The JI and @immunohorizons.bsky.social are looking for a biostatistics editor! This is a unique opportunity to contribute to the advancement of immunological research by ensuring the statistical rigor and methodological soundness of published work. Learn more: ow.ly/qYic50Xmu4V.

Learn how canine cancer models are evaluating new immunotherapies for osteosarcoma, glioma, non-Hodgkin lymphoma, melanoma, uroepithelial cancer, and head and neck cancers in humans in The JI’s special collection on non-traditional animal models: ow.ly/6FRH50XmtjP.

Woodchucks are naturally affected by Woodchuck Hepatitis Virus, with disease progression very similar to hepatitis B in people. This review in the special collection on nontraditional animal models discusses the huge impact of this animal model. 🔗 ow.ly/EQ3r50Xmt9l.

As part of the special collection on non-traditional animal models, researchers discuss how understanding immunity in a range of large animals can expand awareness of immunological processes critical for the maintenance of human health. Learn more: ow.ly/bCtV50Xmt0s.

#DYK We published one of the 6 spookiest discoveries of the year according to @zmescience.bsky.social? As a ghost passes through a wall, the parasitic work Schistosoma mansoni can pass through your skin without being detected. Read more: ow.ly/yIUS50Xl7h3. 📘 ow.ly/189i50Xl7h4

A treat for you this Halloween: the October edition of The Journal of Immunology is online! Featuring a special collection titled. “Beyond the Mouse: Nontraditional Animal Models in Immunology” you don’t want to miss this one. Explore it all: ow.ly/jmK850Xj1K0

Mortality from Pneumocystis #pneumonia (PCP) continues to increase among non-HIV patients. A new study looks at the role of withdrawing glucocorticoid in disease progression to better understand disease progression. Read more in The JI: ow.ly/EXrx50Xj1CR.

This #BriefReview discusses how molecular and blood profiling led to a therapeutic revolution for #AtopicDermatitis and highlights how this translational approach is being applied to advancing the therapeutic pipeline of #alopecia areata. Explore more: ow.ly/1kht50Xj1s5

Data establish c-di-AMP as a key PAMP of B. burgdorferi, the causative agent of #lymedisease which elicits a type I interferon response that can lead to the development of Lyme arthritis, for which a PAMP was previously unidentified. Read more online: ow.ly/jWcl50XesPS.

Don't delay! Submit your abstract for IMMUNOLOGY2026™ before 6 pm today.

New data identified miR-124-3p as a critical regulator of macrophage polarization and acute lung injury (ALI) pathophysiology, providing a potential therapeutic target for managing ALI in lung transplant recipients. Learn more: ow.ly/XsVv50XesKz.

Researchers investigated the role of lectin mannose-binding 1 (LMAN1) in house dust mite induced allergic asthma and found that the loss of LMAN1 led to opposing effects on airway hyperresponsiveness dependent on the sex of mice. Learn more: ow.ly/BZ0750Xb7vs.

Data showed that high-mobility group protein B1 (HMGB1) inhibited IFN-gamma induced PD-L1 expression, enhancing the antitumor effects of T cells and confirming the role of HMGB1 as a prognostic indicator for #lungcancer treated with CAR-T cells. Read more: ow.ly/lZZG50Xb7mk.

When observing wild-type Raji and Jurkat cells following co-culture in the absence of cognate MHC and TCR or superantigen, only 'finger-like' projections were observed at the cell-cell interface. Find the research behind September’s cover image online: ow.ly/NOkn50X6mnH

Targeting the immune checkpoint inhibitory receptor VISTA improved disease severity in a mouse model of neutrophil-mediated arthritis. Researchers investigate the novel therapeutic opportunity for targeting VISTA in this September #TopRead article: ow.ly/iueJ50X6mlo

Get ready for #IMMUNOLOGY2026™! We're heading to the vibrant city of Boston, MA. Prepare for groundbreaking science, incredible networking, and an unforgettable experience. Don't miss your chance to be part of the #immunology community! Learn more: immunology2026.aai.org/abstracts.

Congratulations to new Nobel Laureate and AAI Distinguished Fellow Shimon Sakaguchi, co-winner of the 2025 Nobel Prize in Physiology or Medicine for his foundational discoveries on regulatory T cells and peripheral immune tolerance! Published in The JI in 1995: ow.ly/LGk150X7984.

Less than two weeks left to submit your #IMMUNOLOGY2026™ abstract! Get your research seen on a global stage in Boston, MA and network with your peers. Submit now: immunology2026.aai.org/abstracts.

RTA-480 is currently a therapeutic for Friedrich’s Ataxia that activates NRF2. Researchers explored the therapeutic potential of RTA-408 in #IBD, finding that it modulates T cell homeostasis, metabolism, and inflammation. Learn more: ow.ly/kKKf50X32sk.

🚀 New from AAI: Immunology Explained — a hub for clear, evidence-based insights into how the immune system protects health. Check it out: immunologyexplained.aai.org Find and follow Immunology Explained on TikTok, Facebook, Instagram and YouTube #ImmunologyExplained

Fall is here and so is the September issue of The JI! Available online and full of high-quality research. Read through all the September issue has to offer: ow.ly/uiQo50X32rC.

Neutrophils specialize in producing large amounts of reactive oxygen species to kill microbes. Data suggests that SOD1 is a novel regulatory factor in this oxidative burst that enables the full immunological response of neutrophils. Read more here: ow.ly/5kr350WYaCi.

Data showed that aging in mice impairs the ability to produce anti-HMGB1 IgM, making mice susceptible to the development of insulin resistance, and provides insight into what drives age-related loss of tolerance to fatty foods. Learn more: ow.ly/26Vu50WYa7E.

Researchers characterized the molecular determinants of FcγRIIB expression in human immune models, paving the way for future investigation into the molecular mechanisms responsible for cell lineage-specific FcγR expression. Read more online: ow.ly/xmVB50WY9SI.

Researchers identified matrix metalloproteinase-9 (MMP-9), IL-8, and myeloperoxidase (MPO) as reliable combined biomarkers for the diagnosis of post-infectious bronchiolitis obliterans in children. Learn more in The JI: ow.ly/3U0F50WY8Wt.

An essential conversation during #PeerReviewWeek! We hosted the webinar "How to Be the Reviewer You Want to Have," presented by Dr. Gail A. Bishop, EIC of @jimmunol.bsky.social. It's a key topic for graduate students and post-docs. Watch now: ow.ly/mAXQ50WZ1kH #TBT #PeerReviewWeek

Researchers tested a single-cycle attenuation strategy that deleted glycoprotein L (essential for viral entry) to create strain 68-1 rhesus CMV vectors that generated high frequency, effector-memory-biased, SIV-specific CD8+ T-cell responses. Learn more: ow.ly/jrm450WV7Kx.

Boost your career with an AAI Travel Award! Open to AAI members, these awards provide funding to attend #IMMUNOLOGY2026™. Submit your abstract and apply for an AAI Travel Award by the October 15 deadline. Learn more: ow.ly/cBuc50WYhwq.

This featured article describing a novel immunological method details how researchers combined in vitro culture of plasma cells (PC) with adoptive transfer and timestamping to track the population dynamics of resulting induced PCs in vivo. Learn more: ow.ly/RTt850WV7PC.

In a #CuttingEdge article, researchers used a novel strategy of competitive, mixed male-female donor bone marrow chimeras to determine if sex differences in murine pulmonary type 2 innate lymphocytes result from extrinsic or intrinsic. Read more now: ow.ly/zGqI50WV7u8.

A new #CuttingEdge article reveals that IL-21 is required for normal type 2 memory B cell formation. Because of this, the authors argue against the use of Il-21 as a pan-allergy suppressor. Read the new findings yourself: ow.ly/J16c50WV7wV.

The AAI 2026 Career Awards nomination period closes today! Please help us identify and celebrate our most accomplished AAI members. From outstanding mentors to pioneering researchers, your nominations ensure we recognize the best in our field. Submit a nomination today: www.aai.org/Awards/Career.

An August #TopRead from @carpenterlab.bsky.social demonstrates that heterogeneous nuclear ribonucleoprotein A2B1 is essential for optimal macrophage function, highlighting the role for RNA-binding proteins in mounting effective immune defenses. Read more: ow.ly/NSx150WTnSr.

In a #Top Read from August, @labwaggoner.bsky.social from @cincyresearch.bsky.social discovered that the transcription factor ASCL2 is required for recruitment of NK cells into the spleen and white pulp providing novel insights into NK cell biology. Read more: academic.oup.com/jimmunol/art...

A history of alcohol use disorder increases the risk of death from sepsis. Researchers found that the HIF-1α-PFKP axis regulates glycolysis and phagocytosis in ethanol-exposed macrophages and is a potential therapeutic target in ethanol with sepsis: ow.ly/S5AQ50WOgnB.

🚨 IMMUNOLOGY2026™ abstract submissions are now open! Share your groundbreaking research with the global immunology community. Submit your abstract by October 15: immunology2026.aai.org/abstracts

Data suggest that exhaustion markers contribute to the hyporesponsive profile of lepromatous patients. PD-1 blockade could contribute to the reestablishment of lymphocyte effector action and possibly be incorporated into multidrug therapy for leprosy. ow.ly/Esoj50WOgWm.

Researchers propose that MHC-I biology may require modifications to incorporate TAP-independent pathways of lipopeptide-specific CD8+ cytotoxic T lymphocytes responses. Learn more: ow.ly/SuuN50WJAOm

In this #TopRead article, data demonstrated that TNFR family member CD27 is a metabolic regulator in activated human CD4+ cells, suggesting its essential contribution to T-cell metabolism and its relevance as a therapeutic target. Read more in The JI: ow.ly/bCJk50WJAwi.

Dr. John V Williams and his team characterized the role of CD4+ helper T Cells in response to human metapneumovirus (HMPV), identifying a dominant CD4+ T cell epitope and constructing the first MHC-II tetramer for HMPV. Learn more in this #TopRead article: ow.ly/Hern50WJAB3

Come chat with us at AAI booth 84 at #IUIS2025! Learn about our premier journals– @jimmunol.bsky.social & @immunohorizons.bsky.social– and our on-demand courses. Questions about #IMMUNOLOGY2026™ abstract submissions? We're here to answer them. Plus, enter to win an AAI hat! #ImmunologyWithoutBorders

Data revealed B cell-dependent CD1d expression is critical for the effectiveness of a potent lipid-based adjuvant in augmenting polysaccharide and phosphorylcholine-specific IgG responses, which could help improve #vaccines. Learn more: ow.ly/NG6h50WHbSM.

Five computationally optimized broadly reactive antigens (COBRAs) were designed from influenza A H3N2 viruses that circulated 2018-2022 and showed improved protective efficacy in vaccinated mice and ferrets. Read more: ow.ly/y22c50WHbSf.

New data point to a unique role for Ly49C/I in adaptive NK cell antigen recognition and provide further insight into the mechanism behind adaptive NK cell responses. Ly49G did not appear to play any role in NK cell memory responses. Learn more: ow.ly/hPiR50WHbRP.

Researchers engineered Ab5, a germline-like anti-human epidermal growth factor receptor 2 monoclonal antibody, and enhanced its antibody-dependent cellular cytotoxicity properties through affinity maturation showing notable enhancement of tumor ablation. ow.ly/QOo150WCLlX.

Phase 2 clinical trial data found that the combination of Imprime and pembrolizumab was safe and demonstrated immune activation in tumor tissues and peripheral blood in patients with triple negative #breastcancer. Learn more in The JI: ow.ly/3ZxY50WCL03.

Researchers discovered B cell follicles in nurse shark pancreas and saw antigen-specific antibodies were produced in the pancreas following immunization providing insight into how immune surveillance may function in the absence of lymph nodes. Read more: ow.ly/oF6q50WCKbg

Researchers compared two strains of porcine respiratory coronavirus (PRCV) to elucidate the mechanisms leading to mild or severe disease. Researchers observed 135 strain induced greater pathology while ISU-1 strain triggered mild pathology. Learn more: ow.ly/mac650WznOa.

This Pillars of Immunology article in the Human and Clinical Immunology special collection provides a commentary on 2 pivotal articles from 1993 that shaped the CD40-CD40L field of immunology and impacted understanding of human health. ow.ly/o78O50Wzsbt