Bacterial metabolites induce cell wall remodeling, antifungal resistance, and immune recognition of commensal fungi: Current Biology www.cell.com/current-biol...

Increased prevalence of #autoantibodies neutralizing IFNλ2/3 in young individuals with #CysticFibrosis. New report from Kevin Groen, Emanuela Bruscia, Marc Emmenegger, Benjamin Hale @benhale.bsky.social and colleagues: rupress.org/jhi/article/... #Autoimmunity #Infections

A vaccine to prevent colon cancer. Proof-of-concept for strong immune response and safety via neoantigens given to people carrying mutations for Lynch syndrome nature.com/articles/s41...

Challenging Claims of an Autism Epidemic — Misconceptions and a Path Forward | New England Journal of Medicine www.nejm.org/doi/full/10....

Whoever got this unethical trial cancelled, you just saved some lives. Kennedy, you should be ashamed of yourself for backing it in the first place. www.theguardian.com/us-news/2026...

Immune signature-based uncoupling of checkpoint inhibitor efficacy and toxicity: Immunity www.cell.com/immunity/ful...

"CAR-T therapy has been available on the NHS for several years for certain types of leukaemia and lymphoma but has only now been extended to adults with B-cell ALL." #genetherapy #celltherapy www.bbc.co.uk/news/article...

Great to see two papers out that show the benefits of RSV vaccination (monoclonal treatment) to prevent severe RSV infection. A quick thread to unpick what these vaccines are as there are 2 quite different products in clinical use and it can be confusing what the terminology means. #HealthPolicy 🧵

Monoclonal antibody Lu AG09222 decreased monthly migraine days: www.nejm.org/doi/full/10.... #LongCovid

Chinese Immune Multi-Omics Atlas | Science www.science.org/doi/10.1126/...

HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion: Cell www.cell.com/cell/fulltex...

Just published on @pnas.org how #COVID can lead to loss of dopamine neurons. In mice, it can be mitigated with proper treatment, but in humans we don't know yet. Below you see the reduction of TH (rate-limiting enzyme to produce dopamine) in the brain. This is #LongCovid and also viral Parkinsonism.

IL-17REL disarms inflammation A newly identified decoy receptor for IL-17 cytokines reveals a feedback mechanism that limits mucosal inflammation, linking epithelial and lymphoid cell responses through a common cytokine axis that controls immunity. www.nature.com/artic... 1/5

Your fact of the day: The US Center for Disease Control and Prevention estimates that one in six American citizens suffers a food-borne illness annually. In the UK, the figure is one in 132. bylinetimes.com/2020/02/28/f...

Assumption comes from a series of excellent, big data papers on reduced risk associated with zoster vaccination

I’m excited about the real-life experimental medicine question of whether this will reduce risk of future Alzheimer’s?

Chickenpox vaccine could eradicate the virus in the UK in a decade www.thetimes.com/article/90ad...

Happy 2026!!! #Science #Immunology will celebrate its 10th anniversary this year! 🎉 We start with a look back at our Editors’ Choice of articles published in 2025! This free sample collection will be available online to read until the end of February 2026! bit.ly/SciImm_free #ScienceImmuno10gy

We don't know if the BA.3.2.2 saltation will mirror BA.2.86>JN1. Yet, I'm struck by complacency & cognitive dissonance wrt vax & possible impact. For flu, a handful of HA muts is bad clinically, despite OK ANNUAL vax ND50. BA.3.2.2 is off the map, but apparently all is well...

…but so frustrating and impossible to get tickets! Needs some proper dates with a ticket website that doesn’t just put you on hold..

Looks like flu is wave is likely to be "normal bad" shifted earlier and not bigger this year after all. Latest hospital data came out this afternoon.

Radio 4’s Jane Austen season is absolutely brilliant and wonderful. There is nothing like Radio 4 anywhere in the world, it is so precious.

Reassessing sotrovimab's role in COVID-19: insights and implications - The Lancet Infectious Diseases www.thelancet.com/journals/lan...

Restoring youth to old immune cells: mRNA therapy turns back the clock www.nature.com/articles/d41...

Gene editing cuts blood cholesterol levels in small study | Science | AAAS www.science.org/content/arti...

Job links for those posts with our team: www.imperial.ac.uk/jobs/search-...

Come and join us at Imperial College to work a project looking at mechanisms in Long Covid and ME/CFS We're looking for: A keen, experienced Research Nurse A gifted molecular immunologist with a strong bioinformatics background www.imperial.ac.uk/.../descript.... www.imperial.ac.uk/.../descript....

www.newscientist.com/article/2508... Excellent piece including update on ME/CFS genetics and on our 'Rosetta' project on Long Covid and ME/CFS

Seven feel-good science stories to round up 2025. All too often we forget to celebrate the positives 🧪 #AcademicSky www.nature.com/articles/d41...

The CDC has endorsed ACIP’s decision of revoking universal access in USA to hepatitis B vaccines at birth. The policy had been in place for 34y and was changed despite no new evidence emerging of any risk of vaccination. #HealthPolicy 🧵

Get your flu vaccine and protect Gran at Xmas👇

“I hoped we’d broken that taboo during the pandemic. Masks do help us and there’s nothing wrong with wearing one. It’s sensible. If we could do it for one virus, why are we too proud to do it for another?” @daltmann.bsky.social quoted in (£) www.thetimes.com/life-style/h...

Was on Sky News this morning discussing Flu and whether this was a record bad year or not. Also discussed what we could do and the importance of vaccines, ventilation and wearing a mask if you're ill. youtu.be/_PZiU3R7jac

And in response to headlines like "there is no need for masks", here is the 1 minutes from my interview where I discuss basic preventative measures (including masks!). Also note that NHS stats like A&E and Ambulance waits are lower than same time 3 years ago, even with earlier flu wave.

So, to those who say "masks don't work", cite the flawed Cochrane report, insist upon an unfeasible RCT, accuse folks of panic, and undermine public health on social and mainstream media during a flu/RSV epidemic... 1. Seasonal viruses may be "normal", but they do immense harm.

Following Vinay Prasad and Tracy Hoeg’s allegations that they unearthed evidence of 10 infant deaths in the VAERs reports which they allege are linked to the covid vaccine, this ‘evidence’ still to be shared. Despite this the ‘findings’ look to influence changes in vaccine approvals & trials 🧵

Okay. This is angering me. First of all, “MAN”!? We’re not in the nineteenth century FFS. There’s a better word and it is “Humans”. And secondly - who the f£&k thought HUMANS only learned to control fire 50,000 years ago???!!! www.theguardian.com/science/2025...

Thanks for the kind comments. We’re hugely grateful to @meassociation.org.uk and all those who raised funds to make this possible

Beyond thrilled to hear this news about @daltmann.bsky.social and team receiving serious @meassociation.org.uk funding for an immunology project. Prof Altman has already been a great advocate, and I am thrilled this will enable him to keep working in the field. 👏👏👏👏👏

this is a direct consequence of the decisions made by the US to slash foreign health aid. BUT many European countries (inc UK) have also cut aid.

Astrocytes make up one-quarter of the brain. Nature reports how researchers are learning their value in shaping our behaviour, memory, and health. #Neuroskyence 🧪

“This irresponsible and purposely misleading guidance will lead to more hepatitis B infections in infants and children.” Read our full statement by AAP President Dr. Susan J. Kressly: www.aap.org/en/news-room...

So hard to watch well-established medical advances being discarded willfully 🧪 #MedSky Hepatitis B vaccine guidance set to be rolled back for US babies: what the science says www.nature.com/articles/d41...

Great thread on why hepatitis B is such an issue and why the vaccine at birth was SO important.

RFK Jr.’s hand-picked anti-vax panel has removed any doubt about their obvious bias and destroyed any shred of credibility for their decision-making process. CDC should reject this dangerous suggestion that will simply mean more babies die in the United States.

To be very clear, Kennedy's team is messing with a vaccine which has led to a 99 percent drop in the incidence of hepatitis B, which kills, early and painfully, 25 percent of the people who get it as children. lnk.thebulwark.com/3Xt957M

Excited to share our new @natecoevo.nature.com paper. We identified microbes found across nearly all ruminants that act as the functional backbone of both the rumen ecosystem and the host, with major implications for food security and climate change mitigation. (1/8) www.nature.com/articles/s41...