&
#Crypto
www.nature.com/articles/s41...
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Structural and functional characterization of TgGSK3, a druggable kinase in Toxoplasma gondii - Nature Communications
Researchers identify the cancer drug LY2090314 as a potent inhibitor of Toxoplasma gondii and Cryptosporidium and report the first crystal structure of the parasite kinase TgGSK3 bound to it, validati...
https://www.nature.com/articles/s41467-025-64701-7
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Thiago Carvalho
Le Canard enchaßné
about 16 hours ago
Marine Le Pen et son groupe ont bĂ©nĂ©ficiĂ© Ă l'AssemblĂ©e d'une vĂ©ritable bienveillance de la part des macronistes. La droite et le centre nâhĂ©sitent plus Ă voter les textes de lâextrĂȘme droite. Pour finir de la respectabiliser ?
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Accord migratoire de 1968, budget 2026 : Marine Le Pen fait dĂ©jĂ sa loi Ă lâAssemblĂ©e | Le Canard enchaĂźnĂ©
Marine Le Pen et son groupe bĂ©nĂ©ficient d'une vĂ©ritable bienveillance de la part des macronistes, de la droite et du centre qui nâhĂ©sitent plus Ă voter desâŠ
https://tinyurl.com/yv98k3hn
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The Francis Crick Institute
about 16 hours ago
How does immunotherapy work, and why do some patients respond while others donât? Book our free talk by Samra Turajlic, head of the Cancer Dynamics Lab here at the Crick, Director of
@cruk-mi.bsky.social
and head of the UK-wide MANIFEST programme.
www.eventbrite.co.uk/e/crick-cras...
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Crick Crash Course: Immunotherapy
Our series of morning lectures sharing science from across the Crick in a simple and accessible way continues.
https://www.eventbrite.co.uk/e/crick-crash-course-immunotherapy-tickets-1786942004639?aff=Bsky
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Thiago Carvalho
Journal of Cell Science
about 16 hours ago
Laurence Wilson and Martin Bees use high-speed 3D holographic imaging to capture the flagellar beat of single algal cells, revealing changes in the âhandednessâ of the flagellar shapes at different points in their cycle.
#JCSciliaSI
journals.biologists.com/jcs/article/...
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Melissa Nadia Viviana đž
about 16 hours ago
Chicago Alderman, Andre Vasquez, pulls out a whistle from around his neck and asks fellow Chicago citizens to join the Whistle Brigade that patrols streets and sends whistles to warn neighborhoods of the presence of ICE. "Everyone asks what did they do in 1930s Germany? They did things like this."
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Dr Ross Barnett
about 16 hours ago
tetzoo.com/blog/2025/10...
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Sloth World, 2025 (Part 1) â Tetrapod Zoology
Like me, you are no doubt a big fan of sloths...
https://tetzoo.com/blog/2025/10/8/sloth-world-2025-part-1
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Hungary 1956 'Well over a 100k people fled the country seeking asylum. Among them was a young geneticist named George Rédei, who headed for the Austrian border with a small vial of seeds tucked in his pocket. The seeds belonged to a spindly weed in the mustard family called Arabidopsis thaliana.'
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How a humble weed became a superstar of biology
Arabidopsis thaliana was always an unlikely candidate for the limelight. But 25 years ago, the diminutive thale cress launched the botanical world into the molecular era.
https://knowablemagazine.org/content/article/living-world/2025/how-humble-weed-became-superstar-plant-science?ref=thebrowser.com
about 16 hours ago
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Evan J Albright
1 day ago
Pretty cool. Researchers at Chichen Itza and on the Internet have found many of the missing pieces of the feathered serpent columns atop the Temple of Kukulcan/El Castillo. It's like doing a jigsaw puzzle when someone has thrown some of the pieces outside.
add a skeleton here at some point
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Osterman Ilya
about 20 hours ago
Bacteria can sense when a virus starts shredding their genome â by detecting methylated mononucleotides. Hereâs the story of how we discovered the Metis defense system đ
www.biorxiv.org/content/10.1...
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Otto English
about 17 hours ago
X is designed to radicalise people. The algorithm promotes Elon Musk's agenda to promote racists and people who want violence bought - specifically - to the streets of Britain. Members of Parliament, major institutions and the media should not be there.
news.sky.com/story/the-x-...
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Elon Musk is boosting the British right - and this shows how
Elon Musk is boosting the British right - and this shows how
https://news.sky.com/story/the-x-effect-how-elon-musk-is-boosting-the-british-right-13464487#
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Brady Lab
1 day ago
Interested in learning about the latest and greatest research in how plants respond to excess salt, too little or too much water? Come to the GRC in Salt and Water Stress in Switzerland. Lots of opportunities for all career levels.
www.grc.org/salt-and-wat...
. Please repost!
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2026 Salt and Water Stress in Plants Conference GRC
The 2026 Gordon Research Conference on Salt and Water Stress in Plants will be held in Les Diablerets, Vaud (fr) Switzerland. Apply today to reserve your spot.
https://www.grc.org/salt-and-water-stress-in-plants-conference/2026/
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'Now a new study with an unusually long follow-up period has found that radiation to the chest wall made absolutely no difference in survival among women with early-stage breast cancer who had been treated with mastectomy, lymph-node surgery and advanced anti-cancer drugs.'
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Radiation May Be Unnecessary for Many Breast Cancer Patients
https://www.nytimes.com/2025/11/05/health/breast-cancer-radiation.html
about 17 hours ago
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Thiago Carvalho
Asher Elbein
1 day ago
It would be wrong to call Greenblatt a kapo. The kapos â as justly hated as they were after the Holocaust â often were acting under direct duress. Greenblatt, the self-appointed and self-important functionary-minder of American Jewry, has no such excuse. He's simply a rank bigot
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Ensembl
3 days ago
As new human assemblies become available on
beta.ensembl.org
- which human reference genome will you choose? This article explores the question with insights from Ensemblâs own Fergal Martin -
www.nature.com/articles/s41...
#HumanGenomics
#Pangenomes
#ReferenceGenomes
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Choose your human genome reference wisely - Nature Methods
Scientists can choose between multiple human genome references, and a pangenome reference is coming. Deciding what to use when is not quite straightforward.
https://www.nature.com/articles/s41592-025-02850-9
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Thiago Carvalho
Tom Reaganâs Hat
1 day ago
David Bowie as Tilda Swinton, Tilda Swinton as David Bowie
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Nick Jones
4 days ago
Ecstatic to share out latest research looking at the role of mitochondrial ABHD11 in controlling T-cell responses. We think this may be a viable target for autoimmunity. Please do give it a read, we would love to hear your thoughts.
www.nature.com/articles/s41...
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Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function - Nature Communications
α/ÎČ-hydrolase domain-containing protein 11 (ABHD11) is a mitochondrial hydrolase, and its expression in CD4â+âT-cells has been linked to remission status in rheumatoid arthritis. Here the authors repo...
https://www.nature.com/articles/s41467-025-65417-4
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Thiago Carvalho
The Public Domain Review
1 day ago
Pages from a beautiful hand-written and illustrated treatise on firework design and manufacture published in 1785, including âblue-printsâ for the devices and explosive recipes. See the full book here:
https://publicdomainreview.org/collection/manuscript-handbook-of-firework-design-1785
#Fireworks
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Thiago Carvalho
Anne Carpenter
2 days ago
Required reading for cell biologists to get a sense of basic statistical principles!
www.nature.com/articles/s41...
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Ten essential tips for robust statistics in cell biology - Nature Cell Biology
Statistical thinking is a core part of solid, trustworthy biology. However, many studies still include insufficient sample sizes, have poor experimental design or select an incorrect statistical metho...
https://www.nature.com/articles/s41556-025-01801-y
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In my day we just called this convergence... 'We identified novel sequence-unrelated but structurally similar (SUSS) effector clusters, rich in conserved motifs such as 'CCG' and 'RAYH'.'
elifesciences.org/articles/105...
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Structure-guided secretome analysis of gall-forming microbes offers insights into effector diversity and evolution
Comparative structural genomics identifies unique effector architectures and ankyrin-mediated host targeting, revealing central and conserved strategies that underpin the pathogenicity of diverse gall...
https://elifesciences.org/articles/105185
2 days ago
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Thiago Carvalho
Ruslan Rust
3 days ago
The brain neurovascular epigenome and its association with dementia
@cp-neuron.bsky.social
Great study that maps cell-type-specific regulomes showing that small vessel disease heritability spans the neurovascular unit, incl astrocytes. These findings link vascular risk and Alzheimerâs mechanisms.
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Thiago Carvalho
Melike Eren
2 days ago
www.nature.com/articles/s42...
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Cholesterol metabolic reprogramming mediates microglia-induced chronic neuroinflammation and hinders neurorestoration following stroke - Nature Metabolism
Persistent microglial activation upon ischaemic injury leads to the formation of stroke-associated foamy microglia, perpetuating long-term inflammation, white matter damage and functional impairments....
https://www.nature.com/articles/s42255-025-01379-7
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Thiago Carvalho
Alexander Titz
3 days ago
I am delighted to share our recent collaborative progress towards drug-like glycomimetics for lectins with
@anneimb.bsky.social
and Roche. Published in
@angewandtechemie.bsky.social
#ChemBio
#Glycotime
onlinelibrary.wiley.com/doi/full/10....
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The Parkinson's Disease Drug Tolcapone and Analogues are Potent Glycomimetic Lectin Inhibitors of Pseudomonas aeruginosa LecA
We present Tolcapone and derivatives as a new class of potent glycomimetics for lectin inhibition. Over 3200 Roche in-house compounds were screened experimentally and a subset was biophysically evalu...
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.202508864
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Thiago Carvalho
Jennifer Ouellette
2 days ago
Some stinkbugsâ legs carry a mobile fungal garden
arstechnica.com/science/2025...
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Some stinkbugsâ legs carry a mobile fungal garden
A dedicated organ grows the fungus, which deters parasitic wasps.
https://arstechnica.com/science/2025/11/some-stinkbugs-legs-carry-a-mobile-fungal-garden/
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Thiago Carvalho
Esquerda.Net
2 days ago
Massacre de el-Fasher investigado
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Massacre de el-Fasher investigado
As Forças de Suporte RĂĄpido entraram na cidade depois de 18 meses de cerco e cometeram as maiores atrocidades. Contamos aqui a histĂłria da guerra mais violenta da atualidade, do carniceiro de el-Fasher que se gaba no TikTok de matar 2.000 civis e do seu chefe que traiu o processo revolucionĂĄrio que se viveu atĂ© hĂĄ pouco no paĂs.
http://dlvr.it/TP4Kmr
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Thiago Carvalho
Zohran Kwame Mamdani
4 days ago
Congratulations, Andrew Cuomo! I know how hard you worked for this.
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Jorge Pinto
4 days ago
Podem ver a entrevista completa aqui:
cnnportugal.iol.pt/videos/a-ent...
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Thiago Carvalho
Kevin Gannon (now a Moo Deng fan account)
2 days ago
oh please oh please oh please oh please oh please
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Jacobin
2 days ago
Billionaire Bill Gates says we should back away from urgent emissions cuts and bet instead on tomorrowâs tech. But unless that innovation is democratically controlled, it will serve the same interests that caused the climate crisis in the first place.
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Bill Gates Wants Us to Do Less About the Climate Crisis
Billionaire Bill Gates says we should back away from urgent emissions cuts and bet instead on tomorrowâs tech. But unless that innovation is democratically controlled, it will serve the same interests that caused the climate crisis in the first place.
https://jacobin.com/2025/11/gates-climate-crisis-emissions-technology?utm_source=bluesky&utm_medium=social&utm_campaign&utm_content=ap_n3jhzg2pjm
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Thiago Carvalho
EMBO
2 days ago
The Initiative for Science in Europe, of which EMBO is a member, has just released its statement on the European Commissionâs proposal for the next Multiannual Financial Framework (MFF 2028â34), including Framework Programme 10 (FP10). Read the full statement here:
initiative-se.eu/wp-content/u...
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Thiago Carvalho
Mueller, She Wrote
2 days ago
The woman in this video had just had kidney surgery.
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Nature Metabolism
2 days ago
#Throwback
đ§Ș REVIEW | Futile lipid cycling: from biochemistry to physiology C Wolfrum et al.
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Futile lipid cycling: from biochemistry to physiology - Nature Metabolism
Sharma et al. review the regulation and biological functions of apparently âfutileâ dynamic lipid cycle in regulating whole-body metabolic homeostasis.
https://bit.ly/3LjijRf
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Thiago Carvalho
Genes & Development
2 days ago
đ„ G&D Tapes đ„ G&D author, Haoming Yu tells us about their new study in #genesdev that uses epigenetic editing to probe the role of H3K4me3 at intergenic regulatory elements. Learn more here: âĄïž
https://genesdev.cshlp.org/content/39/21-22/1290.full
Bluma Lesch
@haomingyu.bsky.social
#genesdev
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Harry Lowâs Lab
2 days ago
Please RT. Post-doc opportunity alert! đ„ closing 10th December.. Come join our team (
www.thelowlab.org
) at Imperial, London, working on the structure and mechanism of bacterial secretion systems. For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
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Seema Grewal
3 days ago
Our special issue on âCilia and Flagellaâ is now out! Huge thanks to all (authors + reviewers) who contributed, and to our wonderful Guest Editors (
@cilialab.bsky.social
+
@lottepedersen.bsky.social
) for pulling it together. Happy reading!
#cilia
#flagella
journals.biologists.com/jcs/issue/13...
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Volume 138 Issue 20 | Journal of Cell Science | The Company of Biologists
Journal of Cell Science publishes cutting-edge science encompassing all aspects of cell biology. It is published by The Company of Biologists, a not-for-profit organisation.
https://journals.biologists.com/jcs/issue/138/20
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Thiago Carvalho
Boston Review
2 days ago
âThe incalculable damage left by Bush and Cheneyâs day-in-and-day-out contempt for national and international law includes the power to sweep forward in time and trivialize into a matter of personal preference any future presidentâs adherence to the law.â Elaine Scarry in 2008:
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Presidential Crimes - Boston Review
Torture must be addressed through legal instruments, not simply through the electoral repudiation of bad policy.
https://www.bostonreview.net/articles/elaine-scarry-presidential-crime/
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Nature Cell Biology
2 days ago
âZhang et al. delineate the heterogeneity of core regulatory circuitry in
#glioblastoma
and identify HOXB3 condensation as a vulnerability that may be targeted with a therapeutic peptide in mouse models. đhttps://rdcu.be/eOgQQ
bit.ly/3XdeSxW
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Defining heterogeneity in core regulatory circuitry reveals HOXB3 condensation as a potential target in glioblastoma - Nature Cell Biology
Zhang et al. delineate the heterogeneity of core regulatory circuitry in glioblastoma and identify HOXB3 condensation as a vulnerability that may be targeted with a therapeutic peptide in mouse models...
https://bit.ly/3XdeSxW
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Thiago Carvalho
Lex McMenamin (they/them)
2 days ago
if you want to know what happened to Teen Vogue yesterday, my work wife
@allegrak.bsky.social
â who ran our politics section for 6 years until this past June â said it all in this. can't even pull out a favorite part til I sign my separation letter lol, just read the whole thing.
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What We Lost When Condé Nast Unceremoniously Shuttered Teen Vogue
This article is part of TPM Cafe, TPMâs home for opinion and news...
https://talkingpointsmemo.com/cafe/what-we-lost-when-conde-nast-unceremoniously-shuttered-teen-vogue
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âi could smell the onions and the mustardâ
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2 days ago
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Thiago Carvalho
Kevin Wright
2 days ago
He is so fucking good at this. Agree with him or not, we need more people running for office that can articulate their vision in such a precise and positive way.
add a skeleton here at some point
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Thiago Carvalho
Matthew Cobb
2 days ago
One I missed because I didn't know it existed until after the book was finished â a B&W scan of the cover of Nature marking the 'coming of age' (ie 21st anniversary) of the double helix. I am trying to find a colour image of the original (most libraries stripped off the covers when binding...)
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Thiago Carvalho
Sarah Marzi
2 days ago
@andreaserio.bsky.social
and I are recruiting a postdoc to lead an exciting MNDA-funded project using multi-omics to study long axons in motor neurons and how they shape susceptibility to
#ALS
. Get in touch for any questions and apply by 2 December:
my.corehr.com/pls/kclrecru...
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Still my favorite moment in any American award show ever
www.youtube.com/watch?v=5N0D...
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Ving Rhames Wins Best Actor Mini Series - Golden Globes 1998
YouTube video by Awards Show Network
https://www.youtube.com/watch?v=5N0DTH2wPTo
2 days ago
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Thiago Carvalho
Waggoner Lab
2 days ago
TNBC cells secrete high levels of IL-11 that mediates trans-signaling by forming complexes with the soluble IL-11 receptor and engaging the gp130 receptor on NK cells to resist antitumor function
advanced.onlinelibrary.wiley.com/doi/10.1002/...
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Thiago Carvalho
Journal of Clinical Investigation
2 days ago
Elizabeth Wellberg
@lwellberg.bsky.social
& colleagues present a Review in the JCI series on Clinical innovation and Scientific Progress in GLP-1 Medicine: GLP1 receptor agonists & cancer: current clinical evidence & translational opportunities for preclinical research:
www.jci.org/articles/vie...
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Zohran Kwame Mamdani
2 days ago
Cities thrive not on fear but empathy, on cooperation not division. That's the NYC we know and love. It has found expression in this movement. And it is rising up at the ballot box today. Polls close at 9pm:
zohranfornyc.com/vote
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This is followed by a very big "however". '(...) we examined the number of oncogenic hits required for malignant transformation of whale primary fibroblasts. Unexpectedly, bowhead whale fibroblasts required fewer oncogenic hits to undergo malignant transformation than human fibroblasts.'
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Evidence for improved DNA repair in long-lived bowhead whale - Nature
Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein. &nbs...
https://www.nature.com/articles/s41586-025-09694-5
2 days ago
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Christophe đŹ L
3 days ago
What is the cell type closest to neurons in the differentiation tree? The answer will surprise you! (unless you know about development, or were at
#MiFoBio2025
listening to Pierre Nassoy's talk)
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