Congratulations to all, especially Rockefeller's @veenapadmanaban.bsky.social, a research associate in @sohailtavazoie.bsky.social's lab, and Maria Cecilia Campos Canesso, formerly a postdoc in @danmucida.bsky.social and @victora.bsky.social’s labs. A very well-deserved recognition!

2/ Did adaptive immune cells learn to cooperate before the modern immune system existed? Awardee @affinityborn.bsky.social may redefine what's essential for immune memory & enable alternative immune architectures. 🥳 Congrats Dr. Wesemann! @harvardmed.bsky.social 🙏 #HFScout @victora.bsky.social

In a new preprint we use deep learning on lineage trees to infer the functional form of the relationship between affinity and fitness that controls antibody evolution in germinal centers: arxiv.org/abs/2508.09871 🧵

In the minority here, but I think it would be refreshing and I'd appreciate reading a piece like "On the value of reductionist science". While *incredibly* valuable, not everything *needs* -omics and the like, let alone when only done because it _can_ be done, with an illusion of mechanism.

Oslo University's Johanne Tracey Jacobsen visited CCII this week & shared exciting progress in the application of cutting edge imaging techniques to decode dynamic T-B interactions in the Germinal Center. #Immunology #GerminalCenter www.jjacobsenlab.com

Check it out, a great opportunity for people looking to start their own lab in Japan 👇 www.ccii.med.kyoto-u.ac.jp/en/careers-e...

Germinal center clonal diversity trees as a musical score, a great image to start @victora.bsky.social's CCII seminar, "Replaying germinal center evolution on a quantified affinity landscape" #GerminalCenter #Immunology www.ccii.med.kyoto-u.ac.jp/en/event/the...

Following Daniel @danmucida.bsky.social's session, Angelina Bilate @rockefelleruniv.bsky.social discussed strategies to identify antigen specific T cells. www.science.org/doi/10.1126/...

With a little help from my friend

A great start to a 3-day workshop: Daniel & Angelina Bilate discussing with students & postdocs at @ccii-kyoto.bsky.social all the obstacles faced & strategies to overcome them (or, more drastically, the thorny topic of when to pull the plug on a project). www.ccii.med.kyoto-u.ac.jp/en/event/wor...

Our streamlined Junior PI application process asks you to submit: a cover letter; a research plan; a current curriculum vitae; brief narrative summary of your main research achievements; Contact information for three references #Immunology #Immunotherapy www.ccii.med.kyoto-u.ac.jp/en/careers-e...

Great to be back for the last iteration of this great symposium. It will be missed!

I'm stoked to have this long-term and highly collaborative effort out in the wild. We present an experimental evolution system to quantitatively study the rapid evolutionary dynamics of B-cell affinity maturation. These evolutionary mechanisms underpin antibody responses and immune memory formation.

Another tour de force by the Victora lab. A must read for germinal center aficionados. There goes the weekend!

Wanted to highlight our latest preprint--a huge effort by multiple people and labs, but led primarily by @wsdewitt.github.io, Tatsuya Araki, and Ashni Vora, in a very close wet-dry collaboration with @matsen.bsky.social’s lab at the Hutch www.biorxiv.org/content/10.1...

”replication crisis” has always been hyperbole. Scientists ALWAYS argued, called each other frauds, and eventually land on consensus. A lot of what van Leeuwenhoek observed in the late 1600s was NOT REPRODUCIBLE because nobody could make lenses like him. But he was right, about cells, and bacteria.

Dear uLIPSTIC users, We have been getting reports that, under some more inflammatory settings like TB or chronic LCMV infection, uLIPSTIC-expressing lymphocytes adoptively transferred into cre-negative uLIPSTIC hosts may be rejected at later timepoints (>1 wk).

A collaborative study between the labs of @danmucida.bsky.social and @victora.bsky.social earlier this year showed how immune cells in the gut distinguish between food and harmful pathogens, shedding light on the origins of food allergies: bit.ly/4hyS18b #FoodAllergyAwarenessWeek

New imaging from @victora.bsky.social's lab reveals a built-in safeguard that allows B cell populations to rapidly expand in germinal centers without introducing deleterious mutations. #RockefellerScience

Cool germinal center acrobatics from Juhee Pae et al, check it out! www.nature.com/articles/s41...

Great to have our latest review "The cellular factors that impair the germinal center in advanced age" out @jimmunol.bsky.social. Work led by @wsfoster.bsky.social and Edith Marcial-Juárez. With @sanmarti92.bsky.social creating the beautiful GC images in figure 2. doi.org/10.1093/jimm...

ICYMI by First release - now in print @science.org Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection. buff.ly/3DjNQ1e By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al

In 2024, we reached out to 50 scientists who are doing innovative research around the world. 🧵 You can read our interviews with them in our #50ScientistsThatInspire collection: www.cell.com/topic/cell-d...

Rockefeller hearts science! This heart-shaped germinal center comes from the @victora.bsky.social lab, which studies how antibodies are generated in response to infection and immunization. Happy Valentine’s Day! 📷: Carla Nowosad

Rockefeller's @cicacanesso.bsky.social talks to The Scientist about her recent work with @danmucida.bsky.social and @victora.bsky.social on how cell-cell interactions help drive tolerogenic or inflammatory responses to the maelstrom of antigens passing through the gut.

New research from AAI members @danmucida.bsky.social and @victora.bsky.social @rockefelleruniv.bsky.social unlocked new clues on the mechanism behind food tolerance. Their findings show the delicate balance between tolerating food and defending against infections. Read more: ow.ly/LaP550UQwFJ.

A study from @victora.bsky.social and @danmucida.bsky.social in @science.org reveals how immune cells in the gut distinguish between food and harmful pathogens, shedding light on the origins of both food allergies and intestinal diseases. #RockefellerScience bit.ly/4hyS18b

we all have an emotional support dead famous guy and who he is says a lot about you

I hate the direction lab equipment design has gone in recent years. I don't want touchscreens, I don't want wifi integration, I don't want centrifuges demanding to know what time zone they're in. I just want reliable instruments - with physical buttons - that do the one task they were made for.

I am excited to share our study showing how the immune system strikes a delicate balance between tolerating food and defending against helminth infections. www.science.org/doi/10.1126/....

Glad to see our work with @danmucida.bsky.social and @cicacanesso.bsky.social finally out!

Check out our last pub. from @mfgrp.bsky.social al lab! We discovered that skin commensal microbes induce systemic and local B cell responses upon colonization and took advantage of this knowledge to create topical vaccines using engineered skin microbes. Please read the thread for details.

Thank you @cellpress.bsky.social for highlighting our work! www.cell.com/news-do/50-i...

B CELL FUN FACT: Secrets of the GC #1 Walther Flemming described GCs in 1885 paper "Studies in Tissue Regeneration". He mistakenly thought they were sites of cell birth (hence name) & tingible bodies ("tingiblen Körper") were daughter cells about to be born! link.springer.com/article/10.1...

Max deserves a Nobel. In the meantime, you can nominate someone for the Max Cooper Prize, deadline is April 1st. "Nomination letters of up to 3 pages must articulate how their research has led to advances in immunology research that will have a lasting impact." #Immunology

I feel like this card is attacking me 😭 🧪

Thanks @claireolingy.bsky.social @immunoeditor.bsky.social

Is basic science undervalued? David Glanzman (UCLA) talks about the decline of 'middle class' labs and that "there is no empirical evidence that the translational approach accomplishes this [cures] any better than the traditional one. Claims to the contrary at this point are mere propaganda."

I can't figure out if vaccines work or not. Tough one. I can see why RFK Jr is so concerned. Need Sherlock Holmes on this one.

Just saw this one from a few months ago: www.nature.com/articles/s41... Cool use of LIPSTIC, never crossed my mind to use it for something like this!

Advertise your account with just one image.

For anyone using our K-tag antibody fate-mapping system, we just deposited plasmids encoding for the standard mAbs that should be used to calibrate the anti-Flag and anti-Strep secondary ELISA antibodies. www.addgene.org/browse/artic...

Renewing my yearly bet on Miller/Cooper

Cool new work from @victora.bsky.social & their LIPSTIC system for labelling cells that have interacted in vivo. #Immunology #Immunosky #immunotherapy

Scotland has detected no cases of cervical cancer in women born between 1988-1996 who were fully vaccinated against HPV between the ages of 12 and 13. Vaccines are incredible.

may the force be with him

Mosaic sarbecovirus nanoparticles elicit cross-reactive responses in pre-vaccinated animals~ Pan-sarbecovirus vaccine evaluated in pre-vaccinated monkeys and mice www.sciencedirect.co... 1/10

Opposing effects of pre-existing antibody and memory T cell help on the dynamics of recall germinal centers This nice paper is now out @immunityCP. The pre-print was highlighted here: x.com/Marc_Veld/stat... www.cell.com/immunit...

Online now in Immunity, Ariën Schiepers’ latest paper on secondary germinal centers and original antigen sin www.cell.com/immunity/ful... Full🧵 here: x.com/arien_schiep...