In the #gonad, #sex is not an irrevocable commitment, and requires active maintenance. Artyom Kopp explores a new @plosbiology.org study elucidating the molecular mechanisms that preserve sexual identity in the adult #Drosophila #testis 🧪 Paper: plos.io/4pMT6hq Primer: plos.io/3MRBBxG

In the #gonad, #sex is not an irrevocable commitment, and requires active maintenance. Artyom Kopp explores a new @plosbiology.org study elucidating the molecular mechanisms that preserve sexual identity in the adult #Drosophila #testis 🧪 Paper: plos.io/4pMT6hq Primer: plos.io/3MRBBxG

Slitrk1 & Slitrk2 are structurally & biochemically similar, so what role do they each play in #synapses? This study shows that each acts in distinct #hippocampal subfields & via different binding partners. Relevance to Slitrk2's association with #schizophrenia @plosbiology.org 🧪 plos.io/4qibtuo

In the #gonad, #sex is not an irrevocable commitment, and requires active maintenance. Artyom Kopp explores a new @plosbiology.org study elucidating the molecular mechanisms that preserve sexual identity in the adult #Drosophila #testis 🧪 Paper: plos.io/4pMT6hq Primer: plos.io/3MRBBxG

Slitrk1 & Slitrk2 are structurally & biochemically similar, so what role do they each play in #synapses? This study shows that each acts in distinct #hippocampal subfields & via different binding partners. Relevance to Slitrk2's association with #schizophrenia @plosbiology.org 🧪 plos.io/4qibtuo

Enteroendocrine cells (EECs) in the #gut #epithelium secrete diverse hormones that regulate digestion, energy use & behavior. @jfrawls.bsky.social &co identify EEC subtypes & #hormone profiles in #zebrafish, and explore their lineage relationships @plosbiology.org 🧪 plos.io/49iZKWC

Inside #macrophages, #Salmonella faces Mg2+ scarcity that disrupts cAMP synthesis & metabolism. @npokorzynski.bsky.social @microbelab.bsky.social &co show that PhoP restores control by promoting Mg2+ uptake & directing cAMP production to sustain growth via CRP @plosbiology.org 🧪 plos.io/3Lcav3T

2025 was marked by upheaval and uncertainty for many within the life science community. In this Editorial, we reflect on the past year and highlight some of the many research achievements that give us reasons to be thankful. 🧪 #AcademicSky #biology #EOY #science #roundup plos.io/4j5T3uh

How is somatic gonadal #sex fate maintained throughout adulthood? This study identifies a post-transcriptional mechanism involving repression of the TF Zelda by #miRNAs, safeguarding male identity & preventing activation of the female program in #Drosophila #testis @plosbiology.org 🧪 plos.io/4pMT6hq

Inside #macrophages, #Salmonella faces Mg2+ scarcity that disrupts cAMP synthesis & metabolism. @npokorzynski.bsky.social @microbelab.bsky.social &co show that PhoP restores control by promoting Mg2+ uptake & directing cAMP production to sustain growth via CRP @plosbiology.org 🧪 plos.io/3Lcav3T

How is somatic gonadal #sex fate maintained throughout adulthood? This study identifies a post-transcriptional mechanism involving repression of the TF Zelda by #miRNAs, safeguarding male identity & preventing activation of the female program in #Drosophila #testis @plosbiology.org 🧪 plos.io/4pMT6hq

2025 was marked by upheaval and uncertainty for many within the life science community. In this Editorial, we reflect on the past year and highlight some of the many research achievements that give us reasons to be thankful. 🧪 #AcademicSky #biology #EOY #science #roundup plos.io/4j5T3uh

Enteroendocrine cells (EECs) in the #gut #epithelium secrete diverse hormones that regulate digestion, energy use & behavior. @jfrawls.bsky.social &co identify EEC subtypes & #hormone profiles in #zebrafish, and explore their lineage relationships @plosbiology.org 🧪 plos.io/49iZKWC

Slitrk1 & Slitrk2 are structurally & biochemically similar, so what role do they each play in #synapses? This study shows that each acts in distinct #hippocampal subfields & via different binding partners. Relevance to Slitrk2's association with #schizophrenia @plosbiology.org 🧪 plos.io/4qibtuo

Thoughtful recap of 2025 by Joanna Clarke, including many discoveries made this year & the editors' picks of those we published in @plosbiology.org Want to guess? There are bright yellow worms, unusual mycomembranes, human response to avatars, tit learning strategies, soil science & more 🧪

Lovely celebration of 2025 for @plosbiology.org by my colleague Jo Clarke. My two nominations for this were journals.plos.org/plosbiology/... (by Chaolun Li &co) about worms turned yellow by orpiment, and journals.plos.org/plosbiology/... about a boom in AI-generated articles (by Matt Spick &co)...

Inside #macrophages, #Salmonella faces Mg2+ scarcity that disrupts cAMP synthesis & metabolism. @npokorzynski.bsky.social @microbelab.bsky.social &co show that PhoP restores control by promoting Mg2+ uptake & directing cAMP production to sustain growth via CRP @plosbiology.org 🧪 plos.io/3Lcav3T

How is somatic gonadal #sex fate maintained throughout adulthood? This study identifies a post-transcriptional mechanism involving repression of the TF Zelda by #miRNAs, safeguarding male identity & preventing activation of the female program in #Drosophila #testis @plosbiology.org 🧪 plos.io/4pMT6hq

2025 was marked by upheaval and uncertainty for many within the life science community. In this Editorial, we reflect on the past year and highlight some of the many research achievements that give us reasons to be thankful. 🧪 #AcademicSky #biology #EOY #science #roundup plos.io/4j5T3uh

Enteroendocrine cells (EECs) in the #gut #epithelium secrete diverse hormones that regulate digestion, energy use & behavior. @jfrawls.bsky.social &co identify EEC subtypes & #hormone profiles in #zebrafish, and explore their lineage relationships @plosbiology.org 🧪 plos.io/49iZKWC

Very happy to share the second paper from my postdoc, published today @plosbiology.org. Here, we report that the master regulator of Salmonella virulence usurps the reign of cAMP over metabolism under infection-relevant conditions. journals.plos.org/plosbiology/...

#MachineLearning methods are used to predict #AntimicrobialResistance #AMR from genomic data. @lbarquist.bsky.social &co show that sampling biases driven by population structure severely undermine the accuracy of AMR prediction models even with large datasets @plosbiology.org 🧪 plos.io/4iZ0zXQ

Age-related decline is restricted to specific #neuron types & #brain regions. This study shows components of the #Drosophila escape motor circuit vary in susceptibility to #aging & stressors, with plastic components being vulnerable & hard-wired components robust @plosbiology.org 🧪 plos.io/45gobl9

#MachineLearning methods are used to predict #AntimicrobialResistance #AMR from genomic data. @lbarquist.bsky.social &co show that sampling biases driven by population structure severely undermine the accuracy of AMR prediction models even with large datasets @plosbiology.org 🧪 plos.io/4iZ0zXQ

Age-related decline is restricted to specific #neuron types & #brain regions. This study shows components of the #Drosophila escape motor circuit vary in susceptibility to #aging & stressors, with plastic components being vulnerable & hard-wired components robust @plosbiology.org 🧪 plos.io/45gobl9

Are authors fairly judged by assessing the #journals in which their work is published? @bihutchins.bsky.social &co reveal that most influential papers are published in lower tier journals, and more authors would be better recognized with #ArticleLevelMetrics #ALMs @plosbiology.org 🧪 plos.io/4oV58Ed

AI folks now having to realise what GWAS folks did about studying bacterial genome datasets. Great work by great researchers

#MachineLearning methods are used to predict #AntimicrobialResistance #AMR from genomic data. @lbarquist.bsky.social &co show that sampling biases driven by population structure severely undermine the accuracy of AMR prediction models even with large datasets @plosbiology.org 🧪 plos.io/4iZ0zXQ

Are authors fairly judged by assessing the #journals in which their work is published? @bihutchins.bsky.social &co reveal that most influential papers are published in lower tier journals, and more authors would be better recognized with #ArticleLevelMetrics #ALMs @plosbiology.org 🧪 plos.io/4oV58Ed

Age-related decline is restricted to specific #neuron types & #brain regions. This study shows components of the #Drosophila escape motor circuit vary in susceptibility to #aging & stressors, with plastic components being vulnerable & hard-wired components robust @plosbiology.org 🧪 plos.io/45gobl9

Are authors fairly judged by assessing the #journals in which their work is published? @bihutchins.bsky.social &co reveal that most influential papers are published in lower tier journals, and more authors would be better recognized with #ArticleLevelMetrics #ALMs @plosbiology.org 🧪 plos.io/4oV58Ed

THIS

Excited to share our story nutrition and cell quiescence in sea anemones, great postdoctoral work of @eudaldpascual.bsky.social Finally out in @plosbiology.org And thanks to @msarscentre.bsky.social for the nice news piece: www.uib.no/en/michaelsa...

Single-cell RNA-sequencing based on combinatorial barcoding is pricey and lacks sensitivity. USPPAR is a novel #scRNAseq approach that combines split-pool #barcoding & optimized polydeoxyadenylation, outperforming existing methods without specialized equipment @plosbiology.org 🧪 plos.io/3XUsleH

A reduced rate of synonymous site evolution is often presented as key evidence for #selection on #SynonymousMutations. However, this study shows that paradigmatic low rate in the first 10 codons of bacterial genes is well explained by mutation, NOT selection @plosbiology.org 🧪 plos.io/4s4tIoY

Single-cell RNA-sequencing based on combinatorial barcoding is pricey and lacks sensitivity. USPPAR is a novel #scRNAseq approach that combines split-pool #barcoding & optimized polydeoxyadenylation, outperforming existing methods without specialized equipment @plosbiology.org 🧪 plos.io/3XUsleH

A reduced rate of synonymous site evolution is often presented as key evidence for #selection on #SynonymousMutations. However, this study shows that paradigmatic low rate in the first 10 codons of bacterial genes is well explained by mutation, NOT selection @plosbiology.org 🧪 plos.io/4s4tIoY

💡How does nutrition regulate cell cycle in stem cells? Check out our new paper from @prhsteinmetz.bsky.social lab & @msarscentre.bsky.social, out now in @plosbiology.org (plos.io/48J2o6P) #SeaAnemone #Nematostella #StemCell #CellCycle #Quiescence #TORsignalling 1/12

Single-cell RNA-sequencing based on combinatorial barcoding is pricey and lacks sensitivity. USPPAR is a novel #scRNAseq approach that combines split-pool #barcoding & optimized polydeoxyadenylation, outperforming existing methods without specialized equipment @plosbiology.org 🧪 plos.io/3XUsleH

What links AI-generated peer review, Neanderthal mobility, peat accumulation and antimicrobial resistance with dancing cockatoos, Asian elephants, turning soccer players and Barbie's feet? They all feature, along with much more, in this year's editors' highlights! everyone.plos.org/2025/12/16/e...

A reduced rate of synonymous site evolution is often presented as key evidence for #selection on #SynonymousMutations. However, this study shows that paradigmatic low rate in the first 10 codons of bacterial genes is well explained by mutation, NOT selection @plosbiology.org 🧪 plos.io/4s4tIoY

CDKL5 Deficiency Disorder (CDD) leads to seizures & intellectual disability. This study shows that #Chlamydomonas CDKL5 kinase is activated by the LF2/CDK20 kinase; CDKL5 in turn regulates #intraflagellar transport via protein abundance & phosphorylation #cilia @plosbiology.org 🧪 plos.io/45490eP

CDKL5 Deficiency Disorder (CDD) leads to seizures & intellectual disability. This study shows that #Chlamydomonas CDKL5 kinase is activated by the LF2/CDK20 kinase; CDKL5 in turn regulates #intraflagellar transport via protein abundance & phosphorylation #cilia @plosbiology.org 🧪 plos.io/45490eP

Hepatocyte-to-cholangiocyte transdifferentiation (HCT) may play a role in #liver #regeneration, but how is it regulated? This study shows that HCT bypasses a hepatoblast-like state and requires derepression of an epithelial transcriptional program mediated by GRHL2 @plosbiology.org 🧪 plos.io/48JI3xW

Why so many co-circulating #Klebsiella pneumoniae clones? By studying >7000 isolates, @bananabenana.bsky.social @kelwyres.bsky.social &co identify structured, clone-specific #metabolic specialisation across the population that enables reciprocal cross-feeding @plosbiology.org 🧪 plos.io/4qdC2B2

Is #Bsubtilis a good model for the spore-forming #anthrax #pathogen B. anthracis? This study identifies >150 B. anthracis #sporulation genes and cytologically phenotypes the mutants, revealing similarities & striking differences between model & pathogen @plosbiology.org 🧪 plos.io/3YsvlyZ

Hepatocyte-to-cholangiocyte transdifferentiation (HCT) may play a role in #liver #regeneration, but how is it regulated? This study shows that HCT bypasses a hepatoblast-like state and requires derepression of an epithelial transcriptional program mediated by GRHL2 @plosbiology.org 🧪 plos.io/48JI3xW

Is #Bsubtilis a good model for the spore-forming #anthrax #pathogen B. anthracis? This study identifies >150 B. anthracis #sporulation genes and cytologically phenotypes the mutants, revealing similarities & striking differences between model & pathogen @plosbiology.org 🧪 plos.io/3YsvlyZ

What underlies the dynamics of #RedBloodCell production? Nicola Wilson explores a @plosbiology.org study that suggests a broadly applicable mechanism able to balance the maintenance of the steady-state with an effective stress response 🧪 #erythropoiesis Paper: plos.io/3KDskbX Primer: plos.io/4j4QBV1

CDKL5 Deficiency Disorder (CDD) leads to seizures & intellectual disability. This study shows that #Chlamydomonas CDKL5 kinase is activated by the LF2/CDK20 kinase; CDKL5 in turn regulates #intraflagellar transport via protein abundance & phosphorylation #cilia @plosbiology.org 🧪 plos.io/45490eP