#ResultatScientifique 🔎 Certains gènes antiviraux humains partagent des défenses communes avec les bactéries, révélant une convergence évolutive surprenante 🧬 ✍️ Alexandre Legrand et @lucievirevolte.bsky.social 📕 Nature Ecology and Evolution buff.ly/Su0EdiU

📖Latest from the lab: Evo. characterization #antiviral #SAMD9/9L across #kingdoms🚶‍♀️🦍🦠🧫🖥️: ancient #convergence + #adaptations @natecoevo.nature.com Led by amazing Alexandre Legrand +major contributions by Rémi Demeure & Amandine Chantharath @ciri-lyon.bsky.social 1/n www.nature.com/articles/s41...

Come join us in beautiful Britanny, France in May 2026 for a workshop that I am organizing with @lucievirevolte.bsky.social and @psudmant.bsky.social on Rapid host adaptations to infections: sites.google.com/berkeley.edu...

Super excited to receive the ERC starting grant to explore what phage-bacteria interactions can teach us on host-pathogen conflicts 🤩 I'm immensely grateful to my wonderful team and to present and past mentors 🙏

🦠🧍‍♀️From bacterial to human immunity. We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity. Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social www.science.org/doi/10.1126/...

🚨Our new study out today in Nature Communications. Bats can asymptomatically host multiple viruses while remaining apparently healthy. Here we identify how interferon-mediated responses protect bats and identify molecular adaptations in GBP1. #LZCI Link: www.nature.com/articles/s41...

#standupforscience in Lyon! For science in France and in the world. In solidarity to our American colleagues.

Stand up for science Lyon / Grand Est : *Lyon* 16h00 – Rassemblement place des Terreaux. *Nancy* 10h00 – Débats. Amphithéâtre de la présidence Léopold, 34 cours Léopold, Nancy. 12-30-13h30 – ronde des obstiné·e·s. Place Stanislas, Nancy.

We're hiring a Group Leader in Infection Biology! 🧬 Apply now to join us at the IRIM in Montpellier, and lead cutting-edge research in pathogen virulence, host-pathogen interactions or drug resistance, and shape the future of infection biology! 🦠🧫 Please RT (and follow us!) 🗓️ Deadline: Feb. 28, 2025

#TalentsCNRS 🥉 | Découvrez la vidéo de Lucie Etienne, chercheuse au Centre international de recherche en infectiologie et lauréate de la médaille de bronze du @cnrs.fr en 2024 ! @cnrsbiologie.bsky.social @lucievirevolte.bsky.social @ensdelyon.bsky.social @inserm.fr www.youtube.com/watch?v=jE8b...

Thorough and nice study from @lucievirevolte.bsky.social and colleagues. Bat GBP5.

New paper with @lucievirevolte.bsky.social and @psudmant.bsky.social, led by Lucie Etienne and Amandine Le Corf. The sub-cellular localization of important innate antiviral factor GBP5 has evolved multiple times during bat evolution, with consequences for activity. www.biorxiv.org/content/10.1...

👀Our latest work, led by Amandine Le Corf fantastic PhD student alumni @biorxivpreprint.bsky.social . Great collab @denard.bsky.social @psudmant.bsky.social Genomic and functional #adaptations in #GBP5 highlight specificities of #bat antiviral innate #immunity 🦇🦠 www.biorxiv.org/content/10.1...

New @erc.europa.eu funded #ConvergeAnt paper on phylogenetics and transcriptomics of chitinase gene repertoires in convergent ant-eating mammals finally published in @genomebiolevol.bsky.social doi.org/10.1093/gbe/...

Congratulations @memerman.bsky.social !! So well deserved! Your mentorship is incredible - Thank you

We are looking for a #postdoc to discover cell-autonomous innate immune antiviral factors in mammals, based on newly-identified defense of prokaryotes! #EvoCure #comparativeImmunology #virology Please share @inserm.fr @ciri-lyon.bsky.social @cnrsbiologie.bsky.social ciri.ens-lyon.fr/teams/lp2l/j...

Our paper out @CellCellPress: Structure guided discovery of viral proteins that inhibit host immunity Congrats Erez Yirmiya, Azita Leavitt, Gil Amitai, our collaborators at the Kranzusch lab, and coauthors A 🧵 1/10 www.cell.com/cell/abstrac...

Exciting to see our paper now published 🙌 www.science.org/doi/10.1126/... In this project co-led with @ostermanilya.bsky.social at @soreklab.bsky.social , we show that a bacterial immune system employs a TIR protein and a caspase-like protease, two typical immune components seen in eukaryotes. 🧵👇

Delighted to share our latest work on SARS-CoV-2 Nucleocapsid and Nonsense-Mediated mRNA Decay. 👇 doi.org/10.1093/nar/...

Final thoughts: 💡TRMT1 cleavage & inactivation may be another mechanism by which SARS-CoV-2 manipulates host tRNA modifications and translation! 🦠We think this could impact viral pathogenesis or phenotypes! 💊Our structure might help understand Mpro substrate recognition or different pockets to drug!

Next, with @lucievirevolte.bsky.social we found that the TRMT1 cleavage sequence is highly conserved in mammals, except for some #rodents 🐭, where a Q -> K mutation at the absolutely critical Q residue makes TRMT1 variants with this change entirely resistant to cleavage!... 6/9

📣 Final version of our @elife.bsky.social article is now online! We show how the human tRNA methyltransferase TRMT1 is recognized, cleaved, and inactivated by the SARS-CoV-2 main protease to disrupt host tRNA modification! elifesciences.org/articles/91168 A short bluetorial... 🧵 1/9

🎁 Early Xmas present from your friends at the MRC-University of Glasgow Centre for Virus Research @cvrinfo.bsky.social We're thrilled to unwrap Viro3D - a comprehensive database of virus protein structures: >85,000 predicted structures from 4,400 human & animal viruses! 🦠 viro3d.cvr.gla.ac.uk

Excited to share the major work of my dissertation, out now in @currentbiology.bsky.social! We use Drosophila genetics to dissect the evolution of phage-derived toxins that were horizontally transferred to insects and now function as potent anti-parasitoid defenses (1/n): tinyurl.com/2k9ypyxr

Get ready for ASV 2025! The 2025 American Society for Virology meeting will be hosted by McGill University and held at the Palais des Congrès de Montréal, Montréal, Québec, Canada from July 14 - 17, 2025. Abstract submission, travel award apps, and registration are now open! asv.org/asv2025/regi...

Our work on cellular RNA interactions with MAVS that promote antiviral signaling is finally live. So grateful to our indispensable collaborators as well as reviewers who helped to strengthen our work. #RNA #innateimmunity #virology @ramlabuw.bsky.social www.science.org/doi/10.1126/...

2024 Science Breakthrough of the year: #HIV prevention 💜 www.science.org/content/arti...

Latest preprint from @morielab.bsky.social #CRBM and our team @irim-life.bsky.social! Fantastic collaboration, started over a Zoom on an evening of the lockdown in April 2020 with María exposing us her ideas... >4,5 years later, here are the results! biorxiv.org/content/10.1... 1/5

Working on Negative Strand RNA viruses? Here is the THE meeting you don't want to miss in 2025: #NSV2025! It will take place in vibrant Montpellier, South of France, and is organized by Wendy Barclay, Paul Duprex, Sean Whelan and Olivier Moncorgé Please share widely! #ViroSky #LoveVirology

We can then leverage the wealth of structure predictions and tools available in the post-alphafold era to gain a structural rationale for substrate specificity. Huge shout out to @martinsteinegger.bsky.social for both foldseek and foldmason - couldn't have made this work without these tools!

We found high levels of adaptive evolution in genes expressed in barrier tissue immune cells including 🫁, and/or expressed early during immune responses --> host adaptation likely works best when it cuts infections short early, before pathogens reach high numbers. www.nature.com/articles/s41...

Our Big Fantastic Virus Database (BFVD) is now published NAR! It contains protein structure predictions of major viral clades, enhanced by petabase-scale homology search and it's explorable on the web. 🌐 bfvd.foldseek.com 💾 bfvd.steineggerlab.workers.dev 📄 academic.oup.com/nar/advance-...

Rachel Van Gelder, a recently minted PhD from the lab, shows IL-2 splices IFNG mRNA introns, increasing protein levels via NF-κB signaling. She uncovers a novel role for cytokine-induced splicing in immunity! 🧬 #RNA #Immunology #Research www.embopress.org/doi/full/10....

Let's introduce this new account with an overdue announcement! I officially started my new position as a CNRS permanent researcher @irim-life.bsky.social in October! 🥳 Happy to come back to this vibrant Institute and start a new chapter of my career 😊

New GPU-based MMseqs2: 20x faster searches on a single L40S (approx. as fast as a RTX 4090) vs. a 128-core CPU. This work enables to set up a very cost-efficient ColabFold MSA GPU server. 🧵🧵 📄 www.biorxiv.org/content/10.1... 💾 mmseqs.com 🗞️ developer.nvidia.com/blog/boost-a...

Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!

A starter pack for all virologists out there on the blue side ! Might be missing some people but it’s a good start ! go.bsky.app/DmphBCT

Wonder why bats host many zoonotic viruses? With @lucievirevolte.bsky.social and @psudmant.bsky.social labs and using 8 new Myotis assemblies, we find that DNA viruses drove most host bat adaptation, contrary to human adaptation dominated by RNA viruses. www.biorxiv.org/content/10.1...

Extensive longevity &DNAvirus-driven adaptation in Myotis bats Tremendous work by Juan Manny Vazquez + M Elise Lauterbur🤩 [email protected] &great crew of ppl Awesome collab w. @psudmant.bsky.social & @denard.bsky.social labs to illuminate 🦇 functional evolution www.biorxiv.org/content/10.1...