Researchers characterized the molecular determinants of FcγRIIB expression in human immune models, paving the way for future investigation into the molecular mechanisms responsible for cell lineage-specific FcγR expression. Read more online: ow.ly/xmVB50WY9SI.

Researchers identified matrix metalloproteinase-9 (MMP-9), IL-8, and myeloperoxidase (MPO) as reliable combined biomarkers for the diagnosis of post-infectious bronchiolitis obliterans in children. Learn more in The JI: ow.ly/3U0F50WY8Wt.

An essential conversation during #PeerReviewWeek! We hosted the webinar "How to Be the Reviewer You Want to Have," presented by Dr. Gail A. Bishop, EIC of @jimmunol.bsky.social. It's a key topic for graduate students and post-docs. Watch now: ow.ly/mAXQ50WZ1kH #TBT #PeerReviewWeek

Researchers tested a single-cycle attenuation strategy that deleted glycoprotein L (essential for viral entry) to create strain 68-1 rhesus CMV vectors that generated high frequency, effector-memory-biased, SIV-specific CD8+ T-cell responses. Learn more: ow.ly/jrm450WV7Kx.

Boost your career with an AAI Travel Award! Open to AAI members, these awards provide funding to attend #IMMUNOLOGY2026™. Submit your abstract and apply for an AAI Travel Award by the October 15 deadline. Learn more: ow.ly/cBuc50WYhwq.

This featured article describing a novel immunological method details how researchers combined in vitro culture of plasma cells (PC) with adoptive transfer and timestamping to track the population dynamics of resulting induced PCs in vivo. Learn more: ow.ly/RTt850WV7PC.

In a #CuttingEdge article, researchers used a novel strategy of competitive, mixed male-female donor bone marrow chimeras to determine if sex differences in murine pulmonary type 2 innate lymphocytes result from extrinsic or intrinsic. Read more now: ow.ly/zGqI50WV7u8.

A new #CuttingEdge article reveals that IL-21 is required for normal type 2 memory B cell formation. Because of this, the authors argue against the use of Il-21 as a pan-allergy suppressor. Read the new findings yourself: ow.ly/J16c50WV7wV.

The AAI 2026 Career Awards nomination period closes today! Please help us identify and celebrate our most accomplished AAI members. From outstanding mentors to pioneering researchers, your nominations ensure we recognize the best in our field. Submit a nomination today: www.aai.org/Awards/Career.

An August #TopRead from @carpenterlab.bsky.social demonstrates that heterogeneous nuclear ribonucleoprotein A2B1 is essential for optimal macrophage function, highlighting the role for RNA-binding proteins in mounting effective immune defenses. Read more: ow.ly/NSx150WTnSr.

In a #Top Read from August, @labwaggoner.bsky.social from @cincyresearch.bsky.social discovered that the transcription factor ASCL2 is required for recruitment of NK cells into the spleen and white pulp providing novel insights into NK cell biology. Read more: academic.oup.com/jimmunol/art...

A history of alcohol use disorder increases the risk of death from sepsis. Researchers found that the HIF-1α-PFKP axis regulates glycolysis and phagocytosis in ethanol-exposed macrophages and is a potential therapeutic target in ethanol with sepsis: ow.ly/S5AQ50WOgnB.

🚨 IMMUNOLOGY2026™ abstract submissions are now open! Share your groundbreaking research with the global immunology community. Submit your abstract by October 15: immunology2026.aai.org/abstracts

Data suggest that exhaustion markers contribute to the hyporesponsive profile of lepromatous patients. PD-1 blockade could contribute to the reestablishment of lymphocyte effector action and possibly be incorporated into multidrug therapy for leprosy. ow.ly/Esoj50WOgWm.

Researchers propose that MHC-I biology may require modifications to incorporate TAP-independent pathways of lipopeptide-specific CD8+ cytotoxic T lymphocytes responses. Learn more: ow.ly/SuuN50WJAOm

In this #TopRead article, data demonstrated that TNFR family member CD27 is a metabolic regulator in activated human CD4+ cells, suggesting its essential contribution to T-cell metabolism and its relevance as a therapeutic target. Read more in The JI: ow.ly/bCJk50WJAwi.

Dr. John V Williams and his team characterized the role of CD4+ helper T Cells in response to human metapneumovirus (HMPV), identifying a dominant CD4+ T cell epitope and constructing the first MHC-II tetramer for HMPV. Learn more in this #TopRead article: ow.ly/Hern50WJAB3

Come chat with us at AAI booth 84 at #IUIS2025! Learn about our premier journals– @jimmunol.bsky.social & @immunohorizons.bsky.social– and our on-demand courses. Questions about #IMMUNOLOGY2026™ abstract submissions? We're here to answer them. Plus, enter to win an AAI hat! #ImmunologyWithoutBorders

Data revealed B cell-dependent CD1d expression is critical for the effectiveness of a potent lipid-based adjuvant in augmenting polysaccharide and phosphorylcholine-specific IgG responses, which could help improve #vaccines. Learn more: ow.ly/NG6h50WHbSM.

Five computationally optimized broadly reactive antigens (COBRAs) were designed from influenza A H3N2 viruses that circulated 2018-2022 and showed improved protective efficacy in vaccinated mice and ferrets. Read more: ow.ly/y22c50WHbSf.

New data point to a unique role for Ly49C/I in adaptive NK cell antigen recognition and provide further insight into the mechanism behind adaptive NK cell responses. Ly49G did not appear to play any role in NK cell memory responses. Learn more: ow.ly/hPiR50WHbRP.

Researchers engineered Ab5, a germline-like anti-human epidermal growth factor receptor 2 monoclonal antibody, and enhanced its antibody-dependent cellular cytotoxicity properties through affinity maturation showing notable enhancement of tumor ablation. ow.ly/QOo150WCLlX.

Phase 2 clinical trial data found that the combination of Imprime and pembrolizumab was safe and demonstrated immune activation in tumor tissues and peripheral blood in patients with triple negative #breastcancer. Learn more in The JI: ow.ly/3ZxY50WCL03.

Researchers discovered B cell follicles in nurse shark pancreas and saw antigen-specific antibodies were produced in the pancreas following immunization providing insight into how immune surveillance may function in the absence of lymph nodes. Read more: ow.ly/oF6q50WCKbg

Researchers compared two strains of porcine respiratory coronavirus (PRCV) to elucidate the mechanisms leading to mild or severe disease. Researchers observed 135 strain induced greater pathology while ISU-1 strain triggered mild pathology. Learn more: ow.ly/mac650WznOa.

This Pillars of Immunology article in the Human and Clinical Immunology special collection provides a commentary on 2 pivotal articles from 1993 that shaped the CD40-CD40L field of immunology and impacted understanding of human health. ow.ly/o78O50Wzsbt

In their editorial for the special collection “Human and Clinical Immunology: An Evolving Landscape,” Dr. Roshini Abraham and Dr. Gerald Morris discuss the current pivotal moment of clinical immunology and the benefits of publishing in #TheJI. Read more: ow.ly/xB4Y50Wzn4Y

🚨 AAI is proud to announce the launch of the AAI RESTORE Grants Program, an $8M emergency funding initiative to support scientists whose immunology-focused federal research grants were abruptly terminated or frozen in 2025. 🔗 ow.ly/rwMU50Wy3Mp #AAIRESTORE

Apply today to participate in the AAI Peer-Review Mentorship Program! This program is designed to provide mentorship from seasoned professionals to develop your skills as a peer reviewer of manuscripts submitted to AAI journals. Learn more: ow.ly/qLyn50WuPxA.

In his lecture on “The Generation and Modification of Lymphocyte Antigen Receptor Genes,” Eugene Oltz, @ohiostatemed.bsky.social, described how chromatin accessibility controls where V(D)J recombination occurs during immune cell development. #AAIcourses

#ICYMI: The JI featured a special collection of articles curated by guest editor Patricia Gearhart, highlighting the impact of aging on the immune system with insights into the immunological effects of aging at the cellular level. Learn more: ow.ly/WwZn50WuPuA.

#ICYMI: When studying Nile tilapia as a model, researchers determined that CD8+ T cells reshaped the FasL-dependent strategy throughout evolution, thereby enhancing the precision and specificity of adaptive immunity. Learn more: ow.ly/RPqF50Wslhz.

The June issue’s Pillars of Immunology Commentary revisits the landmark 2007 paper by Foster, Hargreaves, and Medzhitov, which was the first to uncover the mechanistic basis of memory in the innate immune system. Read it in The JI: ow.ly/NxUU50WslaC.

Foam cells are dysfunctional, lipid-laden macrophages. Data indicate that the events underlying foam cell formation are disease- and microenvironment-specific, opening new avenues for disease-specific biomedical research. Learn more: ow.ly/Ah0k50WlLiQ.

#ICYMI: Cytokine-induced killer (CIK) cell therapy improved both progression-free and overall survival in patients with #colorectalcancer. CEA serum levels were identified as a biomarker to predict which patients will respond to CIK therapy. Learn more: academic.oup.com/jimmunol/art... #immunosky

The Hippo signaling pathway is important in regulating host immune responses, but have you thought about its role in fish? Scientists revealed the mechanism of the Hippo pathway in the antimicrobial immunity of a pufferfish, Takifugu obscurus. Read now: academic.oup.com/jimmunol/art... #immunosky

#ICYMI: Researchers shared the development of an assay for quantitative assessment by flow cytometry of selective inhibitor effects on peptide trimming, both in the endogenous MHC-I processing pathway and in cross-presentation. Learn more in The JI: academic.oup.com/jimmunol/art...

Incredibly excited to share my final project from Monash which was recently published in @jimmunol.bsky.social! Together with Jesse Mulder from the Robinson Group @robinsonmj.bsky.social, we found a role for IL-21 in allergy responses by promoting type 2 memory B cell formation. Check it out !👇🏼

In a #CuttingEdge article, researchers identified an in-del generated novel neoepitope that elicited in vivo tumor control in models of prophylaxis and therapy. CD8 T cells elicited by this neoepitope showed notably less exhaustion. Learn more: academic.oup.com/jimmunol/art....

Researchers have described key events in the pulmonary anti-Influenza A (IAV) response of pigs, which open new avenues for developing IAV vaccines and therapies, and enable the better use of pigs as a model for human IAV infection and immunity. Learn more: ow.ly/xjnl50WlNLa

Researchers characterized the transcriptional and chromatin accessibility landscapes of bone marrow and splenic hematopoietic progenitors in breast cancer to understand the hematopoietic consequences of #cancer. Read more: ow.ly/gfEZ50WlLzk.

Data revealed that inducible co-stimulator (ICOS) mediates antitumor immunity by promoting the secretion of cancer-suppressive cytokines, suggesting that activation of ICOS may be a potential therapeutic strategy for #colorectalcancer. Read more: ow.ly/vp4e50WlLvu.

Another #TopRead developed a novel TOX-nanoluciferase-based reporter system that can be used to monitor TOX expression and facilitate the screening of molecules that modulate cytotoxic T-cell exhaustion. Learn more: ow.ly/O9oW50WijyF.

June #TopRead from @ualberta.bsky.social and @wchriuofa.bsky.social found distinct gene expression profiles in CD71+ erythroid cells at various developmental stages, suggesting a critical role for Gal-3 in modulating erythropoiesis and enhancing immunoregulation. Read more: ow.ly/L8uv50WiiFm.

A June #TopRead identified different subtypes of neutrophils in #tuberculosis (TB) patients, indicating that neutrophils might be promising targets for TB host-directed therapy. Learn more: ow.ly/gBgR50WiiCr.

Dr. Otto O. Yang, Professor @UCLA, provides a review of lessons learned in the five years since #COVID19 was identified. Read what research has revealed and what remains to be investigated: ow.ly/XQo950WiiBT.

The June issue of The JI is online now! Find cutting-edge research, reviews, and commentaries on your favorite immunology topics. Read everything now: ow.ly/cVNx50WiiAe

In the US, it is rare to get a #vaccine with #thimerosal. It has been completely removed from childhood vaccines and few #flu vaccines include it. Numerous studies have shown that there is no link between thimerosal and #autism.

A Translating Immunology article re-evaluates B cell depletion strategies, providing an alternative explanation for why CD19 depletion may be effective at achieving complete and durable remission in autoantibody-positive autoimmune diseases. Read more: ow.ly/3XFy50WbZkr