Thanks for recapping the most intriguing #RockefellerScience stories of 2025 with us, Happy New Year! 👩🏽‍🔬 🥂 🦠 🎉 🧬 See the full 2025 #YearInReview here: https://bit.ly/44LtGrW

Scientists in the @alushinlab.bsky.social figured out how cells build a structure that lets them migrate. Unpacking these “finger-like” protein bundles that protrude from cells may lead to novel treatments for #metastasis. #RockefellerScience #YearInReview 🔗: https://bit.ly/3PKErmA

A study from @danmucida.bsky.social and @victora.bsky.social showed how immune cells in the gut distinguish between food and harmful pathogens, shedding light on the origins of #foodallergies. #RockefellerScience #YearInReview 🔗: https://bit.ly/4hyS18b

A study from the #RutaLab explained how the fruit fly brain coordinates courtship and aggressive competition—a framework which could help scientists understand how the human brain balances cooperation and competition. #RockefellerScience #YearInReview 🔗: https://bit.ly/4gI7phV

A study from Erich Jarvis and @darnelr.bsky.social found that a single protein variant found only in humans may have helped shape the emergence of spoken language. When put in mice, the variant altered their vocalizations. #RockefellerScience #YearInReview 🔗: https://bit.ly/3Yfdcoh

A study from the #FriedmanLab identified a neural mechanism involved in leptin resistance, a factor contributing to #obesity. Crucially, they also found a way to reverse it in mice using a well-known drug. #RockefellerScience #YearInReview 🔗: https://bit.ly/3MV0WqC

Clinical trials based on work from the Nussenzweig lab showed that two broadly neutralizing antibodies can keep #HIV suppressed for months. The data suggest that the antibodies may even diminish the viral reservoir itself. #RockefellerScience #YearInReview 🔗: https://bit.ly/4pkY045

A new method from @hirofunabiki.bsky.social dramatically improved cryo-EM’s imaging capabilities, enabling visualization of molecules that are very rare, very small, or hard to produce naturally—including some viruses. #RockefellerScience #YearInReview 🔗: https://bit.ly/4awR4gv

The #StricklandLab discovered that amyloid-beta (Aβ) oligomers and the vascular protein fibrinogen may, when forming a complex, contribute to Alzheimer's disease. #RockefellerScience #YearInReview 🔗: https://bit.ly/44Eh31R

The #StellerLab found that boosting PI31 can prevent neuronal degeneration, restore synaptic function, and significantly extend lifespan in fly and mouse models of rare genetic disorders similar to Parkinson’s. #RockefellerScience #YearInReview 🔗: https://bit.ly/3MOlmSc

Research from the Fuchs lab showed that low levels of the amino acid serine trigger a process that turns hair follicle stem cells into skin repair specialists—and that diet may have a role to play. #RockefellerScience #YearInReview 🔗: https://bit.ly/4jfd9CA

Rockefeller's Li Zhao spent nearly a decade cataloguing evolutionarily young genes. This year, her lab demonstrated how these new genes are regulated and expressed. #RockefellerScience #YearInReview 🔗: https://bit.ly/4jdvwb8

Treatments for autoimmune diseases have big shortcomings, including high cost and supply shortages. A alternative developed this year from the #RavetchLab achieves the same effectiveness at a fraction of the dose. #RockefellerScience #YearInReview 🔗: https://bit.ly/3HFdsbs

A study from the Birsoy lab showed that the antioxidant glutathione, when operating inside mitochondria, is a key factor enabling tumors to spread from the breast to the lung. #RockefellerScience #YearInReview 🔗: https://bit.ly/44GfOPG

Shortly before his death this year, James Hudspeth achieved a groundbreaking technological advancement: the ability to keep a tiny sliver of the cochlea alive and functional outside of the body for the first time. #RockefellerScience #YearInReview 🔗: https://bit.ly/49oaOlo

The #BradyLab identified compounds that appear effective against drug-resistant bacteria using a new technique that could uncover many more antibiotics, as well as help illuminate a previously hidden microbial world. #RockefellerScience #YearInReview 🔗: https://bit.ly/4sjhV6j

The first detailed look at how mosquitoes mate from the Vosshall lab reversed the assumption that male mosquitoes control the process, finding that a subtle female behavior dictates if mating will take place or not. #RockefellerScience #YearInReview 🔗: https://bit.ly/4huwEpL

Neuroscientists have long posited that #memory functions like an on/off switch—either your brain remembers something or it doesn’t. The #RajasethupathyLab discovered that the truth is more complicated. #RockefellerScience #YearInReview 🔗: https://bit.ly/3MoSsrj

The #WalzLab revealed key details about the T cell receptor, which is essential to T cell immunotherapies. The findings could expand T cell therapies, bringing their benefits to a broader group of #cancer patients. #RockefellerScience #YearInReview 🔗: https://bit.ly/3L0r3vK

Winter break is upon us! Stay tuned as we count down the most intriguing #RockefellerScience stories of 2025. #YearInReview

Scientific publishing has a bias against negative results and that hurts science, says Tim Fessenden, editor of @lsajournal.org, a publication of @rupress.org. Here’s how journal editors can help.

The #RajasethupathyLab has identified a gene that improves attention, findings in @natneuro.nature.com#RajasethupathyLabthat may lead to a novel therapeutic approach to calming the mind. The study has implications for treating #ADHD as well as autism and schizophrenia.

A study from the #TarakhovskyLab reveals how diapaused embryonic stem cells maintain their ability to become any cell type. This newly discovered mechanism may explain how immune cells—and even #cancer cells—can survive long periods of metabolic stress.

In @natureportfolio.nature.com: Researchers, including Rockefeller's own Gabriel Victora (@victora.bsky.social), are striving to understand the impact a phenomenon known as original antigenic sin has on immunity to the virus that causes the flu.

Researchers in the #RavetchLab have developed a potential replacement for treating #autoimmunedisease that’s significantly more potent than intravenous immunoglobulin therapy. Learn more in this Q&A with Jeffrey Ravetch and first author Andrew Jones: https://bit.ly/3KTnzLy

Don't miss this Q&A with Leslie Sibener of the #RajasethupathyLab from the @simonsfoundation.org#RajasethupathyLab In it, Sibener discusses her research on how our brains prioritize which memories to hold onto and which to let go.

A new study from the #WalzLab has revealed key details about the T cell receptor, which is essential to T cell immunotherapies. The findings could refine and expand T cell therapies, bringing their benefits to a much broader group of cancer patients.

A growing body of research, including work from Rockefeller's own @sohailtavazoie.bsky.social, suggests tumors rely on proteins and genes that are unique to the nervous system to persist in the body: https://www.nature.com/articles/d41586-025-03943-3

Rifampicin, the main treatment for TB, is losing ground against drug-resistant bacteria. A new study from @rocklabtb.bsky.social and Liz Campbell in @natmicrobiol.nature.com finds that pairing rifampicin with a second inhibitor dramatically boosts the potency of both drugs.

The Stavros Niarchos Foundation Institute for Global Infectious Disease Research at Rockefeller aims to better understand the agents that cause infectious disease and to lower barriers to treatment and prevention globally. Get a closer look:

In creating the first reference brain for the clonal raider ant, @danielkronauer.bsky.social has discovered a surprising individuality of brain characteristics that may yield new insights into the #neuroscience of individuality within animal societies. 🔗: www.rockefeller.edu/news/38754-a...

Rockefeller's @junyuecao.bsky.social has been named a Hevolution/@afar.org New Investigator Awardee in Aging Biology and Geroscience Research. Congratulations, Jun! https://www.afar.org/grantee-profiles/junyue-cao-1

Rockefeller's Elaine Fuchs tells @knowablemag.bsky.social how animals actively reallocate their amino acid resources in times of scarcity. Her research found that when animals were deprived of serine, skin stem cells devoted less effort to making hair.

Congrats to @alercher.bsky.social of the #RiceLab, who has won the 2025 Sidney & Joan Pestka Post-Graduate Award from the @cytokinesociety.bsky.social#RiceLab

This #WorldSoilDay we celebrate Rockefeller's Sean Brady and his Drugs from Dirt research program, which sifts through soil samples from around the world in search of new antibiotics. Learn more in this 2024 piece from the @newyorker.com#WorldSoilDayby Dhruv Khullar:

"Even when we’re carrying out molecular studies on stem cells, my lab is always trying to look at the big picture and adjust the driving questions we ask so that we can bridge the gap between basic science and medicine."

Congrats to Yuanhuang Chen in the Sakmar lab for being awarded a predoctoral fellowship in drug discovery from the @phrmafoundation.bsky.social!

New Rockefeller research from Michael Rout and Brian Chait finds that nuclear pore complex (NPC) machinery is an extraordinarily dynamic system, offering new insights into diseases such as #cancer and #neurodegeneration that are linked to NPC breakdown: https://bit.ly/3KAlrIk

New research from Rockefeller's Michel Nussenzweig and colleagues finds one particular class of immune cells appears to play a crucial role in achieving a functional cure among people with HIV. #worldAIDSday

Cells stop dividing when telomeres become too short, a process known as replicative senescence. A new study from the #deLange lab reveals what drives this, and why cells senesce far earlier under high-oxygen conditions versus low-oxygen ones.

Rockefeller researchers Shixin Liu and Joel Cohen reveal how key regulatory proteins work in a precise hierarchy to meticulously adjust pacing during transcription.

Head to Mosquitos: Cell atlas reveals sex differences in mosquitos – potentially applicable for disease spread management 📷 @oliviagoldman.net, AlexandraDefoe et al @rockefeller.edu in @cellpress.bsky.social ➡️ bpod.org.uk/archive/2025... with John Ankers

New #research from Priya Rajasethupathy shows that long-term memory is formed by a cascade of molecular timers across brain regions. “What we choose to remember is a continuously evolving process rather than a one-time flipping of a switch," she says. 🔗:https://bit.ly/44tpEUT

New #research from Priya Rajasethupathy shows that long-term memory is formed by a cascade of molecular timers across brain regions. “What we choose to remember is a continuously evolving process rather than a one-time flipping of a switch," she says.

How do ant queens get crowned? Listen to Rockefeller's @danielkronauer.bsky.social on @scifri.bsky.social explain how you can take two ant eggs with the exact same genes, and one can grow up to be a queen, the other a worker.

Meet @rockefeller.edu's Leslie Sibener, a Simons Society of Fellows Junior Fellow. Sibener studies how our brains prioritize which memories to hold onto and which to let go: https://www.simonsfoundation.org/leslie-sibener-and-how-our-brains-choose-which-memories-to-keep/ #science #neuroscience

In a new @cp-cellstemcell.bsky.social study, scientists in the Brivanlou lab have used light-inducible gene expression to demonstrate that the formation of the body axes in human embryo models requires an interplay between chemical cues and mechanical forces. #RockefellerScience

Don't miss this fascinating feature article from @laskerfdn.bsky.social about the Lasker Laureates (including Rockefeller's Robert Roeder and David Allis) who devised methods to understand how organisms carefully control gene activity.

A study out this week outlines a more efficient, less costly approach to gene-editing therapy for rare diseases. Rockefeller president Rick Lifton tells @nytimes.com that the approach could ultimately apply to a significant fraction of patients:

Big congrats to Kivanç Birsoy and @junyuecao.bsky.social, who have both been promoted!