The mechanism of STING NF-κB signaling has remained a mystery. An exciting new study from the Paludan lab now uses data throughout animal STING evolution to provide new answers – including isolating white blood cells from turtles and carp! www.nature.com/articles/s41...

Looking for a new approach to studying or eliminating phages? Check out our study introducing anti-phage ASOs (antisense oligos) out in @Nature today. nature.com/articles/s4158…

New short paper from our lab @currentbiology.bsky.social, in which we discover of a new mode of cell motility for choanoflagellates: flagellar gliding. www.cell.com/current-biol... - A 🧵

Come join the Nomburg Lab in lovely Vienna! As our first listing, we have a research technician position available to help support the research and operations of the lab. If you're passionate about virology and innate immunity, apply here! aithyra.onlyfy.jobs/job/3njyn4ey

📣 We are excited to share our latest paper, led by @taliashaler.bsky.social! We explore the transcriptional basis of #microalgae resistance to #viral_infection and identified a core group of resistance-related genes. >> (1/3) #New_Phytologist #Marine_Biology #Viruses

So excited our antibiotic potentiation story is out 🤩 Led by the extraordinary @manonlang.bsky.social with @fox-science.bsky.social & @amazeld.bsky.social +amazing collaborators @immunobladder.bsky.social @imaneelmeouche.bsky.social 🦠 We believe it can make a difference in #AMR infections!

Effector-triggered immunity (ETI) indirectly detects pathogen effector activity on the host cell. Kevin Barthes,Tanita Wein and I examine how prokaryotic and eukaryotic viruses deploy similar effectors that activate ETI, underscoring its central role across the tree of life. tinyurl.com/mr3a3xh2

YAYYYY, Immune systems of choano !!!! Beautiful to see how knowledge about bacterial immune systems illuminate immunology in diverse organisms with the always incredible biochemistry and structural approaches of @kranzuschlab.bsky.social. Wonderful work @yao-li.bsky.social 👏

Thanks to the authors of this piece. I love reading about the work of inspiring pioneers in bacterial genetics. Crazy amount of discoveries! Pioneer of bacterial genetics: the legacy of Esther Miriam Lederberg academic.oup.com/genetics/adv...

📢 New preprint alert! We designed synthetic proteins that can block bacterial immune systems, allowing phages + plasmids to overcome natural defenses. This could transform phage therapy + genetic engineering. Here’s what we found 🧵 Preprint🔗: www.biorxiv.org/content/10.1...

Preprint: De-novo design of proteins that inhibit bacterial defenses Our approach allows silencing defense systems of choice. We show how this approach enables programming of “untransformable” bacteria, and how it can enhance phage therapy applications Congrats Jeremy Garb! tinyurl.com/Syttt 🧵

👏 Huge congrats to @audeber.bsky.social, group leader and head of our Molecular Diversity of Microbes lab, on being named a 2025 Vallee Scholar! Her pioneering work on ancestral immunity opens new perspectives for biomedical innovation. 🔬🌍 @valleefoundation.bsky.social #Science #Immunity

Super cool study revealing the diversity of viral sponges. I love the scale of the work with great experimental assays underlying a systematic approach! Congrats to @romihadary.bsky.social and @reneechang.bsky.social for this beautiful piece of science.

Great study indeed, demonstrating how functional amyloid mediate antiphage defense. Probably many more systems out there working that way!

Very interesting work from Ibarlosa and colleagues regarding functional amyloid forming proteins in prokaryotic immunity. www.nature.com/articles/s41... Check out our News & Views summary of the work as well! rdcu.be/eBHxh

Exciting times ahead! Today marks the first day of the Loeff Lab at Leiden University Medical Center in the Netherlands 🇳🇱. I’m thrilled to begin this new adventure and continue exploring microbial defense mechanisms and their applications through an integrative structural biology approach.

#NewResearch Prion-like proteins in Escherichia coli trigger an abortive infection mechanism in response to phage infection—a process similar to amyloid-mediated immune signalling in fungi and animals. #MicroSky 🦠 www.nature.com/articles/s41...

#NatMicroPicks Ancient Proteins, Modern Immune Insights! 🦠 A conserved protein family member activates inflammation via the Toll-like receptor pathway in mammals highlighting new aspects of human immunity. www.science.org/doi/10.1126/...

We wrote a review on the free nucleotide pool as a central playground in human, bacterial, and plant immunity – now out in Nature Reviews in Immunology www.nature.com/articles/s41... Was fun to write this piece with Dina Hochhauser! Here is a thread to explain the premises 1/

Expression level of anti-phage defence systems controls a trade-off between protection range and autoimmunity By Nitzan Aframian and Avigdor Eldar. www.nature.com/articles/s41...

Thrilled to see our Kiwa story out today! A membrane-associated supercomplex that senses infection and blocks replication and transcription. www.cell.com/cell/fulltex... Huge congratulations to Yi and Zhiying for bringing it home, to Thomas for starting us off, and to all the collaborators.

Very proud to have our lab’s first work published in @cp-cellhostmicrobe.bsky.social! In this work, we use functional metagenomics to find phage defenses from human and soil microbiomes! Congrats to first author @luis840alberto.bsky.social ! www.cell.com/cell-host-mi... (1/3)

Excited to finally share this work! We noticed a pair of genes - a nuclease and a protease - shuffles between antiviral systems. We show how proteolysis activates the nuclease, triggering defense in known and unknown immune contexts. tinyurl.com/2uwwy4ty

NEW Review from @soreklab.bsky.social @dinahoch.bsky.social explains how immune pathways manipulate the availability of nucleotides, chemically modify nucleotides to generate immune signalling molecules, and produce altered nucleotides that poison viral replication #immunosky #microsky #phagesky

Evolutionary molecular biology paying dividends again - this time in finding new modulators of innate immunity - www.science.org/doi/10.1126/...

👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀

Another amazing discovery from the @audeber.bsky.social lab, working with @enzopoirier.bsky.social to demonstrate functional conservation of immune mechanisms across domains of life! Congrats to @hugovaysset.bsky.social and co-authors!!

Wow - an important component of a central human innate immune pathway was discovered based on homology to a bacterial anti-phage defense system A beautiful example showing how new knowledge on bacterial immunity translates to discoveries important for human health

🧬 From bacteria to humans: a new study led by @institutcurie.bsky.social, @institutpasteur.bsky.social & @inserm.fr reveals SIRal, a novel human immune protein with ancestral roots. A new path for immunotherapy? 🔗 Read: www.pasteur.fr/en/press-are...

Protein-centric view of immunity IDs SIRims, a new family of immune proteins conserved across kingdoms of life w/ SIRal driving TLR-driven inflammation and antipathogen defense @science.org @enzopoirier.bsky.social @audeber.bsky.social @hugovaysset.bsky.social www.science.org/doi/10.1126/...

This is cracking research. And the video is great. We are all evolved from hot pondlife. www.youtube.com/watch?v=rqWj...

Fascinating story ⬇️

Crowd favourite @audeber.bsky.social You heard it first @ Lorne Proteins 50th anniversary - the incredible story of bacterial antiphage protein homologs in human, mice, fish... with conserved innate immune function is out now in Science. 🤩🤯 🙌 bsky.app/profile/aude...

1/16 New pre-print from the Sternberg Lab! We uncover how temperate phages can use RNA-guided transcription factors to remodel the flagellar composition of their bacterial host and enhance their fitness. Find the preprint and full story here: tinyurl.com/mshwjd77

simply wonderful science 🤩

Many components of human immunity evolved from ancient pathways in bacteria. A beautiful story from @audeber.bsky.social‬ @enzopoirier.bsky.social‬ leverages this evolutionary connection to discover SIRal as a signaling protein in animal TLR-mediated innate immunity. www.science.org/doi/10.1126/...

🦠🧍‍♀️From bacterial to human immunity. We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity. Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social www.science.org/doi/10.1126/...

Here's our new broad review on the extended mobility of plasmids, about all mechanisms driving and limiting their transfer. From conjugation to conduction, phage-plasmids to hitchers, molecular to evolutionary dynamics, ecology to biotech. The state of affairs. 1/9 academic.oup.com/nar/article/...

Next up from our lab - a ring nuclease with a novel fold which cleaves all cOA species involved in Type III CRISPR defence. It's also found in plasmid and phage genomes, where it presumably functions as an anti-CRISPR. www.biorxiv.org/content/10.1...

Beyond homology: This mind blowing work demonstrates the power of genomics driven analogy for discovery in the era of structure predictions. The diversity of defense systems emerged thx to "guilt by association approaches". New analogies to uncover molecular novelties 👇. 👏 Nitzan, Rotem & al.

So great to the @kranzuschlab.bsky.social here! Incredible work presented earlier this year at the immune system of bacteria conference by super talended Sonomi Yamaguchi dissecting how Clover manipulates nucleotides in bacterial immunity. The structures and mechanism are 🤩🤩

Starting the lab Bluesky account to share a preprint from @aragucci.bsky.social and @sadieantine.bsky.social‬ that reveals molecular principles shared across diverse nuclease-NTPase anti-phage defense systems in bacterial immunity (1/7) www.biorxiv.org/content/10.1...

A new preprint led by Sonomi Yamaguchi in our lab describes a bacterial anti-phage defense system named Clover that uses nucleotide signals to both activate and inhibit host immunity. www.biorxiv.org/content/10.1...

So great to see the work of the lab being brillantly presented at conferences across 🇮🇹🍦🍝, @matthieu-haudiquet.bsky.social on Evolution and Mechanism of Lamassu in FEMS, Milan and Ernest Mordret on LLM for prediction of antiphage systems in GRC Evolutionary Genomics,Tuscany. Check out their work 👇

📢Preprint out! Excited to share my final work from the @soreklab.bsky.social! We mined phage dark matter using structural features shared by anti-defense proteins (viral tools that help phages bypass bacterial immunity) to guide discovery. Found 3 new families targeting immune signaling!

www.youtube.com/watch?v=hMH1... I am very thankful to the @ec.europa.eu for highlighting my research at @institutpasteur.bsky.social . It is a privilege for me to have the opportunity of developing my professional life here.

Excited to share the lab's 1rst preprint! Rapid high-res immunofluorescence is now possible in cultured & environmental diatoms thanks to 4-fold expansion microscopy. A step-change for comparative cell biology in one of the most important phytoplankton groups on the planet 🥳 tinyurl.com/m9s5su7s 1/2

Happy to represent bacterial immunity with great bacterial immunologist Tana Wein at a conference honouring the 40th birthday of Toll discovery, made in Drosophila. Really fun to be celebrating the contribution of diverse organisms to our understanding of immunity 🪰🐘🦠.