Now in #Science #Immunology: @griffithslab.bsky.social report that when #CD8 #TCells encounter their targets, #nucleus localizes to the #ImmuneSynapse (IS) & facilitates delivery of newly synthesized cytokines to the IS. They find nuclear polarization represents key step in #CTL -mediated killing!

Now in #Science #Immunology, @drtesutherland.bsky.social & al report chitinase-like proteins (CLPs) make distinct contributions to airway pathology independent of #IL13- & #IL17 –mediated signaling in 🐀 #asthna model! CLPs orchestrate airway #ECM remodeling, & can be both protective & detrimental!

The September issue of #Science #Immunology is out! This week: METTL1 m⁷G RNA modification of NAD+ #metabolism → #macrophage -mediated #inflammation; proenkaphalin+ #Tregs restrain skin inflamm via control of #nociception; #RNA helicase DDX55 is regulator of naïve #TCell homeostasis scim.ag/3HKC5DP

Way to go, @cnfogg.bsky.social!

Heads up: @science.org is looking for a new research #editor based in the US or UK to handle papers in #InfectiousDiseases (e.g., #virology, #microbiology, #parasitology) & #microbiome research! This is an amazing opportunity, so don't delay! Applications are due 22 SEP!

Heads up: @science.org 's immunology editor @sarahhross.bsky.social and I will both be attending the @iuis-online.bsky.social 19th International Congress next week in the ever enchanting city of #Vienna! We hope to see many of you there!

This week's @science.org #IMMUNOLOGY-themed SPECIAL ISSUE features Reviews by {Kassiotis & Stoye}, {Nahrendorf, Ginhoux, & Swirski}, {Sharma, Gibbons, & Saphire}, & {@jessmetcalf.bsky.social, @grahammunology.bsky.social, Yates, & Cummings} + an absolutely wild & wonderful cover! scim.ag/3UqRrA6

The August issue of #Science #Immunology is out! This week: T peripheral helper cells expressing IGFL2 contribute to rheumatoid #arthritis; vagal TRPV1+ sensory #neurons protect against #influenza virus infection; & transfer of #Tregs alleviates #inflammaging in mice! wwwscience.org/toc/sciimmun...

Out now in #Science #Immunology: Eric Vivier (@univ-amu.fr), Hui Peng, Zhigang Tian (USTC, Hefei), & colleagues report that #FetalLiver #InnateLymphoidCell ( #ILC ) progenitors in mice continue contributing to ILC #hematopoiesis into adulthood in a #BoneMarrow –independent manner!

In #Science #Immunology, @tobiasplowman.bsky.social, Kassiotis, & al report canonical #IL13RA1 expression is negatively regulated by E2 #estrogen & also describe a primate-specific RTE-derived IL-13Rα1 isoform that antagonizes the canonical receptor & attenuates responsiveness to #IL4 and #IL13!

The July issue of #Science #Immunology is out now! This week: • Additional levels of #IL13RA1 gene regulation help explain susceptibility to #allergy! • Spi-B is a #checkpoint of #type2 immunity by restraining #TuftCell activation in gut! New content each week! www.science.org/toc/sciimmun...

I am so delighted to be in #Japan for this year's RIKEN IMS–JSI International Symposium on #Immunology! 🇯🇵 温かく迎えてくれた主催者に感謝する！

To celebrate @focisimmunology.bsky.social 's annual meeting this week, #Science #Immunology has just released a new free sample collection of recent papers with a focus on human immunology! The collection will be available online to read until the end of July 2025! #FOCIS2025 bit.ly/SciImm_free

Out now in #Science #Immunology: using a forward genetic of #ion #channels & #transporters, @stefanfeske.bsky.social & colleagues identified chloride nucleotide-sensitive channel 1A (CLNS1A) to be a critical regulator of #CD4 #TCell proliferation & differentiation!

Recently in #Science #Immunology: Van der Veeken & al @ IMP @viennabiocenter.bsky.social generated 🐁 w auxin-inducible degradable #Foxp3! Tissue #Tregs minimally unaffected @ homeostasis but highly dependent on continuous Foxp3 activity in models of #autoimmunity, #viral #infection, & #cancer !

Recently in #Science #Immunology: researchers @ Weizmann & Tel Aviv Sourasky characterize synovial fluid immune compartment of #PsoriaticArthritis patients. #Immunoproteasome- & #MHCI -related genes ↑ in patients w refractory disease. Targeting immunoproteasome may be possible therapeutic approach!

New in #Science #Immunology: Researchers at Sun Yat-Sen University in Guangzhou report that #BloodCancers expressing PSGL-1 can prevent the #integrin signaling #macrophages need for #phagocytosis. Targeting PSGL-1 improved survival in mouse models of #leukemia, #lymphoma, & #MultipleMyeloma!

This month in #Science #Immunology, Shivangi Dave & André Ballesteros Tato at the #NIH review the noncanonical contributions of #TFollicularHelper ( #TFH ) cells cells to immune regulation beyond their traditional roles in #BCell help! science.org/doi/10.1126/sciimmunol.adr1052

This fantastic work by @emilyaunins.bsky.social, Anthony Phan, @drewweissmanlab.bsky.social, @kingofpathogens.bsky.social, & colleagues is featured on this month's cover of #Science #Immunology!

One of this month's excellent investigator-penned other-journal #ResearchHighlights in #Science #Immunlogy:

The June issue of #Science #Immunology has launched! This week: inducible #FoxP3 degradation in #Tregs; the immune landscape of human #psoriatic #arthritis; & #IL12 gives #mRNA #vaccines a boost! New content every week! Check it out! www.science.org/toc/sciimmun...

You can read (and subscribe to) Christie's *award-winning* Newsletter here: www.science.org/topic/articl... Check it out!

Now in #Science #Immunology: Philips, O'Shea, &al. made mice w human pathogenic #STAT1 activating mutation. Mice had #IFNg -dependent #autoimmunity, but their innatelike lymphocytes produced suboptimal IFNg during viral infection. Exogenous IFNg🚫virus-induced lethality, suggesting possible therapy!

This week in #Science #Immunology: Boisson-Dupuis, @casanovalab.bsky.social, & colleagues identify in 3 unrelated individuals w/ #tuberculosis a rare autosomal recessive complete deficiency in #LY9 linked to impaired #IFNg production by CCR4−CCR6+CXCR3+T-bet+RORγT+ TH1* cells (aka TH1/17 cells)!

In #Science #Immunology, researchers at @stanfordmedicine.bsky.social studied #IFNs in human #fetal #thymus development. They found type I & II IFNs play distinct but critical roles in cortical & medullary thymic #EpithelialCell differentiation!

ICYMI: earlier this month in #Science #Immunology, Ping Chih-Ho & Cheng Lung-Ku labs engineered #CAART cells bearing truncated #IFNg mutant bait to eliminate #Bcells expressing anti-IFN neutralizing #autoantibodies (nAIGAs) in both mouse models & in ex vivo cultures of PBMCs from patients w/ nAIGAs!

This week in #Science #Immunology: Yating Zheng, Adam Courtney & colleagues at @umich.edu tweak #TCell signaling by engineering an optimized form of Herpesvirus saimiri TIP to recruit #LCK kinase to different #STAT proteins. This approach enhanced #CD8 T cell #antitumor responses!

Out now in #Science #Immunology: Christopher Hall & colleagues at @aucklanduni.bsky.social report in #zebrafish that the #circadian clock gene per2 boosts daytime #antibacterial activity in #neutrophils by promoting infection-responsive hmgb1a expression!

In the latest #Science #Immunology: researchers @ Tsinghua U report that #ILC3 augment group #ILC2 #anthelmintic immune responses in 🐁! Upon N. braziliensis infection, ILC3-derived #RANKL synergizes w/ #IL13 to facilitate intestinal #TuftCell expansion, which amplifies ILC2 responses!

This month in #Science #Immunology: @nickmroz.bsky.social, @phagocyticpai.bsky.social, @annamolofskylab.bsky.social, & @arimolofskylab.bsky.social pen an insightful & timely Review on crosstalk between the #nervous system & #type2 immunity! #WeekendRead #neuroimmunology #allergy #Alzheimers #itch

This is a public service announcement: late-breaking abstract submissions for #IUIS2025 will close tomorrow (May 6)! You can submit your abstracts here: iuis2025.org/abstracts/ I hope to see many of you this August in beautiful Vienna!!! #Immunology #Science2025 #CallForAbstracts #IUIS

The May issue of #Science #Immunology is out now! This week: #interferon regulates #thymic epithelial cell differentiation; #efferocytosis determines #alveolar #macrophage functional plasticity: & mapping the #stromal cell landscape of human #LymphNodes! science.org/toc/sciimmunol/10/107

Happy Int'l #DayofImmunology! To celebrate, here are some recent Reviews from the pages of #Science #Immunology!!! First up: Kumagai, Momoi, & Nishikawa survey recent literature on links between #cancer genetic abnormalities & #immunosuppression that cause clinical resistance to #immunotherapy!

The latest research in #Science #Immunology was exquisitely timed for #WorldMalariaDay today! Check out ! 👇👇👇

The April issue of #Science #Immunology is out now! This past week: two papers describe how #skin #inflammation can drive #type2 immune responses in other #mucosal tissues, while a third describes how #hunger perception in the #brain regulates peripheral immune cell dynamics! Check it out!

In sunny Freiburg for the International Symposium on #Perinatal and #EarlyLife #Immunity! www.perinatal-immunity.de/en/symposium...

Check out this just-released Gustavo Gastão Davanzo & @jonykipnis.bsky.social News & Views piece in Nature Immunology covering recent research by @mmr2.bsky.social, Diane Mathis, & colleagues in Science Immunology! Marin-Rodero et al. Sci Immunol 2025 science.org/doi/10.1126/sciimmunol.adu2910

A bold proposal for our troubled times!

This week in #Science #Immunology: researchers @ UTSW & Tianjin Med U generate #STING reporter mice to study patterns of STING expression across tissues & immune cell types! They also report forced STING expression can alter #Tcell development & induce #neutrophil -driven systemic inflammation!

Now in #Science #Immunology: @ejohnwherry.bsky.social & al use Tox-inducible KO mice to show that continuous #TOX expression in established exhausted #CD8 #Tcells (Tex cells) acts as enduring epigenetic control to reinforce Tex cell fate. Findings suggest TOX might be useful therapeutic target!

The March issue is out! This week: TOX-inducible-KO 🐁show how #TOX maintains #exhausted CD8 #Tcell epigenetic fate; visualizing temporal & spatial #STING expression; & UVB-driven #mitochondrial Z-🧬complexed w ZBP1 fuels #autoimmune #photosensitivity via cGAS-STING! science.org/toc/sciimmunol/10/105

To celebrate with the @keystonesymposia.bsky.social #myeloid cell meeting happening now in Hannover, we have released a free collection of 6 recent #Science #Immunology papers focused on myeloid cells! Check 'em out! They will be available until the end of April! bit.ly/SciImm_free #KSmyeloid25

To commemorate #RareDiseaseDay, here are some recent #Science #Immunology research papers that elucidate the immune mechanisms underlying certain rare human diseases and/or report new strategies to treat them! @science.org

This week in #Science #Immunology: researchers @ @uwmadison.bsky.social use #AAV vectors to deliver 2 Abs—one neutralizing #SIV infectivity & killing infected cells via #ADCC & another mediating ADCC but non-neutralizing—to prevent resurgence of SIV replication in #macaques after discontinuing #ART!

"If I had to name a person who has done more for the benefit of human health, with less recognition than anyone else, it would be Maurice Hilleman."—Richard Gallo

ICYMI: earlier this month in #Science #Immunology, bendewals.bsky.social & colleagues reported that #CD22 expression by virtual #MemoryTCells ( #TVM ) inhibits their expansion in response to #IL4 in the context of #helminth infection !

This week in #Science #Immunology: researchers @ @helsinki.fi characterize #immune landscape of deep cervical #LymphNodes in newly diagnosed untreated patients w #MultipleSclerosis! Authors uncover several lines of evidence strengthening possible link btw #MS & Epstein–Barr virus ( #EBV ) infection!

Now in #Science #Immunology: Justin Zhang, Jamie Rossjohn, @pzareie.bsky.social, @niclag.bsky.social, & al. generate LCK-FREE mice expressing mutated form of endogenous LCK that cannot bind to #CD4 or #CD8. These animals show defects in #TCell lineage fidelity & antigen-specific #TCR diversity!

This week in @science.org! Check it out!